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The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of... See more...
Aliases for NFYA Gene
Aliases for NFYA Gene
External Ids for NFYA Gene
- HGNC: 7804
- Entrez Gene: 4800
- Ensembl: ENSG00000001167
- OMIM: 189903
- UniProtKB: P23511
Previous GeneCards Identifiers for NFYA Gene
- GC06P041042
- GC06P041087
- GC06P041148
- GC06P041040
- GC06P040758
- GC06P042924
- GC06P043252
- GC06P041074
- GC06P041309
- GC06P041321
- GC06P041983
- GC06P042629
Summaries for NFYA Gene
-
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for NFYA Gene
NFYA (Nuclear Transcription Factor Y Subunit Alpha) is a Protein Coding gene. Diseases associated with NFYA include Megakaryocytic Leukemia. Among its related pathways are Wnt Signaling Pathway and Pluripotency and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription regulatory region DNA binding.
UniProtKB/Swiss-Prot Summary for NFYA Gene
-
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1.
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NFYA Gene
Genomics for NFYA Gene
GeneHancer (GH) Regulatory Elements for NFYA Gene
Promoters and enhancers for NFYA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NFYA on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the NFYA gene promoter:
-
- CUTL1
- GATA-1
- p53
Genomic Locations for NFYA Gene
Genomic Locations for NFYA Gene
- chr6:41,072,945-41,102,407
- (GRCh38/hg38)
- Size:
- 29,463 bases
- Orientation:
- Plus strand
- chr6:41,040,684-41,070,146
- (GRCh37/hg19)
- Size:
- 29,463 bases
- Orientation:
- Plus strand
Genomic View for NFYA Gene
Genes around NFYA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.1 by HGNC
- 6p21.1 by Entrez Gene
- 6p21.1 by Ensembl
NFYA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NFYA Gene
Proteins for NFYA Gene
-
Protein details for NFYA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P23511-NFYA_HUMAN
- Recommended name:
- Nuclear transcription factor Y subunit alpha
- Protein Accession:
- P23511
- Q8IXU0
Protein attributes for NFYA Gene
- Size:
- 347 amino acids
- Molecular mass:
- 36877 Da
- Quaternary structure:
-
- Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with SP1; the interaction is inhibited by glycosylation of SP1. Interacts with ZHX1. Interacts (via N-terminus) with ZHX2 (via homeobox domain). Interacts with ZFX3.
Protein Expression for NFYA Gene
Post-translational modifications for NFYA Gene
Other Protein References for NFYA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ NFYA Antibody
- Atlas Antibodies Anti-NFYA Antibody
- GeneTex Anti-NFYA antibody
- Novus Biologicals Antibodies for NFYA
-
Abcam antibodies for NFYA
- Invitrogen Antibodies for NFYA (AFLGC-NFYA)
- antibodies-online: Show 42 available NFYA Antibodies ranked by validation data
-
Santa Cruz Biotechnology (SCBT) Antibodies for NFYA
- Sino Biological Antibodies for NFYA
Protein Products
-
Creative Biomart
- Recombinant Human NFYA (NFYA-30385TH)
- Recombinant Human NFYA 293 Cell Lysate (NFYA-3840HCL)
- Recombinant Human NFYA 293 Cell Lysate (NFYA-3841HCL)
- Recombinant Human NFYA (NFYA-379H)
- Recombinant Human NFYA Protein, His-tagged (NFYA-200H)
- Recombinant Human NFYA Protein
- Recombinant Human NFYA Protein, His-tagged (NFYA-203H)
- Recombinant Human NFYA Protein, GST-tagged
- Search Origene for MassSpec and Protein Over-expression Lysates for NFYA
- Origene Custom Protein Services for NFYA
-
Abcam proteins for NFYA
Assay Products
- antibodies-online: Show 3 available NFYA Elisa Kits ranked by validation data
- Compare Top NFYA Elisa Kits
-
Quality Products:
-
Abcam assays for NFYA
No data available for DME Specific Peptides for NFYA Gene
Domains & Families for NFYA Gene
Gene Families for NFYA Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for NFYA Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for NFYA Gene
- GenScript: Design optimal peptide antigens:
-
- Nuclear transcription factor Y subunit A (NFYA_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P23511- Family:
-
- Belongs to the NFYA/HAP2 subunit family.
Function for NFYA Gene
Molecular function for NFYA Gene
- UniProtKB/Swiss-Prot Function:
- Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1.
