Aliases for NFKBID Gene

Aliases for NFKBID Gene

  • NFKB Inhibitor Delta 2 3 5
  • NF-Kappa-B Inhibitor Delta 2 3 4
  • IkappaBNS 2 3 4
  • TA-NFKBH 2 3 4
  • Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Delta 2 3
  • T-Cell Activation NFKB-Like Protein 3 4
  • I-Kappa-B-Delta 3 4
  • IkappaBdelta 3 4
  • IkB-Delta 3 4
  • IkBNS 2 3
  • NFKBID 5
  • IKBNS 4

External Ids for NFKBID Gene

Previous GeneCards Identifiers for NFKBID Gene

  • GC19M041072
  • GC19M036379
  • GC19M032884
  • GC19M036382
  • GC19M036544
  • GC19M037063

Summaries for NFKBID Gene

GeneCards Summary for NFKBID Gene

NFKBID (NFKB Inhibitor Delta) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include NF-kappaB binding. An important paralog of this gene is NFKBIZ.

UniProtKB/Swiss-Prot Summary for NFKBID Gene

  • Regulates the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR). May also regulate TCR-induced negative selection of thymocytes.

Additional gene information for NFKBID Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NFKBID Gene

Genomics for NFKBID Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NFKBID Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J035897 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 620.6 -1.8 -1755 13 ZNF221 SP1 CREB1 GATAD2A PRDM10 ZNF629 LEF1 IKZF1 KDM1A ZNF692 NFKBID TYROBP HCST ENSG00000280194 ZNF567 TMEM147-AS1 ZNF790 ZNF566 ZNF529 ZNF260
GH19J035435 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14.3 +465.6 465570 2.7 GATAD2A PRDM10 IKZF1 ZNF174 JUND PRDM1 MTA2 MTA1 REST IKZF2 ENSG00000232680 lnc-FFAR2-2 ZNF599 NFKBID TMEM147-AS1 FFAR2 LIN37 KRTDAP DMKN CD22
GH19J035430 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 15.3 +470.9 470902 1.6 PKNOX1 MAFG ZNF610 SPI1 HDAC2 KDM1A MEIS2 MTA3 ZNF518A ZNF558 NFKBID ZNF792 FFAR2 ZFP14 RBM42 TYROBP KMT2B KRTDAP DMKN HAUS5
GH19J035912 Promoter/Enhancer 1.3 FANTOM5 Ensembl ENCODE 11 -11.7 -11685 1 IKZF2 TRIM22 PKNOX1 DPF2 RELB RUNX3 FOS BCL11A NBN HDGF TYROBP APLP1 NPHS1 KIRREL2 NFKBID SDHAF1 HCST FFAR2 IGFLR1 U2AF1L4
GH19J035461 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 9.6 +439.4 439352 1.9 SP1 ZNF629 STAT3 RELA RAD21 TCF12 IKZF2 RCOR1 ZNF501 TRIM22 piR-51819-015 TMEM147-AS1 HAUS5 ZNF599 PROSER3 KMT2B RBM42 ZNF146 ZFP82 SDHAF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NFKBID on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NFKBID

Top Transcription factor binding sites by QIAGEN in the NFKBID gene promoter:
  • AML1a
  • ATF-2
  • c-Ets-1
  • c-Jun
  • C/EBPalpha
  • HSF1 (long)
  • HSF1short
  • Pax-4a

Genomic Locations for NFKBID Gene

Genomic Locations for NFKBID Gene
chr19:35,887,630-35,902,303
(GRCh38/hg38)
Size:
14,674 bases
Orientation:
Minus strand
chr19:36,378,555-36,393,205
(GRCh37/hg19)
Size:
14,651 bases
Orientation:
Minus strand

Genomic View for NFKBID Gene

Genes around NFKBID on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFKBID Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFKBID Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFKBID Gene

Proteins for NFKBID Gene

  • Protein details for NFKBID Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NI38-IKBD_HUMAN
    Recommended name:
    NF-kappa-B inhibitor delta
    Protein Accession:
    Q8NI38
    Secondary Accessions:
    • Q8NI39
    • Q9BRG9

    Protein attributes for NFKBID Gene

    Size:
    313 amino acids
    Molecular mass:
    33481 Da
    Quaternary structure:
    • Interacts with NFKB1, RELA and RELB; in the nucleus.

    Alternative splice isoforms for NFKBID Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFKBID Gene

Post-translational modifications for NFKBID Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NFKBID Gene

Domains & Families for NFKBID Gene

Gene Families for NFKBID Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for NFKBID Gene

InterPro:
Blocks:
  • Ankyrin repeat signature
ProtoNet:

Suggested Antigen Peptide Sequences for NFKBID Gene

GenScript: Design optimal peptide antigens:
  • TA-NFKBH (IKBD_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NI38

UniProtKB/Swiss-Prot:

IKBD_HUMAN :
  • Belongs to the NF-kappa-B inhibitor family.
Family:
  • Belongs to the NF-kappa-B inhibitor family.
genes like me logo Genes that share domains with NFKBID: view

Function for NFKBID Gene

Molecular function for NFKBID Gene

UniProtKB/Swiss-Prot Function:
Regulates the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR). May also regulate TCR-induced negative selection of thymocytes.

Phenotypes From GWAS Catalog for NFKBID Gene

Gene Ontology (GO) - Molecular Function for NFKBID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0051059 NF-kappaB binding IEA --
genes like me logo Genes that share ontologies with NFKBID: view
genes like me logo Genes that share phenotypes with NFKBID: view

Animal Models for NFKBID Gene

MGI Knock Outs for NFKBID:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NFKBID

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NFKBID Gene

Localization for NFKBID Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFKBID Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NFKBID gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytosol 3
extracellular 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NFKBID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with NFKBID: view

Pathways & Interactions for NFKBID Gene

PathCards logo

SuperPathways for NFKBID Gene

No Data Available

Gene Ontology (GO) - Biological Process for NFKBID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0006954 inflammatory response IEA --
GO:0032088 negative regulation of NF-kappaB transcription factor activity IEA --
GO:0033085 negative regulation of T cell differentiation in thymus IEA --
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA --
genes like me logo Genes that share ontologies with NFKBID: view

No data available for Pathways by source and SIGNOR curated interactions for NFKBID Gene

Drugs & Compounds for NFKBID Gene

No Compound Related Data Available

Transcripts for NFKBID Gene

mRNA/cDNA for NFKBID Gene

5 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NFKBID

Alternative Splicing Database (ASD) splice patterns (SP) for NFKBID Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13a · 13b ^
SP1: - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - - -
SP5: -
SP6: - - - -
SP7: - - -
SP8:
SP9: -
SP10: -

ExUns: 14 ^ 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for NFKBID Gene

GeneLoc Exon Structure for
NFKBID

Expression for NFKBID Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NFKBID Gene

mRNA differential expression in normal tissues according to GTEx for NFKBID Gene

This gene is overexpressed in Whole Blood (x10.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NFKBID

SOURCE GeneReport for Unigene cluster for NFKBID Gene:

Hs.466531

Evidence on tissue expression from TISSUES for NFKBID Gene

  • Blood(4.6)
  • Bone marrow(2.5)
  • Liver(2.4)
  • Spleen(2.4)
  • Nervous system(2.4)
  • Lymph node(2.4)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with NFKBID: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NFKBID Gene

Orthologs for NFKBID Gene

This gene was present in the common ancestor of animals.

Orthologs for NFKBID Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NFKBID 30 31
  • 99.15 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NFKBID 30 31
  • 87.93 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NFKBID 30 31
  • 86.65 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nfkbid 30
  • 83.71 (n)
Mouse
(Mus musculus)
Mammalia Nfkbid 30 17 31
  • 83.6 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia NFKBID 31
  • 54 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NFKBID 31
  • 49 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NFKBID 31
  • 44 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NFKBID 31
  • 52 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nfkbid 30
  • 61.73 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC101883232 30
  • 54.49 (n)
CT867948.1 31
  • 35 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea C33A11.1 31
  • 11 (a)
OneToMany
Species where no ortholog for NFKBID was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for NFKBID Gene

ENSEMBL:
Gene Tree for NFKBID (if available)
TreeFam:
Gene Tree for NFKBID (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NFKBID: view image

Paralogs for NFKBID Gene

Paralogs for NFKBID Gene

(1) SIMAP similar genes for NFKBID Gene using alignment to 3 proteins:

  • IKBD_HUMAN
  • K7EKM2_HUMAN
  • K7ENW9_HUMAN
genes like me logo Genes that share paralogs with NFKBID: view

Variants for NFKBID Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NFKBID Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs8113704 - p.Val29Ala

Additional dbSNP identifiers (rs#s) for NFKBID Gene

Structural Variations from Database of Genomic Variants (DGV) for NFKBID Gene

Variant ID Type Subtype PubMed ID
dgv51n68 CNV loss 17160897

Variation tolerance for NFKBID Gene

Residual Variation Intolerance Score: 40.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.30; 70.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NFKBID Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NFKBID

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFKBID Gene

Disorders for NFKBID Gene

Additional Disease Information for NFKBID

No disorders were found for NFKBID Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NFKBID Gene

Publications for NFKBID Gene

  1. A Hypermorphic Nfkbid Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8+ T Cells in NOD Mice. (PMID: 30127089) Presa M … Serreze DV (Journal of immunology (Baltimore, Md. : 1950) 2018) 2 3
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3
  4. A translational silencing function of MCPIP1/Regnase-1 specified by the target site context. (PMID: 29471506) Behrens G … Holtmann H (Nucleic acids research 2018) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for NFKBID Gene

  • Signalway Proteins for NFKBID

Sources for NFKBID Gene