The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specifici... See more...

Aliases for NFYB Gene

Aliases for NFYB Gene

  • Nuclear Transcription Factor Y Subunit Beta 2 3 4 5
  • Nuclear Transcription Factor Y Subunit B 3 4
  • CAAT Box DNA-Binding Protein Subunit B 3 4
  • Nuclear Transcription Factor Y, Beta 2 3
  • NF-YB 3 4
  • HAP3 3 4
  • CCAAT-Binding Transcription Factor Subunit A 3
  • Transcription Factor NF-Y, B Subunit 3
  • CBF-A 3
  • CBF-B 3

External Ids for NFYB Gene

Previous GeneCards Identifiers for NFYB Gene

  • GC12M103626
  • GC12M104393
  • GC12M103015
  • GC12M103013
  • GC12M104510
  • GC12M101570

Summaries for NFYB Gene

Entrez Gene Summary for NFYB Gene

  • The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [provided by RefSeq, Jul 2008]

GeneCards Summary for NFYB Gene

NFYB (Nuclear Transcription Factor Y Subunit Beta) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and PERK regulates gene expression. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is DR1.

UniProtKB/Swiss-Prot Summary for NFYB Gene

  • Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.

Gene Wiki entry for NFYB Gene

Additional gene information for NFYB Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NFYB Gene

Genomics for NFYB Gene

GeneHancer (GH) Regulatory Elements for NFYB Gene

Promoters and enhancers for NFYB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NFYB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NFYB gene promoter:
  • AP-2gamma
  • HNF-1
  • HNF-1A
  • HNF-4alpha2
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • YY1

Genomic Locations for NFYB Gene

Genomic Locations for NFYB Gene
chr12:104,117,080-104,138,262
(GRCh38/hg38)
Size:
21,183 bases
Orientation:
Minus strand
chr12:104,510,855-104,532,067
(GRCh37/hg19)
Size:
21,213 bases
Orientation:
Minus strand

Genomic View for NFYB Gene

Genes around NFYB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFYB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFYB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFYB Gene

Proteins for NFYB Gene

  • Protein details for NFYB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25208-NFYB_HUMAN
    Recommended name:
    Nuclear transcription factor Y subunit beta
    Protein Accession:
    P25208
    Secondary Accessions:
    • A8K7B9
    • Q96IY8

    Protein attributes for NFYB Gene

    Size:
    207 amino acids
    Molecular mass:
    22831 Da
    Quaternary structure:
    • Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP.
    SequenceCaution:
    • Sequence=CAA42230.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NFYB Gene

neXtProt entry for NFYB Gene

Post-translational modifications for NFYB Gene

  • Monoubiquitination at Lys-140 plays an important role in transcriptional activation by allowing the deposition of histone H3 methylations as well as histone H2B monoubiquitination at 'Lys-121'.
  • Ubiquitination at Lys140
  • Modification sites at PhosphoSitePlus

Other Protein References for NFYB Gene

No data available for DME Specific Peptides for NFYB Gene

Domains & Families for NFYB Gene

Gene Families for NFYB Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for NFYB Gene

GenScript: Design optimal peptide antigens:
  • Nuclear transcription factor Y subunit B (NFYB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P25208

UniProtKB/Swiss-Prot:

NFYB_HUMAN :
  • Can be divided into 3 domains: the weakly conserved A domain, the highly conserved B domain thought to be involved in subunit interaction and DNA binding, and the Glu-rich C domain.
  • Belongs to the NFYB/HAP3 subunit family.
Domain:
  • Can be divided into 3 domains: the weakly conserved A domain, the highly conserved B domain thought to be involved in subunit interaction and DNA binding, and the Glu-rich C domain.
Family:
  • Belongs to the NFYB/HAP3 subunit family.
genes like me logo Genes that share domains with NFYB: view

Function for NFYB Gene

Molecular function for NFYB Gene

UniProtKB/Swiss-Prot Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
GENATLAS Biochemistry:
nuclear transcription factor NF-Y,B subunit,binding the CCAAT and the inverted CCAT box,Y box (ATGG) motifs in a variety of promoters,similarity with H2B

Phenotypes From GWAS Catalog for NFYB Gene

Gene Ontology (GO) - Molecular Function for NFYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000980 contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding IDA 11256944
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003677 DNA binding IDA,IEA 15243141
GO:0003700 DNA-binding transcription factor activity TAS 1577736
GO:0005515 protein binding IPI 12401788
genes like me logo Genes that share ontologies with NFYB: view
genes like me logo Genes that share phenotypes with NFYB: view

Animal Model Products

CRISPR Products

Transcription Factor Targets for NFYB Gene

Selected GeneGlobe predicted Target genes for NFYB

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and HOMER Transcription for NFYB Gene

Localization for NFYB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFYB Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NFYB gene
Compartment Confidence
nucleus 5
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NFYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15243141
GO:0005654 nucleoplasm TAS --
GO:0016602 CCAAT-binding factor complex IBA,IDA 15243141
GO:0032993 protein-DNA complex IDA 11256944
GO:0090575 RNA polymerase II transcription factor complex IDA 11256944
genes like me logo Genes that share ontologies with NFYB: view

Pathways & Interactions for NFYB Gene

genes like me logo Genes that share pathways with NFYB: view

SIGNOR curated interactions for NFYB Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for NFYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IDA 15243141
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0045540 regulation of cholesterol biosynthetic process TAS --
GO:0045893 positive regulation of transcription, DNA-templated IBA 21873635
GO:1990830 cellular response to leukemia inhibitory factor IEA --
genes like me logo Genes that share ontologies with NFYB: view

Drugs & Compounds for NFYB Gene

No Compound Related Data Available

Transcripts for NFYB Gene

mRNA/cDNA for NFYB Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFYB Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: - -
SP6:
SP7:
SP8: - - - -

Relevant External Links for NFYB Gene

GeneLoc Exon Structure for
NFYB
ECgene alternative splicing isoforms for
NFYB

Expression for NFYB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NFYB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NFYB Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.6), Retina (7.9), and Placenta (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NFYB Gene



Protein tissue co-expression partners for NFYB Gene

NURSA nuclear receptor signaling pathways regulating expression of NFYB Gene:

NFYB

SOURCE GeneReport for Unigene cluster for NFYB Gene:

Hs.84928

Evidence on tissue expression from TISSUES for NFYB Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with NFYB: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NFYB Gene

Orthologs for NFYB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NFYB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFYB 32
  • 100 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NFYB 33
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NFYB 33 32
  • 94.69 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NFYB 33 32
  • 94.04 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nfyb 17 33 32
  • 88.73 (n)
oppossum
(Monodelphis domestica)
Mammalia NFYB 33
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nfyb 32
  • 87.12 (n)
chicken
(Gallus gallus)
Aves NFYB 33 32
  • 86.53 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NFYB 33
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfyb 32
  • 81.32 (n)
Str.5961 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.419 32
zebrafish
(Danio rerio)
Actinopterygii nfyba 33 32
  • 71.08 (n)
OneToMany
nfybb 33
  • 70 (a)
OneToMany
Dr.14764 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.388 32
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008344 32
  • 63 (n)
fruit fly
(Drosophila melanogaster)
Insecta Nf-YB 33 32
  • 58.33 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nfyb-1 33
  • 18 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HAP3 35 33 32
  • 56.75 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR014C 32
  • 53.56 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E10429g 32
  • 51.7 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons NF-YB10 32
  • 64 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6634 32
rice
(Oryza sativa)
Liliopsida Os05g0573500 32
  • 59.52 (n)
Os.22637 32
wheat
(Triticum aestivum)
Liliopsida Ta.4075 32
barley
(Hordeum vulgare)
Liliopsida Hv.7207 32
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6795 33
  • 51 (a)
OneToOne
Cin.811 32
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.811 32
Species where no ortholog for NFYB was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NFYB Gene

ENSEMBL:
Gene Tree for NFYB (if available)
TreeFam:
Gene Tree for NFYB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NFYB: view image

Paralogs for NFYB Gene

Paralogs for NFYB Gene

(3) SIMAP similar genes for NFYB Gene using alignment to 2 proteins:

  • NFYB_HUMAN
  • F8VSL3_HUMAN

Pseudogenes.org Pseudogenes for NFYB Gene

genes like me logo Genes that share paralogs with NFYB: view

Variants for NFYB Gene

Sequence variations from dbSNP and Humsavar for NFYB Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000084724 -- 104,121,885(-) A/C intron_variant
rs1000114938 -- 104,131,252(-) T/C intron_variant
rs1000193172 -- 104,117,348(-) C/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000222079 -- 104,129,166(-) G/A intron_variant
rs1000225745 -- 104,117,683(-) T/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NFYB Gene

Variant ID Type Subtype PubMed ID
dgv2841n54 CNV gain 21841781
esv23395 CNV loss 19812545
esv3580446 CNV loss 25503493
nsv1126319 CNV deletion 24896259
nsv560047 CNV gain 21841781
nsv560048 CNV gain 21841781
nsv819113 CNV gain 19587683
nsv952468 CNV deletion 24416366

Variation tolerance for NFYB Gene

Residual Variation Intolerance Score: 39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NFYB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NFYB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFYB Gene

Disorders for NFYB Gene

Additional Disease Information for NFYB

No disorders were found for NFYB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NFYB Gene

Publications for NFYB Gene

  1. Role of the CCAAT-binding protein CBF/NF-Y in transcription. (PMID: 9612081) Maity SN … de Crombrugghe B (Trends in biochemical sciences 1998) 2 3 23 56
  2. Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination. (PMID: 23332751) Nardini M … Mantovani R (Cell 2013) 3 4 56
  3. Subunits of the heterotrimeric transcription factor NF-Y are imported into the nucleus by distinct pathways involving importin beta and importin 13. (PMID: 15964792) Kahle J … Albig W (Molecular and cellular biology 2005) 3 23 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro. (PMID: 15243141) Chattopadhyay C … Maity SN (Nucleic acids research 2004) 3 4 56

Products for NFYB Gene

Sources for NFYB Gene