This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular sti... See more...

Aliases for NFKB1 Gene

Aliases for NFKB1 Gene

  • Nuclear Factor Kappa B Subunit 1 2 3 5
  • Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 1 2 3 4
  • Nuclear Factor NF-Kappa-B P105 Subunit 2 3 4
  • DNA-Binding Factor KBF1 3 4
  • EBP-1 3 4
  • Nuclear Factor Kappa-B DNA Binding Subunit 3
  • Nuclear Factor NF-Kappa-B P50 Subunit 3
  • NF-Kappabeta 3
  • NF-Kappa-B1 3
  • NF-KappaB 3
  • NFKB-P105 3
  • NFKB-P50 3
  • NFkappaB 3
  • CVID12 3
  • NF-KB1 3
  • NF-KB 3
  • KBF1 3
  • P105 3
  • P50 3

External Ids for NFKB1 Gene

Previous GeneCards Identifiers for NFKB1 Gene

  • GC04P103821
  • GC04P103880
  • GC04P103779
  • GC04P103641
  • GC04P103422
  • GC04P099158

Summaries for NFKB1 Gene

Entrez Gene Summary for NFKB1 Gene

  • This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Feb 2016]

GeneCards Summary for NFKB1 Gene

NFKB1 (Nuclear Factor Kappa B Subunit 1) is a Protein Coding gene. Diseases associated with NFKB1 include Immunodeficiency, Common Variable, 12 and Common Variable Immunodeficiency. Among its related pathways are Cellular Senescence (REACTOME) and Activated TLR4 signalling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is NFKB2.

UniProtKB/Swiss-Prot Summary for NFKB1 Gene

  • NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.

Tocris Summary for NFKB1 Gene

  • NF-kappaB (nuclear factor-kappa B) is a rapidly acting primary transcription factor found in all cell types. It is involved in the cellular responses to stimuli such as cytokines and stress and plays a key role in regulating the immunological response to infections.

Gene Wiki entry for NFKB1 Gene

Additional gene information for NFKB1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NFKB1 Gene

Genomics for NFKB1 Gene

GeneHancer (GH) Regulatory Elements for NFKB1 Gene

Promoters and enhancers for NFKB1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NFKB1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NFKB1 gene promoter:
  • FOXC1
  • Max1
  • Oct-B1
  • oct-B3
  • POU2F1
  • RORalpha1
  • TBP

Genomic Locations for NFKB1 Gene

Genomic Locations for NFKB1 Gene
chr4:102,501,329-102,617,302
(GRCh38/hg38)
Size:
115,974 bases
Orientation:
Plus strand
chr4:103,422,486-103,538,459
(GRCh37/hg19)
Size:
115,974 bases
Orientation:
Plus strand

Genomic View for NFKB1 Gene

Genes around NFKB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFKB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFKB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFKB1 Gene

Proteins for NFKB1 Gene

  • Protein details for NFKB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19838-NFKB1_HUMAN
    Recommended name:
    Nuclear factor NF-kappa-B p105 subunit
    Protein Accession:
    P19838
    Secondary Accessions:
    • A8K5Y5
    • B3KVE8
    • Q68D84
    • Q86V43
    • Q8N4X7
    • Q9NZC0

    Protein attributes for NFKB1 Gene

    Size:
    968 amino acids
    Molecular mass:
    105356 Da
    Quaternary structure:
    • Component of the NF-kappa-B p65-p50 complex. Component of the NF-kappa-B p65-p50 complex. Homodimer; component of the NF-kappa-B p50-p50 complex. Component of the NF-kappa-B p105-p50 complex. Component of the NF-kappa-B p50-c-Rel complex. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Also interacts with MAP3K8. NF-kappa-B p50 subunit interacts with NCOA3 coactivator, which may coactivate NF-kappa-B dependent expression via its histone acetyltransferase activity. Interacts with DSIPI; this interaction prevents nuclear translocation and DNA-binding. Interacts with SPAG9 and UNC5CL. NFKB1/p105 interacts with CFLAR; the interaction inhibits p105 processing into p50. NFKB1/p105 forms a ternary complex with MAP3K8 and TNIP2. Interacts with GSK3B; the interaction prevents processing of p105 to p50. NFKB1/p50 interacts with NFKBIE. NFKB1/p50 interacts with NFKBIZ. Nuclear factor NF-kappa-B p50 subunit interacts with NFKBID (By similarity). Directly interacts with MEN1. Interacts with HIF1AN.

    Three dimensional structures from OCA and Proteopedia for NFKB1 Gene

    Alternative splice isoforms for NFKB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFKB1 Gene

Post-translational modifications for NFKB1 Gene

  • While translation occurs, the particular unfolded structure after the GRR repeat promotes the generation of p50 making it an acceptable substrate for the proteasome. This process is known as cotranslational processing. The processed form is active and the unprocessed form acts as an inhibitor (I kappa B-like), being able to form cytosolic complexes with NF-kappa B, trapping it in the cytoplasm. Complete folding of the region downstream of the GRR repeat precludes processing.
  • Phosphorylation at 'Ser-903' and 'Ser-907' primes p105 for proteolytic processing in response to TNF-alpha stimulation. Phosphorylation at 'Ser-927' and 'Ser-932' are required for BTRC/BTRCP-mediated proteolysis.
  • Polyubiquitination seems to allow p105 processing.
  • S-nitrosylation of Cys-61 affects DNA binding.
  • The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation.
  • Ubiquitination at Lys856
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for NFKB1 Gene

Domains & Families for NFKB1 Gene

Gene Families for NFKB1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for NFKB1 Gene

GenScript: Design optimal peptide antigens:
  • Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (NFKB1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P19838

UniProtKB/Swiss-Prot:

NFKB1_HUMAN :
  • The C-terminus of p105 might be involved in cytoplasmic retention, inhibition of DNA-binding, and transcription activation.
Domain:
  • The C-terminus of p105 might be involved in cytoplasmic retention, inhibition of DNA-binding, and transcription activation.
  • Glycine-rich region (GRR) appears to be a critical element in the generation of p50.
genes like me logo Genes that share domains with NFKB1: view

Function for NFKB1 Gene

Molecular function for NFKB1 Gene

UniProtKB/Swiss-Prot Function:
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.
UniProtKB/Swiss-Prot Induction:
By phorbol ester and TNF.
GENATLAS Biochemistry:
nuclear transcription factor of kappa light chain gene enhancer in B cells,1,(encoding the p105 precursor and the amino-terminal active p50 subunit),NF-kappa B/REL family

Phenotypes From GWAS Catalog for NFKB1 Gene

Gene Ontology (GO) - Molecular Function for NFKB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA 18718911
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 7959007
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA 1406630
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 24434510
genes like me logo Genes that share ontologies with NFKB1: view
genes like me logo Genes that share phenotypes with NFKB1: view

Human Phenotype Ontology for NFKB1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NFKB1 Gene

MGI Knock Outs for NFKB1:

Animal Model Products

CRISPR Products

Transcription Factor Targets for NFKB1 Gene

Selected GeneGlobe predicted Target genes for NFKB1
Targeted motifs for NFKB1 Gene
HOMER Transcription Factor Regulatory Elements motif NFKB1
  • Consensus sequence: GGGGGAATCCCC Submotif: canonical Cell Type: Monocyte

Clone Products

  • Addgene plasmids for NFKB1

No data available for Enzyme Numbers (IUBMB) for NFKB1 Gene

Localization for NFKB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFKB1 Gene

Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NFKB1 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
mitochondrion 4
plasma membrane 1
cytoskeleton 1
peroxisome 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NFKB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IEA,IDA 11819787
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,IEA 11819787
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with NFKB1: view

Pathways & Interactions for NFKB1 Gene

PathCards logo

SuperPathways for NFKB1 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 TNFR1 Pathway
.87
.87
.56
.55
.46
.42
.42
.40
.35
3 4-1BB Pathway
.54
.54
.48
.46
.42
.42
.37
.36
.30
4 Cytosolic sensors of pathogen-associated DNA
5 Toll-like Receptor Signaling Pathway
genes like me logo Genes that share pathways with NFKB1: view

Pathways by source for NFKB1 Gene

100 Qiagen pathways for NFKB1 Gene
  • 14-3-3 Induced Apoptosis
  • 4-1BB Pathway
  • Activation of cAMP-Dependent PKA
  • Activation of NF-KappaB by PKR
  • Activation of PKA through GPCR
1 Cell Signaling Technology pathway for NFKB1 Gene
3 GeneTex pathways for NFKB1 Gene

SIGNOR curated interactions for NFKB1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for NFKB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IMP 19881551
GO:0001818 negative regulation of cytokine production IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with NFKB1: view

Drugs & Compounds for NFKB1 Gene

(52) Drugs for NFKB1 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Thalidomide Approved, Investigational, Withdrawn Pharma Target, antagonist, inhibitor Immunomodulatory agent,sedative drug,angiogenesis inhibitor, TNF-alpha synthesis inhibitor, Immunomodulatory agents 631
Donepezil Approved Pharma Target, inhibitor 311
glycyrrhizin Approved, Experimental Pharma Inhibition, Inhibitor, Target, translocation inhibitor 27
Triflusal Approved, Investigational Pharma Target, antagonist 6
Fish oil Approved Nutra Target, regulator 0

(2) Additional Compounds for NFKB1 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cis,trans-5'-Hydroxythalidomide
  • 5'-OH-Thalidomide
SP 100030
154563-54-9

(3) Tocris Compounds for NFKB1 Gene

Compound Action Cas Number
Pyrrolidinedithiocarbamate ammonium Inhibits NF-kappaB, prevents increase in NOS mRNA 5108-96-3
SP 100030 NF-kappaB and AP-1 dual inhibitor 154563-54-9
Tanshinone IIA Inhibits NF-kappaB and AP-1 DNA binding. Displays antioxidant properties 568-72-9

(32) ApexBio Compounds for NFKB1 Gene

Compound Action Cas Number
2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2- methylphenoxy)acetic acid 317318-70-0
Andrographolide NF-κB signaling Inhibitor 5508-58-7
Bardoxolone Once-a-day treatment for CKD 218600-44-3
Bay 11-7085 NK-κB activation inhibitor 196309-76-9
Bay 11-7821(BAY 11-7082) IKK/NF-κB/TNFα inhibitor 19542-67-7
Caffeic acid 331-39-5
Caffeic Acid Phenethyl Ester NF-κB activation inhibitor 104594-70-9
Cardamonin NF-κB inhibitor 19309-14-9
Dimethylfraxetin 6035-49-0
Emodin Naturally occurring anthraquinone,antiproliferative 518-82-1
Honokiol Antioxidant/antitumor/antiangiogenic agent 35354-74-6
IKK-16 (IKK Inhibitor VII) Selective IκB kinase inhibitor 873225-46-8
IMD 0354 978-62-1
JSH-23 NF-κB inhibitor 749886-87-1
Kaempferol Apoptosis inducer;antioxidant;flavonoid 520-18-3
Luteolin Antioxidant and free radical scavenger 491-70-3
Matrine Alkaloid found in Sophora plant 519-02-8
PR 39 (porcine) 139637-11-9
Pyrrolidinedithiocarbamate ammonium 5108-96-3
QNZ (EVP4593) Potent NF-κB inhibitor 545380-34-5
Ro 106-9920 62645-28-7
SC75741 913822-46-5
Sodium 4-Aminosalicylate 6018-19-5
Sodium 4-amiropparaty Hyalrate 94-16-6
Sodium salicylate 54-21-7
Sulfasalazine NF-κB activation inhibitor 599-79-1
Tanshinone IIA Antioxidant and anti-inflammatory reagent 568-72-9
TPCA-1 IKK-2 inhibitor,potent and selective 507475-17-4
Triptolide IL-2/MMP-3/MMP7/MMP19 inhibitor 38748-32-2
Verbascoside PKC/NF-κB inhibitor 61276-17-3
Withaferin A 5119-48-2
WS6 1421227-53-3
genes like me logo Genes that share compounds with NFKB1: view

Transcripts for NFKB1 Gene

mRNA/cDNA for NFKB1 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for NFKB1

Alternative Splicing Database (ASD) splice patterns (SP) for NFKB1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - -
SP2: - - -
SP3: -
SP4:
SP5:

ExUns: 22 ^ 23 ^ 24a · 24b · 24c
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for NFKB1 Gene

GeneLoc Exon Structure for
NFKB1
ECgene alternative splicing isoforms for
NFKB1

Expression for NFKB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NFKB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NFKB1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.0) and Lymph node (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NFKB1 Gene



Protein tissue co-expression partners for NFKB1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NFKB1 Gene:

NFKB1

SOURCE GeneReport for Unigene cluster for NFKB1 Gene:

Hs.618430

Evidence on tissue expression from TISSUES for NFKB1 Gene

  • Nervous system(4.6)
  • Liver(4.5)
  • Muscle(4.4)
  • Eye(3.3)
  • Lymph node(2.9)
  • Blood(2.8)
  • Lung(2.8)
  • Spleen(2.8)
  • Intestine(2.5)
  • Heart(2.4)
  • Kidney(2.4)
  • Bone marrow(2.3)
  • Pancreas(2.3)
  • Skin(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for NFKB1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • ear
  • eye
  • head
  • hypothalamus
  • meninges
  • middle ear
  • neck
  • pituitary gland
  • sinus
  • skull
  • thyroid
Thorax:
  • bronchus
  • heart
  • lung
Abdomen:
  • adrenal gland
  • intestine
  • large intestine
  • liver
  • small intestine
  • spleen
  • stomach
Pelvis:
  • anus
  • rectum
  • uterus
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • lymph node
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with NFKB1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NFKB1 Gene

Orthologs for NFKB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NFKB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFKB1 33 32
  • 99.69 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 93 (a)
OneToMany
-- 33
  • 67 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NFKB1 33 32
  • 89.87 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NFKB1 33 32
  • 88.96 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nfkb1 17 33 32
  • 84.46 (n)
rat
(Rattus norvegicus)
Mammalia Nfkb1 32