NGF Gene (Protein Coding)

Nerve Growth Factor

GC01M115285
GIFtS:
51
This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensor... See more...

Aliases for NGF Gene

Aliases for NGF Gene

  • Nerve Growth Factor 2 3 5
  • Nerve Growth Factor (Beta Polypeptide) 2 3
  • Beta-Nerve Growth Factor 3 4
  • Beta-NGF 3 4
  • NGFB 3 4
  • Nerve Growth Factor, Beta Subunit 3
  • Pro-Nerve Growth Factor Long 3
  • HSAN5 3
  • NGF 5

External Ids for NGF Gene

Previous HGNC Symbols for NGF Gene

  • NGFB

Previous GeneCards Identifiers for NGF Gene

  • GC01M115630
  • GC01M115828
  • GC01M113686

Summaries for NGF Gene

Entrez Gene Summary for NGF Gene

  • This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]

GeneCards Summary for NGF Gene

NGF (Nerve Growth Factor) is a Protein Coding gene. Diseases associated with NGF include Neuropathy, Hereditary Sensory And Autonomic, Type V and Corneal Ulcer. Among its related pathways are Apoptosis Modulation and Signaling and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and obsolete signal transducer activity, downstream of receptor. An important paralog of this gene is NTF3.

UniProtKB/Swiss-Prot Summary for NGF Gene

  • Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed:14976160, PubMed:20978020). Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (PubMed:20978020) (Probable). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (PubMed:20164177). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity).

Tocris Summary for NGF Gene

  • Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3K and PLCgamma signaling pathways. Four members of the Trk family have been identified.

Gene Wiki entry for NGF Gene

Additional gene information for NGF Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NGF Gene

Genomics for NGF Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for NGF Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J115337 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 256 +0.9 945 2 ZNF600 POLR2A ZIC2 ZBTB10 ZNF341 SIN3A KLF9 ZNF623 ZNF843 RAD21 NGF lnc-TSPAN2-1 NGF-AS1 HSALNG0006267-002 TSPAN2
GH01J115425 Enhancer 1.1 FANTOM5 Ensembl ENCODE 17.5 -90.4 -90431 7.6 JUND CEBPA BRCA1 CEBPB MAX EP300 CTBP1 MAFF CUX1 RFX5 NGF SIKE1 TRIM33 NGF-AS1 ATP1A1-AS1 HSALNG0006273 RF00994-047 VANGL1
GH01J115188 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 13.3 +148.5 148470 3.4 JUND CEBPB MAX EP300 RFX5 SMC3 STAT3 TBP NFE2 RAD21 NGF NGF-AS1 SIKE1 lnc-TSHB-2 HSALNG0006266 TSPAN2
GH01J115314 Enhancer 0.9 Ensembl ENCODE dbSUPER 19.1 +24.0 23970 2 CTBP1 FOXA1 BHLHE40 MNT EGR2 SREBF1 ZFHX2 CEBPB HSALNG0006270 NGF NGF-AS1 ENSG00000285698 HSALNG0006267-002 TSPAN2
GH01J115329 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 14.4 +6.7 6719 4.6 CEBPB BHLHE40 MAX EP300 RXRA RFX5 STAT3 USF2 RAD21 CTCF NGF lnc-TSPAN2-1 NGF-AS1 HSALNG0006267-002 TSPAN2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NGF on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NGF

Top Transcription factor binding sites by QIAGEN in the NGF gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • deltaCREB
  • FOXO1
  • FOXO1a
  • STAT3
  • STAT5A

Genomic Locations for NGF Gene

Latest Assembly
chr1:115,285,904-115,338,770
(GRCh38/hg38)
Size:
52,867 bases
Orientation:
Minus strand

Previous Assembly
chr1:115,828,538-115,880,870
(GRCh37/hg19 by Entrez Gene)
Size:
52,333 bases
Orientation:
Minus strand

chr1:115,828,539-115,880,857
(GRCh37/hg19 by Ensembl)
Size:
52,319 bases
Orientation:
Minus strand

Genomic View for NGF Gene

Genes around NGF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NGF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NGF Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NGF Gene

Proteins for NGF Gene

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  • Protein details for NGF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01138-NGF_HUMAN
    Recommended name:
    Beta-nerve growth factor
    Protein Accession:
    P01138
    Secondary Accessions:
    • A1A4E5
    • Q6FHA0
    • Q96P60
    • Q9P2Q8
    • Q9UKL8

    Protein attributes for NGF Gene

    Size:
    241 amino acids
    Molecular mass:
    26959 Da
    Quaternary structure:
    • Homodimer (PubMed:10490030, PubMed:15131306, PubMed:17196528). The homodimer interacts with a single NTRK1 chain (PubMed:10490030, PubMed:17196528). The homodimer interacts with a single NGFR chain (PubMed:15131306). The NGF dimer interacts with a single SORCS2 chain (via extracellular domain) (By similarity). The NGF precursor (proNGF) binds to a receptor complex formed by SORT1 and NGFR, which leads to NGF endocytosis. Both mature NGF and the immature NGF precursor (proNGF) interact with SORCS2 and with the heterodimer formed by SORCS2 and NGFR (via extracellular domains) (By similarity). The NGF precursor (proNGF) has much higher affinity for SORCS2 than mature NGF. The NGF precursor (proNGF) has much higher affinity for SORT1 than mature NGF (By similarity). Interacts with ADAM10 in a divalent cation-dependent manner (PubMed:20164177).
    SequenceCaution:
    • Sequence=AAH32517.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NGF Gene

neXtProt entry for NGF Gene

Protein Expression for NGF Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NGF Gene

  • Glycosylation at Ser43, Thr46, Asn69, and Asn114
  • Modification sites at PhosphoSitePlus

Other Protein References for NGF Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for NGF
  • Santa Cruz Biotechnology (SCBT) Antibodies for NGF

No data available for DME Specific Peptides for NGF Gene

Domains & Families for NGF Gene

Gene Families for NGF Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Disease related genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for NGF Gene

InterPro:
Blocks:
  • Nerve growth factor

Suggested Antigen Peptide Sequences for NGF Gene

GenScript: Design optimal peptide antigens:
  • Beta-nerve growth factor (NGF_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P01138

UniProtKB/Swiss-Prot:

NGF_HUMAN :
  • Belongs to the NGF-beta family.
Family:
  • Belongs to the NGF-beta family.
genes like me logo Genes that share domains with NGF: view

Function for NGF Gene

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  6. Cell Lines for research

Molecular function for NGF Gene

UniProtKB/Swiss-Prot Function:
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed:14976160, PubMed:20978020). Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (PubMed:20978020) (Probable). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (PubMed:20164177). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity).

LifeMap Function Summary for NGF Gene

It affects the following cells:
NGF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Phenotypes From GWAS Catalog for NGF Gene

Gene Ontology (GO) - Molecular Function for NGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity IEA --
GO:0005102 signaling receptor binding IEA --
GO:0005163 nerve growth factor receptor binding IBA,IPI 14985763
GO:0005515 protein binding IPI 10490030
GO:0008083 growth factor activity IBA 21873635
genes like me logo Genes that share ontologies with NGF: view
genes like me logo Genes that share phenotypes with NGF: view

Human Phenotype Ontology for NGF Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NGF Gene

MGI Knock Outs for NGF:
  • Ngf Ngf<tm1Gne>
  • Ngf Ngf<tm1Ddg>

miRNA for NGF Gene

miRTarBase miRNAs that target NGF

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NGF

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NGF Gene

Localization for NGF Gene

Subcellular locations from UniProtKB/Swiss-Prot for NGF Gene

Secreted. Endosome lumen. Note=ProNGF is endocytosed after binding to the cell surface receptor formed by SORT1 and NGFR. {ECO:0000250 UniProtKB:P01139}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NGF gene
Compartment Confidence
extracellular 5
cytosol 5
endosome 4
golgi apparatus 4
plasma membrane 3
cytoskeleton 3
mitochondrion 3
nucleus 3
peroxisome 2
endoplasmic reticulum 2
lysosome 2

Gene Ontology (GO) - Cellular Components for NGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005768 endosome IEA --
GO:0005796 Golgi lumen TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NGF: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NGF Gene

Pathways & Interactions for NGF Gene

PathCards logo

SuperPathways for NGF Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
2 p75 NTR receptor-mediated signalling
Cell death signalling via NRAGE, NRIF and NADE
.79
NRAGE signals death through JNK
.79
p75 NTR receptor-mediated signalling
.78
Axonal growth stimulation
.01
NADE modulates death signalling
.01
NF-kB is activated and signals survival
.01
NRIF signals cell death from the nucleus
.01
p75NTR negatively regulates cell cycle via SC1
.01
p75NTR recruits signalling complexes
.01
p75NTR regulates axonogenesis
.01
p75NTR signals via NF-kB
.01
3 RET signaling
Frs2-mediated activation
.95
Prolonged ERK activation events
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
NGF signalling via TRKA from the plasma membrane
.87
Signalling by NGF
.81
4 GPCR Pathway
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
5 ERK Signaling
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
genes like me logo Genes that share pathways with NGF: view

Pathways by source for NGF Gene

1 Sino Biological pathway for NGF Gene
6 GeneGo (Thomson Reuters) pathways for NGF Gene
  • Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
  • Apoptosis and survival Apoptotic TNF-family pathways
  • Apoptosis and survival NGF signaling pathway
  • Apoptosis and survival Role of CDK5 in neuronal death and survival
  • Development MAG-dependent inhibition of neurite outgrowth
63 Qiagen pathways for NGF Gene
  • 14-3-3 and Regulation of BAD Activity
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
1 Cell Signaling Technology pathway for NGF Gene

SIGNOR curated interactions for NGF Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for NGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity TAS --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA 21873635
GO:0007422 peripheral nervous system development IBA 21873635
GO:0007613 memory IBA 21873635
genes like me logo Genes that share ontologies with NGF: view

Drugs & Compounds for NGF Gene

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(100) Drugs for NGF Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clenbuterol Approved, Investigational, Vet_approved Pharma Target, stimulator 7
Methadone Approved Pharma 418
Alprostadil Approved, Investigational Pharma 113
Polaprezinc Experimental Pharma Target, agonist 5
Tanezumab Investigational Pharma 40

(53) Additional Compounds for NGF Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
AG 879
148741-30-4
LM11A 31 dihydrochloride
1243259-19-9

(4) Tocris Compounds for NGF Gene

Compound Action Cas Number
AG 879 TrkA inhibitor 148741-30-4
BDNF (human) Activates TrkB and p75 receptors 218441-99-7
LM11A 31 dihydrochloride Nonpeptide p75NTR ligand; neuroprotective 1243259-19-9
TLQP 21 VGF-derived peptide 869988-94-3

(2) ApexBio Compounds for NGF Gene

Compound Action Cas Number
Cyclotraxin B 1203586-72-4
Ro 08-2750 antagonist of nerve growth factor (NGF) 37854-59-4
genes like me logo Genes that share compounds with NGF: view

Transcripts for NGF Gene

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mRNA/cDNA for NGF Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NGF

Alternative Splicing Database (ASD) splice patterns (SP) for NGF Gene

No ASD Table

Relevant External Links for NGF Gene

GeneLoc Exon Structure for
NGF

Expression for NGF Gene

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  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NGF Gene

mRNA expression in normal human tissues for NGF Gene
mRNA expression by BioGPS for NGF GenemRNA expression by GTEx for NGF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NGF Gene

This gene is overexpressed in Heart - Atrial Appendage (x4.7), Ovary (x4.6), and Artery - Aorta (x4.2).

Protein differential expression in normal tissues from HIPED for NGF Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NGF Gene



Protein tissue co-expression partners for NGF Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NGF

SOURCE GeneReport for Unigene cluster for NGF Gene:

Hs.2561

Evidence on tissue expression from TISSUES for NGF Gene

  • Nervous system(4.7)
  • Blood(4.5)
  • Eye(4.5)
  • Adrenal gland(3.4)
  • Muscle(2.9)
  • Heart(2.8)
  • Skin(2.6)
  • Kidney(2.3)
  • Bone(2.3)
  • Bone marrow(2.2)
  • Intestine(2.2)
  • Liver(2.1)
  • Spleen(2.1)
  • Lung(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for NGF Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • immune
  • integumentary
  • nervous
  • skeleton
Regions:
Head and neck:
  • brain
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
Thorax:
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood vessel
  • skin
  • spinal column
  • spinal cord
  • vertebrae
genes like me logo Genes that share expression patterns with NGF: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt for NGF Gene

Orthologs for NGF Gene

This gene was present in the common ancestor of chordates.

Orthologs for NGF Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia NGF 29 30
  • 99.03 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia NGF 29 30
  • 87.97 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia NGF 29
  • 87.41 (n)
NGFB 30
  • 76 (a)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Ngf 29
  • 85.62 (n)
Mouse
(Mus musculus)
 Mammalia Ngf 29 16 30
  • 85.48 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia NGF 30
  • 68 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves NGF 29 30
  • 70.23 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia NGFB 30
  • 56 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia ngf 29
  • 69.05 (n)
Zebrafish
(Danio rerio)
 Actinopterygii ngf 30
  • 51 (a)
 OneToMany
ntf7 29 30
  • 44 (a)
 OneToMany
Species where no ortholog for NGF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NGF Gene

ENSEMBL:
Gene Tree for NGF (if available)
TreeFam:
Gene Tree for NGF (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NGF: view image
Alliance of Genome Resources:
Additional Orthologs for NGF

Paralogs for NGF Gene

Paralogs for NGF Gene

(3) SIMAP similar genes for NGF Gene using alignment to 1 proteins:

  • NGF_HUMAN
genes like me logo Genes that share paralogs with NGF: view

Variants for NGF Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NGF Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
1000642 Uncertain Significance: Congenital sensory neuropathy with selective loss of small myelinated fibers 115,286,408(-) T/C
NM_002506.3(NGF):c.388A>G (p.Arg130Gly) 		MISSENSE
1024609 Uncertain Significance: Congenital sensory neuropathy with selective loss of small myelinated fibers 115,286,609(-) C/T
NM_002506.3(NGF):c.187G>A (p.Val63Met) 		MISSENSE
1028026 Uncertain Significance: Congenital sensory neuropathy with selective loss of small myelinated fibers 115,286,572(-) C/T
NM_002506.3(NGF):c.224G>A (p.Arg75Lys) 		MISSENSE
834309 Uncertain Significance: Congenital sensory neuropathy with selective loss of small myelinated fibers 115,286,234(-) C/G
NM_002506.3(NGF):c.562G>C (p.Gly188Arg) 		MISSENSE
835507 Uncertain Significance: Congenital sensory neuropathy with selective loss of small myelinated fibers 115,286,478(-) C/G
NM_002506.3(NGF):c.318G>C (p.Glu106Asp) 		MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NGF Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NGF Gene

Variant ID Type Subtype PubMed ID
esv26121 CNV loss 19812545
esv34370 CNV gain 17911159
nsv159371 CNV deletion 16902084
nsv818389 CNV gain 17921354

Variation tolerance for NGF Gene

Residual Variation Intolerance Score: 43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.58; 86.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NGF Gene

Human Gene Mutation Database (HGMD)
NGF
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NGF
Leiden Open Variation Database (LOVD)
NGF

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NGF Gene

Disorders for NGF Gene

MalaCards: The human disease database

(130) MalaCards diseases for NGF Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search NGF in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NGF_HUMAN
  • Neuropathy, hereditary sensory and autonomic, 5 (HSAN5) [MIM:608654]: A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable. {ECO:0000269 PubMed:14976160, ECO:0000269 PubMed:20978020, ECO:0000269 PubMed:22302274}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for NGF

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
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No data available for Genatlas for NGF Gene

Publications for NGF Gene

  1. A novel NGF mutation clarifies the molecular mechanism and extends the phenotypic spectrum of the HSAN5 neuropathy. (PMID: 20978020) Carvalho OP … Woods CG (Journal of medical genetics 2011) 3 4 72
  2. Variation in the BDNF and NGFB genes in German atopic dermatitis patients. (PMID: 19038326) Hoffjan S … Stemmler S (Molecular and cellular probes 2009) 3 22 40
  3. SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population. (PMID: 18780967) Cozza A … Pellegrini S (Journal of Alzheimer's disease : JAD 2008) 3 22 40
  4. Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder. (PMID: 18179783) Ribasés M … Bayés M (Biological psychiatry 2008) 3 22 40
  5. A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception. (PMID: 14976160) Einarsdottir E … Holmberg M (Human molecular genetics 2004) 3 4 72

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