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This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
NFKB2 (Nuclear Factor Kappa B Subunit 2) is a Protein Coding gene. Diseases associated with NFKB2 include Immunodeficiency, Common Variable, 10 and Immunodeficiency, Common Variable, 1. Among its related pathways are GDNF-Family Ligands and Receptor Interactions and Folate Metabolism. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is NFKB1.
NF-kappaB (nuclear factor-kappa B) is a rapidly acting primary transcription factor found in all cell types. It is involved in the cellular responses to stimuli such as cytokines and stress and plays a key role in regulating the immunological response to infections.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | -- |
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 12835724 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 12835724 |
GO:0003677 | DNA binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IDA | 15677444 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IDA | 15677444 |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated TLR4 signalling | ||
2 | Cytosolic sensors of pathogen-associated DNA | ||
3 | Toll-Like receptor Signaling Pathways |
Mucin expression in CF via TLRs, EGFR signaling pathways
.42
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
.33
|
|
4 | Immune response NFAT in immune response |
Immune response ICOS pathway in T-helper cell
.56
Immune response NFAT in immune response
.56
|
Immune response T cell receptor signaling pathway
.52
Immune response CD28 signaling
.52
|
5 | Apoptosis Pathway |
.39
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA | -- |
GO:0002268 | follicular dendritic cell differentiation | IEA | -- |
GO:0002467 | germinal center formation | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IDA | 8360178 |
GO:0006954 | inflammatory response | IBA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Donepezil | Approved | Pharma | Target, inhibitor | 317 | ||
Glucosamine | Approved, Investigational | Pharma | Target, antagonist | 88 | ||
glycyrrhizin | Approved, Experimental | Pharma | Inhibitor, Inhibition, Target, translocation inhibitor | 26 | ||
Fish oil | Approved | Nutra | Target, regulator | 0 | ||
Sulfasalazine | Approved | Pharma | Inhibitor, Inhibition | NF-κB activation inhibitor | 84 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
SP 100030 |
|
154563-54-9 |
|
|
Compound | Action | Cas Number |
---|---|---|
Pyrrolidinedithiocarbamate ammonium | Inhibits NF-kappaB, prevents increase in NOS mRNA | 5108-96-3 |
SP 100030 | NF-kappaB and AP-1 dual inhibitor | 154563-54-9 |
Tanshinone IIA | Inhibits NF-kappaB and AP-1 DNA binding. Displays antioxidant properties | 568-72-9 |
Compound | Action | Cas Number |
---|---|---|
Andrographolide | NF-κB signaling Inhibitor | 5508-58-7 |
Bay 11-7085 | NK-κB activation inhibitor | 196309-76-9 |
Bay 11-7821(BAY 11-7082) | IKK/NF-κB/TNFα inhibitor | 19542-67-7 |
Caffeic Acid Phenethyl Ester | NF-κB activation inhibitor | 104594-70-9 |
Emodin | Naturally occurring anthraquinone,antiproliferative | 518-82-1 |
Honokiol | Antioxidant/antitumor/antiangiogenic agent | 35354-74-6 |
IKK-16 (IKK Inhibitor VII) | Selective IκB kinase inhibitor | 873225-46-8 |
IMD 0354 | 978-62-1 | |
JSH-23 | NF-κB inhibitor | 749886-87-1 |
Kaempferol | Apoptosis inducer;antioxidant;flavonoid | 520-18-3 |
Luteolin | Antioxidant and free radical scavenger | 491-70-3 |
Matrine | Alkaloid found in Sophora plant | 519-02-8 |
QNZ (EVP4593) | Potent NF-κB inhibitor | 545380-34-5 |
SC75741 | 913822-46-5 | |
Sodium 4-Aminosalicylate | 6018-19-5 | |
Sodium salicylate | 54-21-7 | |
Sulfasalazine | NF-κB activation inhibitor | 599-79-1 |
Tanshinone IIA | Antioxidant and anti-inflammatory reagent | 568-72-9 |
TPCA-1 | IKK-2 inhibitor,potent and selective | 507475-17-4 |
Triptolide | IL-2/MMP-3/MMP7/MMP19 inhibitor | 38748-32-2 |
Verbascoside | PKC/NF-κB inhibitor | 61276-17-3 |
WS6 | 1421227-53-3 |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: |
ExUns: | 17b | · | 17c | ^ | 18 | ^ | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||||
SP9: | |||||||||||||||||||||||||||
SP10: | |||||||||||||||||||||||||||
SP11: | |||||||||||||||||||||||||||
SP12: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NFKB2 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | NFKB2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NFKB2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Nfkb2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Nfkb2 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | NFKB2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NFKB2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | nfkb2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | nfkb2 30 31 |
|
OneToOne | |
wufa03b02 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | REL2 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | dl 32 |
|
|
|
Dif 32 |
|
|
|||
Rel 31 32 |
|
OneToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1675 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
636589 | Uncertain Significance: not provided | 102,401,906(+) | C/T | MISSENSE_VARIANT | |
636912 | Uncertain Significance: not provided | 102,399,710(+) | C/A | MISSENSE_VARIANT | |
636989 | Uncertain Significance: not provided | 102,398,463(+) | C/T | MISSENSE_VARIANT | |
642159 | Uncertain Significance: Common variable immunodeficiency 10 | 102,399,589(+) | A/G | MISSENSE_VARIANT | |
643932 | Uncertain Significance: Common variable immunodeficiency 10 | 102,400,434(+) | C/G | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
immunodeficiency, common variable, 10 |
|
|
immunodeficiency, common variable, 1 |
|
|
common variable immunodeficiency |
|
|
lymphoma |
|
|
immunodeficiency 10 |
|
|