Aliases for NFIB Gene
External Ids for NFIB Gene
Previous GeneCards Identifiers for NFIB Gene
GeneCards Summary for NFIB Gene
NFIB (Nuclear Factor I B) is a Protein Coding gene. Diseases associated with NFIB include Macrocephaly, Acquired, With Impaired Intellectual Development and Alacrima, Achalasia, And Mental Retardation Syndrome. Among its related pathways are RNA Polymerase III Transcription Initiation and Pathways Affected in Adenoid Cystic Carcinoma. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is NFIA.
UniProtKB/Swiss-Prot Summary for NFIB Gene
Transcriptional activator of GFAP, essential for proper brain development (PubMed:30388402). Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.