Aliases for NFYC Gene
External Ids for NFYC Gene
Previous GeneCards Identifiers for NFYC Gene
This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
GeneCards Summary for NFYC Gene
NFYC (Nuclear Transcription Factor Y Subunit Gamma) is a Protein Coding gene. Diseases associated with NFYC include Choroid Plexus Cancer and Thelaziasis. Among its related pathways are Unfolded Protein Response (UPR) and Regulation of cholesterol biosynthesis by SREBP (SREBF). Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is DRAP1.
UniProtKB/Swiss-Prot Summary for NFYC Gene
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.