Aliases for NEUROD4 Gene

Aliases for NEUROD4 Gene

  • Neuronal Differentiation 4 2 3 5
  • BHLHa4 2 3 4
  • ATH-3 2 3 4
  • Atoh3 2 3 4
  • Class A Basic Helix-Loop-Helix Protein 4 3 4
  • Neurogenic Differentiation Factor 4 3 4
  • Neurogenic Differentiation 4 2 3
  • Protein Atonal Homolog 3 3 4
  • MATH-3 2 3
  • ATH3 3 4
  • NEUROD4 5
  • NeuroD4 4
  • BHLHA4 4
  • MATH3 3
  • ATOH3 4

External Ids for NEUROD4 Gene

Previous GeneCards Identifiers for NEUROD4 Gene

  • GC12P055534
  • GC12P055130
  • GC12P053699
  • GC12P055413
  • GC12P052453

Summaries for NEUROD4 Gene

GeneCards Summary for NEUROD4 Gene

NEUROD4 (Neuronal Differentiation 4) is a Protein Coding gene. Diseases associated with NEUROD4 include Amelogenesis Imperfecta, Type Iiia and Panhypopituitarism, X-Linked. Gene Ontology (GO) annotations related to this gene include protein dimerization activity. An important paralog of this gene is NEUROD1.

UniProtKB/Swiss-Prot Summary for NEUROD4 Gene

  • Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina (By similarity).

Additional gene information for NEUROD4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NEUROD4 Gene

Genomics for NEUROD4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NEUROD4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J055019 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 600.7 +0.0 27 0.8 REST ZNF512 ZNF143 PKNOX1 RCOR1 POLR2A HDAC1 SIN3A NKRF ZNF766 NEUROD4 lnc-TESPA1-3 OR9K2
GH12J055020 Enhancer 0.3 FANTOM5 dbSUPER 605.6 +0.9 876 0 NEUROD4 OR6C3 OR6C65 OR9K2 OR6C75 OR6C6 OR6C2 OR10A7 OR6C74 OR6C76
GH12J054976 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.3 -38.4 -38376 9.9 SP1 LEF1 POLR2A BACH1 STAT3 GABPA ZNF143 PKNOX1 MTA1 SMAD5 TESPA1 NEUROD4 DCD LOC107984515 LOC105369778 MUCL1
GH12J054990 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -28.6 -28570 2.3 PRDM1 IKZF2 POLR2A PKNOX1 EED DPF2 RELB CEBPB RUNX3 GATAD2B NEUROD4 TESPA1 NCKAP1L LOC107984515 lnc-TESPA1-1
GH12J054932 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 9.9 -84.7 -84700 5.6 LEF1 BACH1 JUND FOXA1 ZNF143 REST CTCF SOX6 GATAD2B EP300 TESPA1 NEUROD4 MUCL1 NCKAP1L OR6C65 OR6C3 piR-54768-003 piR-30444-079 LOC105369778
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NEUROD4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NEUROD4

Top Transcription factor binding sites by QIAGEN in the NEUROD4 gene promoter:
  • AP-1
  • c-Ets-1
  • CUTL1
  • HNF-1
  • HNF-1A
  • HSF2
  • Ik-1
  • Olf-1
  • SRF
  • SRF (504 AA)

Genomic Locations for NEUROD4 Gene

Genomic Locations for NEUROD4 Gene
chr12:55,019,974-55,030,017
(GRCh38/hg38)
Size:
10,044 bases
Orientation:
Plus strand
chr12:55,413,729-55,423,801
(GRCh37/hg19)
Size:
10,073 bases
Orientation:
Plus strand

Genomic View for NEUROD4 Gene

Genes around NEUROD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEUROD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEUROD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEUROD4 Gene

Proteins for NEUROD4 Gene

  • Protein details for NEUROD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HD90-NDF4_HUMAN
    Recommended name:
    Neurogenic differentiation factor 4
    Protein Accession:
    Q9HD90
    Secondary Accessions:
    • B2RAC9

    Protein attributes for NEUROD4 Gene

    Size:
    331 amino acids
    Molecular mass:
    37041 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein.

neXtProt entry for NEUROD4 Gene

Post-translational modifications for NEUROD4 Gene

  • Serine or threonine phosphorylation within the basic region may regulate neurogenic activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NEUROD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for NEUROD4
  • Boster Bio Antibodies for NEUROD4
  • Santa Cruz Biotechnology (SCBT) Antibodies for NEUROD4

No data available for DME Specific Peptides for NEUROD4 Gene

Domains & Families for NEUROD4 Gene

Gene Families for NEUROD4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for NEUROD4 Gene