- GENATLAS Biochemistry:
- nuclear transcription factor NF-Y,A subunit,binding the CCAAT and the inverted CCAT box,Y box (ATGG) motifs in a variety of promoters,interacting with P/CAF
Phenotypes From GWAS Catalog for NFYA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | ISS | -- |
| GO:0000980 | contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding | IDA | 11256944 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | NAS | 19274049 |
| GO:0003677 | DNA binding | IDA | 15243141 |
| GO:0003700 | DNA-binding transcription factor activity | TAS | 1774067 |
Phenotypes for NFYA Gene
- MGI mutant phenotypes for NFYA:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for NFYA:
Animal Models for NFYA Gene
- MGI Knock Outs for NFYA:
-
- Nfya Nfya<tm1.1Mait>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for NFYA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NFYA
- genomics-online: gRNA clones - Search for available NFYA gRNA products
- Overview of 139 available NFYA gene related products
- Applied Biological Materials (abm): CRISPR Clones for NFYA - Select products 50% OFF >
- * NFYA CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * NFYA CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for NFYA
miRNA for NFYA Gene
- miRTarBase miRNAs that target NFYA
-
- hsa-mir-140-3p (MIRT021682)
- hsa-mir-7-5p (MIRT025877)
- hsa-mir-192-5p (MIRT026722)
- hsa-mir-221-3p (MIRT046947)
- hsa-mir-203a-3p (MIRT053441)
- hsa-mir-4668-5p (MIRT566629)
- hsa-mir-548aw (MIRT566630)
- hsa-mir-1468-3p (MIRT566631)
- hsa-mir-548x-5p (MIRT566632)
- hsa-mir-548g-5p (MIRT566633)
- hsa-mir-548f-5p (MIRT566634)
- hsa-mir-548aj-5p (MIRT566635)
- hsa-mir-3613-3p (MIRT566636)
- hsa-mir-6835-3p (MIRT566637)
- hsa-mir-4282 (MIRT566638)
- hsa-mir-548e-5p (MIRT566639)
- hsa-mir-4713-5p (MIRT626150)
- hsa-mir-6845-3p (MIRT626151)
- hsa-mir-2116-3p (MIRT626152)
- hsa-mir-532-3p (MIRT626153)
- hsa-mir-150-5p (MIRT626154)
- hsa-mir-645 (MIRT626155)
- hsa-mir-361-3p (MIRT626156)
- hsa-mir-4286 (MIRT626157)
- hsa-mir-4301 (MIRT626158)
- hsa-mir-6777-3p (MIRT626159)
- hsa-mir-4478 (MIRT626160)
- hsa-mir-4419b (MIRT626161)
- hsa-mir-3929 (MIRT626162)
- hsa-mir-552-5p (MIRT701436)
- hsa-mir-1238-3p (MIRT701437)
- hsa-mir-6839-3p (MIRT701438)
- hsa-mir-4507 (MIRT701439)
- hsa-mir-3940-5p (MIRT701440)
- hsa-mir-502-5p (MIRT701441)
- hsa-mir-4326 (MIRT701442)
- hsa-mir-629-5p (MIRT701443)
Transcription Factor Targets for NFYA Gene
Targeted motifs for NFYA Gene
HOMER Transcription Factor Regulatory Elements motif NFYA
- Consensus sequence: AGCCAATCGG Submotif: canonical Cell Type: NA
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for NFYA
- Browse OriGene Inhibitory RNA Products For NFYA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NFYA
- genomics-online: shRNA clones - Search for available NFYA shRNA products
- Overview of 139 available NFYA gene related products
Clone Products
-
- MG204581
- MG223083
- MR204581
- MR204581L3
- MR204581L3V
- MR204581L4
- MR204581L4V
- MR223083
- MR223083L3
- MR223083L3V
- MR223083L4
- MR223083L4V
- RC205981
- RC205981L3
- RC205981L3V
- RC205981L4
- RC205981L4V
- RC213263
- RC213263L1
- RC213263L1V
- RC213263L2
- RC213263L2V
- RC213263L3
- RC213263L3V
- RC213263L4
- RC213263L4V
- RG205981
- RG213263
- RR211726
- RR211726L1
- RR211726L1V
- RR211726L2
- RR211726L2V
- RR211726L3
- RR211726L3V
- RR211726L4
- RR211726L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NFYA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NFYA
- genomics-online: cdna clones - Search for available NFYA CDNA products
- Overview of 139 available NFYA gene related products
- orf clones - Search for available NFYA ORF products
- Overview of 139 available NFYA gene related products
- Applied Biological Materials (abm): Clones for NFYA - Select products 50% OFF >
- * NFYA as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * NFYA tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for NFYA Gene
Localization for NFYA Gene
Subcellular locations from UniProtKB/Swiss-Prot for NFYA Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,TAS | 15243141 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0016602 | CCAAT-binding factor complex | IDA | 15243141 |
| GO:0032993 | protein-DNA complex | IDA | 11256944 |
| GO:0090575 | RNA polymerase II transcription factor complex | IDA | 11256944 |
Pathways & Interactions for NFYA Gene
Pathways by source for NFYA Gene
5 BioSystems pathways for NFYA Gene
2 KEGG pathways for NFYA Gene
1 GeneGo (Thomson Reuters) pathway for NFYA Gene
Interacting Proteins for NFYA Gene
Selected Interacting proteins:
P23511-NFYA_HUMAN
ENSP00000345702
for NFYA Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for NFYA
