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Aliases for NFIC Gene

Aliases for NFIC Gene

  • Nuclear Factor I C 2 3 5
  • Nuclear Factor I/C (CCAAT-Binding Transcription Factor) 2 3
  • CCAAT-Box-Binding Transcription Factor 3 4
  • TGGCA-Binding Protein 3 4
  • NF-I/C 3 4
  • NF1-C 3 4
  • NFI 3 4
  • CTF 3 4
  • CCAAT-Binding Transcription Factor 2
  • Nuclear Factor 1 C-Type 3
  • Nuclear Factor 1/C 4
  • Nuclear Factor I/C 4
  • NFI-C 4
  • CTF5 3
  • NF-I 3

External Ids for NFIC Gene

Previous HGNC Symbols for NFIC Gene

  • NFI

Previous GeneCards Identifiers for NFIC Gene

  • GC19P003458
  • GC19P003306
  • GC19P003318
  • GC19P003319
  • GC19P003310
  • GC19P003126

Summaries for NFIC Gene

Entrez Gene Summary for NFIC Gene

  • The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for NFIC Gene

NFIC (Nuclear Factor I C) is a Protein Coding gene. Diseases associated with NFIC include Common Wart and Marshall-Smith Syndrome. Among its related pathways are RNA Polymerase III Transcription Initiation and FOXA1 transcription factor network. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is NFIA.

UniProtKB/Swiss-Prot for NFIC Gene

  • Recognizes and binds the palindromic sequence 5-TTGGCNNNNNGCCAA-3 present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

Gene Wiki entry for NFIC Gene

Additional gene information for NFIC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFIC Gene

Genomics for NFIC Gene

GeneHancer (GH) Regulatory Elements for NFIC Gene

Promoters and enhancers for NFIC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J003363 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 651.6 +53.3 53334 8.1 HDGF SMAD1 ARNT YBX1 ZNF2 YY1 POLR2B ZNF213 ZNF143 ZNF263 NFIC CACTIN-AS1 CACTIN YJU2 ZNF77 APBA3 LMNB2 PIAS4 ENSG00000267139 ZNF555
GH19J003357 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 652.5 +45.8 45825 5.5 HDGF SIN3A DMAP1 YY1 POLR2B ZNF207 ZNF143 SP3 MXD4 ZNF592 FZR1 NFIC CACTIN ZNF77 ZNF555 TLE2 GNA11 CACTIN-AS1 YJU2 MATK
GH19J003314 Enhancer 0.5 FANTOM5 650.7 0.0 -19 0.5 ZSCAN4 REST NFIC LOC105372244
GH19J003402 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 22.6 +91.8 91751 7.9 FOXA2 MLX ARID4B YY1 ZNF121 ATF7 FOS RXRA ZHX2 MIER2 NFIC APBA3 CACTIN-AS1 YJU2 ENSG00000267139 CACTIN ENSG00000268670 ENSG00000269807 SH3GL1 ZNF77
GH19J003450 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 17.8 +137.9 137923 3.9 ATF1 MLX SIN3A BRCA1 ZNF280A ATF7 FOS RUNX3 RXRA ZNF623 ZNF77 NFIC CACTIN GNA11 TLE2 YJU2 SMIM24 GNA15 ENSG00000279599
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NFIC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NFIC gene promoter:
  • AP-1
  • GR
  • GR-alpha

Genomic Locations for NFIC Gene

Genomic Locations for NFIC Gene
chr19:3,314,403-3,469,217
(GRCh38/hg38)
Size:
154,815 bases
Orientation:
Plus strand
chr19:3,359,561-3,469,215
(GRCh37/hg19)
Size:
109,655 bases
Orientation:
Plus strand

Genomic View for NFIC Gene

Genes around NFIC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFIC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFIC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFIC Gene

Proteins for NFIC Gene

  • Protein details for NFIC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08651-NFIC_HUMAN
    Recommended name:
    Nuclear factor 1 C-type
    Protein Accession:
    P08651
    Secondary Accessions:
    • A8K1H0
    • B7Z4U5
    • B7Z9C3
    • K7EMU1
    • P08652
    • Q14932
    • Q9UPJ3
    • Q9UPJ9
    • Q9UPK0
    • Q9UPK1

    Protein attributes for NFIC Gene

    Size:
    508 amino acids
    Molecular mass:
    55675 Da
    Quaternary structure:
    • Binds DNA as a homodimer.

    Alternative splice isoforms for NFIC Gene

neXtProt entry for NFIC Gene

Post-translational modifications for NFIC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NFIC Gene

Domains & Families for NFIC Gene

Gene Families for NFIC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for NFIC Gene

Graphical View of Domain Structure for InterPro Entry

P08651

UniProtKB/Swiss-Prot:

NFIC_HUMAN :
  • Belongs to the CTF/NF-I family.
Family:
  • Belongs to the CTF/NF-I family.
genes like me logo Genes that share domains with NFIC: view

Function for NFIC Gene

Molecular function for NFIC Gene

UniProtKB/Swiss-Prot Function:
Recognizes and binds the palindromic sequence 5-TTGGCNNNNNGCCAA-3 present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
GENATLAS Biochemistry:
nuclear transcription factor I C,DNA binding protein

Phenotypes From GWAS Catalog for NFIC Gene

Gene Ontology (GO) - Molecular Function for NFIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 1524678
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0000987 proximal promoter sequence-specific DNA binding IEA --
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA 1524678
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with NFIC: view
genes like me logo Genes that share phenotypes with NFIC: view

Animal Models for NFIC Gene

MGI Knock Outs for NFIC:

