The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specifici... See more...

Aliases for NFYB Gene

Aliases for NFYB Gene

  • Nuclear Transcription Factor Y Subunit Beta 2 3 4 5
  • NF-YB 2 3 4
  • HAP3 2 3 4
  • Nuclear Transcription Factor Y Subunit B 3 4
  • CAAT Box DNA-Binding Protein Subunit B 3 4
  • Nuclear Transcription Factor Y, Beta 2 3
  • CBF-A 2 3
  • CCAAT-Binding Transcription Factor Subunit A 3
  • Transcription Factor NF-Y, B Subunit 3
  • CBF-B 3
  • NFYB 5

External Ids for NFYB Gene

Previous GeneCards Identifiers for NFYB Gene

  • GC12M103626
  • GC12M104393
  • GC12M103015
  • GC12M103013
  • GC12M104510
  • GC12M101570

Summaries for NFYB Gene

Entrez Gene Summary for NFYB Gene

  • The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [provided by RefSeq, Jul 2008]

GeneCards Summary for NFYB Gene

NFYB (Nuclear Transcription Factor Y Subunit Beta) is a Protein Coding gene. Diseases associated with NFYB include Inflammatory Bowel Disease 10 and Thelaziasis. Among its related pathways are Unfolded Protein Response (UPR) and Regulation of cholesterol biosynthesis by SREBP (SREBF). Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is DR1.

UniProtKB/Swiss-Prot Summary for NFYB Gene

  • Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.

Gene Wiki entry for NFYB Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NFYB Gene

Genomics for NFYB Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NFYB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NFYB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NFYB

Top Transcription factor binding sites by QIAGEN in the NFYB gene promoter:
  • AP-2gamma
  • HNF-1
  • HNF-1A
  • HNF-4alpha2
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • YY1

Genomic Locations for NFYB Gene

Latest Assembly
chr12:104,117,086-104,138,241
(GRCh38/hg38)
Size:
21,156 bases
Orientation:
Minus strand

Previous Assembly
chr12:104,510,864-104,531,988
(GRCh37/hg19 by Entrez Gene)
Size:
21,125 bases
Orientation:
Minus strand

chr12:104,510,855-104,532,067
(GRCh37/hg19 by Ensembl)
Size:
21,213 bases
Orientation:
Minus strand

Genomic View for NFYB Gene

Genes around NFYB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFYB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFYB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFYB Gene

Proteins for NFYB Gene

  • Protein details for NFYB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25208-NFYB_HUMAN
    Recommended name:
    Nuclear transcription factor Y subunit beta
    Protein Accession:
    P25208
    Secondary Accessions:
    • A8K7B9
    • Q96IY8

    Protein attributes for NFYB Gene

    Size:
    207 amino acids
    Molecular mass:
    22831 Da
    Quaternary structure:
    • Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP.
    SequenceCaution:
    • Sequence=CAA42230.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NFYB Gene

neXtProt entry for NFYB Gene

Post-translational modifications for NFYB Gene

  • Monoubiquitination at Lys-140 plays an important role in transcriptional activation by allowing the deposition of histone H3 methylations as well as histone H2B monoubiquitination at 'Lys-121'.
  • Ubiquitination at Lys140
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NFYB Gene

Domains & Families for NFYB Gene

Gene Families for NFYB Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for NFYB Gene

InterPro:
Blocks:
  • CCAAT-binding transcription factor subunit A signature
  • Transcription factor CBF/NF-Y/archaeal histone

Suggested Antigen Peptide Sequences for NFYB Gene

GenScript: Design optimal peptide antigens:
  • Nuclear transcription factor Y subunit B (NFYB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P25208

UniProtKB/Swiss-Prot:

NFYB_HUMAN :
  • Can be divided into 3 domains: the weakly conserved A domain, the highly conserved B domain thought to be involved in subunit interaction and DNA binding, and the Glu-rich C domain.
  • Belongs to the NFYB/HAP3 subunit family.
Domain:
  • Can be divided into 3 domains: the weakly conserved A domain, the highly conserved B domain thought to be involved in subunit interaction and DNA binding, and the Glu-rich C domain.
Family:
  • Belongs to the NFYB/HAP3 subunit family.
genes like me logo Genes that share domains with NFYB: view

Function for NFYB Gene

Molecular function for NFYB Gene

UniProtKB/Swiss-Prot Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
GENATLAS Biochemistry:
nuclear transcription factor NF-Y,B subunit,binding the CCAAT and the inverted CCAT box,Y box (ATGG) motifs in a variety of promoters,similarity with H2B

Phenotypes From GWAS Catalog for NFYB Gene

Gene Ontology (GO) - Molecular Function for NFYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 contributes_to transcription regulatory region sequence-specific DNA binding IDA 11256944
GO:0000978 contributes_to RNA polymerase II proximal promoter sequence-specific DNA binding IDA 11256944
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IGI 11306579
GO:0003677 DNA binding IEA,IDA 15243141
genes like me logo Genes that share ontologies with NFYB: view
genes like me logo Genes that share phenotypes with NFYB: view

Transcription Factor Targets for NFYB Gene

Selected GeneGlobe predicted Target genes for NFYB

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NFYB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and HOMER Transcription for NFYB Gene

Localization for NFYB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFYB Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NFYB gene
Compartment Confidence
nucleus 5
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NFYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin ISA --
GO:0005634 nucleus IBA,IDA 11306579
GO:0005654 nucleoplasm TAS --
GO:0016602 CCAAT-binding factor complex IBA,IDA 15243141
GO:0032993 protein-DNA complex IDA 11256944
genes like me logo Genes that share ontologies with NFYB: view

Pathways & Interactions for NFYB Gene

genes like me logo Genes that share pathways with NFYB: view

SIGNOR curated interactions for NFYB Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for NFYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IDA 15243141
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0045540 regulation of cholesterol biosynthetic process TAS --
GO:0045893 positive regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 11306579
genes like me logo Genes that share ontologies with NFYB: view

Drugs & Compounds for NFYB Gene

No Compound Related Data Available

Transcripts for NFYB Gene

mRNA/cDNA for NFYB Gene

1 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NFYB

Alternative Splicing Database (ASD) splice patterns (SP) for NFYB Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: - -
SP6:
SP7:
SP8: - - - -

Relevant External Links for NFYB Gene

GeneLoc Exon Structure for
NFYB

Expression for NFYB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NFYB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NFYB Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.6), Retina (7.9), and Placenta (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NFYB Gene



Protein tissue co-expression partners for NFYB Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NFYB

SOURCE GeneReport for Unigene cluster for NFYB Gene:

Hs.84928

Evidence on tissue expression from TISSUES for NFYB Gene

  • Nervous system(2.9)
  • Skin(2.4)
  • Lung(2.1)
  • Muscle(2.1)
  • Liver(2.1)
  • Heart(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with NFYB: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NFYB Gene

Orthologs for NFYB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NFYB Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NFYB 29
  • 100 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia NFYB 30
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia NFYB 29 30
  • 94.69 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NFYB 29 30
  • 94.04 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Nfyb 29 16 30
  • 88.73 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NFYB 30
  • 88 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nfyb 29
  • 87.12 (n)
Chicken
(Gallus gallus)
Aves NFYB 29 30
  • 86.53 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NFYB 30
  • 97 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nfyb 29
  • 81.32 (n)
Str.5961 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.419 29
Zebrafish
(Danio rerio)
Actinopterygii nfyba 29 30
  • 71.08 (n)
OneToMany
nfybb 30
  • 70 (a)
OneToMany
Dr.14764 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.388 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008344 29
  • 63 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Nf-YB 29 30
  • 58.33 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea nfyb-1 30
  • 18 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HAP3 29 30 32
  • 56.75 (n)
OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AFR014C 29
  • 53.56 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E10429g 29
  • 51.7 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons NF-YB10 29
  • 64 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6634 29
Rice
(Oryza sativa)
Liliopsida Os05g0573500 29
  • 59.52 (n)
Os.22637 29
Barley
(Hordeum vulgare)
Liliopsida Hv.7207 29
Wheat
(Triticum aestivum)
Liliopsida Ta.4075 29
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6795 30
  • 51 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.811 29
Species where no ortholog for NFYB was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NFYB Gene

ENSEMBL:
Gene Tree for NFYB (if available)
TreeFam:
Gene Tree for NFYB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NFYB: view image
Alliance of Genome Resources:
Additional Orthologs for NFYB

Paralogs for NFYB Gene

Paralogs for NFYB Gene

(3) SIMAP similar genes for NFYB Gene using alignment to 2 proteins:

  • NFYB_HUMAN
  • F8VSL3_HUMAN

Pseudogenes.org Pseudogenes for NFYB Gene

genes like me logo Genes that share paralogs with NFYB: view

Variants for NFYB Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NFYB Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NFYB Gene

Variant ID Type Subtype PubMed ID
dgv2841n54 CNV gain 21841781
esv23395 CNV loss 19812545
esv3580446 CNV loss 25503493
nsv1126319 CNV deletion 24896259
nsv560047 CNV gain 21841781
nsv560048 CNV gain 21841781
nsv819113 CNV gain 19587683
nsv952468 CNV deletion 24416366

Variation tolerance for NFYB Gene

Residual Variation Intolerance Score: 39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NFYB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NFYB
Leiden Open Variation Database (LOVD)
NFYB

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NFYB Gene

Disorders for NFYB Gene

MalaCards: The human disease database

(3) MalaCards diseases for NFYB Gene - From: COP

Disorder Aliases PubMed IDs
inflammatory bowel disease 10
  • ibd10
thelaziasis
  • infection by thelazia
schopf-schulz-passarge syndrome
  • ssps
- elite association - COSMIC cancer census association via MalaCards
Search NFYB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NFYB

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with NFYB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NFYB Gene

Publications for NFYB Gene

  1. Role of the CCAAT-binding protein CBF/NF-Y in transcription. (PMID: 9612081) Maity SN … de Crombrugghe B (Trends in biochemical sciences 1998) 2 3 22
  2. Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination. (PMID: 23332751) Nardini M … Mantovani R (Cell 2013) 3 4
  3. Subunits of the heterotrimeric transcription factor NF-Y are imported into the nucleus by distinct pathways involving importin beta and importin 13. (PMID: 15964792) Kahle J … Albig W (Molecular and cellular biology 2005) 3 22
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. p73 competes with co-activators and recruits histone deacetylase to NF-Y in the repression of PDGF beta-receptor. (PMID: 15454570) Uramoto H … Funa K (Journal of cell science 2004) 3 22

Products for NFYB Gene

Sources for NFYB Gene