Aliases for NGFR Gene
Aliases for NGFR Gene
External Ids for NGFR Gene
- HGNC: 7809
- Entrez Gene: 4804
- Ensembl: ENSG00000064300
- OMIM: 162010
- UniProtKB: P08138
Previous GeneCards Identifiers for NGFR Gene
- GC17P047283
- GC17P050052
- GC17P047914
- GC17P048047
- GC17P044927
- GC17P047572
- GC17P042937
Summaries for NGFR Gene
-
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]
GeneCards Summary for NGFR Gene
NGFR (Nerve Growth Factor Receptor) is a Protein Coding gene. Diseases associated with NGFR include Infiltrative Basal Cell Carcinoma and Prurigo Nodularis. Among its related pathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and Akt Signaling. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and transmembrane signaling receptor activity.
UniProtKB/Swiss-Prot for NGFR Gene
-
Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.
-
Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3K and PLCgamma signaling pathways. Four members of the Trk family have been identified.
Additional gene information for NGFR Gene
- Monarch Initiative
- Search for NGFR at DataMed
- Search for NGFR at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NGFR Gene
Genomics for NGFR Gene
GeneHancer (GH) Regulatory Elements for NGFR Gene
Promoters and enhancers for NGFR Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH17J049494 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE | 650.7 | 0.0 | -3 | 0.6 | ZNF335 GLIS2 ZNF143 KLF7 SP3 ZBTB11 REST ZNF398 KLF16 ZBTB26 | NGFR ENSG00000279036 LINC02075 | |
| GH17J049496 | Enhancer | 0.8 | ENCODE | 650.7 | +1.3 | 1281 | 0.2 | ATF1 RB1 SIN3A KLF14 RAD21 YY1 ZNF335 GLIS2 ZNF143 CREM | ENSG00000279036 NGFR | |
| GH17J049495 | Enhancer | 0.3 | ENCODE | 650.7 | -0.9 | -899 | 0.2 | ZSCAN4 | NGFR ENSG00000279036 LINC02075 | |
| GH17J049469 | Enhancer | 0.7 | Ensembl ENCODE | 12.8 | -24.4 | -24381 | 2.3 | KLF1 NFIC ZFP36 RCOR1 ZIC2 CHD2 | NGFR PHB ENSG00000250186 RPL21P124 DLX3 ENSG00000248172 LINC02075 ENSG00000262039 | |
| GH17J049519 | Enhancer | 0.5 | ENCODE | 17.5 | +26.0 | 25968 | 3.7 | GATA3 POLR2A IKZF1 RCOR1 GATAD2B CHD2 | NGFR PHB ENSG00000250186 RPL21P124 NXPH3 LOC100288866 ENSG00000248172 DLX3 MIR6165 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around NGFR on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the NGFR gene promoter:
-
- AP-1
- c-Jun
- ATF-2
- AP-2alpha
- AP-2alpha isoform 2
- AP-2alpha isoform 3
- AP-2alpha isoform 4
- AP-2alphaA
Regulatory Element Products
Genomic Locations for NGFR Gene
Genomic Locations for NGFR Gene
- chr17:49,495,293-49,515,020
- (GRCh38/hg38)
- Size:
- 19,728 bases
- Orientation:
- Plus strand
- chr17:47,572,655-47,592,382
- (GRCh37/hg19)
- Size:
- 19,728 bases
- Orientation:
- Plus strand
Genomic View for NGFR Gene
Genes around NGFR on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.33 by Entrez Gene
- 17q21.33 by HGNC
- 17q21.33 by Ensembl
NGFR Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NGFR Gene
Proteins for NGFR Gene
-
Protein details for NGFR Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P08138-TNR16_HUMAN
- Recommended name:
- Tumor necrosis factor receptor superfamily member 16
- Protein Accession:
- P08138
- B2R961
- B4E096
Protein attributes for NGFR Gene
- Size:
- 427 amino acids
- Molecular mass:
- 45183 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with RTN4R. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor. Interacts (via death domain) with RAB31. Interacts with LINGO1 and NRADD. Interacts with MAGED1; the interaction antagonizes the association NGFR:NTRK1.
Three dimensional structures from OCA and Proteopedia for NGFR Gene
Protein Expression for NGFR Gene
Post-translational modifications for NGFR Gene
- N- and O-glycosylated.
- O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.
- Phosphorylated on serine residues.
- Glycosylation at Asn60
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- TNR16_HUMAN (611)
Other Protein References for NGFR Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for NGFR (NGF R/TNFRSF16)
-
Custom Antibody ServicesOriGene Antibodies for NGFR
- Novus Biologicals Antibodies for NGFR
-
Abcam antibodies for NGFR
- Invitrogen Antibodies for NGFR (AFLGC-NGFR)
- antibodies-online: Search results for 300 available NGFR Antibodies ranked by validation data
- Compare Top NGFR Antibodies
-
Recommended
- 179 WB Antibodies (anti-human)
- 21 FACS Antibodies (anti-human)
- 17 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 9 IHC Antibodies (anti-human)
- 4 ICFC Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 81 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 76 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- GeneTex NGFR Antibody for NGFR
-
Custom Antibody ServicesProSci Antibodies for NGFR
-
Santa Cruz Biotechnology (SCBT) Antibodies for NGFR
- Sino Biological Antibodies for NGFR
Protein Products
- R&D Systems Proteins and Enzymes for NGFR (NGF R/TNFRSF16)
-
OriGene Purified Proteins for NGFR
- Search Origene for MassSpec and Protein Over-expression Lysates for NGFR
- Origene Custom Protein Services for NGFR
- Sino Biological Recombinant Proteins for NGFR
- Sino Biological Cell Lysates for NGFR
- ProSpec Recombinant Proteins for NGFR
- Search GeneTex for Proteins for NGFR
-
ProSci Proteins for NGFR
-
Abcam proteins for NGFR
Assay Products
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for NGFR (NGF R/TNFRSF16)
-
Boster Bio ELISA Kits for NGFR
-
Abcam assays for NGFR
No data available for DME Specific Peptides for NGFR Gene
Domains & Families for NGFR Gene
Gene Families for NGFR Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for NGFR Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for NGFR Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P08138- Domain:
-
- Death domain is responsible for interaction with RANBP9.
- The extracellular domain is responsible for interaction with NTRK1.
Function for NGFR Gene
Molecular function for NGFR Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.
- GENATLAS Biochemistry:
- nerve growth factor receptor p75,low affinity (tumor necrosis factor receptor,TNFR superfamily,member 16),see also NTRK1
Phenotypes From GWAS Catalog for NGFR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004888 | transmembrane signaling receptor activity | TAS | 1846035 |
| GO:0005031 | tumor necrosis factor-activated receptor activity | IBA | -- |
| GO:0005035 | death receptor activity | IGI | 11927634 |
| GO:0005515 | protein binding | IPI | 11756426 |
| GO:0005516 | calmodulin binding | IDA | 24914971 |
Phenotypes for NGFR Gene
- MGI mutant phenotypes for NGFR:
-
inferred from 7 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- limbs/digits/tail phenotype
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- integument phenotype
- taste/olfaction phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- craniofacial phenotype
- liver/biliary system phenotype
- skeleton phenotype
- normal phenotype
- hearing/vestibular/ear phenotype
- renal/urinary system phenotype
- adipose tissue phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for NGFR:
Animal Models for NGFR Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for NGFR
-
CRISPR Products
-
OriGene CRISPR knockouts for NGFR
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NGFR
- genomics-online: gRNA clones - Search results for 108 available NGFR gene related products
- Overview of 108 available NGFR gene related products
- Applied Biological Materials CRISPR for NGFR
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NGFR
- GenScript: Design CRISPR guide RNA sequences for NGFR
miRNA for NGFR Gene
- miRTarBase miRNAs that target NGFR
-
- hsa-mir-335-5p (MIRT016762)
- hsa-mir-3978 (MIRT472210)
- hsa-mir-6745 (MIRT472211)
- hsa-mir-363-5p (MIRT472212)
- hsa-mir-4651 (MIRT472213)
- hsa-mir-608 (MIRT472214)
- hsa-mir-7110-5p (MIRT472215)
- hsa-mir-6842-5p (MIRT472216)
- hsa-mir-6752-5p (MIRT472217)
- hsa-mir-6785-5p (MIRT472218)
- hsa-mir-6883-5p (MIRT472219)
- hsa-mir-4728-5p (MIRT472220)
- hsa-mir-149-3p (MIRT472221)
- hsa-mir-7113-5p (MIRT472222)
- hsa-mir-6754-5p (MIRT472223)
- hsa-mir-4270 (MIRT472224)
- hsa-mir-4441 (MIRT472225)
- hsa-mir-1972 (MIRT472226)
- hsa-mir-6732-5p (MIRT472227)
- hsa-mir-4756-5p (MIRT472228)
- hsa-mir-4739 (MIRT472229)
- hsa-mir-1321 (MIRT472230)
- hsa-mir-6507-3p (MIRT472231)
- hsa-mir-296-5p (MIRT734977)
- hsa-mir-133a-3p (MIRT734978)
- hsa-mir-1275 (MIRT736928)
- hsa-mir-1909-3p (MIRT738361)
- hsa-mir-2392 (MIRT739172)
- hsa-mir-3179 (MIRT740740)
