Aliases for NFYB Gene
External Ids for NFYB Gene
Previous GeneCards Identifiers for NFYB Gene
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [provided by RefSeq, Jul 2008]
GeneCards Summary for NFYB Gene
NFYB (Nuclear Transcription Factor Y Subunit Beta) is a Protein Coding gene. Diseases associated with NFYB include Inflammatory Bowel Disease 10 and Thelaziasis. Among its related pathways are Unfolded Protein Response (UPR) and Regulation of cholesterol biosynthesis by SREBP (SREBF). Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is DR1.
UniProtKB/Swiss-Prot Summary for NFYB Gene
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.