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This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]
NGF (Nerve Growth Factor) is a Protein Coding gene. Diseases associated with NGF include Neuropathy, Hereditary Sensory And Autonomic, Type V and Autonomic Neuropathy. Among its related pathways are Neuroscience and NGF Pathway. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and obsolete signal transducer activity, downstream of receptor. An important paralog of this gene is NTF3.
Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3K and PLCgamma signaling pathways. Four members of the Trk family have been identified.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004857 | enzyme inhibitor activity | IEA | -- |
GO:0005102 | signaling receptor binding | IEA | -- |
GO:0005163 | nerve growth factor receptor binding | IBA,IPI | 14985763 |
GO:0005515 | protein binding | IPI | 10490030 |
GO:0008083 | growth factor activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0005768 | endosome | IEA | -- |
GO:0005796 | Golgi lumen | TAS | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
2 | p75 NTR receptor-mediated signalling | ||
3 | RET signaling | ||
4 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
5 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000186 | activation of MAPKK activity | TAS | -- |
GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | TAS | -- |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IBA | 21873635 |
GO:0007422 | peripheral nervous system development | IBA | 21873635 |
GO:0007613 | memory | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Clenbuterol | Approved, Investigational, Vet_approved | Pharma | Target, stimulator | 7 | ||
Methadone | Approved | Pharma | 402 | |||
Alprostadil | Approved, Investigational | Pharma | 101 | |||
Polaprezinc | Experimental | Pharma | Target, agonist | 5 | ||
Tanezumab | Investigational | Pharma | 40 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
AG 879 |
|
148741-30-4 |
|
|||
LM11A 31 dihydrochloride |
|
1243259-19-9 |
|
|
Compound | Action | Cas Number |
---|---|---|
AG 879 | TrkA inhibitor | 148741-30-4 |
BDNF (human) | Activates TrkB and p75 receptors | 218441-99-7 |
LM11A 31 dihydrochloride | Nonpeptide p75NTR ligand; neuroprotective | 1243259-19-9 |
TLQP 21 | VGF-derived peptide | 869988-94-3 |
Compound | Action | Cas Number |
---|---|---|
Cyclotraxin B | 1203586-72-4 | |
Ro 08-2750 | antagonist of nerve growth factor (NGF) | 37854-59-4 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NGF 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NGF 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NGF 30 |
|
||
NGFB 31 |
|
OneToOne | |||
Rat (Rattus norvegicus) |
Mammalia | Ngf 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Ngf 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | NGF 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | NGF 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NGFB 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ngf 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ngf 31 |
|
OneToMany | |
ntf7 30 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
637364 | Uncertain Significance: Charcot-Marie-Tooth disease | 115,286,236(-) | C/T | MISSENSE_VARIANT | |
637470 | Uncertain Significance: Congenital sensory neuropathy with selective loss of small myelinated fibers; Charcot-Marie-Tooth disease | 115,286,116(-) | G/T | MISSENSE_VARIANT | |
637471 | Uncertain Significance: Charcot-Marie-Tooth disease | 115,286,113(-) | GCC/G | FRAMESHIFT_VARIANT | |
640133 | Uncertain Significance: Congenital sensory neuropathy with selective loss of small myelinated fibers | 115,286,636(-) | C/T | MISSENSE_VARIANT | |
641309 | Uncertain Significance: Congenital sensory neuropathy with selective loss of small myelinated fibers | 115,286,357(-) | T/A | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
neuropathy, hereditary sensory and autonomic, type v |
|
|
autonomic neuropathy |
|
|
corneal ulcer |
|
|
interstitial cystitis |
|
|
anhidrosis |
|