Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NEUROG1 Gene

Aliases for NEUROG1 Gene

  • Neurogenin 1 2 3 5
  • Neurogenic Basic-Helix-Loop-Helix Protein 3 4
  • Class A Basic Helix-Loop-Helix Protein 6 3 4
  • Neurogenic Differentiation Factor 3 3 4
  • Neurogenic Differentiation 3 2 3
  • NEUROD3 3 4
  • BHLHa6 3 4
  • NGN-1 3 4
  • Neurogenin-1 3
  • NeuroD3 4
  • Math4C 3
  • BHLHA6 4
  • Ngn1 3
  • NGN1 4
  • AKA 3
  • NGN 4

External Ids for NEUROG1 Gene

Previous HGNC Symbols for NEUROG1 Gene

  • NEUROD3

Previous GeneCards Identifiers for NEUROG1 Gene

  • GC05M134706
  • GC05M134900
  • GC05M134946
  • GC05M134897
  • GC05M130057

Summaries for NEUROG1 Gene

GeneCards Summary for NEUROG1 Gene

NEUROG1 (Neurogenin 1) is a Protein Coding gene. Diseases associated with NEUROG1 include Deafness, Autosomal Dominant 52 and Cerebellar Liponeurocytoma. Among its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell and Signaling pathways regulating pluripotency of stem cells. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein dimerization activity. An important paralog of this gene is NEUROG2.

UniProtKB/Swiss-Prot for NEUROG1 Gene

  • Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5-CANNTG-3). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).

Gene Wiki entry for NEUROG1 Gene

Additional gene information for NEUROG1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEUROG1 Gene

Genomics for NEUROG1 Gene

GeneHancer (GH) Regulatory Elements for NEUROG1 Gene

Promoters and enhancers for NEUROG1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J135536 Enhancer 0.8 ENCODE 650.7 -0.3 -277 0.2 KLF17 ZNF2 YY1 ZNF335 GLIS2 SCRT2 KLF7 SP3 ZEB2 ZNF398 NEUROG1 PIR49934
GH05J135388 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.7 +140.7 140731 12.8 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 H2AFY DDX46 ENSG00000270021 SMAD5 C5orf66 NEUROG1 LOC105379188 ENSG00000248753 ENSG00000270892 ENSG00000253927
GH05J135488 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.8 +46.1 46104 2.2 FOXA2 SIN3A ZNF48 GLIS2 ZNF213 KLF7 SP3 SP5 NFYC NFIL3 NEUROG1 ENSG00000250167 CXCL14 TIFAB ENSG00000249639 JADE2 ENSG00000270021
GH05J135433 Enhancer 1.3 VISTA Ensembl ENCODE 10.9 +101.0 101024 3.1 BCOR ELF3 TFAP4 ARID4B ZMYM3 ZBTB40 POLR2A ADNP SMARCA5 CEBPB ENSG00000249639 H2AFY NEUROG1 ENSG00000270021 DCANP1
GH05J135482 Enhancer 1.2 ENCODE dbSUPER 11.1 +53.6 53580 0.6 HDGF FOXA2 MLX ARID4B DMAP1 GLI4 ZNF48 ETS1 GATA2 ZNF416 SMAD5 DDX46 ENSG00000250167 NEUROG1 CXCL14 TGFBI C5orf66 ENSG00000254239 TIFAB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NEUROG1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NEUROG1 gene promoter:
  • STAT3
  • FAC1
  • AREB6
  • TBP
  • Pax-2
  • IRF-1
  • Pax-2a
  • USF-1
  • USF-1:USF-2
  • Pax-4a

Genomic Locations for NEUROG1 Gene

Genomic Locations for NEUROG1 Gene
chr5:135,534,282-135,535,949
(GRCh38/hg38)
Size:
1,668 bases
Orientation:
Minus strand
chr5:134,869,972-134,871,639
(GRCh37/hg19)
Size:
1,668 bases
Orientation:
Minus strand

Genomic View for NEUROG1 Gene

Genes around NEUROG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEUROG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEUROG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEUROG1 Gene

Proteins for NEUROG1 Gene

  • Protein details for NEUROG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92886-NGN1_HUMAN
    Recommended name:
    Neurogenin-1
    Protein Accession:
    Q92886
    Secondary Accessions:
    • Q5U0Q9
    • Q96HE1

    Protein attributes for NEUROG1 Gene

    Size:
    237 amino acids
    Molecular mass:
    25718 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein.

neXtProt entry for NEUROG1 Gene

Post-translational modifications for NEUROG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NEUROG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NEUROG1 Gene

Domains & Families for NEUROG1 Gene

Gene Families for NEUROG1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for NEUROG1 Gene

Suggested Antigen Peptide Sequences for NEUROG1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NEUROG1: view

No data available for UniProtKB/Swiss-Prot for NEUROG1 Gene

Function for NEUROG1 Gene

Molecular function for NEUROG1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5-CANNTG-3). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).

Phenotypes From GWAS Catalog for NEUROG1 Gene

Gene Ontology (GO) - Molecular Function for NEUROG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0000989 transcription factor activity, transcription factor binding ISS --
GO:0003677 DNA binding ISS --
GO:0003682 chromatin binding ISS,IEA --
GO:0003700 DNA binding transcription factor activity TAS 8816493
genes like me logo Genes that share ontologies with NEUROG1: view
genes like me logo Genes that share phenotypes with NEUROG1: view

Animal Models for NEUROG1 Gene

MGI Knock Outs for NEUROG1:

Animal Model Products

miRNA for NEUROG1 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEUROG1 Gene

Localization for NEUROG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEUROG1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEUROG1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for NEUROG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0043025 neuronal cell body IEA --
GO:0043204 perikaryon IEA --
genes like me logo Genes that share ontologies with NEUROG1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NEUROG1 Gene

Pathways & Interactions for NEUROG1 Gene

genes like me logo Genes that share pathways with NEUROG1: view

Gene Ontology (GO) - Biological Process for NEUROG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS 8816493
GO:0007275 multicellular organism development IEA --
GO:0007356 thorax and anterior abdomen determination IGI 23419067
genes like me logo Genes that share ontologies with NEUROG1: view

No data available for SIGNOR curated interactions for NEUROG1 Gene

Drugs & Compounds for NEUROG1 Gene

(2) Drugs for NEUROG1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for NEUROG1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NEUROG1: view

Transcripts for NEUROG1 Gene

mRNA/cDNA for NEUROG1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NEUROG1 Gene

Neurogenin 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEUROG1 Gene

No ASD Table

Relevant External Links for NEUROG1 Gene

GeneLoc Exon Structure for
NEUROG1
ECgene alternative splicing isoforms for
NEUROG1

Expression for NEUROG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NEUROG1 Gene

mRNA differential expression in normal tissues according to GTEx for NEUROG1 Gene

This gene is overexpressed in Testis (x18.4) and Ovary (x5.7).

Protein differential expression in normal tissues from HIPED for NEUROG1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NEUROG1 Gene



Protein tissue co-expression partners for NEUROG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NEUROG1 Gene:

NEUROG1

SOURCE GeneReport for Unigene cluster for NEUROG1 Gene:

Hs.248149

mRNA Expression by UniProt/SwissProt for NEUROG1 Gene:

Q92886-NGN1_HUMAN
Tissue specificity: Expression restricted to the embryonic nervous system.

Evidence on tissue expression from TISSUES for NEUROG1 Gene

  • Nervous system(4.6)
  • Eye(4.2)
genes like me logo Genes that share expression patterns with NEUROG1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NEUROG1 Gene

Orthologs for NEUROG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEUROG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEUROG1 34 33
  • 99.44 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NEUROG1 34 33
  • 86.36 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NEUROG1 34 33
  • 86.36 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Neurog1 33
  • 85.09 (n)
mouse
(Mus musculus)
Mammalia Neurog1 16 34 33
  • 84.95 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NEUROG1 34
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NEUROG1 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves NEUROG1 33
  • 72.55 (n)
lizard
(Anolis carolinensis)
Reptilia NEUROG1 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia neurog1 33
  • 55.45 (n)
zebrafish
(Danio rerio)
Actinopterygii neurog1 34 33 33
  • 62.5 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta tap 34
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 18 (a)
OneToMany
Species where no ortholog for NEUROG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEUROG1 Gene

ENSEMBL:
Gene Tree for NEUROG1 (if available)
TreeFam:
Gene Tree for NEUROG1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NEUROG1: view image

Paralogs for NEUROG1 Gene

(2) SIMAP similar genes for NEUROG1 Gene using alignment to 2 proteins:

  • NGN1_HUMAN
  • F1T0H3_HUMAN
genes like me logo Genes that share paralogs with NEUROG1: view

Variants for NEUROG1 Gene

Sequence variations from dbSNP and Humsavar for NEUROG1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1002229573 -- 135,536,298(-) G/C upstream_transcript_variant
rs1003000187 -- 135,536,013(-) C/T upstream_transcript_variant
rs1003116167 -- 135,536,220(-) G/A upstream_transcript_variant
rs1003355140 -- 135,534,553(-) G/T 3_prime_UTR_variant
rs1005059711 -- 135,534,614(-) A/G 3_prime_UTR_variant

Variation tolerance for NEUROG1 Gene

Residual Variation Intolerance Score: 37.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NEUROG1 Gene

Human Gene Mutation Database (HGMD)
NEUROG1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEUROG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NEUROG1 Gene

Disorders for NEUROG1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for NEUROG1 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
deafness, autosomal dominant 52
  • dfna52
cerebellar liponeurocytoma
  • lipomatous medulloblastoma
moebius syndrome
  • mbs
ear malformation
  • cup ear
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NEUROG1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NEUROG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEUROG1 Gene

Publications for NEUROG1 Gene

  1. Stable expression of neurogenin 1 induces LGR5, a novel stem cell marker, in an immortalized human neural stem cell line HB1.F3. (PMID: 19813087) Satoh J … Kim SU (Cellular and molecular neurobiology 2010) 3 22 58
  2. The basic helix-loop-helix region of human neurogenin 1 is a monomeric natively unfolded protein which forms a "fuzzy" complex upon DNA binding. (PMID: 20102160) Aguado-Llera D … Neira JL (Biochemistry 2010) 3 22 58
  3. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) Gratacòs M … Psychiatric Genetics Network Group (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 44 58
  4. Basic helix-loop-helix transcription factor NEUROG1 and schizophrenia: effects on illness susceptibility, MRI brain morphometry and cognitive abilities. (PMID: 18799289) Ho BC … Wassink TH (Schizophrenia research 2008) 3 44 58
  5. Association between the 5q31.1 gene neurogenin1 and schizophrenia. (PMID: 17044100) Fanous AH … Kendler KS (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007) 3 44 58

Products for NEUROG1 Gene

Sources for NEUROG1 Gene

Content
Loading form....