InterPro:
Blocks:
  • Basic helix-loop-helix dimerization domain bHLH
ProtoNet:

Suggested Antigen Peptide Sequences for NEUROD4 Gene

GenScript: Design optimal peptide antigens:
  • Protein atonal homolog 3 (NDF4_HUMAN)
genes like me logo Genes that share domains with NEUROD4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NEUROD4 Gene

Function for NEUROD4 Gene

Molecular function for NEUROD4 Gene

UniProtKB/Swiss-Prot Function:
Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina (By similarity).
GENATLAS Biochemistry:
neurogenesis regulator D4,rat homolog

Phenotypes From GWAS Catalog for NEUROD4 Gene

Gene Ontology (GO) - Molecular Function for NEUROD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003677 DNA binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with NEUROD4: view
genes like me logo Genes that share phenotypes with NEUROD4: view

Animal Models for NEUROD4 Gene

MGI Knock Outs for NEUROD4:

Animal Model Products

CRISPR Products

miRNA for NEUROD4 Gene

miRTarBase miRNAs that target NEUROD4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEUROD4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEUROD4 Gene

Localization for NEUROD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEUROD4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEUROD4 gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
cytosol 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for NEUROD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NEUROD4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NEUROD4 Gene

Pathways & Interactions for NEUROD4 Gene

PathCards logo

SuperPathways for NEUROD4 Gene

No Data Available

SIGNOR curated interactions for NEUROD4 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for NEUROD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0007219 Notch signaling pathway IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with NEUROD4: view

No data available for Pathways by source for NEUROD4 Gene

Drugs & Compounds for NEUROD4 Gene

No Compound Related Data Available

Transcripts for NEUROD4 Gene

mRNA/cDNA for NEUROD4 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEUROD4

Alternative Splicing Database (ASD) splice patterns (SP) for NEUROD4 Gene

No ASD Table

Relevant External Links for NEUROD4 Gene

GeneLoc Exon Structure for
NEUROD4

Expression for NEUROD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NEUROD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NEUROD4 Gene

This gene is overexpressed in Pituitary (x50.0).

Protein differential expression in normal tissues from HIPED for NEUROD4 Gene

This gene is overexpressed in Plasma (52.6) and Serum (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NEUROD4 Gene



Protein tissue co-expression partners for NEUROD4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NEUROD4

SOURCE GeneReport for Unigene cluster for NEUROD4 Gene:

Hs.591024

Evidence on tissue expression from TISSUES for NEUROD4 Gene

  • Nervous system(4.5)
  • Eye(2.6)
genes like me logo Genes that share expression patterns with NEUROD4: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEUROD4 Gene

Orthologs for NEUROD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEUROD4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NEUROD4 30 31
  • 99.3 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NEUROD4 30 31
  • 90.33 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NEUROD4 30 31
  • 89.7 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Neurod4 30 17 31
  • 87.37 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Neurod4 30
  • 85.96 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia NEUROD4 31
  • 67 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NEUROD4 30 31
  • 73.13 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NEUROD4 31
  • 78 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia neurod4 30
  • 64.86 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xath-3 30
Zebrafish
(Danio rerio)
Actinopterygii neurod4 30 31
  • 61.04 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea cnd-1 31
  • 38 (a)
ManyToMany
ngn-1 31
  • 34 (a)
ManyToMany
Species where no ortholog for NEUROD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for NEUROD4 Gene

ENSEMBL:
Gene Tree for NEUROD4 (if available)
TreeFam:
Gene Tree for NEUROD4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NEUROD4: view image

Paralogs for NEUROD4 Gene

(5) SIMAP similar genes for NEUROD4 Gene using alignment to 1 proteins:

  • NDF4_HUMAN
genes like me logo Genes that share paralogs with NEUROD4: view

Variants for NEUROD4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NEUROD4 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
720718 Benign: not provided 55,026,721(+) C/G SYNONYMOUS_VARIANT
rs76064726 - p.Lys68Thr

Additional dbSNP identifiers (rs#s) for NEUROD4 Gene

Variation tolerance for NEUROD4 Gene

Residual Variation Intolerance Score: 76.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NEUROD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEUROD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NEUROD4 Gene

Disorders for NEUROD4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NEUROD4 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NEUROD4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with NEUROD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEUROD4 Gene

Publications for NEUROD4 Gene

  1. beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the gene encoding the basic helix-loop-helix transcription factor neurogenic differentiation 4 (NEUROD4) in Japanese patients with MODY. (PMID: 11078465) Horikawa Y … Bell GI (Diabetes 2000) 3 4 23 41
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) Gratacòs M … Psychiatric Genetics Network Group (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 41
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3

Products for NEUROD4 Gene

Sources for NEUROD4 Gene