Aliases for NFYC Gene
- Nuclear Transcription Factor Y Subunit Gamma 2 3 4 5
- Nuclear Transcription Factor Y Subunit C 3 4
- CAAT Box DNA-Binding Protein Subunit C 3 4
- Nuclear Transcription Factor Y, Gamma 2 3
- Transactivator HSM-1/2 3 4
- NF-YC 3 4
- CCAAT Transcription Binding Factor Subunit Gamma 3
- Histone H1 Transcription Factor Large Subunit 2A 3
External Ids for NFYC Gene
Previous GeneCards Identifiers for NFYC Gene
This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
GeneCards Summary for NFYC Gene
NFYC (Nuclear Transcription Factor Y Subunit Gamma) is a Protein Coding gene. Diseases associated with NFYC include Choroid Plexus Cancer and Atypical Choroid Plexus Papilloma. Among its related pathways are Direct p53 effectors and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is DRAP1.
UniProtKB/Swiss-Prot Summary for NFYC Gene
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.