Aliases for NGF Gene
Aliases for NGF Gene
External Ids for NGF Gene
- HGNC: 7808
- Entrez Gene: 4803
- Ensembl: ENSG00000134259
- OMIM: 162030
- UniProtKB: P01138
Previous HGNC Symbols for NGF Gene
- NGFB
Previous GeneCards Identifiers for NGF Gene
- GC01M115630
- GC01M115828
- GC01M113686
Summaries for NGF Gene
-
This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]
GeneCards Summary for NGF Gene
NGF (Nerve Growth Factor) is a Protein Coding gene. Diseases associated with NGF include Neuropathy, Hereditary Sensory And Autonomic, Type V and Autonomic Neuropathy. Among its related pathways are ERK Signaling and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and obsolete signal transducer activity, downstream of receptor. An important paralog of this gene is NTF3.
UniProtKB/Swiss-Prot for NGF Gene
-
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).
-
Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3K and PLCgamma signaling pathways. Four members of the Trk family have been identified.
Additional gene information for NGF Gene
- Monarch Initiative
- Search for NGF at DataMed
- Search for NGF at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NGF Gene
Genomics for NGF Gene
GeneHancer (GH) Regulatory Elements for NGF Gene
Promoters and enhancers for NGF Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01J115337 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE dbSUPER | 656.1 | +0.3 | 292 | 1.5 | ZSCAN4 SIN3A ZNF2 ZNF335 ZNF121 ZNF23 GLIS2 ZNF366 ZNF398 ZNF623 | NGF ENSG00000228035 | |
| GH01J115329 | Enhancer | 1.4 | FANTOM5 Ensembl ENCODE dbSUPER | 14.4 | +6.3 | 6333 | 4.6 | JUN MAX CEBPG RFX5 ZNF366 FOS TRIM24 SOX6 RXRA BHLHE40 | NGF ENSG00000228035 | |
| GH01J115188 | Enhancer | 1.4 | FANTOM5 Ensembl ENCODE dbSUPER | 13.3 | +148.1 | 148111 | 3.1 | JUN MAX SIN3A RFX5 POLR2A SMC3 NFE2 FOSL2 FOS MAFK | NGF ENSG00000228035 SIKE1 GC01P115161 LOC105378917 | |
| GH01J115411 | Enhancer | 1 | Ensembl ENCODE | 17.6 | -73.4 | -73401 | 0.4 | FOXA2 FEZF1 RAD21 RFX5 YY1 ZNF366 ZSCAN5C ZNF350 RCOR1 FOS | NGF TRIM33 ENSG00000228035 ENSG00000226973 | |
| GH01J115314 | Enhancer | 0.8 | ENCODE dbSUPER | 19 | +23.6 | 23567 | 1.3 | MNT FOXA1 SREBF1 CTBP1 ZFHX2 POLR2A MAFK EGR2 | NGF ENSG00000228035 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around NGF on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the NGF gene promoter:
-
- AP-2alpha isoform 4
- AP-2alpha isoform 3
- AP-2alpha isoform 2
- AP-2alpha
- AP-2alphaA
- FOXO1a
- FOXO1
- STAT3
- deltaCREB
- STAT5A
Regulatory Element Products
Genomic Locations for NGF Gene
Genomic Locations for NGF Gene
- chr1:115,285,916-115,338,384
- (GRCh38/hg38)
- Size:
- 52,469 bases
- Orientation:
- Minus strand
- chr1:115,828,537-115,880,857
- (GRCh37/hg19)
- Size:
- 52,321 bases
- Orientation:
- Minus strand
Genomic View for NGF Gene
Genes around NGF on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.2 by Entrez Gene
- 1p13.2 by HGNC
- 1p13.2 by Ensembl
NGF Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NGF Gene
Proteins for NGF Gene
-
Protein details for NGF Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P01138-NGF_HUMAN
- Recommended name:
- Beta-nerve growth factor
- Protein Accession:
- P01138
- A1A4E5
- Q6FHA0
- Q96P60
- Q9P2Q8
- Q9UKL8
Protein attributes for NGF Gene
- Size:
- 241 amino acids
- Molecular mass:
- 26959 Da
- Quaternary structure:
-
- Homodimer. Interacts with ADAM10 in a divalent cation-dependent manner.
- SequenceCaution:
-
- Sequence=AAH32517.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for NGF Gene
Post-translational modifications for NGF Gene
Other Protein References for NGF Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for NGF (beta-NGF)
- Novus Biologicals Antibodies for NGF
-
Abcam antibodies for NGF
- Invitrogen Antibodies for NGF (AFLGC-NGF)
- antibodies-online: Search results for 211 available NGFB Antibodies ranked by validation data
- Compare Top NGFB Antibodies
-
Recommended
- 54 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 FACS Antibodies (anti-mouse)
- 3 Func Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 2 EIA Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 2 Neut Antibodies (anti-mouse)
- 100 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 FACS Antibodies (anti-human)
- 4 Neut Antibodies (anti-human)
- 3 Func Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 2 EIA Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 CC Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 46 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 Neut Antibody (anti-rat)
- GeneTex NGF Antibody for NGF
-
Custom Antibody ServicesProSci Antibodies for NGF
-
Santa Cruz Biotechnology (SCBT) Antibodies for NGF
- Sino Biological Antibodies for NGF
Protein Products
- R&D Systems Proteins and Enzymes for NGF (beta-NGF)
- Search Origene for MassSpec and Protein Over-expression Lysates for NGF
- Origene Custom Protein Services for NGF
- Sino Biological Recombinant Proteins for NGF
- Sino Biological Cell Lysates for NGF
- ProSpec Recombinant Proteins for NGF
- GeneTex Proteins for NGF
-
Abcam proteins for NGF
Assay Products
- R&D Systems ELISAs, Luminex Assays, and other biochemical assays for NGF (beta-NGF)
- Novus Biologicals ELISA Kits for NGF
- Sino Biological Assays for NGF
No data available for DME Specific Peptides for NGF Gene
Domains & Families for NGF Gene
Gene Families for NGF Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- Disease related genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for NGF Gene
Suggested Antigen Peptide Sequences for NGF Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P01138- Family:
-
- Belongs to the NGF-beta family.
Function for NGF Gene
Molecular function for NGF Gene
- UniProtKB/Swiss-Prot Function:
- Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).
LifeMap Function Summary for NGF Gene
It affects the following cells:
- Ovary
NGF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
- Spinal Cord
- Neurons
- Brain
Phenotypes From GWAS Catalog for NGF Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004857 | enzyme inhibitor activity | IEA | -- |
| GO:0005102 | signaling receptor binding | IEA | -- |
| GO:0005163 | nerve growth factor receptor binding | IPI | 14985763 |
| GO:0005515 | protein binding | IPI | 10490030 |
| GO:0008083 | growth factor activity | IBA | -- |
Phenotypes for NGF Gene
- MGI mutant phenotypes for NGF:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for NGF:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for NGF
-
CRISPR Products
-
OriGene CRISPR knockouts for NGF
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NGF
- genomics-online: gRNA clones - Search results for 124 available NGFB gene related products
- Overview of 124 available NGFB gene related products
- Applied Biological Materials CRISPR for NGF
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NGF
miRNA for NGF Gene
- miRTarBase miRNAs that target NGF
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NGF
- Browse OriGene Inhibitory RNA Products For NGF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NGF
- genomics-online: shRNA clones - Search results for 124 available NGFB gene related products
- Overview of 124 available NGFB gene related products
Clone Products
- Sino Biological Human cDNA Clone for NGF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NGF
- Applied Biological Materials Clones for NGF
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
- ESI BIO PureStem 4D20.8, NCr-fac Progenitor and PureStem E15, Meso-prx/latp Progenitor for NGF
-
Horizon Cell Lines for NGF
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NGF Gene
Localization for NGF Gene
Subcellular locations from UniProtKB/Swiss-Prot for NGF Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| golgi apparatus | 5 |
| endosome | 5 |
| cytoskeleton | 3 |
| nucleus | 3 |
| plasma membrane | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| lysosome | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IBA,TAS | -- |
| GO:0005615 | extracellular space | IBA | -- |
| GO:0005768 | endosome | TAS | -- |
| GO:0005796 | Golgi lumen | TAS | -- |
| GO:0008021 | synaptic vesicle | IBA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for NGF Gene
Pathways & Interactions for NGF Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
.74
.66
|
.65
.61
.60
.57
|
| 2 | p75 NTR receptor-mediated signalling | ||
| 3 | RET signaling | ||
| 4 | GPCR Pathway |
.73
.62
|
.55
|
| 5 | ERK Signaling |
.61
.58
|
.49
|
Pathways by source for NGF Gene
1 Sino Biological pathway for NGF Gene
6 BioSystems pathways for NGF Gene
29 Reactome pathways for NGF Gene
6 GeneGo (Thomson Reuters) pathways for NGF Gene
2 R&D Systems pathways for NGF Gene
63 Qiagen pathways for NGF Gene
1 Cell Signaling Technology pathway for NGF Gene
Interacting Proteins for NGF Gene
Selected Interacting proteins:
P01138-NGF_HUMAN
ENSP00000358525
for NGF Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for NGF
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000186 | activation of MAPKK activity | TAS | -- |
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | TAS | -- |
| GO:0007018 | microtubule-based movement | TAS | -- |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IBA | -- |
| GO:0007267 | cell-cell signaling | IBA | -- |
Drugs & Compounds for NGF Gene
(94) Drugs for NGF Gene - From: DrugBank, PharmGKB, ClinicalTrials, DGIdb, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Clenbuterol | Approved, Investigational, Vet_approved | Pharma | Target, stimulator | 3 | ||
| Polaprezinc | Approved, Investigational | Pharma | Target, agonist | 2 | ||
| Methadone | Approved | Pharma | 341 | |||
| RI 624 | Investigational | Pharma | Target | 0 | ||
| CERE-110 | Investigational | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| AG 879 |
|
148741-30-4 |
|
|||
| LM11A 31 dihydrochloride |
|
1243259-19-9 |
|
|
(4) Tocris Compounds for NGF Gene
| Compound | Action | Cas Number |
|---|---|---|
| AG 879 | TrkA inhibitor | 148741-30-4 |
| BDNF (human) | Activates TrkB and p75 receptors | 218441-99-7 |
| LM11A 31 dihydrochloride | Nonpeptide p75NTR ligand; neuroprotective | 1243259-19-9 |
| TLQP 21 | VGF-derived peptide | 869988-94-3 |
Drug Products
Transcripts for NGF Gene
mRNA/cDNA for NGF Gene
- (3) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (22) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000369512 1047 bps (uc001efu.2)
Unigene Clusters for NGF Gene
CRISPR Products
-
OriGene CRISPR knockouts for NGF
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NGF
- genomics-online: gRNA clones - Search results for 124 available NGFB gene related products
- Overview of 124 available NGFB gene related products
- Applied Biological Materials CRISPR for NGF
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NGF
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NGF
- Browse OriGene Inhibitory RNA Products For NGF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NGF
- genomics-online: shRNA clones - Search results for 124 available NGFB gene related products
- Overview of 124 available NGFB gene related products
Clone Products
- Sino Biological Human cDNA Clone for NGF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NGF
- Applied Biological Materials Clones for NGF
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for NGF Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Eye (Sensory Organs)
-
Epithelial Cells
- Limbal Basal Epithelial Cells Limbus Epithelium
- Duct Cells Pancreatic Ducts
- Encapsulated choroid plexus cells (NTCELL)
- Glial Cells (Uncategorized)
- NULL (Nervous System)
- Brain (Nervous System)
- Peripheral Nervous System (Nervous System)
-
Heart (Cardiovascular System)
- Mature Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Mature Cardiac Fibroblasts Myocardium
-
Ovary (Reproductive System)
- Ovarian Somatic Cells Ovigerous Cord
-
Pancreas (Endocrine System)
- Duct Cells Pancreatic Ducts
- Neural Crest (Gastrulation Derivatives)
- Lateral Plate Mesoderm (Gastrulation Derivatives)
- Paraxial Mesoderm (Gastrulation Derivatives)
- Motor Neurons (Nervous System)
- Neurons
- Spinal Cord (Nervous System)
- Astrocytes (Nervous System)
mRNA differential expression in normal tissues according to GTEx for NGF Gene
This gene is overexpressed in Heart - Atrial Appendage (x4.7), Ovary (x4.6), and Artery - Aorta (x4.2).
This gene is overexpressed in Breast (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NGF Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of NGF Gene:
NGFSOURCE GeneReport for Unigene cluster for NGF Gene:
Hs.2561Evidence on tissue expression from TISSUES for NGF Gene
- Nervous system(4.8)
- Blood(4.5)
- Eye(4.5)
- Adrenal gland(3.9)
- Muscle(2.6)
- Skin(2.5)
- Heart(2.4)
Phenotype-based relationships between genes and organs from Gene ORGANizer for NGF Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- immune
- integumentary
- nervous
- skeleton
Regions:
Head and neck:
- brain
- head
- jaw
- mandible
- maxilla
- mouth
- neck
- skull
Thorax:
- chest wall
- clavicle
- rib
- rib cage
- scapula
- sternum
Pelvis:
- pelvis
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood vessel
- skin
- spinal column
- spinal cord
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for NGF
-
OriGene qPCR primer pairs and template standards for NGF
- genomics-online: primer clones - Search results for 124 available NGFB gene related products
- Overview of 124 available NGFB gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt for NGF Gene
Orthologs for NGF Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NGF 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | NGF 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | NGF 33 |
|
||
| NGFB 34 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Ngf 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Ngf 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | NGF 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NGF 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | NGFB 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ngf 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ngf 34 |
|
OneToMany | |
| ntf7 34 33 |
|
OneToMany |
- Species where no ortholog for NGF was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for NGF Gene
- ENSEMBL:
- Gene Tree for NGF (if available)
- TreeFam:
- Gene Tree for NGF (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NGF: view image
Paralogs for NGF Gene
Variants for NGF Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1011323001 | uncertain-significance, Congenital sensory neuropathy with selective loss of small myelinated fibers | 115,286,425(-) | G/A | coding_sequence_variant, missense_variant | |
| rs11466110 | benign, Congenital sensory neuropathy with selective loss of small myelinated fibers | 115,286,582(-) | C/T | coding_sequence_variant, missense_variant | |
| rs11466111 | conflicting-interpretations-of-pathogenicity, Congenital sensory neuropathy with selective loss of small myelinated fibers | 115,286,557(-) | C/T | coding_sequence_variant, missense_variant | |
| rs11466112 | pathogenic, Congenital sensory neuropathy with selective loss of small myelinated fibers, Neuropathy, hereditary sensory and autonomic, 5 (HSAN5) [MIM:608654] | 115,286,135(-) | G/A | coding_sequence_variant, missense_variant | |
| rs147763877 | uncertain-significance, Congenital sensory neuropathy with selective loss of small myelinated fibers, not specified | 115,286,461(-) | G/C/T | coding_sequence_variant, missense_variant |
Residual Variation Intolerance Score:
43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.58;
86.12% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NGF Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NGF Gene
Disorders for NGF Gene
(78) MalaCards diseases for NGF Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| neuropathy, hereditary sensory and autonomic, type v |
|
|
| autonomic neuropathy |
|
|
| corneal ulcer |
|
|
| anhidrosis |
|
|
| cystitis |
|
Search NGF in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
NGF_HUMAN- Neuropathy, hereditary sensory and autonomic, 5 (HSAN5) [MIM:608654]: A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable. {ECO:0000269 PubMed:14976160, ECO:0000269 PubMed:20978020, ECO:0000269 PubMed:22302274}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for NGF
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for NGF Gene
Publications for NGF Gene
- A novel NGF mutation clarifies the molecular mechanism and extends the phenotypic spectrum of the HSAN5 neuropathy. (PMID: 20978020) Carvalho OP … Woods CG (Journal of medical genetics 2011) 3 4 58
- Nerve growth factor promotes cardiac repair following myocardial infarction. (PMID: 20360245) Meloni M … Emanueli C (Circulation research 2010) 3 22 58
- Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VI. (PMID: 20164177) Wijeyewickrema LC … Andrews RK (The Journal of biological chemistry 2010) 3 4 58
- Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) Gratacòs M … Psychiatric Genetics Network Group (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 44 58
- Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PMID: 19258923) Siezen CL … Janssen R (The Pediatric infectious disease journal 2009) 3 44 58
Products for NGF Gene
- R&D Systems Antibodies for NGF (beta-NGF)
- R&D Systems Proteins and Enzymes for NGF (beta-NGF)
- R&D Systems ELISAs, Luminex Assays, and other biochemical assays for NGF (beta-NGF)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
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- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
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- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for NGF
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for NGF
- Origene Custom Protein Services for NGF
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NGF
- Browse OriGene Inhibitory RNA Products For NGF
- OriGene qPCR primer pairs for NGF
- OriGene qPCR primer pairs and template standards for NGF
- OriGene CRISPR knockouts for NGF
- OriGene ORF clones in human for NGF
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NGF
- GenScript: Next-day shipping of latest version cDNA ORF clones for NGF in any vector
- GenScript Custom Purified and Recombinant Proteins Services for NGF
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- GenScript Custom overexpressing Cell Line Services for NGF
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- Design optimal peptide antigens
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- Gene Mutant Library, Variants up to 10^11
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- Sino Biological Human cDNA Clone for NGF
- Sino Biological Recombinant Proteins for NGF
- Sino Biological Cell Lysates for NGF
- Sino Biological Antibodies for NGF
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- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for NGF
- Novus Biologicals proteins and lysates for NGF
- Novus Biologicals ELISA Kits for NGF
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for NGF
- Abcam proteins for NGF
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for NGF
- ESI BIO PureStem 4D20.8, NCr-fac Progenitor and PureStem E15, Meso-prx/latp Progenitor for NGF
- Invitrogen Antibodies for NGF (AFLGC-NGF)
- Cyagen custom Knockout/knockin (KOKI) mouse models for NGF
- antibodies-online: Search results for 211 available NGFB Antibodies ranked by validation data
- Compare Top NGFB Antibodies
- Recommended
- 54 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 FACS Antibodies (anti-mouse)
- 3 Func Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 2 EIA Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 2 Neut Antibodies (anti-mouse)
- 100 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 FACS Antibodies (anti-human)
- 4 Neut Antibodies (anti-human)
- 3 Func Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 2 EIA Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 CC Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 46 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 Neut Antibody (anti-rat)
- antibodies-online: Search results for 61 available NGFB Elisa Kits ranked by validation data
- Compare Top NGFB Elisa Kits
- antibodies-online: Search results for 89 available NGFB Proteins ranked by validation data
- Compare Top NGFB Proteins
- GeneTex NGF Antibody for NGF
- GeneTex Proteins for NGF
- Santa Cruz Biotechnology (SCBT) Antibodies for NGF
- Search Santa Cruz Biotechnology (SCBT) for NGF siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NGF
- Custom Antibody ServicesProSci Antibodies for NGF
- Horizon Cell Lines for NGF
- genomics-online: cdna clones - Search results for 124 available NGFB gene related products
- Overview of 124 available NGFB gene related products
- orf clones - Search results for 124 available NGFB gene related products
- Overview of 124 available NGFB gene related products
- genomics-online: gRNA clones - Search results for 124 available NGFB gene related products
- Overview of 124 available NGFB gene related products
- genomics-online: primer clones - Search results for 124 available NGFB gene related products
- Overview of 124 available NGFB gene related products
- genomics-online: shRNA clones - Search results for 124 available NGFB gene related products
- Overview of 124 available NGFB gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NGF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NGF
- GeneCopoeia miRNA 3'UTR Target clone products for NGF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NGF
Sources for NGF Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt