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Aliases for NFATC2IP Gene
Aliases for NFATC2IP Gene
- Nuclear Factor Of Activated T Cells 2 Interacting Protein 2 3 5
- NIP45 2 3 4
- Nuclear Factor Of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 Interacting Protein 2 3
- Nuclear Factor Of Activated T-Cells, Cytoplasmic 2-Interacting Protein 3 4
- 45 KDa NF-AT-Interacting Protein 3 4
- 45 KDa NFAT-Interacting Protein 3 4
External Ids for NFATC2IP Gene
- HGNC: 25906
- Entrez Gene: 84901
- Ensembl: ENSG00000176953
- OMIM: 614525
- UniProtKB: Q8NCF5
Previous GeneCards Identifiers for NFATC2IP Gene
- GC16P028870
- GC16P028962
- GC16P026830
Summaries for NFATC2IP Gene
GeneCards Summary for NFATC2IP Gene
NFATC2IP (Nuclear Factor Of Activated T Cells 2 Interacting Protein) is a Protein Coding gene. Diseases associated with NFATC2IP include Friedreich Ataxia 2 and Tuberculous Empyema. An important paralog of this gene is SUMO2.
UniProtKB/Swiss-Prot Summary for NFATC2IP Gene
-
In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).
Additional gene information for NFATC2IP Gene
- HGNC(25906)
- Entrez Gene(84901)
- Ensembl(ENSG00000176953)
- OMIM(614525)
- UniProtKB(Q8NCF5)
- Open Targets Platform(ENSG00000176953)
- Search for NFATC2IP at DataMed
- Search for NFATC2IP at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NFATC2IP Gene
Genomics for NFATC2IP Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NFATC2IP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NFATC2IP on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NFATC2IP
- Top Transcription factor binding sites by QIAGEN in the NFATC2IP gene promoter:
-
- LCR-F1
- STAT1
- STAT1alpha
- STAT1beta
- STAT2
- STAT3
- STAT4
- STAT5A
- STAT5B
- STAT6
Genomic Locations for NFATC2IP Gene
Genomic Locations for NFATC2IP Gene
- chr16:28,950,807-28,967,097
- (GRCh38/hg38)
- Size:
- 16,291 bases
- Orientation:
- Plus strand
- chr16:28,962,128-28,978,418
- (GRCh37/hg19)
- Size:
- 16,291 bases
- Orientation:
- Plus strand
Genomic View for NFATC2IP Gene
Genes around NFATC2IP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p11.2 by HGNC
- 16p11.2 by Entrez Gene
- 16p11.2 by Ensembl
NFATC2IP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NFATC2IP Gene
Proteins for NFATC2IP Gene
-
Protein details for NFATC2IP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NCF5-NF2IP_HUMAN
- Recommended name:
- NFATC2-interacting protein
- Protein Accession:
- Q8NCF5
- B7Z4G5
- Q66K34
- Q6NVK1
- Q8NFR2
- Q96ST9
Protein attributes for NFATC2IP Gene
- Size:
- 419 amino acids
- Molecular mass:
- 45817 Da
- Quaternary structure:
-
- Interacts with NFATC2, TRAF1, TRAF2 and PRMT1. Interacts with UBE2I/UBC9 (By similarity).
- SequenceCaution:
-
- Sequence=AAM49721.1; Type=Frameshift; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for NFATC2IP Gene
Protein Expression for NFATC2IP Gene
Post-translational modifications for NFATC2IP Gene
- Methylation at the N-terminus by PRMT1 modulates interaction with the NFAT complex and results in augmented cytokine production.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for NFATC2IP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ NFATc2IP Antibody
- Novus Biologicals Antibodies for NFATC2IP
-
Abcam antibodies for NFATC2IP
- Invitrogen Antibodies for NFATC2IP (AFLGC-NFATC2IP)
-
Boster Bio Antibodies for NFATC2IP
-
Santa Cruz Biotechnology (SCBT) Antibodies for NFATC2IP
Protein Products
-
OriGene Purified Proteins for NFATC2IP
- Search Origene for MassSpec and Protein Over-expression Lysates for NFATC2IP
- Origene Custom Protein Services for NFATC2IP
- antibodies-online: Show 6 available NFATC2IP Proteins ranked by validation data
- Compare Top NFATC2IP Proteins
-
Quality Products:
-
Abcam proteins for NFATC2IP
No data available for DME Specific Peptides for NFATC2IP Gene
Domains & Families for NFATC2IP Gene
Gene Families for NFATC2IP Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for NFATC2IP Gene
- InterPro:
- Blocks:
-
- Ubiquitin domain
- ProtoNet:
Suggested Antigen Peptide Sequences for NFATC2IP Gene
- GenScript: Design optimal peptide antigens:
-
- Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein (NF2IP_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NFATC2IP Gene
Function for NFATC2IP Gene
Molecular function for NFATC2IP Gene
- UniProtKB/Swiss-Prot Function:
- In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).
