NGFR Gene (Protein Coding)

Nerve Growth Factor Receptor

GC17P049495
GIFtS:
47
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008] See more...

Aliases for NGFR Gene

Aliases for NGFR Gene

  • Nerve Growth Factor Receptor 2 3 5
  • Tumor Necrosis Factor Receptor Superfamily Member 16 3 4
  • Low Affinity Neurotrophin Receptor P75NTR 3 4
  • Low-Affinity Nerve Growth Factor Receptor 3 4
  • TNFR Superfamily, Member 16 2 3
  • NGF Receptor 3 4
  • Gp80-LNGFR 3 4
  • TNFRSF16 3 4
  • P75 ICD 3 4
  • Nerve Growth Factor Receptor (TNFR Superfamily, Member 16) 2
  • Low Affinity Nerve Growth Factor Receptor 2
  • CD271 Antigen 4
  • P75(NTR) 3
  • P75NTR 3
  • CD271 3

External Ids for NGFR Gene

Previous GeneCards Identifiers for NGFR Gene

  • GC17P047283
  • GC17P050052
  • GC17P047914
  • GC17P048047
  • GC17P044927
  • GC17P047572
  • GC17P042937

Summaries for NGFR Gene

Entrez Gene Summary for NGFR Gene

  • Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]

GeneCards Summary for NGFR Gene

NGFR (Nerve Growth Factor Receptor) is a Protein Coding gene. Diseases associated with NGFR include Prurigo Nodularis and Infiltrative Basal Cell Carcinoma. Among its related pathways are p75(NTR)-mediated signaling and NGF Pathway. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and transmembrane signaling receptor activity. An important paralog of this gene is TNFRSF11A.

UniProtKB/Swiss-Prot Summary for NGFR Gene

  • Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138).

Tocris Summary for NGFR Gene

  • Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3K and PLCgamma signaling pathways. Four members of the Trk family have been identified.

Gene Wiki entry for NGFR Gene

Additional gene information for NGFR Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NGFR Gene

Genomics for NGFR Gene

GeneHancer (GH) Regulatory Elements for NGFR Gene

Promoters and enhancers for NGFR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NGFR on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NGFR

Top Transcription factor binding sites by QIAGEN in the NGFR gene promoter:
  • AP-1
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • ATF-2
  • c-Jun

Genomic Locations for NGFR Gene

Genomic Locations for NGFR Gene
chr17:49,495,293-49,515,020
(GRCh38/hg38)
Size:
19,728 bases
Orientation:
Plus strand
chr17:47,572,655-47,592,382
(GRCh37/hg19)
Size:
19,728 bases
Orientation:
Plus strand

Genomic View for NGFR Gene

Genes around NGFR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NGFR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NGFR Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NGFR Gene

Proteins for NGFR Gene

Products:

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  2. Protein
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  • Protein details for NGFR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08138-TNR16_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 16
    Protein Accession:
    P08138
    Secondary Accessions:
    • B2R961
    • B4E096

    Protein attributes for NGFR Gene

    Size:
    427 amino acids
    Molecular mass:
    45183 Da
    Quaternary structure:
    • Homodimer; disulfide-linked (By similarity). Heterodimer with SORCS2. The extracellular domains of the heterodimer bind NGF (PubMed:22155786, PubMed:24908487). The cytoplasmic region of the heterodimer binds TRIO. NGF binding mediates dissociation of TRIO from the receptor complex (PubMed:22155786). Interacts with RTN4R (PubMed:19052207). Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9 (PubMed:10514511, PubMed:9915784, PubMed:10544233, PubMed:12963025). Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1 (PubMed:11244088). Interacts with BEX1 (By similarity). Interacts with BEX3 (By similarity). Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor (By similarity). Interacts (via death domain) with RAB31 (By similarity). Interacts with LINGO1 (PubMed:14966521). Interacts with NRADD (By similarity). Interacts with MAGED1; the interaction antagonizes the association NGFR:NTRK1 (By similarity). Interacts (via death domain) with ARHGDIA and RIPK2 (PubMed:26646181).

    Three dimensional structures from OCA and Proteopedia for NGFR Gene

    Alternative splice isoforms for NGFR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NGFR Gene

Protein Expression for NGFR Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NGFR Gene

Other Protein References for NGFR Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NGFR Gene

Domains & Families for NGFR Gene

Gene Families for NGFR Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NGFR Gene

Blocks:
  • TNFR/CD27/30/40/95 cysteine-rich region
  • Death domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NGFR Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51424, highly similar to Tumor necrosis factor receptor superfamilymember 16 (B4E096_HUMAN)
  • p75 ICD (TNR16_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08138

UniProtKB/Swiss-Prot:

TNR16_HUMAN :
  • The death domain mediates interaction with RANBP9 (By similarity). It also mediates interaction with ARHGDIA and RIPK2 (PubMed:26646181).
Domain:
  • The death domain mediates interaction with RANBP9 (By similarity). It also mediates interaction with ARHGDIA and RIPK2 (PubMed:26646181).
  • The extracellular domain is responsible for interaction with NTRK1.
genes like me logo Genes that share domains with NGFR: view

Function for NGFR Gene

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  2. CRISPR
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Molecular function for NGFR Gene

UniProtKB/Swiss-Prot Function:
Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138).
GENATLAS Biochemistry:
nerve growth factor receptor p75,low affinity (tumor necrosis factor receptor,TNFR superfamily,member 16),see also NTRK1

Phenotypes From GWAS Catalog for NGFR Gene

Gene Ontology (GO) - Molecular Function for NGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 amyloid-beta binding TAS 26871627
GO:0004888 transmembrane signaling receptor activity TAS 1846035
GO:0005035 death receptor activity IGI,IBA 11927634
GO:0005515 protein binding IEA,IPI 11756426
GO:0005516 calmodulin binding IDA 24914971
genes like me logo Genes that share ontologies with NGFR: view
genes like me logo Genes that share phenotypes with NGFR: view

Animal Models for NGFR Gene

MGI Knock Outs for NGFR:
  • Ngfr Ngfr<tm1Jae>
  • Ngfr Ngfr<tm1Gdc>
  • Ngfr Ngfr<tm1b(EUCOMM)Wtsi>
  • Ngfr Ngfr<tm1a(EUCOMM)Wtsi>
  • Ngfr Ngfr<tm1.2Vk>

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for NGFR

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NGFR Gene

Localization for NGFR Gene

Subcellular locations from UniProtKB/Swiss-Prot for NGFR Gene

Cell membrane; Single-pass type I membrane protein. Perikaryon. Cell projection, growth cone. Cell projection, dendritic spine.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NGFR gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
endosome 4
cytosol 4
cytoskeleton 3
mitochondrion 2
endoplasmic reticulum 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005623 cell IEA --
GO:0005654 nucleoplasm TAS --
GO:0005768 endosome TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NGFR: view

Pathways & Interactions for NGFR Gene

PathCards logo

SuperPathways for NGFR Gene

SuperPathway Contained pathways
1 p75 NTR receptor-mediated signalling
Cell death signalling via NRAGE, NRIF and NADE
.79
NRAGE signals death through JNK
.79
p75 NTR receptor-mediated signalling
.78
Axonal growth inhibition (RHOA activation)
.01
Axonal growth stimulation
.01
NADE modulates death signalling
.01
NF-kB is activated and signals survival
.01
NRIF signals cell death from the nucleus
.01
p75NTR negatively regulates cell cycle via SC1
.01
p75NTR recruits signalling complexes
.01
p75NTR regulates axonogenesis
.01
p75NTR signals via NF-kB
.01
Regulated proteolysis of p75NTR
.01
2 Apoptotic Pathways in Synovial Fibroblasts
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
Rac1 Pathway
.65
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Nuclear Receptor Activation by Vitamin-A
.57
3 PEDF Induced Signaling
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Glucocorticoid Receptor Signaling
.43
Cytokine-cytokine receptor interaction
.43
4 TGF-Beta Pathway
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
JNK Pathway
.51
5 Development HGF signaling pathway
Development Neurotrophin family signaling
.44
Apoptosis and survival Role of CDK5 in neuronal death and survival
.37
Neurotrophin signaling pathway
.36
genes like me logo Genes that share pathways with NGFR: view

Pathways by source for NGFR Gene

1 Sino Biological pathway for NGFR Gene
5 GeneGo (Thomson Reuters) pathways for NGFR Gene
  • Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
  • Apoptosis and survival Apoptotic TNF-family pathways
  • Apoptosis and survival Role of CDK5 in neuronal death and survival
  • Development MAG-dependent inhibition of neurite outgrowth
  • Development Neurotrophin family signaling
3 Tocris pathways for NGFR Gene
47 Qiagen pathways for NGFR Gene
  • 14-3-3 and Regulation of BAD Activity
  • Actin-Based Motility by Rho Family GTPases
  • Activation of PKC through GPCR
  • Akt Signaling
  • Antioxidant Action of Vitamin-C
1 Cell Signaling Technology pathway for NGFR Gene

SIGNOR curated interactions for NGFR Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for NGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001678 cellular glucose homeostasis ISS --
GO:0006886 intracellular protein transport ISS --
GO:0006915 apoptotic process IEA --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS --
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with NGFR: view

Drugs & Compounds for NGFR Gene

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  1. Drug

(38) Drugs for NGFR Gene - From: DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
BDNF Pharma 0
neurotrophin-3 Pharma 0
neurotrophin-4 Pharma 0
NGF Pharma 0
CXB909 Pharma 0

(36) Additional Compounds for NGFR Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
AG 879
148741-30-4
LM11A 31 dihydrochloride
1243259-19-9

(4) Tocris Compounds for NGFR Gene

Compound Action Cas Number
AG 879 TrkA inhibitor 148741-30-4
BDNF (human) Activates TrkB and p75 receptors 218441-99-7
LM11A 31 dihydrochloride Nonpeptide p75NTR ligand; neuroprotective 1243259-19-9
TLQP 21 VGF-derived peptide 869988-94-3
genes like me logo Genes that share compounds with NGFR: view

Transcripts for NGFR Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for NGFR Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for NGFR

Alternative Splicing Database (ASD) splice patterns (SP) for NGFR Gene

No ASD Table

Relevant External Links for NGFR Gene

GeneLoc Exon Structure for
NGFR

Expression for NGFR Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NGFR Gene

mRNA expression in normal human tissues for NGFR Gene
mRNA expression by BioGPS for NGFR GenemRNA expression by GTEx for NGFR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NGFR Gene

This gene is overexpressed in Nerve - Tibial (x9.4).

Protein differential expression in normal tissues from HIPED for NGFR Gene

This gene is overexpressed in Retina (39.4) and Fetal testis (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NGFR Gene



Protein tissue co-expression partners for NGFR Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NGFR

SOURCE GeneReport for Unigene cluster for NGFR Gene:

Hs.415768

Evidence on tissue expression from TISSUES for NGFR Gene

  • Nervous system(4.8)
  • Eye(4.3)
  • Liver(4.3)
  • Adrenal gland(2.6)
  • Muscle(2.2)
  • Heart(2.1)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with NGFR: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NGFR Gene

Orthologs for NGFR Gene

This gene was present in the common ancestor of chordates.

Orthologs for NGFR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia NGFR 31 30
  • 99.45 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia NGFR 31 30
  • 92.58 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia NGFR 31 30
  • 92.51 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Ngfr 17 31 30
  • 87.84 (n)
rat
(Rattus norvegicus)
 Mammalia Ngfr 30
  • 86.73 (n)
oppossum
(Monodelphis domestica)
 Mammalia NGFR 31
  • 73 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia NGFR 31
  • 71 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves NGFR 31 30
  • 75.83 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia NGFR 31
  • 62 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100493992 30
  • 60.33 (n)
African clawed frog
(Xenopus laevis)
 Amphibia p75NTRa 30
zebrafish
(Danio rerio)
 Actinopterygii ngfrb 31 31 30
  • 58.82 (n)
 OneToMany
NGFR (2 of 3) 31
  • 47 (a)
 OneToMany
Species where no ortholog for NGFR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NGFR Gene

ENSEMBL:
Gene Tree for NGFR (if available)
TreeFam:
Gene Tree for NGFR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NGFR: view image

Paralogs for NGFR Gene

Variants for NGFR Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NGFR Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
709492 Benign: not provided 49,511,882(+) C/G INTRON_VARIANT
717336 Likely Benign: not provided 49,512,814(+) G/A SYNONYMOUS_VARIANT
717409 Benign: not provided 49,506,423(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
724414 Benign: not provided 49,506,485(+) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
736086 Benign: not provided 49,502,059(+) C/T INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for NGFR Gene

Structural Variations from Database of Genomic Variants (DGV) for NGFR Gene

Variant ID Type Subtype PubMed ID
nsv833473 CNV gain+loss 17160897

Variation tolerance for NGFR Gene

Residual Variation Intolerance Score: 27.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NGFR Gene

Human Gene Mutation Database (HGMD)
NGFR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NGFR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NGFR Gene

Disorders for NGFR Gene

MalaCards: The human disease database

(41) MalaCards diseases for NGFR Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prurigo nodularis
  • nodular prurigo
infiltrative basal cell carcinoma
  • skin infiltrating basal cell carcinoma
spinal cord injury
  • spinal cord injuries
anhidrosis
  • absence of sweating
pheochromocytoma
  • pcc
- elite association - COSMIC cancer census association via MalaCards
Search NGFR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NGFR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NGFR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NGFR Gene

Publications for NGFR Gene

  1. SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population. (PMID: 18780967) Cozza A … Pellegrini S (Journal of Alzheimer's disease : JAD 2008) 3 23 41 54
  2. TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. (PMID: 10514511) Ye X … Bredesen DE (The Journal of biological chemistry 1999) 3 4 23 54
  3. Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation. (PMID: 10544233) Irie S … Sato TA (FEBS letters 1999) 3 4 23 54
  4. Expression and structure of the human NGF receptor. (PMID: 3022937) Johnson D … Chao M (Cell 1986) 2 3 4 54
  5. Structural basis of death domain signaling in the p75 neurotrophin receptor. (PMID: 26646181) Lin Z … Ibanez CF (eLife 2015) 3 4 54

ExternalLinks

View latest publications for NGFR gene in Mastermind

Products for NGFR Gene

  • Addgene plasmids for NGFR
  • Signalway ELISA kits for NGFR
  • Signalway Proteins for NGFR

Sources for NGFR Gene