Animal Model Products

miRNA for NFIC Gene

miRTarBase miRNAs that target NFIC

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NFIC Gene

Localization for NFIC Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFIC Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NFIC gene
Compartment Confidence
nucleus 5
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (4)
  • Nucleoli fibrillar center (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NFIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA,IDA --
genes like me logo Genes that share ontologies with NFIC: view

Pathways & Interactions for NFIC Gene

genes like me logo Genes that share pathways with NFIC: view

Gene Ontology (GO) - Biological Process for NFIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IGI 1524678
GO:0006260 DNA replication IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II TAS 8710515
genes like me logo Genes that share ontologies with NFIC: view

No data available for SIGNOR curated interactions for NFIC Gene

Drugs & Compounds for NFIC Gene

(4) Drugs for NFIC Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for NFIC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NFIC: view

Transcripts for NFIC Gene

Unigene Clusters for NFIC Gene

Nuclear factor I/C (CCAAT-binding transcription factor):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFIC Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: - - -
SP3: - -

Relevant External Links for NFIC Gene

GeneLoc Exon Structure for
NFIC
ECgene alternative splicing isoforms for
NFIC

Expression for NFIC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NFIC Gene

mRNA differential expression in normal tissues according to GTEx for NFIC Gene

This gene is overexpressed in Muscle - Skeletal (x4.9).

Protein differential expression in normal tissues from HIPED for NFIC Gene

This gene is overexpressed in Ovary (12.0) and Fetal testis (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NFIC Gene



Protein tissue co-expression partners for NFIC Gene

NURSA nuclear receptor signaling pathways regulating expression of NFIC Gene:

NFIC

SOURCE GeneReport for Unigene cluster for NFIC Gene:

Hs.170131

Evidence on tissue expression from TISSUES for NFIC Gene

  • Nervous system(4.9)
  • Liver(4.6)
  • Heart(4.4)
  • Eye(3.3)
  • Lung(3)
  • Muscle(2.8)
  • Kidney(2.4)
  • Skin(2)
genes like me logo Genes that share expression patterns with NFIC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NFIC Gene

Orthologs for NFIC Gene

This gene was present in the common ancestor of animals.

Orthologs for NFIC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFIC 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFIC 34 33
  • 94.14 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NFIC 34 33
  • 93.07 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nfic 33
  • 89.6 (n)
mouse
(Mus musculus)
Mammalia Nfic 16 34 33
  • 89.28 (n)
oppossum
(Monodelphis domestica)
Mammalia NFIC 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NFIC 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 94 (a)
OneToMany
NFIC 33
  • 86.06 (n)
-- 34
  • 84 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia NFIC 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfic 33
  • 72.64 (n)
zebrafish
(Danio rerio)
Actinopterygii nfic 34
  • 84 (a)
OneToOne
LOC100005568 33
  • 77.36 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta NFI 33
  • 68.4 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2380 35
  • 41 (a)
NfI 34
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nfi-1 34 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToMany
Species where no ortholog for NFIC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NFIC Gene

ENSEMBL:
Gene Tree for NFIC (if available)
TreeFam:
Gene Tree for NFIC (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NFIC: view image

Paralogs for NFIC Gene

Paralogs for NFIC Gene

(5) SIMAP similar genes for NFIC Gene using alignment to 2 proteins:

  • NFIC_HUMAN
  • Q6FI30_HUMAN
genes like me logo Genes that share paralogs with NFIC: view

Variants for NFIC Gene

Sequence variations from dbSNP and Humsavar for NFIC Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000065890 -- 3,364,784(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000090492 -- 3,465,985(+) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000094901 -- 3,401,500(+) C/T intron_variant
rs1000120621 -- 3,388,949(+) G/A intron_variant
rs1000127923 -- 3,396,756(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NFIC Gene

Variant ID Type Subtype PubMed ID
nsv953948 CNV deletion 24416366
nsv833712 CNV loss 17160897
nsv526602 CNV loss 19592680
nsv509717 CNV insertion 20534489
nsv479906 CNV novel sequence insertion 20440878
nsv470114 CNV loss 18288195
nsv1149132 CNV deletion 26484159
nsv1133439 CNV deletion 24896259
nsv1131386 CNV deletion 24896259
nsv1126507 CNV deletion 24896259
nsv1121965 CNV deletion 24896259
nsv1118804 CNV deletion 24896259
nsv1116291 CNV deletion 24896259
nsv1112742 CNV deletion 24896259
nsv1071498 CNV deletion 25765185
nsv1071497 CNV deletion 25765185
nsv1058546 CNV gain 25217958
esv3643464 CNV loss 21293372
esv3643462 CNV loss 21293372
esv3555881 CNV deletion 23714750
esv2717945 CNV deletion 23290073
esv2671745 CNV deletion 23128226
esv1167286 CNV deletion 17803354

Variation tolerance for NFIC Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NFIC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NFIC

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFIC Gene

Disorders for NFIC Gene

MalaCards: The human disease database

(3) MalaCards diseases for NFIC Gene - From: DISEASES

Disorder Aliases PubMed IDs
common wart
marshall-smith syndrome
  • mrshss
peripheral nervous system neoplasm
  • neoplasm of peripheral nerve
- elite association - COSMIC cancer census association via MalaCards
Search NFIC in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NFIC

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NFIC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NFIC Gene

Publications for NFIC Gene

  1. Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH. (PMID: 7590749) Qian F … Sippel AE (Genomics 1995) 2 3 22 58
  2. A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs. (PMID: 3398920) Santoro C … Tjian R (Nature 1988) 2 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H … Hirschhorn JN (Nature 2010) 3 44 58
  5. Nuclear factor I transcription factors regulate IGF binding protein 5 gene transcription in human osteoblasts. (PMID: 18809517) Pérez-Casellas LA … Linkhart TA (Biochimica et biophysica acta 2009) 3 22 58

Products for NFIC Gene

Sources for NFIC Gene

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