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Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]
NGFR (Nerve Growth Factor Receptor) is a Protein Coding gene. Diseases associated with NGFR include Prurigo Nodularis and Infiltrative Basal Cell Carcinoma. Among its related pathways are Neuroscience and Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and transmembrane signaling receptor activity. An important paralog of this gene is TNFRSF1B.
Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3K and PLCgamma signaling pathways. Four members of the Trk family have been identified.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001540 | amyloid-beta binding | TAS | 26871627 |
GO:0004888 | transmembrane signaling receptor activity | TAS | 1846035 |
GO:0005035 | death receptor activity | IBA,IGI | 11927634 |
GO:0005515 | protein binding | IPI | 11756426 |
GO:0005516 | calmodulin binding | IDA | 24914971 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005623 | cell | IEA | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005768 | endosome | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | p75 NTR receptor-mediated signalling | ||
2 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
|
PPAR Pathway
.66
Rac1 Pathway
.65
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Nuclear Receptor Activation by Vitamin-A
.57
|
3 | PEDF Induced Signaling |
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
|
Glucocorticoid Receptor Signaling
.43
|
4 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
|
JAK-STAT Pathway
.57
JNK Pathway
.51
|
5 | Development HGF signaling pathway |
Development Neurotrophin family signaling
.44
Apoptosis and survival Role of CDK5 in neuronal death and survival
.37
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001678 | cellular glucose homeostasis | ISS | -- |
GO:0006886 | intracellular protein transport | ISS | -- |
GO:0006915 | apoptotic process | IEA | -- |
GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | TAS | -- |
GO:0007165 | signal transduction | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
AG 879 |
|
148741-30-4 |
|
|
||
LM11A 31 dihydrochloride |
|
1243259-19-9 |
|
|
Compound | Action | Cas Number |
---|---|---|
AG 879 | TrkA inhibitor | 148741-30-4 |
BDNF (human) | Activates TrkB and p75 receptors | 218441-99-7 |
LM11A 31 dihydrochloride | Nonpeptide p75NTR ligand; neuroprotective | 1243259-19-9 |
TLQP 21 | VGF-derived peptide | 869988-94-3 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NGFR 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NGFR 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NGFR 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ngfr 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ngfr 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | NGFR 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | NGFR 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | NGFR 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NGFR 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100493992 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | p75NTRa 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ngfrb 30 31 31 |
|
OneToMany | |
NGFR (2 of 3) 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
709492 | Benign: not provided | 49,511,882(+) | C/G | INTRON_VARIANT | |
717336 | Likely Benign: not provided | 49,512,814(+) | G/A | SYNONYMOUS_VARIANT | |
717409 | Benign: not provided | 49,506,423(+) | C/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
724414 | Benign: not provided | 49,506,485(+) | C/T | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
736086 | Benign: not provided | 49,502,059(+) | C/T | INTRON_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
prurigo nodularis |
|
|
infiltrative basal cell carcinoma |
|
|
spinal cord injury |
|
|
anhidrosis |
|
|
pheochromocytoma |
|