Aliases for NFYB Gene
External Ids for NFYB Gene
Previous GeneCards Identifiers for NFYB Gene
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [provided by RefSeq, Jul 2008]
GeneCards Summary for NFYB Gene
NFYB (Nuclear Transcription Factor Y Subunit Beta) is a Protein Coding gene. Diseases associated with NFYB include Inflammatory Bowel Disease 10 and Thelaziasis. Among its related pathways are Tuberculosis and Validated targets of C-MYC transcriptional repression. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is DR1.
UniProtKB/Swiss-Prot Summary for NFYB Gene
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.