Aliases for NFAM1 Gene
External Ids for NFAM1 Gene
Previous GeneCards Identifiers for NFAM1 Gene
The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. [provided by RefSeq, Jul 2008]
GeneCards Summary for NFAM1 Gene
NFAM1 (NFAT Activating Protein With ITAM Motif 1) is a Protein Coding gene. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity.
UniProtKB/Swiss-Prot for NFAM1 Gene
May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking.