This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat ... See more...

Aliases for NFKBIZ Gene

Aliases for NFKBIZ Gene

  • NFKB Inhibitor Zeta 2 3 5
  • IL-1 Inducible Nuclear Ankyrin-Repeat Protein 2 3 4
  • NF-Kappa-B Inhibitor Zeta 2 3 4
  • INAP 2 3 4
  • MAIL 2 3 4
  • Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Zeta 2 3
  • Molecule Possessing Ankyrin Repeats Induced By Lipopolysaccharide 3 4
  • I-Kappa-B-Zeta 3 4
  • IkappaBzeta 3 4
  • IkB-Zeta 3 4
  • IKBZ 3 4
  • Ikappa B-Zeta Variant 3 3
  • IkappaB-Zeta 3
  • FLJ34463 2
  • NFKBIZ 5

External Ids for NFKBIZ Gene

Previous GeneCards Identifiers for NFKBIZ Gene

  • GC03P103051
  • GC03P101546
  • GC03P098915

Summaries for NFKBIZ Gene

Entrez Gene Summary for NFKBIZ Gene

  • This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for NFKBIZ Gene

NFKBIZ (NFKB Inhibitor Zeta) is a Protein Coding gene. Diseases associated with NFKBIZ include Myxoid Liposarcoma. Among its related pathways are Transcriptional misregulation in cancer and MAPK Erk Pathway. Gene Ontology (GO) annotations related to this gene include transcription coregulator activity. An important paralog of this gene is NFKBID.

UniProtKB/Swiss-Prot Summary for NFKBIZ Gene

  • Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (By similarity).

Gene Wiki entry for NFKBIZ Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NFKBIZ Gene

Genomics for NFKBIZ Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NFKBIZ Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NFKBIZ on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NFKBIZ

Top Transcription factor binding sites by QIAGEN in the NFKBIZ gene promoter:
  • C/EBPbeta
  • CREB
  • deltaCREB
  • Nkx2-2

Genomic Locations for NFKBIZ Gene

Genomic Locations for NFKBIZ Gene
chr3:101,827,990-101,861,022
(GRCh38/hg38)
Size:
33,033 bases
Orientation:
Plus strand
chr3:101,546,834-101,579,869
(GRCh37/hg19)
Size:
33,036 bases
Orientation:
Plus strand

Genomic View for NFKBIZ Gene

Genes around NFKBIZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFKBIZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFKBIZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFKBIZ Gene

Proteins for NFKBIZ Gene

  • Protein details for NFKBIZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYH8-IKBZ_HUMAN
    Recommended name:
    NF-kappa-B inhibitor zeta
    Protein Accession:
    Q9BYH8
    Secondary Accessions:
    • B3KNR2
    • D3DN54
    • Q8IUL4
    • Q8NAZ8

    Protein attributes for NFKBIZ Gene

    Size:
    718 amino acids
    Molecular mass:
    78061 Da
    Quaternary structure:
    • Interacts with NFKB1/p50. Interacts with RELA.

    Alternative splice isoforms for NFKBIZ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFKBIZ Gene

Post-translational modifications for NFKBIZ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NFKBIZ Gene

Domains & Families for NFKBIZ Gene

Gene Families for NFKBIZ Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for NFKBIZ Gene

InterPro:
Blocks:
  • Ankyrin repeat signature
ProtoNet:

Suggested Antigen Peptide Sequences for NFKBIZ Gene

GenScript: Design optimal peptide antigens:
  • Molecule possessing ankyrin repeats induced by lipopolysaccharide (IKBZ_HUMAN)
genes like me logo Genes that share domains with NFKBIZ: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NFKBIZ Gene

Function for NFKBIZ Gene

Molecular function for NFKBIZ Gene

UniProtKB/Swiss-Prot Function:
Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (By similarity).
UniProtKB/Swiss-Prot Induction:
By TNF, IL1/interleukin-1 and bacterial lipopolysaccharides (LPS).

Phenotypes From GWAS Catalog for NFKBIZ Gene

Gene Ontology (GO) - Molecular Function for NFKBIZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 25107474
genes like me logo Genes that share ontologies with NFKBIZ: view
genes like me logo Genes that share phenotypes with NFKBIZ: view

Animal Models for NFKBIZ Gene

MGI Knock Outs for NFKBIZ:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NFKBIZ

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NFKBIZ Gene

Localization for NFKBIZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFKBIZ Gene

Nucleus. Note=Aggregated in dot-like structures. Colocalizes with NCOR2.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NFKBIZ gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
  • Cytoplasmic bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NFKBIZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0016607 nuclear speck IDA --
GO:0036464 cytoplasmic ribonucleoprotein granule IDA --
genes like me logo Genes that share ontologies with NFKBIZ: view

Pathways & Interactions for NFKBIZ Gene

genes like me logo Genes that share pathways with NFKBIZ: view

Pathways by source for NFKBIZ Gene

2 Sino Biological pathways for NFKBIZ Gene
1 KEGG pathway for NFKBIZ Gene
1 Cell Signaling Technology pathway for NFKBIZ Gene