- hsa-mir-3202 (MIRT741156)
- hsa-mir-3605-5p (MIRT741514)
- hsa-mir-4525 (MIRT745917)
- hsa-mir-4665-5p (MIRT746766)
- hsa-mir-4723-5p (MIRT747659)
- hsa-mir-4747-5p (MIRT748256)
- hsa-mir-5010-5p (MIRT749499)
- hsa-mir-5196-5p (MIRT750040)
- hsa-mir-5698 (MIRT751292)
- hsa-mir-6132 (MIRT752322)
- hsa-mir-625-5p (MIRT752598)
- hsa-mir-6511b-5p (MIRT753204)
- hsa-mir-6516-5p (MIRT753354)
- hsa-mir-6722-3p (MIRT753874)
- hsa-mir-6811-5p (MIRT756691)
- hsa-mir-6825-5p (MIRT757001)
- hsa-mir-6836-5p (MIRT757216)
- hsa-mir-6870-5p (MIRT757992)
- hsa-mir-6894-5p (MIRT758781)
- hsa-mir-7106-5p (MIRT758876)
- hsa-mir-7111-5p (MIRT759049)
- hsa-mir-9500 (MIRT760895)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NGFR
- Browse OriGene Inhibitory RNA Products For NGFR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NGFR
- genomics-online: shRNA clones - Search results for 108 available NGFR gene related products
- Overview of 108 available NGFR gene related products
Clone Products
- Sino Biological Human cDNA Clone for NGFR
- Addgene plasmids for NGFR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NGFR
- Applied Biological Materials Clones for NGFR
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for NGFR (NGF R/TNFRSF16)
Cell Line Products
-
Horizon Cell Lines for NGFR
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NGFR Gene
Localization for NGFR Gene
Subcellular locations from UniProtKB/Swiss-Prot for NGFR Gene
- Membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| endosome | 5 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005634 | nucleus | IBA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005768 | endosome | TAS | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for NGFR Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | p75 NTR receptor-mediated signalling | ||
| 2 | Apoptotic Pathways in Synovial Fibroblasts |
.74
|
.66
.65
.61
.60
|
| 3 | PEDF Induced Signaling |
.47
|
|
| 4 | TGF-Beta Pathway |
.60
|
.57
.51
|
| 5 | Development HGF signaling pathway | ||
Pathways by source for NGFR Gene
1 Sino Biological pathway for NGFR Gene
5 BioSystems pathways for NGFR Gene
17 Reactome pathways for NGFR Gene
8 KEGG pathways for NGFR Gene
5 GeneGo (Thomson Reuters) pathways for NGFR Gene
1 R&D Systems pathway for NGFR Gene
3 Tocris pathways for NGFR Gene
47 Qiagen pathways for NGFR Gene
1 Cell Signaling Technology pathway for NGFR Gene
Interacting Proteins for NGFR Gene
Selected Interacting proteins:
P08138-TNR16_HUMAN
ENSP00000172229
for NGFR Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for NGFR
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006886 | intracellular protein transport | ISS | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | TAS | -- |
| GO:0006954 | inflammatory response | IBA | -- |
| GO:0006955 | immune response | IBA | -- |
Drugs & Compounds for NGFR Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Fludarabine | Approved | Pharma | DNA synthsis inhibitor | 1231,1231 | ||
| Aldesleukin | Approved | Pharma | 419 | |||
| Cyclophosphamide | Approved, Investigational | Pharma | Nitrogen mustard alkylating agent and prodrug. | 3113 | ||
| Mesna | Approved, Investigational | Pharma | 275 | |||
| Vidarabine | Approved, Investigational | Pharma | 542 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| AG 879 |
|
148741-30-4 |
|
|
||
| LM11A 31 dihydrochloride |
|
1243259-19-9 |
|
|
(4) Tocris Compounds for NGFR Gene
| Compound | Action | Cas Number |
|---|---|---|
| AG 879 | TrkA inhibitor | 148741-30-4 |
| BDNF (human) | Activates TrkB and p75 receptors | 218441-99-7 |
| LM11A 31 dihydrochloride | Nonpeptide p75NTR ligand; neuroprotective | 1243259-19-9 |
| TLQP 21 | VGF-derived peptide | 869988-94-3 |
Drug Products
Transcripts for NGFR Gene
mRNA/cDNA for NGFR Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (81) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000172229 3417 bps (uc002ioz.5)
- ENST00000509200 703 bps (uc060hbg.1)
- ENST00000504201 1840 bps (uc060hbh.1)
Unigene Clusters for NGFR Gene
CRISPR Products
-
OriGene CRISPR knockouts for NGFR
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NGFR
- genomics-online: gRNA clones - Search results for 108 available NGFR gene related products
- Overview of 108 available NGFR gene related products
- Applied Biological Materials CRISPR for NGFR
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NGFR
- GenScript: Design CRISPR guide RNA sequences for NGFR
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NGFR
- Browse OriGene Inhibitory RNA Products For NGFR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NGFR
- genomics-online: shRNA clones - Search results for 108 available NGFR gene related products
- Overview of 108 available NGFR gene related products
Clone Products
- Sino Biological Human cDNA Clone for NGFR
- Addgene plasmids for NGFR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NGFR
- Applied Biological Materials Clones for NGFR
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for NGFR (NGF R/TNFRSF16)
Expression for NGFR Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Peripheral Nervous System (Nervous System)
- Immature Schwann Cells Peripheral Nerve Domain
- Schwann Precursor Cells Peripheral Nerve Domain
- Schwann cells
- Schwann cells
- Schwann-like cells(Chi GF et. al. 2010)
- Glial Cells (Uncategorized)
- Neural Crest (Gastrulation Derivatives)
-
Mesenchymal Stem Cells
- Bone Marrow Stromal Cells Pelvic Girdle
- Bone Marrow Stromal Cells Bone Marrow
- Dental Pulp Stem Cells Dental Pulp
-
Gonad
- Developing Peritubular Myoid Cells Testis Cord
- Mesonephric cells Mesonephros
-
Testis (Reproductive System)
- Developing Peritubular Myoid Cells Testis Cord
-
Eye (Sensory Organs)
- Limbal Basal Epithelial Cells Limbus Epithelium
-
Epithelial Cells
- Limbal Basal Epithelial Cells Limbus Epithelium
-
Limb (Muscoskeletal System)
- Bone Marrow Stromal Cells Pelvic Girdle
-
Intermediate Mesoderm (Gastrulation Derivatives)
- Mesonephric cells Mesonephros
-
Bone (Muscoskeletal System)
- Bone Marrow Stromal Cells Bone Marrow
-
Cartilage (Muscoskeletal System)
- Bone Marrow Stromal Cells Bone Marrow
-
Tooth (Integumentary System)
- Dental Pulp Stem Cells Dental Pulp
- Brain (Nervous System)
- Lung (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for NGFR Gene
This gene is overexpressed in Nerve - Tibial (x9.4).
This gene is overexpressed in Retina (39.4) and Fetal testis (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NGFR Gene
NURSA nuclear receptor signaling pathways regulating expression of NGFR Gene:
NGFRSOURCE GeneReport for Unigene cluster for NGFR Gene:
Hs.415768Evidence on tissue expression from TISSUES for NGFR Gene
- Nervous system(4.8)
- Eye(4.3)
- Liver(4.3)
- Adrenal gland(2.6)
- Muscle(2.2)
- Heart(2.1)
- Skin(2.1)
Primer Products
-
OriGene qPCR primer pairs for NGFR
-
OriGene qPCR primer pairs and template standards for NGFR
- genomics-online: primer clones - Search results for 108 available NGFR gene related products
- Overview of 108 available NGFR gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NGFR Gene
Orthologs for NGFR Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NGFR 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | NGFR 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | NGFR 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ngfr 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ngfr 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | NGFR 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | NGFR 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NGFR 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | NGFR 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100493992 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | p75NTRa 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ngfrb 34 34 33 |
|
OneToMany | |
| NGFR (2 of 3) 34 |
|
OneToMany |
- Species where no ortholog for NGFR was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for NGFR Gene
- ENSEMBL:
- Gene Tree for NGFR (if available)
- TreeFam:
- Gene Tree for NGFR (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NGFR: view image
Paralogs for NGFR Gene
No data available for Paralogs for NGFR Gene
Variants for NGFR Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000066714 | -- | 49,504,900(+) | T/C | intron_variant | |
| rs1000072361 | -- | 49,502,355(+) | G/A | intron_variant | |
| rs1000089383 | -- | 49,495,259(+) | C/T | upstream_transcript_variant | |
| rs1000155098 | -- | 49,496,560(+) | C/A | intron_variant | |
| rs1000224647 | -- | 49,501,773(+) | T/C | intron_variant |
Residual Variation Intolerance Score:
27.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.64;
56.79% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NGFR Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NGFR Gene
Disorders for NGFR Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| infiltrative basal cell carcinoma |
|
|
| prurigo nodularis |
|
|
| anhidrosis |
|
|
| olfactory neuroblastoma |
|
|
| skin sarcoma |
|
|
Search NGFR in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NGFR
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for NGFR Gene
Publications for NGFR Gene
- SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population. (PMID: 18780967) Cozza A … Pellegrini S (Journal of Alzheimer's disease : JAD 2008) 3 22 44 58
- TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. (PMID: 10514511) Ye X … Bredesen DE (The Journal of biological chemistry 1999) 3 4 22 58
- Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation. (PMID: 10544233) Irie S … Sato TA (FEBS letters 1999) 3 4 22 58
- Expression and structure of the human NGF receptor. (PMID: 3022937) Johnson D … Chao M (Cell 1986) 2 3 4 58
- Role of the neurotrophin network in eating disorders' subphenotypes: body mass index and age at onset of the disease. (PMID: 20219210) Gratacòs M … Estivill X (Journal of psychiatric research 2010) 3 44 58
Products for NGFR Gene
- R&D Systems Antibodies for NGFR (NGF R/TNFRSF16)
- R&D Systems Proteins and Enzymes for NGFR (NGF R/TNFRSF16)
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for NGFR (NGF R/TNFRSF16)
- R&D Systems cDNA Clones for NGFR (NGF R/TNFRSF16)
- Browse Human Proteins and Enzymes
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- Custom Antibody ServicesOriGene Antibodies for NGFR
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for NGFR
- Search Origene for MassSpec and Protein Over-expression Lysates for NGFR
- Origene Custom Protein Services for NGFR
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NGFR
- Browse OriGene Inhibitory RNA Products For NGFR
- OriGene qPCR primer pairs for NGFR
- OriGene qPCR primer pairs and template standards for NGFR
- OriGene CRISPR knockouts for NGFR
- OriGene ORF clones in human for NGFR
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NGFR
- GenScript: Next-day shipping of latest version cDNA ORF clones for NGFR in any vector
- GenScript Custom Purified and Recombinant Proteins Services for NGFR
- GenScript Custom Assay Services for NGFR
- GenScript Custom overexpressing Cell Line Services for NGFR
- GenScript: Design CRISPR guide RNA sequences for NGFR
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for NGFR
- Sino Biological Human cDNA Clone for NGFR
- Sino Biological Recombinant Proteins for NGFR
- Sino Biological Cell Lysates for NGFR
- Sino Biological Antibodies for NGFR
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for NGFR
- Novus Biologicals lysates and proteins for NGFR
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
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- Abcam antibodies for NGFR
- Abcam proteins for NGFR
- Abcam assays for NGFR
- Find your target
- Browse Primary Antibodies
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- ProSpec Recombinant Proteins for NGFR
- Invitrogen Antibodies for NGFR (AFLGC-NGFR)
- Cyagen custom Knockout/knockin (KOKI) mouse models for NGFR
- Addgene plasmids for NGFR
- antibodies-online: Search results for 300 available NGFR Antibodies ranked by validation data
- Compare Top NGFR Antibodies
- Recommended
- 179 WB Antibodies (anti-human)
- 21 FACS Antibodies (anti-human)
- 17 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 9 IHC Antibodies (anti-human)
- 4 ICFC Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 81 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 76 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- antibodies-online: Search results for 15 available NGFR Elisa Kits ranked by validation data
- Compare Top NGFR Elisa Kits
- antibodies-online: Search results for 23 available NGFR Proteins ranked by validation data
- Compare Top NGFR Proteins
- GeneTex NGFR Antibody for NGFR
- Search GeneTex for Proteins for NGFR
- Santa Cruz Biotechnology (SCBT) Antibodies for NGFR
- Search Santa Cruz Biotechnology (SCBT) for NGFR siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NGFR
- Custom Antibody ServicesProSci Antibodies for NGFR
- ProSci Proteins for NGFR
- Horizon Cell Lines for NGFR
- genomics-online: cdna clones - Search results for 108 available NGFR gene related products
- Overview of 108 available NGFR gene related products
- orf clones - Search results for 108 available NGFR gene related products
- Overview of 108 available NGFR gene related products
- genomics-online: gRNA clones - Search results for 108 available NGFR gene related products
- Overview of 108 available NGFR gene related products
- genomics-online: primer clones - Search results for 108 available NGFR gene related products
- Overview of 108 available NGFR gene related products
- genomics-online: shRNA clones - Search results for 108 available NGFR gene related products
- Overview of 108 available NGFR gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NGFR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NGFR
- GeneCopoeia miRNA 3'UTR Target clone products for NGFR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NGFR
Sources for NGFR Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt