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Aliases for NGDN Gene

Aliases for NGDN Gene

  • Neuroguidin 2 3 3 5
  • Centromere Accumulated Nuclear Protein 1 3 4
  • Neuroguidin, EIF4E Binding Protein 2 3
  • EIF4E-Binding Protein 3 4
  • C14orf120 3 4
  • CANu1 3 4
  • Eukaryotic Initiation Factor 4E And CPEB Binding Protein 3
  • Chromosome 14 Open Reading Frame 120 2
  • Lpd-2 3
  • LCP5 3
  • NGD 3

External Ids for NGDN Gene

Previous HGNC Symbols for NGDN Gene

  • C14orf120

Previous GeneCards Identifiers for NGDN Gene

  • GC14P023009
  • GC14P023924
  • GC14P004055

Summaries for NGDN Gene

Entrez Gene Summary for NGDN Gene

  • Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NGDN Gene

NGDN (Neuroguidin) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NGDN Gene

  • Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs.

Additional gene information for NGDN Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NGDN Gene

Genomics for NGDN Gene

GeneHancer (GH) Regulatory Elements for NGDN Gene

Promoters and enhancers for NGDN Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I022976 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 160.1 -489.7 -489722 7.6 MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 E2F8 ZNF143 AJUBA ACIN1 NGDN PRMT5 C14orf93 HAUS4 RBM23 LOC102724814 PABPN1 MMP14
GH14I023056 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 72.9 -412.0 -412031 3 HDGF PKNOX1 CLOCK MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YBX1 CDH24 LOC105370705 ACIN1 NGDN RBM23 PRMT5 PABPN1 MMP14 SLC22A17 LOC102724814
GH14I022927 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 61.6 -540.0 -540021 3.2 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 ZNF548 SP3 PRMT5 LOC101926933 TRR-ACG1-3 HAUS4 NGDN ACIN1 RBM23 LOC102724814 PABPN1 SLC7A8
GH14I024187 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 66.9 +718.7 718682 2.6 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 IPO4 NGDN RNA5SP383 KHNYN RNF31 NFATC4 LOC102724814 ENSG00000259321 SDR39U1 SLC22A17
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NGDN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NGDN gene promoter:

Genomic Locations for NGDN Gene

Genomic Locations for NGDN Gene
40,235 bases
Plus strand

Genomic View for NGDN Gene

Genes around NGDN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NGDN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NGDN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NGDN Gene

Proteins for NGDN Gene

  • Protein details for NGDN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K760
    • Q9Y400

    Protein attributes for NGDN Gene

    315 amino acids
    Molecular mass:
    35894 Da
    Quaternary structure:
    • Interacts with CPEB1 and EIF4E.

    Alternative splice isoforms for NGDN Gene


neXtProt entry for NGDN Gene

Post-translational modifications for NGDN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NGDN Gene

No data available for DME Specific Peptides for NGDN Gene

Domains & Families for NGDN Gene

Gene Families for NGDN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NGDN Gene


Suggested Antigen Peptide Sequences for NGDN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SAS10 family.
  • Belongs to the SAS10 family.
genes like me logo Genes that share domains with NGDN: view

Function for NGDN Gene

Molecular function for NGDN Gene

UniProtKB/Swiss-Prot Function:
Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs.

Phenotypes From GWAS Catalog for NGDN Gene

Gene Ontology (GO) - Molecular Function for NGDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,IDA 22658674
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NGDN: view
genes like me logo Genes that share phenotypes with NGDN: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NGDN Gene

Localization for NGDN Gene

Subcellular locations from UniProtKB/Swiss-Prot for NGDN Gene

Nucleus. Nucleus, nucleolus. Chromosome, centromere. Cytoplasm. Cell projection, axon. Cell projection, dendrite. Cell projection, filopodium. Note=Detected in axons, dendrites and filopodia. Colocalized with EIF4E in neurites (By similarity). Translocated from nucleolus to nuclear foci in response to UV damage. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NGDN gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NGDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0005634 nucleus IDA --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IBA,IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NGDN: view

Pathways & Interactions for NGDN Gene

No Data Available

Gene Ontology (GO) - Biological Process for NGDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006417 regulation of translation IEA --
genes like me logo Genes that share ontologies with NGDN: view

No data available for Pathways by source and SIGNOR curated interactions for NGDN Gene

Drugs & Compounds for NGDN Gene

No Compound Related Data Available

Transcripts for NGDN Gene

Unigene Clusters for NGDN Gene

Neuroguidin, EIF4E binding protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NGDN Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - -
SP6: -
SP7: -

Relevant External Links for NGDN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NGDN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NGDN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NGDN Gene

This gene is overexpressed in Lung (36.4) and CD8 Tcells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NGDN Gene

Protein tissue co-expression partners for NGDN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NGDN Gene:


SOURCE GeneReport for Unigene cluster for NGDN Gene:


Evidence on tissue expression from TISSUES for NGDN Gene

  • Nervous system(4.6)
  • Muscle(4.5)
genes like me logo Genes that share expression patterns with NGDN: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NGDN Gene

Orthologs for NGDN Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NGDN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NGDN 33 34
  • 99.46 (n)
(Canis familiaris)
Mammalia NGDN 33 34
  • 91.7 (n)
(Bos Taurus)
Mammalia NGDN 33 34
  • 90.36 (n)
(Rattus norvegicus)
Mammalia Ngdn 33
  • 86.67 (n)
(Mus musculus)
Mammalia Ngdn 33 16 34
  • 86.02 (n)
(Monodelphis domestica)
Mammalia NGDN 34
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia NGDN 34
  • 82 (a)
(Anolis carolinensis)
Reptilia NGDN 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ngdn 33
  • 60.75 (n)
LOC395016 33
(Danio rerio)
Actinopterygii ngdn 33 34
  • 58.5 (n)
zgc66416 33
fruit fly
(Drosophila melanogaster)
Insecta CG11030 33 34
  • 52.78 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008697 33
  • 52.59 (n)
(Caenorhabditis elegans)
Secernentea lpd-2 33 34
  • 48.47 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G07840 33
  • 44.12 (n)
(Oryza sativa)
Liliopsida Os01g0911000 33
  • 45.3 (n)
Species where no ortholog for NGDN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NGDN Gene

Gene Tree for NGDN (if available)
Gene Tree for NGDN (if available)

Paralogs for NGDN Gene

No data available for Paralogs for NGDN Gene

Variants for NGDN Gene

Sequence variations from dbSNP and Humsavar for NGDN Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000009557 -- 23,474,579(+) A/C/G intron_variant
rs1000615173 -- 23,476,038(+) G/A coding_sequence_variant, missense_variant
rs1000677117 -- 23,473,991(+) C/G intron_variant
rs1001025190 -- 23,475,674(+) G/A intron_variant
rs1001403420 -- 23,474,974(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NGDN Gene

Variant ID Type Subtype PubMed ID
nsv1040319 CNV gain 25217958

Variation tolerance for NGDN Gene

Residual Variation Intolerance Score: 80% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.13; 51.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NGDN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NGDN Gene

Disorders for NGDN Gene

Additional Disease Information for NGDN

No disorders were found for NGDN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NGDN Gene

Publications for NGDN Gene

  1. CANu1, a novel nucleolar protein, accumulated on centromere in response to DNA damage. (PMID: 18547334) Sihn CR … Kim SH (Genes to cells : devoted to molecular & cellular mechanisms 2008) 3 4 58
  2. Translational control by neuroguidin, a eukaryotic initiation factor 4E and CPEB binding protein. (PMID: 16705177) Jung MY … Richter JD (Molecular and cellular biology 2006) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for NGDN Gene

Sources for NGDN Gene

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