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Aliases for NGB Gene

Aliases for NGB Gene

  • Neuroglobin 2 3 3 5

External Ids for NGB Gene

Previous GeneCards Identifiers for NGB Gene

  • GC14M075237
  • GC14M071548
  • GC14M075721
  • GC14M076801
  • GC14M077731
  • GC14M057899

Summaries for NGB Gene

Entrez Gene Summary for NGB Gene

  • This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq, Jul 2008]

GeneCards Summary for NGB Gene

NGB (Neuroglobin) is a Protein Coding gene. Diseases associated with NGB include Pleural Cancer and Stroke, Ischemic. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxygen binding.

UniProtKB/Swiss-Prot for NGB Gene

  • Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.

Additional gene information for NGB Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NGB Gene

Genomics for NGB Gene

GeneHancer (GH) Regulatory Elements for NGB Gene

Promoters and enhancers for NGB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J077181 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 10.6 +89.5 89520 1.5 PKNOX1 SIN3A ZNF2 ZNF48 NCOA2 ETS1 ZNF335 GLIS2 ZNF143 EGR2 TMEM63C ZDHHC22 NGB FAM204DP GC14M077202 ENSG00000201384 ENSG00000259164
GH14J077312 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11 -44.2 -44159 5.7 PKNOX1 CLOCK FOXA2 ARID4B SIN3A ZNF2 ZNF143 FOS YY2 REST TMED8 GSTZ1 NGB ZDHHC22 ENSG00000201384 SAMD15 VIPAS39 AHSA1 TMEM63C POMT2
GH14J077301 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.6 -33.8 -33771 6.5 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 ZNF2 ZNF207 FOS JUNB MXD4 VIPAS39 IRF2BPL GSTZ1 ALKBH1 NGB MIR1260A ZDHHC22 ENSG00000201384 TMED8 SAMD15
GH14J077157 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.8 +112.8 112779 1.1 ZNF473 ZSCAN4 FOS SMARCA5 ZNF398 GMEB1 IKZF1 ZNF341 ZBTB33 ZNF24 TMEM63C POMT2 ENSG00000201384 NGB NOXRED1 SNW1 ZDHHC22 FAM204DP ENSG00000259164
GH14J077084 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 9.1 +184.1 184120 6.1 PKNOX1 NFIB NEUROD1 SIN3A BMI1 RFX5 FOS RCOR1 HCFC1 GATAD2B ENSG00000258473 TMEM63C IRF2BPL VASH1 NGB LINC02288 GC14P077095
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NGB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NGB gene promoter:
  • deltaCREB
  • CREB
  • c-Ets-1
  • Evi-1
  • GATA-1
  • MIF-1
  • AREB6
  • HEN1

Genomic Locations for NGB Gene

Genomic Locations for NGB Gene
chr14:77,265,483-77,271,312
(GRCh38/hg38)
Size:
5,830 bases
Orientation:
Minus strand
chr14:77,731,826-77,737,655
(GRCh37/hg19)
Size:
5,830 bases
Orientation:
Minus strand

Genomic View for NGB Gene

Genes around NGB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NGB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NGB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NGB Gene

Proteins for NGB Gene

  • Protein details for NGB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPG2-NGB_HUMAN
    Recommended name:
    Neuroglobin
    Protein Accession:
    Q9NPG2

    Protein attributes for NGB Gene

    Size:
    151 amino acids
    Molecular mass:
    16933 Da
    Quaternary structure:
    • Monomer. Homodimer and homotetramer; disulfide-linked (By similarity). Interacts with 14-3-3.

    Three dimensional structures from OCA and Proteopedia for NGB Gene

neXtProt entry for NGB Gene

Post-translational modifications for NGB Gene

  • A redox disulfide bond regulates the heme pocket coordination and the rate of nitrite reduction to NO.
  • Phosphorylated in vitro by ERK1, ERK2 and PKA, and in vivo during hypoxia. Phosphorylation increases nitrite reductase activity.

Other Protein References for NGB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NGB Gene

Domains & Families for NGB Gene

Gene Families for NGB Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for NGB Gene

Suggested Antigen Peptide Sequences for NGB Gene

Graphical View of Domain Structure for InterPro Entry

Q9NPG2

UniProtKB/Swiss-Prot:

NGB_HUMAN :
  • Belongs to the globin family.
Family:
  • Belongs to the globin family.
genes like me logo Genes that share domains with NGB: view

Function for NGB Gene

Molecular function for NGB Gene

UniProtKB/Swiss-Prot Function:
Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.

Gene Ontology (GO) - Molecular Function for NGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005344 oxygen carrier activity TAS 11029004
GO:0005515 protein binding IPI 25416956
GO:0019825 oxygen binding IEA --
GO:0020037 heme binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NGB: view
genes like me logo Genes that share phenotypes with NGB: view

Animal Models for NGB Gene

MGI Knock Outs for NGB:
  • Ngb Ngb<tm1.2Geno>

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NGB Gene

Localization for NGB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NGB Gene

Perikaryon. Cytoplasm. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NGB gene
Compartment Confidence
mitochondrion 5
cytosol 5
nucleus 3
plasma membrane 1
extracellular 1

Gene Ontology (GO) - Cellular Components for NGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0043204 perikaryon IEA --
genes like me logo Genes that share ontologies with NGB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NGB Gene

Pathways & Interactions for NGB Gene

No Data Available

Gene Ontology (GO) - Biological Process for NGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0015671 oxygen transport TAS --
genes like me logo Genes that share ontologies with NGB: view

No data available for Pathways by source and SIGNOR curated interactions for NGB Gene

Drugs & Compounds for NGB Gene

(8) Drugs for NGB Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
heme Pharma Agonist 0

(7) Additional Compounds for NGB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NGB: view

Transcripts for NGB Gene

mRNA/cDNA for NGB Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(23) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NGB Gene

Neuroglobin:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NGB Gene

No ASD Table

Relevant External Links for NGB Gene

GeneLoc Exon Structure for
NGB
ECgene alternative splicing isoforms for
NGB

Expression for NGB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NGB Gene

mRNA differential expression in normal tissues according to GTEx for NGB Gene

This gene is overexpressed in Brain - Hypothalamus (x15.1), Brain - Cortex (x8.3), Brain - Frontal Cortex (BA9) (x7.2), and Pituitary (x4.5).

Protein differential expression in normal tissues from HIPED for NGB Gene

This gene is overexpressed in Colon (55.5) and Rectum (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NGB Gene



Protein tissue co-expression partners for NGB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NGB Gene:

NGB

SOURCE GeneReport for Unigene cluster for NGB Gene:

Hs.274363

mRNA Expression by UniProt/SwissProt for NGB Gene:

Q9NPG2-NGB_HUMAN
Tissue specificity: Predominantly expressed in brain, the strongest expression is seen in the frontal lobe, the subthalamic nucleus and the thalamus.

Evidence on tissue expression from TISSUES for NGB Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with NGB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for NGB Gene

Orthologs for NGB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NGB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NGB 34 33
  • 99.78 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NGB 34 33
  • 92.94 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NGB 34 33
  • 91.39 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ngb 16 34 33
  • 88.52 (n)
rat
(Rattus norvegicus)
Mammalia Ngb 33
  • 87.2 (n)
oppossum
(Monodelphis domestica)
Mammalia NGB 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NGB 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves NGB 34 33
  • 75.84 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NGB 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ngb 33
  • 65.29 (n)
zebrafish
(Danio rerio)
Actinopterygii ngb 34 33
  • 62 (n)
OneToOne
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7992 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YHB1 36
Species where no ortholog for NGB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NGB Gene

ENSEMBL:
Gene Tree for NGB (if available)
TreeFam:
Gene Tree for NGB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NGB: view image

Paralogs for NGB Gene

No data available for Paralogs for NGB Gene

Variants for NGB Gene

Sequence variations from dbSNP and Humsavar for NGB Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000009936 -- 77,267,347(-) C/G intron_variant
rs1000055334 -- 77,269,720(-) C/G intron_variant
rs1000841511 -- 77,271,210(-) C/A 5_prime_UTR_variant
rs1001299686 -- 77,271,652(-) /G upstream_transcript_variant
rs1001417178 -- 77,265,797(-) C/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for NGB Gene

Variant ID Type Subtype PubMed ID
esv1739588 CNV deletion 17803354
esv2748901 CNV deletion 23290073
nsv1361 CNV deletion 18451855

Variation tolerance for NGB Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NGB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NGB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NGB Gene

Disorders for NGB Gene

MalaCards: The human disease database

(2) MalaCards diseases for NGB Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
pleural cancer
  • neoplasm of pleura
stroke, ischemic
  • cerebrovascular accident
- elite association - COSMIC cancer census association via MalaCards
Search NGB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NGB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NGB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NGB Gene

Publications for NGB Gene

  1. A vertebrate globin expressed in the brain. (PMID: 11029004) Burmester T … Hankeln T (Nature 2000) 2 3 4 22 58
  2. Zebrafish neuroglobin is a cell-membrane-penetrating globin. (PMID: 18416560) Watanabe S … Wakasugi K (Biochemistry 2008) 3 4 22 58
  3. Association between Ngb polymorphisms and ischemic stroke in the Southern Chinese Han population. (PMID: 19087291) Lin Y … Wu ZY (BMC medical genetics 2008) 3 22 44 58
  4. Coupling of the heme and an internal disulfide bond in human neuroglobin. (PMID: 15036292) Hamdane D … Marden MC (Micron (Oxford, England : 1993) 2004) 3 4 22 58
  5. Human brain neuroglobin structure reveals a distinct mode of controlling oxygen affinity. (PMID: 12962627) Pesce A … Bolognesi M (Structure (London, England : 1993) 2003) 3 4 22 58

Products for NGB Gene

Sources for NGB Gene

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