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Aliases for NFE2L3 Gene

Aliases for NFE2L3 Gene

  • Nuclear Factor, Erythroid 2 Like 3 2 3 5
  • Nuclear Factor, Erythroid Derived 2, Like 3 3 4
  • NF-E2-Related Factor 3 3 4
  • NFE2-Related Factor 3 3 4
  • NRF3 3 4
  • Nuclear Factor-Erythroid 2 P45-Related Factor 3 3
  • Nuclear Factor Erythroid 2-Related Factor 3 3
  • Nuclear Factor (Erythroid-Derived 2)-Like 3 2
  • Nuclear Factor, Erythroid 2-Like 3 2

External Ids for NFE2L3 Gene

Previous GeneCards Identifiers for NFE2L3 Gene

  • GC07P025834
  • GC07P025934
  • GC07P025965
  • GC07P026158
  • GC07P026191

Summaries for NFE2L3 Gene

Entrez Gene Summary for NFE2L3 Gene

  • This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. [provided by RefSeq, Mar 2009]

GeneCards Summary for NFE2L3 Gene

NFE2L3 (Nuclear Factor, Erythroid 2 Like 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is NFE2L1.

UniProtKB/Swiss-Prot for NFE2L3 Gene

  • Activates erythroid-specific, globin gene expression.

Gene Wiki entry for NFE2L3 Gene

Additional gene information for NFE2L3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFE2L3 Gene

Genomics for NFE2L3 Gene

GeneHancer (GH) Regulatory Elements for NFE2L3 Gene

Promoters and enhancers for NFE2L3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J026151 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 650.7 +3.8 3833 9.7 HDGF PKNOX1 SMAD1 SIN3A IRF4 ETS1 ZNF121 POLR2B ZNF766 ZNF207 NFE2L3 HNRNPA2B1 SNX10 CBX3 LOC105375304 ENSG00000273237
GH07J026180 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +28.8 28794 0.8 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 E2F8 ATF7 PAF1 NFE2L3 HNRNPA2B1 CBX3 GC07P026176 GC07M026184
GH07J025892 Enhancer 1.2 Ensembl ENCODE 10.7 -258.0 -257981 3.6 PKNOX1 FOXA2 SIN3A IRF4 YY1 ETS1 ZNF213 ARID2 ZNF143 ATF7 MIR148A NFE2L3 LOC100506236 LOC105375200
GH07J026096 Enhancer 1 Ensembl ENCODE 11.8 -54.7 -54708 1.5 EGR1 ATF7 IKZF2 EGR2 CEBPB ZNF398 ELF1 ZEB2 ZNF518A ZFP69B NFE2L3 HNRNPA2B1 CBX3 LOC105375198 GC07P026071 LOC105375199
GH07J026078 Enhancer 1 Ensembl ENCODE 11.3 -73.1 -73080 0.5 PKNOX1 ATF1 RB1 RAD21 ZNF335 EGR1 ZSCAN5C SCRT2 ZNF143 THAP11 NFE2L3 HNRNPA2B1 CBX3 LOC105375304 GC07P026071 LOC105375198 LOC105375199
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NFE2L3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NFE2L3 gene promoter:
  • Egr-2
  • NCX
  • Pax-5
  • FOXO1a
  • FOXO1
  • POU2F1a
  • POU2F1
  • MyoD
  • POU3F2
  • Arnt

Genomic Locations for NFE2L3 Gene

Genomic Locations for NFE2L3 Gene
34,911 bases
Plus strand
34,911 bases
Plus strand

Genomic View for NFE2L3 Gene

Genes around NFE2L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFE2L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFE2L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFE2L3 Gene

Proteins for NFE2L3 Gene

  • Protein details for NFE2L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear factor erythroid 2-related factor 3
    Protein Accession:
    Secondary Accessions:
    • Q6NUS0
    • Q7Z498
    • Q86UJ4
    • Q86VR5
    • Q9UQA4

    Protein attributes for NFE2L3 Gene

    694 amino acids
    Molecular mass:
    76154 Da
    Quaternary structure:
    • Heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE).
    • Sequence=AAP22344.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA76288.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for NFE2L3 Gene

Post-translational modifications for NFE2L3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NFE2L3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NFE2L3 Gene

Domains & Families for NFE2L3 Gene

Gene Families for NFE2L3 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Transcription factors

Protein Domains for NFE2L3 Gene

Suggested Antigen Peptide Sequences for NFE2L3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the bZIP family. CNC subfamily.
  • Belongs to the bZIP family. CNC subfamily.
genes like me logo Genes that share domains with NFE2L3: view

Function for NFE2L3 Gene

Molecular function for NFE2L3 Gene

UniProtKB/Swiss-Prot Function:
Activates erythroid-specific, globin gene expression.
GENATLAS Biochemistry:
nuclear factor (erythroid-derived 2)-like 3,Capncollar (CNC) family of transcription factor,highly expressed in placenta,B cell and monocyte lineage

Phenotypes From GWAS Catalog for NFE2L3 Gene

Gene Ontology (GO) - Molecular Function for NFE2L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IBA --
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with NFE2L3: view
genes like me logo Genes that share phenotypes with NFE2L3: view

Animal Models for NFE2L3 Gene

MGI Knock Outs for NFE2L3:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NFE2L3 Gene

Localization for NFE2L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFE2L3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NFE2L3 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NFE2L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with NFE2L3: view

Pathways & Interactions for NFE2L3 Gene

SuperPathways for NFE2L3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NFE2L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA,IBA --
GO:0006366 transcription by RNA polymerase II TAS 10037736
genes like me logo Genes that share ontologies with NFE2L3: view

No data available for Pathways by source and SIGNOR curated interactions for NFE2L3 Gene

Drugs & Compounds for NFE2L3 Gene

No Compound Related Data Available

Transcripts for NFE2L3 Gene

mRNA/cDNA for NFE2L3 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(132) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NFE2L3 Gene

Nuclear factor (erythroid-derived 2)-like 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFE2L3 Gene

No ASD Table

Relevant External Links for NFE2L3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NFE2L3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NFE2L3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NFE2L3 Gene

NURSA nuclear receptor signaling pathways regulating expression of NFE2L3 Gene:


SOURCE GeneReport for Unigene cluster for NFE2L3 Gene:


mRNA Expression by UniProt/SwissProt for NFE2L3 Gene:

Tissue specificity: Highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for NFE2L3 Gene

  • Kidney(4.1)
genes like me logo Genes that share expression patterns with NFE2L3: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NFE2L3 Gene

Orthologs for NFE2L3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NFE2L3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NFE2L3 34 33
  • 98.99 (n)
(Canis familiaris)
Mammalia NFE2L3 34 33
  • 83.52 (n)
(Bos Taurus)
Mammalia NFE2L3 34 33
  • 83.5 (n)
(Mus musculus)
Mammalia Nfe2l3 16 34 33
  • 77.49 (n)
(Rattus norvegicus)
Mammalia Nfe2l3 33
  • 76.32 (n)
(Ornithorhynchus anatinus)
Mammalia NFE2L3 34
  • 58 (a)
(Anolis carolinensis)
Reptilia NFE2L3 34
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nfe2l3 33
  • 56.25 (n)
Str.17162 33
(Danio rerio)
Actinopterygii nfe2l3 34
  • 29 (a)
fruit fly
(Drosophila melanogaster)
Insecta cnc 34 35
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 16 (a)
Species where no ortholog for NFE2L3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFE2L3 Gene

Gene Tree for NFE2L3 (if available)
Gene Tree for NFE2L3 (if available)
Evolutionary constrained regions (ECRs) for NFE2L3: view image

Paralogs for NFE2L3 Gene

Paralogs for NFE2L3 Gene

(3) SIMAP similar genes for NFE2L3 Gene using alignment to 3 proteins:

  • A4D178_HUMAN
  • U3KQ19_HUMAN Pseudogenes for NFE2L3 Gene

genes like me logo Genes that share paralogs with NFE2L3: view

Variants for NFE2L3 Gene

Sequence variations from dbSNP and Humsavar for NFE2L3 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000014363 -- 26,187,415(+) G/T downstream_transcript_variant
rs1000028102 -- 26,172,226(+) T/C intron_variant
rs1000159250 -- 26,185,838(+) T/C 3_prime_UTR_variant
rs1000185130 -- 26,175,225(+) T/G intron_variant
rs1000427915 -- 26,150,439(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NFE2L3 Gene

Variant ID Type Subtype PubMed ID
dgv1877e212 CNV gain 25503493
esv1335165 CNV deletion 17803354
esv1600800 CNV insertion 17803354
esv22494 CNV loss 19812545
esv2659850 CNV deletion 23128226
esv2671129 CNV deletion 23128226
esv2734156 CNV deletion 23290073
esv3541363 CNV deletion 23714750
esv3541364 CNV deletion 23714750
esv3612615 CNV gain 21293372
esv3612621 CNV gain 21293372
esv3612626 CNV gain 21293372
esv3612627 CNV loss 21293372
esv3612628 CNV loss 21293372
esv3612629 CNV loss 21293372
esv3612631 CNV loss 21293372
esv3891090 CNV gain 25118596
nsv1028727 CNV gain 25217958
nsv1034358 CNV gain 25217958
nsv1074081 CNV deletion 25765185
nsv1076879 CNV deletion 25765185
nsv1145127 CNV deletion 24896259
nsv606432 CNV gain 21841781
nsv7393 OTHER inversion 18451855
nsv970807 CNV duplication 23825009

Variation tolerance for NFE2L3 Gene

Residual Variation Intolerance Score: 70.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.73; 66.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NFE2L3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFE2L3 Gene

Disorders for NFE2L3 Gene

Additional Disease Information for NFE2L3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NFE2L3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NFE2L3 Gene

Publications for NFE2L3 Gene

  1. Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. (PMID: 10037736) Kobayashi A … Yamamoto M (The Journal of biological chemistry 1999) 2 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. Endoplasmic reticulum association and N-linked glycosylation of the human Nrf3 transcription factor. (PMID: 17976382) Nouhi Z … Blank V (FEBS letters 2007) 3 22 58
  5. Functional and placental expression analysis of the human NRF3 transcription factor. (PMID: 15388789) Chénais B … Blank V (Molecular endocrinology (Baltimore, Md.) 2005) 3 22 58

Products for NFE2L3 Gene

Sources for NFE2L3 Gene

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