Phenotypes From GWAS Catalog for NFATC2IP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | -- |
Phenotypes for NFATC2IP Gene
- MGI mutant phenotypes for NFATC2IP:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for NFATC2IP:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased vaccinia virus (VACV) infection
- Decreased transferrin (TF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Decreased ionizing radiation sensitivity
- Synthetic lethal with imatinib mesylate
Animal Models for NFATC2IP Gene
- MGI Knock Outs for NFATC2IP:
-
- Nfatc2ip Nfatc2ip<tm1.1Glm>
Animal Model Products
-
Taconic Biosciences Mouse Models for NFATC2IP
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NFATC2IP - Select products 50% OFF >
- * NFATC2IP CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NFATC2IP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NFATC2IP
-
Santa Cruz Biotechnology (SCBT) CRISPR for NFATC2IP
miRNA for NFATC2IP Gene
- miRTarBase miRNAs that target NFATC2IP
-
- hsa-miR-122-5p (MIRT003082)
- hsa-miR-155-5p (MIRT004056)
- hsa-miR-760 (MIRT036770)
- hsa-miR-92b-3p (MIRT040580)
- hsa-miR-193b-3p (MIRT041603)
- hsa-miR-20b-5p (MIRT042400)
- hsa-miR-31-5p (MIRT049893)
- hsa-let-7a-5p (MIRT052601)
- hsa-miR-19a-3p (MIRT074500)
- hsa-miR-19b-3p (MIRT074501)
- hsa-miR-16-2-3p (MIRT074502)
- hsa-miR-195-3p (MIRT074503)
- hsa-miR-3662 (MIRT074509)
- hsa-miR-32-5p (MIRT142703)
- hsa-miR-92a-3p (MIRT142704)
- hsa-miR-142-3p (MIRT142774)
- hsa-miR-3671 (MIRT195037)
- hsa-miR-17-5p (MIRT250443)
- hsa-miR-20a-5p (MIRT250444)
- hsa-miR-93-5p (MIRT250445)
- hsa-miR-106b-5p (MIRT250448)
- hsa-miR-371a-5p (MIRT250451)
- hsa-miR-372-5p (MIRT250452)
- hsa-miR-373-5p (MIRT250453)
- hsa-miR-519d-3p (MIRT250457)
- hsa-miR-616-5p (MIRT250459)
- hsa-miR-3653-5p (MIRT250468)
- hsa-miR-371b-5p (MIRT250470)
- hsa-miR-6778-3p (MIRT250472)
- hsa-miR-3674 (MIRT499703)
- hsa-miR-744-3p (MIRT499704)
- hsa-miR-4474-5p (MIRT499705)
- hsa-miR-4423-5p (MIRT499706)
- hsa-miR-6501-5p (MIRT499707)
- hsa-miR-4732-5p (MIRT499708)
- hsa-miR-6832-5p (MIRT499709)
- hsa-miR-8086 (MIRT499710)
- hsa-miR-4781-3p (MIRT499711)
- hsa-miR-129-5p (MIRT522326)
- hsa-miR-374b-3p (MIRT556000)
- hsa-miR-4766-3p (MIRT556001)
- mmu-miR-3470b (MIRT598068)
- hsa-miR-498 (MIRT655864)
- hsa-miR-4279 (MIRT655865)
- hsa-miR-548ax (MIRT655866)
- hsa-miR-548ao-5p (MIRT655867)
- hsa-miR-1976 (MIRT655868)
- hsa-miR-6727-3p (MIRT655869)
- hsa-miR-6747-3p (MIRT655870)
- hsa-miR-4722-3p (MIRT655871)
- hsa-miR-2861 (MIRT687492)
- hsa-miR-5589-5p (MIRT687493)
- hsa-miR-4731-5p (MIRT687494)
- hsa-miR-661 (MIRT687495)
- hsa-miR-939-3p (MIRT687496)
- hsa-miR-520h (MIRT687497)
- hsa-miR-520g-3p (MIRT687498)
- hsa-miR-512-3p (MIRT687499)
- hsa-miR-5587-5p (MIRT723528)
- hsa-miR-203b-3p (MIRT723529)
- hsa-miR-7158-3p (MIRT723530)
- hsa-miR-323a-5p (MIRT723531)
- hsa-miR-6801-5p (MIRT723532)
- hsa-miR-4483 (MIRT723533)
- hsa-miR-1293 (MIRT723534)
- hsa-miR-4680-5p (MIRT723535)
- hsa-miR-4635 (MIRT723536)
- hsa-miR-6823-5p (MIRT723537)
- hsa-miR-3658 (MIRT785043)
- hsa-miR-6758-3p (MIRT788581)
- hsa-miR-7856-5p (MIRT789613)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NFATC2IP
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NFATC2IP
Clone Products
- Applied Biological Materials (abm): Clones for NFATC2IP - Select products 50% OFF >
- * NFATC2IP as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for NFATC2IP
- Addgene plasmids for NFATC2IP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NFATC2IP
Cell Line Products
-
Horizon Cell Lines for NFATC2IP
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NFATC2IP Gene
Localization for NFATC2IP Gene
Subcellular locations from UniProtKB/Swiss-Prot for NFATC2IP Gene