Gene Ontology (GO) - Biological Process for NFKBIZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0006954 inflammatory response IEA --
GO:0050729 positive regulation of inflammatory response IMP 23071313
GO:0050852 T cell receptor signaling pathway IEA,ISS --
GO:2000321 positive regulation of T-helper 17 cell differentiation IEA,ISS --
genes like me logo Genes that share ontologies with NFKBIZ: view

No data available for SIGNOR curated interactions for NFKBIZ Gene

Drugs & Compounds for NFKBIZ Gene

No Compound Related Data Available

Transcripts for NFKBIZ Gene

mRNA/cDNA for NFKBIZ Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NFKBIZ

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFKBIZ Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1: - - -
SP2: - - -
SP3: -
SP4: - -
SP5: -
SP6:

Relevant External Links for NFKBIZ Gene

GeneLoc Exon Structure for
NFKBIZ

Expression for NFKBIZ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NFKBIZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NFKBIZ Gene

This gene is overexpressed in Fallopian Tube (x4.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NFKBIZ

SOURCE GeneReport for Unigene cluster for NFKBIZ Gene:

Hs.319171

mRNA Expression by UniProt/SwissProt for NFKBIZ Gene:

Q9BYH8-IKBZ_HUMAN
Tissue specificity: Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart.

Evidence on tissue expression from TISSUES for NFKBIZ Gene

  • Nervous system(4.7)
  • Lung(4.6)
  • Blood(4.6)
  • Bone marrow(3)
  • Spleen(3)
  • Skin(2.9)
  • Intestine(2.8)
  • Lymph node(2.7)
  • Liver(2.7)
  • Heart(2.4)
  • Kidney(2.4)
  • Muscle(2.3)
genes like me logo Genes that share expression patterns with NFKBIZ: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NFKBIZ Gene

Orthologs for NFKBIZ Gene

This gene was present in the common ancestor of animals.

Orthologs for NFKBIZ Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NFKBIZ 30 31
  • 99.68 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NFKBIZ 30
  • 88.04 (n)
MAIL 31
  • 85 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia NFKBIZ 30
  • 87.82 (n)
MAIL 31
  • 87 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nfkbiz 30
  • 87.66 (n)
Mouse
(Mus musculus)
Mammalia Nfkbiz 30 17 31
  • 82.54 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia NFKBIZ 31
  • 75 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NFKBIZ 31
  • 74 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NFKBIZ 30 31
  • 72.03 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NFKBIZ 31
  • 65 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nfkbiz 30
  • 61.23 (n)
Zebrafish
(Danio rerio)
Actinopterygii nfkbiz 31
  • 50 (a)
OneToOne
Dr.20590 30
Worm
(Caenorhabditis elegans)
Secernentea C33A11.1 31
  • 16 (a)
OneToMany
Species where no ortholog for NFKBIZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for NFKBIZ Gene

ENSEMBL:
Gene Tree for NFKBIZ (if available)
TreeFam:
Gene Tree for NFKBIZ (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NFKBIZ: view image

Paralogs for NFKBIZ Gene

Paralogs for NFKBIZ Gene

(1) SIMAP similar genes for NFKBIZ Gene using alignment to 5 proteins:

  • IKBZ_HUMAN
  • C9J5G8_HUMAN
  • C9J5I7_HUMAN
  • C9JZ23_HUMAN
  • H7C5S1_HUMAN
genes like me logo Genes that share paralogs with NFKBIZ: view

Variants for NFKBIZ Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NFKBIZ Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs3821727 - p.Thr307Ser

Additional dbSNP identifiers (rs#s) for NFKBIZ Gene

Structural Variations from Database of Genomic Variants (DGV) for NFKBIZ Gene

Variant ID Type Subtype PubMed ID
nsv953238 CNV duplication 24416366

Variation tolerance for NFKBIZ Gene

Residual Variation Intolerance Score: 32.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NFKBIZ Gene

Human Gene Mutation Database (HGMD)
NFKBIZ
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NFKBIZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFKBIZ Gene

Disorders for NFKBIZ Gene

MalaCards: The human disease database

(1) MalaCards diseases for NFKBIZ Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
myxoid liposarcoma
  • liposarcoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NFKBIZ

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with NFKBIZ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NFKBIZ Gene

Publications for NFKBIZ Gene

  1. A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding. (PMID: 16513645) Totzke G … Schulze-Osthoff K (The Journal of biological chemistry 2006) 2 3 4
  2. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) International Multiple Sclerosis Genetics Consortium … Compston A (Nature 2011) 3 41
  3. NFKBIZ polymorphisms and susceptibility to pneumococcal disease in European and African populations. (PMID: 19798075) Chapman SJ … Hill AV (Genes and immunity 2010) 3 41
  4. Innate immunity of the ocular surface and ocular surface inflammatory disorders. (PMID: 18813073) Ueta M (Cornea 2008) 3 41
  5. IL-1beta-specific up-regulation of neutrophil gelatinase-associated lipocalin is controlled by IkappaB-zeta. (PMID: 16622025) Cowland JB … Borregaard N (Journal of immunology (Baltimore, Md. : 1950) 2006) 3 4

Products for NFKBIZ Gene

Sources for NFKBIZ Gene