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Aliases for NFYC Gene

Aliases for NFYC Gene

  • Nuclear Transcription Factor Y Subunit Gamma 2 3 3 5
  • Nuclear Transcription Factor Y Subunit C 3 4
  • CAAT Box DNA-Binding Protein Subunit C 3 4
  • Nuclear Transcription Factor Y, Gamma 2 3
  • Transactivator HSM-1/2 3 4
  • NF-YC 3 4
  • CCAAT Transcription Binding Factor Subunit Gamma 3
  • Histone H1 Transcription Factor Large Subunit 2A 3
  • Transcription Factor NF-Y, C Subunit 3
  • CCAAT Binding Factor Subunit C 3
  • Transactivator HSM-1 3
  • H1TF2A 3
  • CBF-C 3
  • CBFC 3
  • HAP5 3
  • HSM 3

External Ids for NFYC Gene

Previous GeneCards Identifiers for NFYC Gene

  • GC01P041192
  • GC01P040160
  • GC01P040620
  • GC01P040570
  • GC01P040533
  • GC01P040826
  • GC01P040929
  • GC01P039275
  • GC01P041159

Summaries for NFYC Gene

Entrez Gene Summary for NFYC Gene

  • This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

GeneCards Summary for NFYC Gene

NFYC (Nuclear Transcription Factor Y Subunit Gamma) is a Protein Coding gene. Among its related pathways are Regulation of cholesterol biosynthesis by SREBP (SREBF) and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is POLE4.

UniProtKB/Swiss-Prot for NFYC Gene

  • Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5-CCAAT-3 box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.

Gene Wiki entry for NFYC Gene

Additional gene information for NFYC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFYC Gene

Genomics for NFYC Gene

GeneHancer (GH) Regulatory Elements for NFYC Gene

Promoters and enhancers for NFYC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J040708 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 656.9 +19.7 19668 6.1 PKNOX1 SMAD1 FOXA2 ARNT ARID4B FEZF1 DMAP1 YY1 SLC30A9 POLR2B NFYC EXO5 RLF RIMS3 TRIT1 LOC105378674 NFYC-AS1 MIR30E MIR30C1 LOC105378672
GH01J040690 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 669.7 +1.1 1131 4.4 ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 SP3 NFYC MEF2D RIMS3 NFYC-AS1 NFYC EXO5 ENSG00000259943 TRIT1 LOC105378674 ZFP69 SLFNL1 MIR30E
GH01J040256 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 30 -433.8 -433757 3.2 ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 ENSG00000259943 ZMPSTE24 PPIE EXO5 PPIEL TRIT1 RLF NFYC-AS1 NFYC LOC105378672
GH01J040976 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 23.3 +287.6 287634 6.1 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B CTPS1 GC01M040907 EXO5 SLFNL1 NFYC ENSG00000235358 RLF SCMH1 FOXO6
GH01J040096 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 22.1 -594.4 -594431 1.5 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF766 PPT1 PPIE EXO5 TRIT1 NFYC PPIEL PABPC4 RLF LOC101929516 CAP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NFYC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NFYC gene promoter:
  • YY1
  • Sp1
  • NRSF form 1
  • NRSF form 2

Genomic Locations for NFYC Gene

Genomic Locations for NFYC Gene
chr1:40,691,570-40,771,603
(GRCh38/hg38)
Size:
80,034 bases
Orientation:
Plus strand
chr1:41,157,242-41,237,275
(GRCh37/hg19)
Size:
80,034 bases
Orientation:
Plus strand

Genomic View for NFYC Gene

Genes around NFYC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFYC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFYC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFYC Gene

Proteins for NFYC Gene

  • Protein details for NFYC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13952-NFYC_HUMAN
    Recommended name:
    Nuclear transcription factor Y subunit gamma
    Protein Accession:
    Q13952
    Secondary Accessions:
    • B4DUS6
    • B4DW63
    • D3DPV9
    • F8VWM3
    • Q59GY4
    • Q5T6K8
    • Q5T6K9
    • Q5T6L1
    • Q5TZR6
    • Q92869
    • Q9HBX1
    • Q9NXB5
    • Q9UM67
    • Q9UML0
    • Q9UMT7

    Protein attributes for NFYC Gene

    Size:
    458 amino acids
    Molecular mass:
    50302 Da
    Quaternary structure:
    • Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding.
    SequenceCaution:
    • Sequence=BAD92212.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NFYC Gene

    Alternative splice isoforms for NFYC Gene

neXtProt entry for NFYC Gene

Post-translational modifications for NFYC Gene

  • Ubiquitination at Lys92, isoforms=2, 3, 5, 6, 771, and isoforms=2, 3, 4, 5, 6, 736
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NFYC Gene

Domains & Families for NFYC Gene

Gene Families for NFYC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for NFYC Gene

Graphical View of Domain Structure for InterPro Entry

Q13952

UniProtKB/Swiss-Prot:

NFYC_HUMAN :
  • Belongs to the NFYC/HAP5 subunit family.
Family:
  • Belongs to the NFYC/HAP5 subunit family.
genes like me logo Genes that share domains with NFYC: view

Function for NFYC Gene

Molecular function for NFYC Gene

UniProtKB/Swiss-Prot Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5-CCAAT-3 box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
GENATLAS Biochemistry:
nuclear transcription factor NF-Y,C subunit,binding the CCAAT and the inverted CCAT box,Y box (ATGG) motifs,in a variety of promoters,similarity with H2A

Phenotypes From GWAS Catalog for NFYC Gene

Gene Ontology (GO) - Molecular Function for NFYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000980 contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding IDA 11256944
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0003677 DNA binding IEA,IDA 15243141
genes like me logo Genes that share ontologies with NFYC: view
genes like me logo Genes that share phenotypes with NFYC: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NFYC

CRISPR Products

miRNA for NFYC Gene

miRTarBase miRNAs that target NFYC

Transcription Factor Targets for NFYC Gene

Selected GeneGlobe predicted Target genes for NFYC

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NFYC

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and HOMER Transcription for NFYC Gene

Localization for NFYC Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFYC Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NFYC gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NFYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 15243141
GO:0005654 nucleoplasm IDA,TAS --
GO:0016602 CCAAT-binding factor complex IDA 15243141
GO:0032993 protein-DNA complex IDA 11256944
GO:0090575 RNA polymerase II transcription factor complex IDA 11256944
genes like me logo Genes that share ontologies with NFYC: view

Pathways & Interactions for NFYC Gene

genes like me logo Genes that share pathways with NFYC: view

Gene Ontology (GO) - Biological Process for NFYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IDA 15243141
GO:0006357 regulation of transcription by RNA polymerase II TAS 10446203
GO:0006366 transcription by RNA polymerase II IEA --
GO:0006457 protein folding TAS 10446203
genes like me logo Genes that share ontologies with NFYC: view

No data available for SIGNOR curated interactions for NFYC Gene

Drugs & Compounds for NFYC Gene

No Compound Related Data Available

Transcripts for NFYC Gene

Unigene Clusters for NFYC Gene

Nuclear transcription factor Y, gamma:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NFYC

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFYC Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - -
SP6: -
SP7:
SP8:
SP9: -
SP10: - -

Relevant External Links for NFYC Gene

GeneLoc Exon Structure for
NFYC
ECgene alternative splicing isoforms for
NFYC

Expression for NFYC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NFYC Gene

Protein differential expression in normal tissues from HIPED for NFYC Gene

This gene is overexpressed in Ovary (8.7) and Oral epithelium (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NFYC Gene



NURSA nuclear receptor signaling pathways regulating expression of NFYC Gene:

NFYC

SOURCE GeneReport for Unigene cluster for NFYC Gene:

Hs.713051

Evidence on tissue expression from TISSUES for NFYC Gene

  • Nervous system(4.9)
  • Lung(4.3)
  • Intestine(3.8)
  • Stomach(3.6)
  • Kidney(3.5)
  • Eye(2.9)
  • Liver(2.7)
  • Muscle(2.4)
  • Pancreas(2.3)
  • Heart(2.2)
  • Spleen(2.2)
  • Blood(2.1)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with NFYC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NFYC Gene

Orthologs for NFYC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NFYC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFYC 34 33
  • 99.7 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NFYC 34
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NFYC 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NFYC 34 33
  • 95.21 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NFYC 34 33
  • 94.81 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nfyc 16 34 33
  • 92.74 (n)
rat
(Rattus norvegicus)
Mammalia Nfyc 33
  • 91.94 (n)
chicken
(Gallus gallus)
Aves NFYC 34 33
  • 84.73 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 94 (a)
OneToMany
-- 34
  • 88 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nfyc 33
  • 79.34 (n)
MGC75886 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6752 33
zebrafish
(Danio rerio)
Actinopterygii nfyc 34 33
  • 77.98 (n)
OneToOne
wufb98f01 33
fruit fly
(Drosophila melanogaster)
Insecta CG3075 35
  • 60 (a)
Nf-YC 34
  • 19 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nfyc-1 34
  • 19 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HAP5 34
  • 26 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.7826 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1103 33
rice
(Oryza sativa)
Liliopsida Os.24566 33
corn
(Zea mays)
Liliopsida Zm.17510 33
barley
(Hordeum vulgare)
Liliopsida Hv.10173 33
wheat
(Triticum aestivum)
Liliopsida Ta.7755 33
sea squirt
(Ciona savignyi)
Ascidiacea Cin.12254 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12254 33
Species where no ortholog for NFYC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NFYC Gene

ENSEMBL:
Gene Tree for NFYC (if available)
TreeFam:
Gene Tree for NFYC (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NFYC: view image

Paralogs for NFYC Gene

Paralogs for NFYC Gene

(11) SIMAP similar genes for NFYC Gene using alignment to 9 proteins:

  • NFYC_HUMAN
  • E9PI99_HUMAN
  • E9PIG7_HUMAN
  • E9PJA8_HUMAN
  • E9PL11_HUMAN
  • E9PQR2_HUMAN
  • H0Y803_HUMAN
  • Q5T6K5_HUMAN
  • Q5T6K7_HUMAN

Pseudogenes.org Pseudogenes for NFYC Gene

genes like me logo Genes that share paralogs with NFYC: view

Variants for NFYC Gene

Sequence variations from dbSNP and Humsavar for NFYC Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
VAR_035702 A breast cancer sample p.Gln165His
rs1000013139 -- 40,716,985(+) T/A/C genic_upstream_transcript_variant, intron_variant
rs1000025325 -- 40,761,170(+) A/C intron_variant
rs1000043897 -- 40,769,491(+) T/A intron_variant
rs1000059839 -- 40,747,009(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NFYC Gene

Variant ID Type Subtype PubMed ID
esv2663905 CNV deletion 23128226
esv3577821 CNV loss 25503493
esv3577822 CNV loss 25503493
esv8923 CNV gain 19470904
nsv1137251 CNV deletion 24896259
nsv610 CNV insertion 18451855

Variation tolerance for NFYC Gene

Residual Variation Intolerance Score: 34.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NFYC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NFYC

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFYC Gene

Disorders for NFYC Gene

Additional Disease Information for NFYC

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NFYC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NFYC Gene

Publications for NFYC Gene

  1. Cloning and expression of human NF-YC. (PMID: 9249075) Bellorini M … Mantovani R (Gene 1997) 2 3 4 22 58
  2. Isolation and sequence analysis of the cDNA encoding subunit C of human CCAAT-binding transcription factor. (PMID: 9332362) Dmitrenko V … Kavsan V (Gene 1997) 3 4 22 58
  3. Chromosomal assignment and tissue expression of CBF-C/NFY-C, the third subunit of the mammalian CCAAT-binding factor. (PMID: 8921405) Sinha S … de Crombrugghe B (Genomics 1996) 2 3 22 58
  4. Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination. (PMID: 23332751) Nardini M … Mantovani R (Cell 2013) 3 4 58
  5. Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women. (PMID: 21507922) Ramsuran V … Ndung'u T (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2011) 3 44 58

Products for NFYC Gene

Sources for NFYC Gene

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