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The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]
NFYA (Nuclear Transcription Factor Y Subunit Alpha) is a Protein Coding gene. Among its related pathways are Tuberculosis and Spinocerebellar ataxia. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription regulatory region DNA binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000976 | contributes_to transcription regulatory region sequence-specific DNA binding | IDA | 11256944 |
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | ISS | -- |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IBA | 21873635 |
GO:0003677 | DNA binding | IDA | 15243141 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | TAS,IDA | 15243141 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0016602 | CCAAT-binding factor complex | IBA,IDA | 15243141 |
GO:0032993 | protein-DNA complex | IDA | 11256944 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IDA | 15243141 |
GO:0006366 | transcription by RNA polymerase II | TAS | 2000400 |
GO:0010723 | positive regulation of transcription from RNA polymerase II promoter in response to iron | IBA | 21873635 |
GO:0045540 | regulation of cholesterol biosynthetic process | TAS | -- |
GO:0045893 | positive regulation of transcription, DNA-templated | ISS | -- |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||
SP5: | - | - | - | - |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NFYA 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | NFYA 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NFYA 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | NFYA 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NFYA 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Nfya 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Nfya 30 |
|
||
Chicken (Gallus gallus) |
Aves | NFYA 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NFYA 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | nfya 30 |
|
||
MGC76011 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.418 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | nfya 30 31 |
|
OneToMany | |
nfyal 30 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | Nf-YA 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | nfya-2 31 |
|
OneToMany | |
nfya-1 31 |
|
OneToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HAP2 31 33 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1117437 | CNV | tandem duplication | 24896259 |
nsv602970 | CNV | gain | 21841781 |
No disorders were found for NFYA Gene.