- Nucleus. Cytoplasm. Note=TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm and prevents its translocation to the nucleus. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for NFATC2IP Gene
Pathways by source for NFATC2IP Gene
1 GeneTex pathway for NFATC2IP Gene
Interacting Proteins for NFATC2IP Gene
Selected Interacting proteins:
Q8NCF5-NF2IP_HUMAN
ENSP00000324792
for NFATC2IP Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for NFATC2IP
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001816 | cytokine production | IEA,IBA | 21873635 |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IEA,IBA | 21873635 |
No data available for SIGNOR curated interactions for NFATC2IP Gene
Transcripts for NFATC2IP Gene
mRNA/cDNA for NFATC2IP Gene
- 1 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000320805 4569 nts (view in UCSC)
- ENST00000562977 638 nts (view in UCSC)
- ENST00000564978 2350 nts (view in UCSC)
- ENST00000565752 823 nts (view in UCSC)
- ENST00000565919 576 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NFATC2IP - Select products 50% OFF >
- * NFATC2IP CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NFATC2IP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NFATC2IP
-
Santa Cruz Biotechnology (SCBT) CRISPR for NFATC2IP
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NFATC2IP
- Browse OriGene Inhibitory RNA Products For NFATC2IP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NFATC2IP
Clone Products
- Applied Biological Materials (abm): Clones for NFATC2IP - Select products 50% OFF >
- * NFATC2IP as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for NFATC2IP
- Addgene plasmids for NFATC2IP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NFATC2IP
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||
| SP8: | - |
Relevant External Links for NFATC2IP Gene
- GeneLoc Exon Structure for
- NFATC2IP
Expression for NFATC2IP Gene
This gene is overexpressed in CD8 Tcells (15.3), Testis (12.2), Fetal ovary (9.3), NK cells (7.4), CD4 Tcells (6.6), Blymphocyte (6.5), and Monocytes (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NFATC2IP Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NFATC2IP
SOURCE GeneReport for Unigene cluster for NFATC2IP Gene:
Hs.513470Evidence on tissue expression from TISSUES for NFATC2IP Gene
- Nervous system(4.6)
- Eye(4.4)
- Liver(4.3)
- Skin(2.3)
- Blood(2.3)
- Spleen(2.1)
- Bone marrow(2)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs for NFATC2IP
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NFATC2IP Gene
Orthologs for NFATC2IP Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | NFATC2IP 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | NFATC2IP 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | NFATC2IP 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Nfatc2ip 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Nfatc2ip 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | NFATC2IP 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | NFATC2IP 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | nfatc2ip 30 31 |
|
OneToOne |
- Species where no ortholog for NFATC2IP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for NFATC2IP Gene
- ENSEMBL:
- Gene Tree for NFATC2IP (if available)
- TreeFam:
- Gene Tree for NFATC2IP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NFATC2IP: view image
Paralogs for NFATC2IP Gene
Variants for NFATC2IP Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NFATC2IP Gene
| SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs7201257 | - | p.Arg33Trp |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2830n100 | CNV | gain | 25217958 |
| dgv2831n100 | CNV | gain | 25217958 |
| dgv4987n54 | CNV | gain | 21841781 |
| esv2758640 | CNV | gain+loss | 17122850 |
| esv33811 | CNV | loss | 17666407 |
| esv3570454 | CNV | gain | 25503493 |
| esv3892826 | CNV | gain+loss | 25118596 |
| nsv1059555 | CNV | gain | 25217958 |
| nsv457480 | CNV | gain | 19166990 |
| nsv518648 | CNV | loss | 19592680 |
| nsv519100 | CNV | gain | 19592680 |
| nsv571805 | CNV | loss | 21841781 |
| nsv571808 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.89;
67.57% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NFATC2IP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NFATC2IP
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFATC2IP Gene
Disorders for NFATC2IP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| friedreich ataxia 2 |
|
|
| tuberculous empyema |
|
|
| tracheal cancer |
|
|
| tracheitis |
|
|
| cone-rod dystrophy 2 |
|
|
Search NFATC2IP in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NFATC2IP
No data available for UniProtKB/Swiss-Prot and Genatlas for NFATC2IP Gene
Publications for NFATC2IP Gene
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
- Proteins with two SUMO-like domains in chromatin-associated complexes: the RENi (Rad60-Esc2-NIP45) family. (PMID: 15698469) Novatchkova M … Eisenhaber F (BMC bioinformatics 2005) 2 3
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
ExternalLinks
Products for NFATC2IP Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for NFATC2IP
- Search Origene for MassSpec and Protein Over-expression Lysates for NFATC2IP
- Origene Custom Protein Services for NFATC2IP
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NFATC2IP
- Browse OriGene Inhibitory RNA Products For NFATC2IP
- OriGene qPCR primer pairs for NFATC2IP
- OriGene CRISPR knockouts for NFATC2IP
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NFATC2IP
- Sino Biological Human cDNA Clone for NFATC2IP
- Browse Sino Biological Recombinant Proteins
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- Novus Biologicals Antibodies for NFATC2IP
- Novus Biologicals proteins and lysates for NFATC2IP
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- Taconic Biosciences Mouse Models for NFATC2IP
- Find your next knockout model in the Taconic Knockout Repository
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- Invitrogen Antibodies for NFATC2IP (AFLGC-NFATC2IP)
- VectorBuilder Custom and pre-made DNA vectors for NFATC2IP (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for NFATC2IP (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for NFATC2IP (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for NFATC2IP CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for NFATC2IP
- Addgene plasmids for NFATC2IP
- antibodies-online: Show 4 available NFATC2IP Antibodies ranked by validation data
- Compare Top NFATC2IP Antibodies
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- antibodies-online: Search results for available NFATC2IP related products ranked by validation data
- antibodies-online: Show 6 available NFATC2IP Proteins ranked by validation data
- Compare Top NFATC2IP Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for NFATC2IP
- Search Santa Cruz Biotechnology (SCBT) for NFATC2IP siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NFATC2IP
- Horizon Cell Lines for NFATC2IP
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NFATC2IP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NFATC2IP
- Search GeneCopoeia for miRNA 3'UTR Target clone products for NFATC2IP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NFATC2IP
- Boster Bio Antibodies for NFATC2IP
- Browse Boster Bio ELISA Kits
Sources for NFATC2IP Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB