Aliases for NFIC Gene
External Ids for NFIC Gene
Previous HGNC Symbols for NFIC Gene
Previous GeneCards Identifiers for NFIC Gene
The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for NFIC Gene
NFIC (Nuclear Factor I C) is a Protein Coding gene. Diseases associated with NFIC include Mechanical Ectropion and Marshall-Smith Syndrome. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and RNA Polymerase III Transcription Initiation. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is NFIA.
UniProtKB/Swiss-Prot Summary for NFIC Gene
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.