Aliases for NEXN-AS1 Gene

RNA type for NEXN-AS1 Gene

lncRNA

Aliases for NEXN-AS1 Gene

External Ids for NEXN-AS1 Gene

Previous HGNC Symbols for NEXN-AS1 Gene

  • C1orf118

Previous GeneCards Identifiers for NEXN-AS1 Gene

  • GC01M078348
  • GC01M077881
  • GC01M077883
  • GC01M077891
  • GC01M077901

Summaries for NEXN-AS1 Gene

GeneCards Summary for NEXN-AS1 Gene

NEXN-AS1 (NEXN Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with NEXN-AS1 include Lung Cancer.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NEXN-AS1 Gene

Genomics for NEXN-AS1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NEXN-AS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J077886 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 255.9 -0.6 -618 6.5 IKZF1 ZNF600 ZNF580 ZNF10 POLR2A ZIC2 ZBTB10 CEBPB REST ZNF341 NEXN NEXN-AS1 NONHSAG001877.2 USP33 GIPC2 FUBP1 IFI44 MN309174-007 DNAJB4
GH01J077884 Enhancer 0.2 FANTOM5 0.7 +4.6 4553 0.3 MIGA1 NEXN NEXN-AS1 HSALNG0004595
GH01J077882 Enhancer 0.2 FANTOM5 0.4 +6.9 6948 0.3 MIGA1 ZZZ3 HSALNG0004595 NEXN NEXN-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NEXN-AS1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for NEXN-AS1 Gene

Latest Assembly
chr1:77,880,769-77,889,539
(GRCh38/hg38)
Size:
8,771 bases
Orientation:
Minus strand

Previous Assembly
chr1:78,347,033-78,355,224
(GRCh37/hg19 by Entrez Gene)
Size:
8,192 bases
Orientation:
Minus strand

chr1:78,347,033-78,355,224
(GRCh37/hg19 by Ensembl)
Size:
8,192 bases
Orientation:
Minus strand

Genomic View for NEXN-AS1 Gene

Genes around NEXN-AS1 on UCSC Golden Path with GeneCards custom track
NEXN-AS1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
NEXN-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEXN-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEXN-AS1 Gene

Proteins for NEXN-AS1 Gene

  • Protein details for NEXN-AS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBZ9-NEAS1_HUMAN
    Recommended name:
    Putative uncharacterized protein NEXN-AS1
    Protein Accession:
    Q8NBZ9

    Protein attributes for NEXN-AS1 Gene

    Size:
    246 amino acids
    Molecular mass:
    25156 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NEXN-AS1 Gene

Post-translational modifications for NEXN-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NEXN-AS1 Gene

Domains & Families for NEXN-AS1 Gene

Gene Families for NEXN-AS1 Gene

genes like me logo Genes that share domains with NEXN-AS1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NEXN-AS1 Gene

Function for NEXN-AS1 Gene

Phenotypes From GWAS Catalog for NEXN-AS1 Gene

Phenotypes for NEXN-AS1 Gene

GenomeRNAi human phenotypes for NEXN-AS1:
genes like me logo Genes that share phenotypes with NEXN-AS1: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NEXN-AS1 Gene

Localization for NEXN-AS1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEXN-AS1 gene
Compartment Confidence
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NEXN-AS1 Gene

Pathways & Interactions for NEXN-AS1 Gene

PathCards logo

SuperPathways for NEXN-AS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NEXN-AS1 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for NEXN-AS1 Gene

Drugs & Compounds for NEXN-AS1 Gene

No Compound Related Data Available

Transcripts for NEXN-AS1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for NEXN-AS1 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000032A8EE_9606 lncRNA 2295 4

RefSeq: NR_103535,

Ensembl: ENST00000421331 (view in UCSC) ,

LNCipedia: NEXN-AS1:1,

NONCODE: NONHSAT004050.2,

URS00001D23AB_9606 lncRNA 731 3

LncBook: HSALNT0009225,

LNCipedia: NEXN-AS1:2,

NONCODE: NONHSAT004051.2,

URS0000D57DF4_9606 lncRNA 8399 1

LNCipedia: NEXN-AS1:3,

URS0000EB91E0_9606 lncRNA 2295 1

LncBook: HSALNT0289376,

URS0001BED699_9606 lncRNA 2292 1

LncBook: HSALNT0289376,

NEXN-AS1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for NEXN-AS1 Gene

2 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :

CRISPR products for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEXN-AS1

Alternative Splicing Database (ASD) splice patterns (SP) for NEXN-AS1 Gene

No ASD Table

Relevant External Links for NEXN-AS1 Gene

GeneLoc Exon Structure for
NEXN-AS1

Expression for NEXN-AS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NEXN-AS1 Gene

mRNA differential expression in normal tissues according to GTEx for NEXN-AS1 Gene

This gene is overexpressed in Muscle - Skeletal (x7.2) and Heart - Left Ventricle (x5.6).

Protein differential expression in normal tissues from HIPED for NEXN-AS1 Gene

This gene is overexpressed in CD4 Tcells (67.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NEXN-AS1 Gene



Protein tissue co-expression partners for NEXN-AS1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NEXN-AS1

SOURCE GeneReport for Unigene cluster for NEXN-AS1 Gene:

Hs.632414
genes like me logo Genes that share expression patterns with NEXN-AS1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEXN-AS1 Gene

Orthologs for NEXN-AS1 Gene

Evolution for NEXN-AS1 Gene

ENSEMBL:
Gene Tree for NEXN-AS1 (if available)
TreeFam:
Gene Tree for NEXN-AS1 (if available)
Alliance of Genome Resources:
Additional Orthologs for NEXN-AS1

No data available for Orthologs for NEXN-AS1 Gene

Paralogs for NEXN-AS1 Gene

No data available for Paralogs for NEXN-AS1 Gene

Variants for NEXN-AS1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NEXN-AS1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs528439602 Uncertain Significance: Hypertrophic cardiomyopathy; Dilated Cardiomyopathy, Dominant 77,888,598(-) A/ACGG
NM_001172309.1(NEXN):c.-212_-210GGC[7]
NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR
rs587781100 Benign: not specified 77,888,754(-) T/C
NM_144573.3(NEXN):c.-58T>C
NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NEXN-AS1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NEXN-AS1 Gene

Variant ID Type Subtype PubMed ID
esv2329300 CNV deletion 18987734
nsv1137774 CNV deletion 24896259

Additional Variant Information for NEXN-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEXN-AS1
Leiden Open Variation Database (LOVD)
NEXN-AS1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NEXN-AS1 Gene

Disorders for NEXN-AS1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NEXN-AS1 Gene - From: LNC and COP

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NEXN-AS1

genes like me logo Genes that share disorders with NEXN-AS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEXN-AS1 Gene

Publications for NEXN-AS1 Gene

  1. A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer. (PMID: 27713484) Yuan H … Wei Q (Scientific reports 2016) 2 3 72
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Long noncoding RNA NEXN-AS1 mitigates atherosclerosis by regulating the actin-binding protein NEXN. (PMID: 30589415) Hu YW … Ye S (The Journal of clinical investigation 2019) 3
  4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3

Products for NEXN-AS1 Gene

Sources for NEXN-AS1 Gene