Free for academic non-profit institutions. Other users need a Commercial license
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008] See more...
Aliases for NGFR Gene
Aliases for NGFR Gene
External Ids for NGFR Gene
- HGNC: 7809
- NCBI Entrez Gene: 4804
- Ensembl: ENSG00000064300
- OMIM®: 162010
- UniProtKB/Swiss-Prot: P08138
Previous GeneCards Identifiers for NGFR Gene
- GC17P047283
- GC17P050052
- GC17P047914
- GC17P048047
- GC17P044927
- GC17P047572
- GC17P042937
Summaries for NGFR Gene
-
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]
GeneCards Summary for NGFR Gene
NGFR (Nerve Growth Factor Receptor) is a Protein Coding gene. Diseases associated with NGFR include Prurigo Nodularis and Infiltrative Basal Cell Carcinoma. Among its related pathways are p75 NTR receptor-mediated signalling and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and transmembrane signaling receptor activity. An important paralog of this gene is TNFRSF11A.
UniProtKB/Swiss-Prot Summary for NGFR Gene
-
Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138).
-
Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3K and PLCgamma signaling pathways. Four members of the Trk family have been identified.
Additional gene information for NGFR Gene
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NGFR Gene
Genomics for NGFR Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NGFR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NGFR on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NGFR
- Top Transcription factor binding sites by QIAGEN in the NGFR gene promoter:
-
- AP-1
- AP-2alpha
- AP-2alpha isoform 2
- AP-2alpha isoform 3
- AP-2alpha isoform 4
- AP-2alphaA
- ATF-2
- c-Jun
Genomic Locations for NGFR Gene
Latest Assembly
- chr17:49,495,293-49,515,008
- (GRCh38/hg38)
- Size:
- 19,716 bases
- Orientation:
- Plus strand
Previous Assembly
- chr17:47,572,655-47,592,370
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 19,716 bases
- Orientation:
- Plus strand
Genomic View for NGFR Gene
Genes around NGFR on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.33 by HGNC
- 17q21.33 by Entrez Gene
- 17q21.33 by Ensembl
NGFR Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NGFR Gene
Proteins for NGFR Gene
-
Protein details for NGFR Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P08138-TNR16_HUMAN
- Recommended name:
- Tumor necrosis factor receptor superfamily member 16
- Protein Accession:
- P08138
- B2R961
- B4E096
Protein attributes for NGFR Gene
- Size:
- 427 amino acids
- Molecular mass:
- 45183 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked (By similarity). Heterodimer with SORCS2. The extracellular domains of the heterodimer bind NGF (PubMed:22155786, PubMed:24908487). The cytoplasmic region of the heterodimer binds TRIO. NGF binding mediates dissociation of TRIO from the receptor complex (PubMed:22155786). Interacts with RTN4R (PubMed:19052207). Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9 (PubMed:10514511, PubMed:9915784, PubMed:10544233, PubMed:12963025). Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1 (PubMed:11244088). Interacts with BEX1 (By similarity). Interacts with BEX3 (By similarity). Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor (By similarity). Interacts (via death domain) with RAB31 (By similarity). Interacts with LINGO1 (PubMed:14966521). Interacts with NRADD (By similarity). Interacts with MAGED1; the interaction antagonizes the association NGFR:NTRK1 (By similarity). Interacts (via death domain) with ARHGDIA and RIPK2 (PubMed:26646181).
Three dimensional structures from OCA and Proteopedia for NGFR Gene
Protein Expression for NGFR Gene
Post-translational modifications for NGFR Gene
Other Protein References for NGFR Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences NGFR / CD271 / TNR16 Antibody and NGFR / CD271 / TNR16 Monoclonal Antibody
-
BioLegend
- CD271 (NGFR) Antibody (345103)
- CD271 (NGFR) Antibody (345102)
- CD271 (NGFR) Antibody (345104)
- CD271 (NGFR) Antibody (345101)
- CD271 (NGFR) Antibody (345106)
- CD271 (NGFR) Antibody (345105)
- CD271 (NGFR) Antibody (345107)
- CD271 (NGFR) Antibody (345108)
- CD271 (NGFR) Antibody (345110)
- CD271 (NGFR) Antibody (345109)
- PerCP/Cyanine5.5 CD271 (NGFR) Antibody (345112)
- PerCP/Cyanine5.5 CD271 (NGFR) Antibody (345111)
- Purified anti-human CD271 (p75NTR)
- Anti-CD271 (p75NTR)
- CD271 (NGFR) Antibody (345114)
- CD271 (NGFR) Antibody (345113)
- CD271 (NGFR) Antibody (345118)
- CD271 (NGFR) Antibody (345119)
- APC/Fire(TM) 750 CD271 (NGFR) Antibody (345116)
- CD271 (NGFR) Antibody (345117)
- APC/Fire(TM) 750 CD271 (NGFR) Antibody (345115)
- CD271 (NGFR) Antibody (345120)
-
Custom Antibody ServicesOriGene Antibodies for NGFR
- AM00235BT-N
- AM00235PU-N
- AM06398SU-N
- AM10123SU-N
- AM31842AC-N
- AM31842BT-N
- AM31842FC-N
- AM31842PU-N
- AM31842RP-N
- AP05556PU-N
- AP07713PU-N
- AP20406PU-N
- AP31775PU-N
- CF812984
- CF812986
- CF812989
- CF812990
- CF812991
- CF812998
- CF812999
- TA303032
- TA306246
- TA323002
- TA323003
- TA326223
- TA327268
- TA327714
- TA328682
- TA328683
- TA328684
- TA336800
- TA347559
- TA812984
- TA812984S
- TA812986
- TA812986S
- TA812989
- TA812989S
- TA812990
- TA812990S
- TA812991
- TA812991S
- TA812998
- TA812998S
- TA812999
- TA812999S
- TA890037
- TA890037S
- Novus Biologicals Antibodies for NGFR
-
Abcam antibodies for NGFR
- Invitrogen Antibodies for NGFR (AFLGC-Ngfr)
- antibodies-online: Show 103 available NGFR Antibodies ranked by validation data
- Compare Top NGFR Antibodies
-
Recommended
- 207 WB Antibodies (anti-human)
- 63 IHC (f) Antibodies (anti-human)
- 32 IHC (p) Antibodies (anti-human)
- 18 FACS Antibodies (anti-human)
- 18 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 ICFC Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 99 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 6 IHC (p) Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 93 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
-
Custom Antibody ServicesProSci Antibodies for NGFR
-
Santa Cruz Biotechnology (SCBT) Antibodies for NGFR
- Sino Biological Antibodies for NGFR
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for NGFR
- Origene Custom Protein Services for NGFR
- Sino Biological Recombinant Proteins for NGFR
- Sino Biological Cell Lysates for NGFR
- ProSpec Recombinant Proteins for NGFR
-
Abcam proteins for NGFR
Assay products for research
- G Biosciences Immunotag™ Human NGFR (p75 neurotrophin receptor) ELISA
- RayBiotech Human NGF R ELISA
-
Custom Assay ServicesOriGene ELISA Kits for NGFR
-
Abcam assays for NGFR
No data available for DME Specific Peptides for NGFR Gene
Domains & Families for NGFR Gene
Gene Families for NGFR Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for NGFR Gene
- InterPro:
- Blocks:
-
- TNFR/CD27/30/40/95 cysteine-rich region
- Death domain
Suggested Antigen Peptide Sequences for NGFR Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ51424, highly similar to Tumor necrosis factor receptor superfamilymember 16 (B4E096_HUMAN)
- p75 ICD (TNR16_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P08138UniProtKB/Swiss-Prot:
TNR16_HUMAN :- The death domain mediates interaction with RANBP9 (By similarity). It also mediates interaction with ARHGDIA and RIPK2 (PubMed:26646181).
- Domain:
-
- The death domain mediates interaction with RANBP9 (By similarity). It also mediates interaction with ARHGDIA and RIPK2 (PubMed:26646181).
- The extracellular domain is responsible for interaction with NTRK1.
Function for NGFR Gene
Molecular function for NGFR Gene
- UniProtKB/Swiss-Prot Function:
- Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138).
- GENATLAS Biochemistry:
- nerve growth factor receptor p75,low affinity (tumor necrosis factor receptor,TNFR superfamily,member 16),see also NTRK1
Phenotypes From GWAS Catalog for NGFR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001540 | amyloid-beta binding | TAS | 26871627 |
| GO:0004888 | transmembrane signaling receptor activity | TAS | 1846035 |
| GO:0005035 | death receptor activity | IBA,IGI | 11927634 |
| GO:0005515 | protein binding | IPI | 11756426 |
| GO:0005516 | calmodulin binding | IDA | 24914971 |
Phenotypes for NGFR Gene
- MGI mutant phenotypes for NGFR:
-
inferred from 7 alleles
- normal phenotype
- nervous system phenotype
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cellular phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- immune system phenotype
- respiratory system phenotype
- mortality/aging
- renal/urinary system phenotype
- liver/biliary system phenotype
- hematopoietic system phenotype
- digestive/alimentary phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- integument phenotype
- craniofacial phenotype
- adipose tissue phenotype
- taste/olfaction phenotype
- GenomeRNAi human phenotypes for NGFR:
Animal Models for NGFR Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for NGFR - Starting at $85 >
- * NGFR CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for NGFR
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NGFR
-
Santa Cruz Biotechnology (SCBT) CRISPR for NGFR
miRNA for NGFR Gene
- miRTarBase miRNAs that target NGFR
-
- hsa-miR-335-5p (MIRT016762)
- hsa-miR-3978 (MIRT472210)
- hsa-miR-6745 (MIRT472211)
- hsa-miR-363-5p (MIRT472212)
- hsa-miR-4651 (MIRT472213)
- hsa-miR-608 (MIRT472214)
- hsa-miR-7110-5p (MIRT472215)
- hsa-miR-6842-5p (MIRT472216)
- hsa-miR-6752-5p (MIRT472217)
- hsa-miR-6785-5p (MIRT472218)
- hsa-miR-6883-5p (MIRT472219)
- hsa-miR-4728-5p (MIRT472220)
- hsa-miR-149-3p (MIRT472221)
- hsa-miR-7113-5p (MIRT472222)
- hsa-miR-6754-5p (MIRT472223)
- hsa-miR-4270 (MIRT472224)
- hsa-miR-4441 (MIRT472225)
- hsa-miR-1972 (MIRT472226)
- hsa-miR-6732-5p (MIRT472227)
- hsa-miR-4756-5p (MIRT472228)
- hsa-miR-4739 (MIRT472229)
- hsa-miR-1321 (MIRT472230)
- hsa-miR-6507-3p (MIRT472231)
- mmu-miR-466l-5p (MIRT591790)
- mmu-miR-3102-5p (MIRT591791)
- mmu-miR-466i-5p (MIRT591792)
- mmu-miR-466k (MIRT591793)
- mmu-miR-466d-5p (MIRT591794)
- mmu-miR-1968-5p (MIRT600590)
- mmu-miR-5102 (MIRT600591)
- hsa-miR-296-5p (MIRT734977)
- hsa-miR-133a-3p (MIRT734978)
- hsa-miR-1275 (MIRT736928)
- hsa-miR-1909-3p (MIRT738361)
- hsa-miR-2392 (MIRT739172)
- hsa-miR-3179 (MIRT740740)
- hsa-miR-3202 (MIRT741156)
- hsa-miR-3605-5p (MIRT741514)
- hsa-miR-4525 (MIRT745917)
- hsa-miR-4665-5p (MIRT746766)
- hsa-miR-4723-5p (MIRT747659)
- hsa-miR-4747-5p (MIRT748256)
- hsa-miR-5010-5p (MIRT749499)
- hsa-miR-5196-5p (MIRT750040)
- hsa-miR-5698 (MIRT751292)
- hsa-miR-6132 (MIRT752322)
- hsa-miR-625-5p (MIRT752598)
- hsa-miR-6511b-5p (MIRT753204)
- hsa-miR-6516-5p (MIRT753354)
- hsa-miR-6722-3p (MIRT753874)
- hsa-miR-6811-5p (MIRT756691)
- hsa-miR-6825-5p (MIRT757001)
- hsa-miR-6836-5p (MIRT757216)
- hsa-miR-6870-5p (MIRT757992)
- hsa-miR-6894-5p (MIRT758781)
- hsa-miR-7106-5p (MIRT758876)
- hsa-miR-7111-5p (MIRT759049)
- hsa-miR-9500 (MIRT760895)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NGFR
- Browse OriGene Inhibitory RNA Products For NGFR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NGFR
Clone products for research
- Applied Biological Materials (abm): Clones for NGFR - Starting at $45 >
- * NGFR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for NGFR
- Addgene plasmids for NGFR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NGFR
Cell Lines for research
-
Horizon Cell Lines for NGFR
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NGFR Gene
Localization for NGFR Gene
Subcellular locations from UniProtKB/Swiss-Prot for NGFR Gene
- Cell membrane. Single-pass type I membrane protein. Perikaryon. Cell projection, growth cone. Cell projection, dendritic spine.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 5 |
| endosome | 4 |
| cytosol | 4 |
| cytoskeleton | 3 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
- Plasma membrane (3)
- Nucleoplasm (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005768 | endosome | TAS | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for NGFR Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | p75 NTR receptor-mediated signalling | ||
| 2 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
|
PPAR Pathway
.66
Rac1 Pathway
.65
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Nuclear Receptor Activation by Vitamin-A
.57
|
| 3 | PEDF Induced Signaling |
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
|
Glucocorticoid Receptor Signaling
.43
|
| 4 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
|
JAK-STAT Pathway
.57
JNK Pathway
.51
|
| 5 | Development HGF signaling pathway |
Development Neurotrophin family signaling
.44
Apoptosis and survival Role of CDK5 in neuronal death and survival
.37
|
|
Pathways by source for NGFR Gene
1 Sino Biological pathway for NGFR Gene
5 BioSystems pathways for NGFR Gene
17 Reactome pathways for NGFR Gene
8 KEGG pathways for NGFR Gene
5 GeneGo (Thomson Reuters) pathways for NGFR Gene
- Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
- Apoptosis and survival Apoptotic TNF-family pathways
- Apoptosis and survival Role of CDK5 in neuronal death and survival
- Development MAG-dependent inhibition of neurite outgrowth
- Development Neurotrophin family signaling
3 R&D Systems pathways for NGFR Gene
3 Tocris pathways for NGFR Gene
47 Qiagen pathways for NGFR Gene
- 14-3-3 and Regulation of BAD Activity
- Actin-Based Motility by Rho Family GTPases
- Activation of PKC through GPCR
- Akt Signaling
- Antioxidant Action of Vitamin-C
1 Cell Signaling Technology pathway for NGFR Gene
Interacting Proteins for NGFR Gene
Selected Interacting proteins:
P08138-TNR16_HUMAN
ENSP00000172229
for NGFR Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for NGFR
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001678 | cellular glucose homeostasis | ISS | -- |
| GO:0006886 | intracellular protein transport | ISS | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | TAS | -- |
| GO:0007165 | signal transduction | IEA | -- |
Drugs & Compounds for NGFR Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| AG 879 |
|
148741-30-4 |
|
|
||
| LM11A 31 dihydrochloride |
|
1243259-19-9 |
|
|
(4) Tocris Compounds for NGFR Gene
| Compound | Action | Cas Number |
|---|---|---|
| AG 879 | TrkA inhibitor | 148741-30-4 |
| BDNF (human) | Activates TrkB and p75 receptors | 218441-99-7 |
| LM11A 31 dihydrochloride | Nonpeptide p75NTR ligand; neuroprotective | 1243259-19-9 |
| TLQP 21 | VGF-derived peptide | 869988-94-3 |
Drug products for research
Transcripts for NGFR Gene
mRNA/cDNA for NGFR Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000172229 3408 nts (view in UCSC)
- ENST00000504201 1840 nts (view in UCSC)
- ENST00000509200 703 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for NGFR - Starting at $85 >
- * NGFR CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for NGFR
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NGFR
-
Santa Cruz Biotechnology (SCBT) CRISPR for NGFR
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NGFR
- Browse OriGene Inhibitory RNA Products For NGFR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NGFR
Clone products for research
- Applied Biological Materials (abm): Clones for NGFR - Starting at $45 >
- * NGFR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for NGFR
- Addgene plasmids for NGFR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NGFR
Relevant External Links for NGFR Gene
- GeneLoc Exon Structure for
- NGFR
Expression for NGFR Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Peripheral Nervous System (Nervous System)
- Immature Schwann Cells Peripheral Nerve Domain
- Schwann Precursor Cells Peripheral Nerve Domain
- Schwann cells
- Schwann cells
- Schwann-like cells(Chi GF et. al. 2010)
- Glial Cells (Uncategorized)
- Neural Crest (Gastrulation Derivatives)
-
Mesenchymal Stem Cells
- Bone Marrow Stromal Cells Pelvic Girdle
- Bone Marrow Stromal Cells Bone Marrow
- Dental Pulp Stem Cells Dental Pulp
-
Gonad
- Developing Peritubular Myoid Cells Testis Cord
- Mesonephric cells Mesonephros
-
Testis (Reproductive System)
- Developing Peritubular Myoid Cells Testis Cord
-
Eye (Sensory Organs)
- Limbal Basal Epithelial Cells Limbus Epithelium
-
Epithelial Cells
- Limbal Basal Epithelial Cells Limbus Epithelium
-
Limb (Muscoskeletal System)
- Bone Marrow Stromal Cells Pelvic Girdle
-
Intermediate Mesoderm (Gastrulation Derivatives)
- Mesonephric cells Mesonephros
-
Bone (Muscoskeletal System)
- Bone Marrow Stromal Cells Bone Marrow
-
Cartilage (Muscoskeletal System)
- Bone Marrow Stromal Cells Bone Marrow
-
Tooth (Integumentary System)
- Dental Pulp Stem Cells Dental Pulp
- Brain (Nervous System)
- Lung (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for NGFR Gene
This gene is overexpressed in Nerve - Tibial (x9.4).
This gene is overexpressed in Retina (39.4) and Fetal testis (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NGFR Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NGFR
SOURCE GeneReport for Unigene cluster for NGFR Gene:
Hs.415768Evidence on tissue expression from TISSUES for NGFR Gene
- Nervous system(4.8)
- Liver(4.5)
- Eye(4.3)
- Heart(2.7)
- Adrenal gland(2.7)
- Muscle(2.5)
- Skin(2.4)
- Spleen(2.4)
- Blood(2.3)
- Kidney(2.2)
- Bone marrow(2.2)
- Intestine(2.2)
- Lymph node(2.1)
- Bone(2)
Primer products for research
-
OriGene qPCR primer pairs for NGFR
-
OriGene qPCR primer pairs and template standards for NGFR
Gene Expression Assays for research
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NGFR Gene
Orthologs for NGFR Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | NGFR 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | NGFR 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | NGFR 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ngfr 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ngfr 29 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | NGFR 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | NGFR 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | NGFR 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | NGFR 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100493992 29 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | p75NTRa 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ngfrb 29 30 30 |
|
OneToMany | |
| NGFR (2 of 3) 30 |
|
OneToMany |
- Species where no ortholog for NGFR was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for NGFR Gene
- ENSEMBL:
- Gene Tree for NGFR (if available)
- TreeFam:
- Gene Tree for NGFR (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NGFR: view image
- Alliance of Genome Resources:
- Additional Orthologs for NGFR
Paralogs for NGFR Gene
Variants for NGFR Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NGFR Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs116693011 | Benign: not provided | 49,506,423(+) |
C/T NM_002507.4(NGFR):c.333C>T (p.Tyr111=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS | |
| rs140781803 | Benign: not provided | 49,506,485(+) |
C/T NM_002507.4(NGFR):c.395C>T (p.Ser132Leu) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT | |
| rs141901124 | Benign: not provided | 49,511,949(+) |
G/A NM_002507.4(NGFR):c.879G>A (p.Thr293=) |
SYNONYMOUS | |
| rs151178709 | Benign: not provided | 49,512,910(+) |
C/T NM_002507.4(NGFR):c.1185C>T (p.Ser395=) |
SYNONYMOUS | |
| rs1597861987 | Likely Benign: not provided | 49,506,408(+) |
G/A NM_002507.4(NGFR):c.318G>A (p.Val106=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
27.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.64;
56.79% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NGFR Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NGFR Gene
Disorders for NGFR Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| prurigo nodularis |
|
|
| infiltrative basal cell carcinoma |
|
|
| spinal cord injury |
|
|
| anhidrosis |
|
|
| diabetic neuropathy |
|
|
Search NGFR in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NGFR
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for NGFR Gene
Publications for NGFR Gene
- SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population. (PMID: 18780967) Cozza A … Pellegrini S (Journal of Alzheimer's disease : JAD 2008) 3 22 40
- Neurotrophic factor-related gene polymorphisms and adult attention deficit hyperactivity disorder (ADHD) score in a high-risk male population. (PMID: 18428117) Conner AC … Thome J (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 22 40
- TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. (PMID: 10514511) Ye X … Bredesen DE (The Journal of biological chemistry 1999) 3 4 22
- Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation. (PMID: 10544233) Irie S … Sato TA (FEBS letters 1999) 3 4 22
- Expression and structure of the human NGF receptor. (PMID: 3022937) Johnson D … Chao M (Cell 1986) 2 3 4
ExternalLinks
Products for NGFR Gene
- View all 19 R&D Systems NGFR (NGFR/TNFRSF16) Products
- View all R&D Systems NGFR (NGFR/TNFRSF16) Proteins and Enzymes
- View all 14 R&D Systems NGFR (NGFR/TNFRSF16) Primary Antibodies
- View all R&D Systems NGFR (NGFR/TNFRSF16) ELISAs
- View all R&D Systems NGFR (NGFR/TNFRSF16) Simple Plex Assays
- View all R&D Systems NGFR (NGFR/TNFRSF16) Proteome Profiler Antibody Arrays
- View all R&D Systems NGFR (NGFR/TNFRSF16) cDNA Clones
- Learn more about R&D Systems custom NGFR antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for NGFR
- AM00235BT-N
- AM00235PU-N
- AM06398SU-N
- AM10123SU-N
- AM31842AC-N
- AM31842BT-N
- AM31842FC-N
- AM31842PU-N
- AM31842RP-N
- AP05556PU-N
- AP07713PU-N
- AP20406PU-N
- AP31775PU-N
- CF812984
- CF812986
- CF812989
- CF812990
- CF812991
- CF812998
- CF812999
- TA303032
- TA306246
- TA323002
- TA323003
- TA326223
- TA327268
- TA327714
- TA328682
- TA328683
- TA328684
- TA336800
- TA347559
- TA812984
- TA812984S
- TA812986
- TA812986S
- TA812989
- TA812989S
- TA812990
- TA812990S
- TA812991
- TA812991S
- TA812998
- TA812998S
- TA812999
- TA812999S
- TA890037
- TA890037S
- Custom Assay ServicesOriGene ELISA Kits for NGFR
- Search Origene for MassSpec and Protein Over-expression Lysates for NGFR
- Origene Custom Protein Services for NGFR
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NGFR
- Browse OriGene Inhibitory RNA Products For NGFR
- OriGene qPCR primer pairs for NGFR
- OriGene qPCR primer pairs and template standards for NGFR
- OriGene CRISPR knockouts for NGFR
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NGFR
- Sino Biological Human cDNA Clone for NGFR
- Sino Biological Recombinant Proteins for NGFR
- Sino Biological Cell Lysates for NGFR
- Sino Biological Antibodies for NGFR
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for NGFR
- Novus Biologicals proteins and lysates for NGFR
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for NGFR
- Abcam proteins for NGFR
- Abcam assays for NGFR
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for NGFR (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for NGFR (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for NGFR (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for NGFR CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for NGFR
- Addgene plasmids for NGFR
- antibodies-online: Show 103 available NGFR Antibodies ranked by validation data
- Compare Top NGFR Antibodies
- Recommended
- 207 WB Antibodies (anti-human)
- 63 IHC (f) Antibodies (anti-human)
- 32 IHC (p) Antibodies (anti-human)
- 18 FACS Antibodies (anti-human)
- 18 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 ICFC Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 99 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 6 IHC (p) Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 93 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- antibodies-online: Show 25 available NGFR Elisa Kits ranked by validation data
- Compare Top NGFR Elisa Kits
- antibodies-online: Show 22 available NGFR Proteins ranked by validation data
- Compare Top NGFR Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for NGFR
- Search Santa Cruz Biotechnology (SCBT) for NGFR siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NGFR
- Custom Antibody ServicesProSci Antibodies for NGFR
- Search for NGFR Proteins at ProSci
- Horizon Cell Lines for NGFR
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NGFR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NGFR
- Search GeneCopoeia for miRNA 3'UTR Target clone products for NGFR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NGFR
Sources for NGFR Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources