Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]).[supplied by OMIM, Mar 2008] See more...

Aliases for NGDN Gene

Aliases for NGDN Gene

  • Neuroguidin 2 3 4 5
  • Centromere Accumulated Nuclear Protein 1 3 4
  • Neuroguidin, EIF4E Binding Protein 2 3
  • EIF4E-Binding Protein 3 4
  • C14orf120 3 4
  • CANu1 3 4
  • Eukaryotic Initiation Factor 4E And CPEB Binding Protein 3
  • Chromosome 14 Open Reading Frame 120 2
  • Lpd-2 3
  • LCP5 3
  • NGD 3

External Ids for NGDN Gene

Previous HGNC Symbols for NGDN Gene

  • C14orf120

Previous GeneCards Identifiers for NGDN Gene

  • GC14P023009
  • GC14P023924
  • GC14P004055

Summaries for NGDN Gene

Entrez Gene Summary for NGDN Gene

  • Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NGDN Gene

NGDN (Neuroguidin) is a Protein Coding gene. Diseases associated with NGDN include Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1. An important paralog of this gene is UTP3.

UniProtKB/Swiss-Prot Summary for NGDN Gene

  • Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs.

Additional gene information for NGDN Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NGDN Gene

Genomics for NGDN Gene

GeneHancer (GH) Regulatory Elements for NGDN Gene

Promoters and enhancers for NGDN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NGDN on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NGDN

Top Transcription factor binding sites by QIAGEN in the NGDN gene promoter:
  • c-Myc
  • COMP1
  • E47
  • GATA-1
  • HOXA5
  • Max1
  • RSRFC4
  • Tal-1

Genomic Locations for NGDN Gene

Genomic Locations for NGDN Gene
chr14:23,469,628-23,509,862
(GRCh38/hg38)
Size:
40,235 bases
Orientation:
Plus strand
chr14:23,938,897-23,979,071
(GRCh37/hg19)
Size:
40,175 bases
Orientation:
Plus strand

Genomic View for NGDN Gene

Genes around NGDN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NGDN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NGDN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NGDN Gene

Proteins for NGDN Gene

  • Protein details for NGDN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEJ9-NGDN_HUMAN
    Recommended name:
    Neuroguidin
    Protein Accession:
    Q8NEJ9
    Secondary Accessions:
    • A8K760
    • Q9Y400

    Protein attributes for NGDN Gene

    Size:
    315 amino acids
    Molecular mass:
    35894 Da
    Quaternary structure:
    • Interacts with CPEB1 and EIF4E.
    Miscellaneous:
    • [Isoform 2]: May be due to a competing donor splice site.

    Alternative splice isoforms for NGDN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NGDN Gene

Post-translational modifications for NGDN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NGDN Gene

No data available for DME Specific Peptides for NGDN Gene

Domains & Families for NGDN Gene

Gene Families for NGDN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NGDN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NGDN Gene

GenScript: Design optimal peptide antigens:
  • EIF4E-binding protein (NGDN_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NEJ9

UniProtKB/Swiss-Prot:

NGDN_HUMAN :
  • Belongs to the SAS10 family.
Family:
  • Belongs to the SAS10 family.
genes like me logo Genes that share domains with NGDN: view

Function for NGDN Gene

Molecular function for NGDN Gene

UniProtKB/Swiss-Prot Function:
Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs.

Phenotypes From GWAS Catalog for NGDN Gene

Gene Ontology (GO) - Molecular Function for NGDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NGDN: view
genes like me logo Genes that share phenotypes with NGDN: view

Animal Models for NGDN Gene

MGI Knock Outs for NGDN:
  • Ngdn Ngdn<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NGDN

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NGDN Gene

Localization for NGDN Gene

Subcellular locations from UniProtKB/Swiss-Prot for NGDN Gene

Nucleus. Nucleus, nucleolus. Chromosome, centromere. Cytoplasm. Cell projection, axon. Cell projection, dendrite. Cell projection, filopodium. Note=Detected in axons, dendrites and filopodia. Colocalized with EIF4E in neurites (By similarity). Translocated from nucleolus to nuclear foci in response to UV damage. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NGDN gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
peroxisome 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NGDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IBA,IDA --
genes like me logo Genes that share ontologies with NGDN: view

Pathways & Interactions for NGDN Gene

PathCards logo

SuperPathways for NGDN Gene

No Data Available

Gene Ontology (GO) - Biological Process for NGDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA 21873635
GO:0006417 regulation of translation IEA --
genes like me logo Genes that share ontologies with NGDN: view

No data available for Pathways by source and SIGNOR curated interactions for NGDN Gene

Drugs & Compounds for NGDN Gene

No Compound Related Data Available

Transcripts for NGDN Gene

mRNA/cDNA for NGDN Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NGDN

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NGDN Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - -
SP6: -
SP7: -
SP8:
SP9:

Relevant External Links for NGDN Gene

GeneLoc Exon Structure for
NGDN

Expression for NGDN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NGDN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NGDN Gene

This gene is overexpressed in Lung (36.4) and CD8 Tcells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NGDN Gene



Protein tissue co-expression partners for NGDN Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NGDN

SOURCE GeneReport for Unigene cluster for NGDN Gene:

Hs.9043

Evidence on tissue expression from TISSUES for NGDN Gene

  • Nervous system(4.6)
  • Muscle(4.5)
genes like me logo Genes that share expression patterns with NGDN: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NGDN Gene

Orthologs for NGDN Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NGDN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NGDN 31 30
  • 99.46 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NGDN 31 30
  • 91.7 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NGDN 31 30
  • 90.36 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ngdn 30
  • 86.67 (n)
mouse
(Mus musculus)
Mammalia Ngdn 17 31 30
  • 86.02 (n)
oppossum
(Monodelphis domestica)
Mammalia NGDN 31
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NGDN 31
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NGDN 31
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ngdn 30
  • 60.75 (n)
LOC395016 30
zebrafish
(Danio rerio)
Actinopterygii ngdn 31 30
  • 58.5 (n)
OneToOne
zgc66416 30
fruit fly
(Drosophila melanogaster)
Insecta CG11030 31 30
  • 52.78 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008697 30
  • 52.59 (n)
worm
(Caenorhabditis elegans)
Secernentea lpd-2 31 30
  • 48.47 (n)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G07840 30
  • 44.12 (n)
rice
(Oryza sativa)
Liliopsida Os01g0911000 30
  • 45.3 (n)
Species where no ortholog for NGDN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NGDN Gene

ENSEMBL:
Gene Tree for NGDN (if available)
TreeFam:
Gene Tree for NGDN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NGDN: view image

Paralogs for NGDN Gene

Paralogs for NGDN Gene

genes like me logo Genes that share paralogs with NGDN: view

Variants for NGDN Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NGDN Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs10149626 - p.Val15Leu
rs17093050 - p.Lys308Ile

Additional dbSNP identifiers (rs#s) for NGDN Gene

Structural Variations from Database of Genomic Variants (DGV) for NGDN Gene

Variant ID Type Subtype PubMed ID
nsv1040319 CNV gain 25217958

Variation tolerance for NGDN Gene

Residual Variation Intolerance Score: 80% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.13; 51.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NGDN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NGDN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NGDN Gene

Disorders for NGDN Gene

MalaCards: The human disease database

(1) MalaCards diseases for NGDN Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search NGDN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NGDN

genes like me logo Genes that share disorders with NGDN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NGDN Gene

Publications for NGDN Gene

  1. CANu1, a novel nucleolar protein, accumulated on centromere in response to DNA damage. (PMID: 18547334) Sihn CR … Kim SH (Genes to cells : devoted to molecular & cellular mechanisms 2008) 3 4 54
  2. Translational control by neuroguidin, a eukaryotic initiation factor 4E and CPEB binding protein. (PMID: 16705177) Jung MY … Richter JD (Molecular and cellular biology 2006) 2 3 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 54

Products for NGDN Gene

Sources for NGDN Gene