Aliases for NFYC Gene
External Ids for NFYC Gene
Previous GeneCards Identifiers for NFYC Gene
This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
GeneCards Summary for NFYC Gene
NFYC (Nuclear Transcription Factor Y Subunit Gamma) is a Protein Coding gene. Diseases associated with NFYC include Choroid Plexus Cancer and Thelaziasis. Among its related pathways are Tuberculosis and Validated targets of C-MYC transcriptional repression. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is DRAP1.
UniProtKB/Swiss-Prot Summary for NFYC Gene
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.