SIGNOR curated interactions for NFYA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IDA | 15243141 |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006366 | transcription by RNA polymerase II | TAS | 2000400 |
| GO:0045540 | regulation of cholesterol biosynthetic process | TAS | -- |
| GO:0045893 | positive regulation of transcription, DNA-templated | ISS | -- |
Drugs & Compounds for NFYA Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
-
Creative Biomart
- Recombinant Human NFYA (NFYA-30385TH)
- Recombinant Human NFYA 293 Cell Lysate (NFYA-3840HCL)
- Recombinant Human NFYA 293 Cell Lysate (NFYA-3841HCL)
- Recombinant Human NFYA (NFYA-379H)
- Recombinant Human NFYA Protein, His-tagged (NFYA-200H)
- Recombinant Human NFYA Protein
- Recombinant Human NFYA Protein, His-tagged (NFYA-203H)
- Recombinant Human NFYA Protein, GST-tagged
Transcripts for NFYA Gene
mRNA/cDNA for NFYA Gene
- (2) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (196) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000341376 3811 bps (ENST00000341376.10)
- ENST00000353205 1660 bps (ENST00000353205.5)
CRISPR Products
-
OriGene CRISPR knockouts for NFYA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NFYA
- genomics-online: gRNA clones - Search for available NFYA gRNA products
- Overview of 139 available NFYA gene related products
- Applied Biological Materials (abm): CRISPR Clones for NFYA - Select products 50% OFF >
- * NFYA CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * NFYA CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for NFYA
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for NFYA
- Browse OriGene Inhibitory RNA Products For NFYA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NFYA
- genomics-online: shRNA clones - Search for available NFYA shRNA products
- Overview of 139 available NFYA gene related products
Clone Products
-
- MG204581
- MG223083
- MR204581
- MR204581L3
- MR204581L3V
- MR204581L4
- MR204581L4V
- MR223083
- MR223083L3
- MR223083L3V
- MR223083L4
- MR223083L4V
- RC205981
- RC205981L3
- RC205981L3V
- RC205981L4
- RC205981L4V
- RC213263
- RC213263L1
- RC213263L1V
- RC213263L2
- RC213263L2V
- RC213263L3
- RC213263L3V
- RC213263L4
- RC213263L4V
- RG205981
- RG213263
- RR211726
- RR211726L1
- RR211726L1V
- RR211726L2
- RR211726L2V
- RR211726L3
- RR211726L3V
- RR211726L4
- RR211726L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NFYA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NFYA
- genomics-online: cdna clones - Search for available NFYA CDNA products
- Overview of 139 available NFYA gene related products
- orf clones - Search for available NFYA ORF products
- Overview of 139 available NFYA gene related products
- Applied Biological Materials (abm): Clones for NFYA - Select products 50% OFF >
- * NFYA as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * NFYA tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||
| SP5: | - | - | - | - |
Expression for NFYA Gene
This gene is overexpressed in Pancreas (15.2), CD8 Tcells (8.2), Blymphocyte (7.7), Peripheral blood mononuclear cells (7.4), and Retina (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NFYA Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of NFYA Gene:
NFYASOURCE GeneReport for Unigene cluster for NFYA Gene:
Hs.10441Evidence on tissue expression from TISSUES for NFYA Gene
- Liver(4.4)
- Nervous system(2.8)
Primer Products
-
OriGene qPCR primer pairs for NFYA
-
OriGene qPCR primer pairs and template standards for NFYA
- genomics-online: primer clones - Search for available NFYA Primer products
- Overview of 139 available NFYA gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NFYA Gene
Orthologs for NFYA Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NFYA 33 32 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | NFYA 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | NFYA 33 32 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | NFYA 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | NFYA 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Nfya 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Nfya 32 |
|
||
| chicken (Gallus gallus) |
Aves | NFYA 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | NFYA 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | nfya 32 |
|
||
| MGC76011 32 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.418 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | nfya 33 32 |
|
OneToMany | |
| nfyal 33 32 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Nf-YA 33 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | nfya-2 33 |
|
OneToMany | |
| nfya-1 33 |
|
OneToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HAP2 35 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToOne |
- Species where no ortholog for NFYA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for NFYA Gene
- ENSEMBL:
- Gene Tree for NFYA (if available)
- TreeFam:
- Gene Tree for NFYA (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NFYA: view image
Paralogs for NFYA Gene
No data available for Paralogs for NFYA Gene
Variants for NFYA Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000074411 | -- | 41,089,112(+) | T/C | intron_variant | |
| rs1000078279 | -- | 41,102,389(+) | C/A/G | 3_prime_UTR_variant | |
| rs1000128522 | -- | 41,096,700(+) | G/A | intron_variant | |
| rs1000201091 | -- | 41,094,838(+) | T/C | intron_variant | |
| rs1000225000 | -- | 41,086,060(+) | A/C/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1117437 | CNV | tandem duplication | 24896259 |
| nsv602970 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
23.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.65;
13.92% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NFYA Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NFYA
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFYA Gene
Disorders for NFYA Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| megakaryocytic leukemia |
|
|
Search NFYA in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NFYA
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for NFYA Gene
Publications for NFYA Gene
- O-GlcNAcylation of Sp1 interrupts Sp1 interaction with NF-Y. (PMID: 19302979) Lim K … Chang HI (Biochemical and biophysical research communications 2009) 3 4 23 56
- Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3. (PMID: 12659632) Yamada K … Miyamoto K (The Biochemical journal 2003) 3 4 23 56
- Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination. (PMID: 23332751) Nardini M … Mantovani R (Cell 2013) 3 4 56
- Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation. (PMID: 16959611) Di Agostino S … Piaggio G (Cancer cell 2006) 3 23 56
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
ExternalLinks
Products for NFYA Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
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- Origene sirna, shrna, and RNAi products in human, mouse, rat for NFYA
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- OriGene qPCR primer pairs for NFYA
- OriGene qPCR primer pairs and template standards for NFYA
- OriGene CRISPR knockouts for NFYA
- MG204581
- MG223083
- MR204581
- MR204581L3
- MR204581L3V
- MR204581L4
- MR204581L4V
- MR223083
- MR223083L3
- MR223083L3V
- MR223083L4
- MR223083L4V
- RC205981
- RC205981L3
- RC205981L3V
- RC205981L4
- RC205981L4V
- RC213263
- RC213263L1
- RC213263L1V
- RC213263L2
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- RC213263L4
- RC213263L4V
- RG205981
- RG213263
- RR211726
- RR211726L1
- RR211726L1V
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- RR211726L2V
- RR211726L3
- RR211726L3V
- RR211726L4
- RR211726L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NFYA
- Sino Biological Human cDNA Clone for NFYA
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- Sino Biological Antibodies for NFYA
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- Novus Biologicals Antibodies for NFYA
- Novus Biologicals proteins and lysates for NFYA
- Browse Antibodies
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- Abcam antibodies for NFYA
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- Browse Primary Antibodies
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- Invitrogen Antibodies for NFYA (AFLGC-NFYA)
- antibodies-online: Show 42 available NFYA Antibodies ranked by validation data
- antibodies-online: Show 3 available NFYA Elisa Kits ranked by validation data
- Compare Top NFYA Elisa Kits
- Quality Products:
- antibodies-online: Show 12 available NFYA Proteins ranked by validation data
- Compare Top NFYA Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for NFYA
- Search Santa Cruz Biotechnology (SCBT) for NFYA siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NFYA
- genomics-online: cdna clones - Search for available NFYA CDNA products
- Overview of 139 available NFYA gene related products
- orf clones - Search for available NFYA ORF products
- Overview of 139 available NFYA gene related products
- genomics-online: gRNA clones - Search for available NFYA gRNA products
- Overview of 139 available NFYA gene related products
- genomics-online: primer clones - Search for available NFYA Primer products
- Overview of 139 available NFYA gene related products
- genomics-online: shRNA clones - Search for available NFYA shRNA products
- Overview of 139 available NFYA gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NFYA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NFYA
- Search GeneCopoeia for miRNA 3'UTR Target clone products for NFYA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NFYA
Sources for NFYA Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource