External Ids for NGB Gene
Previous GeneCards Identifiers for NGB Gene
This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq, Jul 2008]
GeneCards Summary for NGB Gene
NGB (Neuroglobin) is a Protein Coding gene. Diseases associated with NGB include Stroke, Ischemic and Intracranial Berry Aneurysm. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxygen binding.
UniProtKB/Swiss-Prot Summary for NGB Gene
Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.