This gene encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. The protein product of this gene also plays a role in the differentiation and survival of midbrain dopaminergic neurons. [provided by ... See more...

Aliases for NEUROG2 Gene

Aliases for NEUROG2 Gene

  • Neurogenin 2 2 3 5
  • Class A Basic Helix-Loop-Helix Protein 8 3 4
  • Protein Atonal Homolog 4 3 4
  • Neurogenin-2 3 4
  • BHLHa8 3 4
  • NGN2 3 4
  • Math4A 3
  • BHLHA8 4
  • Atoh4 3
  • Ngn-2 3
  • ATOH4 4
  • NGN-2 4

External Ids for NEUROG2 Gene

Previous GeneCards Identifiers for NEUROG2 Gene

  • GC00U990846
  • GC04M113715
  • GC04M113827
  • GC04M113893
  • GC04M113792
  • GC04M113654
  • GC04M113434
  • GC04M109166

Summaries for NEUROG2 Gene

Entrez Gene Summary for NEUROG2 Gene

  • This gene encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. The protein product of this gene also plays a role in the differentiation and survival of midbrain dopaminergic neurons. [provided by RefSeq, Apr 2012]

GeneCards Summary for NEUROG2 Gene

NEUROG2 (Neurogenin 2) is a Protein Coding gene. Diseases associated with NEUROG2 include Retinitis Pigmentosa 58 and Neuropathy, Hereditary Sensory And Autonomic, Type Iii. Among its related pathways are Dopaminergic Neurogenesis and Neuroscience. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and E-box binding. An important paralog of this gene is NEUROG1.

UniProtKB/Swiss-Prot Summary for NEUROG2 Gene

  • Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').

Gene Wiki entry for NEUROG2 Gene

Additional gene information for NEUROG2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NEUROG2 Gene

Genomics for NEUROG2 Gene

GeneHancer (GH) Regulatory Elements for NEUROG2 Gene

Promoters and enhancers for NEUROG2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J112514 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 500.7 +0.4 379 2.8 SIN3A NRF1 CTCF ZIC2 REST ZBTB10 ZBTB26 HES1 RCOR1 EZH2 ENSG00000249509 NEUROG2 NEUROG2-AS1 ZGRF1 ENSG00000272567 LARP7
GH04J112510 Enhancer 0.5 FANTOM5 21.7 +6.0 5979 0.3 USF1 GATA3 IKZF1 TCF7 SUZ12 GATA2 EZH2 RUNX3 NEUROG2 ENSG00000249509 ANK2 NEUROG2-AS1 piR-34822-250
GH04J112317 Enhancer 0.8 dbSUPER 11.5 +197.4 197406 2 CBFB ZNF384 POLR2A SRF ZNF207 MEF2B CHD1 NBN BATF IRF4 ENSG00000249509 NEUROG2 lnc-AP1AR-1 ALPK1 lnc-ALPK1-2 piR-52079-162
GH04J112328 Enhancer 0.7 ENCODE 11.7 +188.1 188100 0.1 RXRA CTCF EP300 JUND RAD21 TRIM22 SMC3 CBFB CEBPG BATF LARP7 ZGRF1 ENSG00000249509 NEUROG2 lnc-AP1AR-1 RTEL1P1 ALPK1 lnc-ALPK1-2
GH04J112361 Enhancer 0.8 Ensembl ENCODE 10.6 +154.6 154582 1.2 POLR2A RELA RXRA MEF2B TCF12 EBF1 NFIA NR2F6 EP300 SP1 ENSG00000249509 NEUROG2 FR873489 RTEL1P1 ALPK1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NEUROG2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NEUROG2

Top Transcription factor binding sites by QIAGEN in the NEUROG2 gene promoter:
  • COMP1
  • CP2
  • GR
  • GR-alpha
  • GR-beta
  • HEN1
  • Lmo2
  • NRSF form 1
  • POU3F2 (N-Oct-5a)
  • S8

Genomic Locations for NEUROG2 Gene

Genomic Locations for NEUROG2 Gene
chr4:112,513,516-112,516,180
(GRCh38/hg38)
Size:
2,665 bases
Orientation:
Minus strand
chr4:113,434,672-113,437,328
(GRCh37/hg19)
Size:
2,657 bases
Orientation:
Minus strand

Genomic View for NEUROG2 Gene

Genes around NEUROG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEUROG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEUROG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEUROG2 Gene

Proteins for NEUROG2 Gene

  • Protein details for NEUROG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2A3-NGN2_HUMAN
    Recommended name:
    Neurogenin-2
    Protein Accession:
    Q9H2A3
    Secondary Accessions:
    • Q8N416

    Protein attributes for NEUROG2 Gene

    Size:
    272 amino acids
    Molecular mass:
    28621 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein.

neXtProt entry for NEUROG2 Gene

Post-translational modifications for NEUROG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NEUROG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NEUROG2 Gene

Domains & Families for NEUROG2 Gene

Gene Families for NEUROG2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for NEUROG2 Gene

Blocks:
  • Basic helix-loop-helix dimerization domain bHLH
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NEUROG2 Gene

GenScript: Design optimal peptide antigens:
  • Protein atonal homolog 4 (NGN2_HUMAN)
genes like me logo Genes that share domains with NEUROG2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NEUROG2 Gene

Function for NEUROG2 Gene

Molecular function for NEUROG2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').

Phenotypes From GWAS Catalog for NEUROG2 Gene

Gene Ontology (GO) - Molecular Function for NEUROG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003677 DNA binding IEA --
GO:0046983 protein dimerization activity IEA --
GO:0070888 E-box binding ISS --
genes like me logo Genes that share ontologies with NEUROG2: view
genes like me logo Genes that share phenotypes with NEUROG2: view

Animal Models for NEUROG2 Gene

MGI Knock Outs for NEUROG2:

miRNA for NEUROG2 Gene

miRTarBase miRNAs that target NEUROG2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEUROG2 Gene

Localization for NEUROG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEUROG2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEUROG2 gene
Compartment Confidence
nucleus 5
extracellular 3
plasma membrane 2
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for NEUROG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NEUROG2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NEUROG2 Gene

Pathways & Interactions for NEUROG2 Gene

genes like me logo Genes that share pathways with NEUROG2: view

Pathways by source for NEUROG2 Gene

1 BioSystems pathway for NEUROG2 Gene
1 Cell Signaling Technology pathway for NEUROG2 Gene

SIGNOR curated interactions for NEUROG2 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for NEUROG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with NEUROG2: view

Drugs & Compounds for NEUROG2 Gene

No Compound Related Data Available

Transcripts for NEUROG2 Gene

mRNA/cDNA for NEUROG2 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEUROG2 Gene

No ASD Table

Relevant External Links for NEUROG2 Gene

GeneLoc Exon Structure for
NEUROG2

Expression for NEUROG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NEUROG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NEUROG2 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NEUROG2 Gene



Protein tissue co-expression partners for NEUROG2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NEUROG2

SOURCE GeneReport for Unigene cluster for NEUROG2 Gene:

Hs.744415

Evidence on tissue expression from TISSUES for NEUROG2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with NEUROG2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEUROG2 Gene

Orthologs for NEUROG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEUROG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEUROG2 31 30
  • 97.67 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NEUROG2 31 30
  • 90.56 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NEUROG2 31 30
  • 88.4 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Neurog2 30
  • 84.79 (n)
mouse
(Mus musculus)
Mammalia Neurog2 17 31 30
  • 83.9 (n)
oppossum
(Monodelphis domestica)
Mammalia NEUROG2 31
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves NEUROG2 30
  • 71.06 (n)
lizard
(Anolis carolinensis)
Reptilia NEUROG2 31
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia X-NGNR-1b 30
fruit fly
(Drosophila melanogaster)
Insecta tap 31
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 18 (a)
OneToMany
Species where no ortholog for NEUROG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NEUROG2 Gene

ENSEMBL:
Gene Tree for NEUROG2 (if available)
TreeFam:
Gene Tree for NEUROG2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NEUROG2: view image

Paralogs for NEUROG2 Gene

(3) SIMAP similar genes for NEUROG2 Gene using alignment to 1 proteins:

  • NGN2_HUMAN
genes like me logo Genes that share paralogs with NEUROG2: view

Variants for NEUROG2 Gene

Additional dbSNP identifiers (rs#s) for NEUROG2 Gene

Variation tolerance for NEUROG2 Gene

Residual Variation Intolerance Score: 71.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NEUROG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEUROG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for NEUROG2 Gene

Disorders for NEUROG2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for NEUROG2 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NEUROG2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NEUROG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEUROG2 Gene

Publications for NEUROG2 Gene

  1. Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease. (PMID: 19879328) Deng S … Jankovic J (Neuroscience letters 2010) 3 23 41 54
  2. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G … Riley BP (Human molecular genetics 2010) 3 41 54
  3. Neurospheres derived from human embryoid bodies treated with retinoic Acid show an increase in nestin and ngn2 expression that correlates with the proportion of tyrosine hydroxylase-positive cells. (PMID: 17784840) Kumar M … Mani S (Stem cells and development 2007) 3 23 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission. (PMID: 29791859) Nehme R … Eggan K (Cell reports 2018) 3 54

Products for NEUROG2 Gene

Sources for NEUROG2 Gene