The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a tra... See more...

Aliases for NFKBIB Gene

Aliases for NFKBIB Gene

  • NFKB Inhibitor Beta 2 3 5
  • NF-Kappa-B Inhibitor Beta 2 3 4
  • Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Beta 2 3
  • Thyroid Receptor-Interacting Protein 9 3 4
  • TR-Interacting Protein 9 3 4
  • I-Kappa-B-Beta 3 4
  • NF-Kappa-BIB 3 4
  • IkappaBbeta 3 4
  • IkB-Beta 3 4
  • TRIP-9 3 4
  • IkB-B 3 4
  • TRIP9 3 4
  • IKBB 3 4

External Ids for NFKBIB Gene

Previous GeneCards Identifiers for NFKBIB Gene

  • GC19P040002
  • GC19P039781
  • GC19P044066
  • GC19P044082
  • GC19P039390
  • GC19P035837

Summaries for NFKBIB Gene

Entrez Gene Summary for NFKBIB Gene

  • The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]

GeneCards Summary for NFKBIB Gene

NFKBIB (NFKB Inhibitor Beta) is a Protein Coding gene. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and ERK Signaling. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and transcription coactivator activity. An important paralog of this gene is NFKBIA.

UniProtKB/Swiss-Prot Summary for NFKBIB Gene

  • Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

Gene Wiki entry for NFKBIB Gene

Additional gene information for NFKBIB Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NFKBIB Gene

Genomics for NFKBIB Gene

GeneHancer (GH) Regulatory Elements for NFKBIB Gene

Promoters and enhancers for NFKBIB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J038898 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.2 227 3.8 FOXK2 ZBTB40 ZNF217 EP300 SIN3A NRF1 TCF12 POLR2G USF1 SP1 NFKBIB lnc-CCER2-1 SIRT2 piR-39446 HNRNPL FBL ENSG00000269688 PLEKHG2 RN7SL566P ACTN4
GH19J038673 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 6.3 -204.1 -204109 43.3 EP300 ZNF217 CTCF ZSCAN5C TCF12 POLR2G USF1 SP1 NCOR1 RBAK ENSG00000267375 ZNF573 ZNF607 ACTN4 CAPN12 SUPT5H PAK4 ENSG00000267152 PAF1 CATSPERG
GH19J039052 Enhancer 1 Ensembl ENCODE 10.8 +153.7 153676 2.7 ZNF217 CTCF RBAK ZNF639 ZBTB10 ZNF623 REST RAD21 CTBP1 TRIM22 FBXO27 PAK4 NFKBIB SIRT2 RF01210-188 RF00017-2974
GH19J039061 Enhancer 0.7 ENCODE dbSUPER 10.8 +161.9 161899 0 RBAK ZEB1 ZBTB17 ZNF133 ZNF280D SPI1 GATA2 ETV6 EED ZSCAN4 RF00017-2974 FBXO27 PAK4 SIRT2 NFKBIB RF01210-188
GH19J038934 Enhancer 0.6 ENCODE 12.3 +34.8 34760 0.8 FOXA2 SAP130 ZNF205 SPI1 FOXP1 ARID4B SOX5 RXRB FOXA1 ZNF7 piR-37170-033 piR-54987-061 piR-51189 FBXO17 SARS2 NFKBIB SIRT2 ERVK9-11 ENSG00000269547
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NFKBIB on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NFKBIB

Top Transcription factor binding sites by QIAGEN in the NFKBIB gene promoter:
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for NFKBIB Gene

Genomic Locations for NFKBIB Gene
chr19:38,899,657-38,908,894
(GRCh38/hg38)
Size:
9,238 bases
Orientation:
Plus strand
chr19:39,390,340-39,399,534
(GRCh37/hg19)
Size:
9,195 bases
Orientation:
Plus strand

Genomic View for NFKBIB Gene

Genes around NFKBIB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFKBIB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFKBIB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFKBIB Gene

Proteins for NFKBIB Gene

  • Protein details for NFKBIB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15653-IKBB_HUMAN
    Recommended name:
    NF-kappa-B inhibitor beta
    Protein Accession:
    Q15653
    Secondary Accessions:
    • A8K3F4
    • Q96BJ7

    Protein attributes for NFKBIB Gene

    Size:
    356 amino acids
    Molecular mass:
    37771 Da
    Quaternary structure:
    • Interacts with THRB (via ligand-binding domain) (PubMed:7776974). Interacts with RELA and REL (By similarity). Interacts with COMMD1 (PubMed:16573520). Interacts with inhibitor kappa B-interacting Ras-like NKIRAS1 and NKIRAS2 (PubMed:10657303, PubMed:12672800, PubMed:15024091).

    Alternative splice isoforms for NFKBIB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFKBIB Gene

Post-translational modifications for NFKBIB Gene

  • Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for NFKBIB Gene

Domains & Families for NFKBIB Gene

Gene Families for NFKBIB Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for NFKBIB Gene

Blocks:
  • Ankyrin repeat signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NFKBIB Gene

GenScript: Design optimal peptide antigens:
  • Thyroid receptor-interacting protein 9 (IKBB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15653

UniProtKB/Swiss-Prot:

IKBB_HUMAN :
  • Belongs to the NF-kappa-B inhibitor family.
Family:
  • Belongs to the NF-kappa-B inhibitor family.
genes like me logo Genes that share domains with NFKBIB: view

Function for NFKBIB Gene

Molecular function for NFKBIB Gene

UniProtKB/Swiss-Prot Function:
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
GENATLAS Biochemistry:
nuclear transcription factor of kappa light chain gene enhancer in B cells (NF-kappa B) inhibitor ar beta,sequestering it in the cytcytoplasm,also inhibiting NF-kappa B DNA binding

Phenotypes From GWAS Catalog for NFKBIB Gene

Gene Ontology (GO) - Molecular Function for NFKBIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity TAS 7776974
GO:0005515 protein binding IPI,IEA 10498867
genes like me logo Genes that share ontologies with NFKBIB: view
genes like me logo Genes that share phenotypes with NFKBIB: view

Animal Models for NFKBIB Gene

MGI Knock Outs for NFKBIB:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NFKBIB Gene

Localization for NFKBIB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFKBIB Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NFKBIB gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NFKBIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NFKBIB: view

Pathways & Interactions for NFKBIB Gene

PathCards logo

SuperPathways for NFKBIB Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 TNFR1 Pathway
.87
.87
.56
.55
.52
.46
.42
.40
3 4-1BB Pathway
.54
.54
.48
.46
.42
.37
.36
.30
4 Cytosolic sensors of pathogen-associated DNA
5 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
genes like me logo Genes that share pathways with NFKBIB: view

Pathways by source for NFKBIB Gene

46 GeneGo (Thomson Reuters) pathways for NFKBIB Gene
  • Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
  • Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
  • Apoptosis and survival APRIL and BAFF signaling
  • Apoptosis and survival Lymphotoxin-beta receptor signaling
  • Apoptosis and survival TNFR1 signaling pathway
57 Qiagen pathways for NFKBIB Gene
  • 4-1BB Pathway
  • Activation of NF-KappaB by PKR
  • Activation of PKA through GPCR
  • Antioxidant Action of Vitamin-C
  • Apoptosis through Death Receptors
1 Cell Signaling Technology pathway for NFKBIB Gene

SIGNOR curated interactions for NFKBIB Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for NFKBIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated TAS 7776974
GO:0007165 signal transduction TAS 7776974
GO:0071222 cellular response to lipopolysaccharide IEA --
GO:1903508 positive regulation of nucleic acid-templated transcription IEA --
genes like me logo Genes that share ontologies with NFKBIB: view

Drugs & Compounds for NFKBIB Gene

(4) Drugs for NFKBIB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for NFKBIB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NFKBIB: view

Transcripts for NFKBIB Gene

mRNA/cDNA for NFKBIB Gene

5 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFKBIB Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7
SP1:
SP2: - - -
SP3: - -
SP4: -

Relevant External Links for NFKBIB Gene

GeneLoc Exon Structure for
NFKBIB

Expression for NFKBIB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NFKBIB Gene

Protein differential expression in normal tissues from HIPED for NFKBIB Gene

This gene is overexpressed in Blymphocyte (15.4), Peripheral blood mononuclear cells (14.4), and Testis (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NFKBIB Gene



Protein tissue co-expression partners for NFKBIB Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NFKBIB

SOURCE GeneReport for Unigene cluster for NFKBIB Gene:

Hs.9731

mRNA Expression by UniProt/SwissProt for NFKBIB Gene:

Q15653-IKBB_HUMAN
Tissue specificity: Expressed in all tissues examined.

Evidence on tissue expression from TISSUES for NFKBIB Gene

  • Liver(4.4)
  • Lung(4.4)
  • Pancreas(4.3)
  • Nervous system(2.5)
  • Blood(2.3)
  • Heart(2)
genes like me logo Genes that share expression patterns with NFKBIB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NFKBIB Gene

Orthologs for NFKBIB Gene

This gene was present in the common ancestor of animals.

Orthologs for NFKBIB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFKBIB 31 30
  • 98.88 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NFKBIB 31 30
  • 88.01 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NFKBIB 31 30
  • 86.65 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nfkbib 17 31 30
  • 80.66 (n)
rat
(Rattus norvegicus)
Mammalia Nfkbib 30
  • 80.19 (n)
oppossum
(Monodelphis domestica)
Mammalia NFKBIB 31
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 30 (a)
ManyToMany
chicken
(Gallus gallus)
Aves NFKBIB 30
  • 63.31 (n)
lizard
(Anolis carolinensis)
Reptilia NFKBIB 31
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-110c7.1 30
  • 50.64 (n)
NFKBIB 31
  • 29 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta cact 31
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 18 (a)
OneToMany
Species where no ortholog for NFKBIB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFKBIB Gene

ENSEMBL:
Gene Tree for NFKBIB (if available)
TreeFam:
Gene Tree for NFKBIB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NFKBIB: view image

Paralogs for NFKBIB Gene

Paralogs for NFKBIB Gene

(1) SIMAP similar genes for NFKBIB Gene using alignment to 5 proteins:

  • IKBB_HUMAN
  • G5E9C2_HUMAN
  • H0YFH0_HUMAN
  • I3L1A4_HUMAN
  • I3L4X3_HUMAN
genes like me logo Genes that share paralogs with NFKBIB: view

Variants for NFKBIB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NFKBIB Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs17886215 - p.Arg339Trp

Additional dbSNP identifiers (rs#s) for NFKBIB Gene

Structural Variations from Database of Genomic Variants (DGV) for NFKBIB Gene

Variant ID Type Subtype PubMed ID
esv2414967 CNV deletion 18987734
esv2718538 CNV deletion 23290073
esv2718539 CNV deletion 23290073
esv3793 CNV loss 18987735
nsv1140435 CNV deletion 24896259
nsv1147421 CNV deletion 26484159
nsv1160616 CNV duplication 26073780
nsv820174 CNV gain 19587683

Variation tolerance for NFKBIB Gene

Residual Variation Intolerance Score: 30.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 32.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NFKBIB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NFKBIB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFKBIB Gene

Disorders for NFKBIB Gene

Additional Disease Information for NFKBIB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NFKBIB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NFKBIB Gene

Publications for NFKBIB Gene

  1. Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. (PMID: 18434448) Dieguez-Gonzalez R … Gonzalez A (Annals of the rheumatic diseases 2009) 3 23 41 54
  2. Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. (PMID: 15024091) Chen Y … Ghosh G (Molecular and cellular biology 2004) 3 4 23 54
  3. KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta x NF-kappaB complexes. (PMID: 12672800) Chen Y … Ghosh G (The Journal of biological chemistry 2003) 3 4 23 54
  4. A subclass of Ras proteins that regulate the degradation of IkappaB. (PMID: 10657303) Fenwick C … Ghosh S (Science (New York, N.Y.) 2000) 3 4 23 54
  5. Assignment of the IkappaB-beta gene NFKBIB to human chromosome band 19q13.1 by in situ hybridization. (PMID: 9763672) Okamoto T … Sonta S (Cytogenetics and cell genetics 1998) 2 3 23 54

Products for NFKBIB Gene