Aliases for NFATC3 Gene
External Ids for NFATC3 Gene
Previous GeneCards Identifiers for NFATC3 Gene
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]
GeneCards Summary for NFATC3 Gene
NFATC3 (Nuclear Factor Of Activated T Cells 3) is a Protein Coding gene. Diseases associated with NFATC3 include Crouzon Syndrome With Acanthosis Nigricans and Leukostasis. Among its related pathways are Oxytocin signaling pathway and Human cytomegalovirus infection. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is NFATC4.
UniProtKB/Swiss-Prot Summary for NFATC3 Gene
Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Along with NFATC4, involved in embryonic heart development (By similarity).
NFAT (Nuclear Factor of Activated T-Cells) proteins are transcription factors that are integral for the development and function of the immune system. Five NFAT isoforms have been identified to date, NFATC1-C4 and NFAT5.