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Aliases for NEURL3 Gene
Aliases for NEURL3 Gene
External Ids for NEURL3 Gene
- HGNC: 25162
- Entrez Gene: 93082
- Ensembl: ENSG00000163121
- OMIM: 617206
- UniProtKB: Q96EH8
Previous GeneCards Identifiers for NEURL3 Gene
- GC02M097163
- GC02M091124
Summaries for NEURL3 Gene
GeneCards Summary for NEURL3 Gene
NEURL3 (Neuralized E3 Ubiquitin Protein Ligase 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is NEURL1B.
UniProtKB/Swiss-Prot Summary for NEURL3 Gene
-
E3 ubiquitin-protein ligase. Seems to utilize UBE2E1. In vitro, generates polyubiquitin chains via non-canonical lysine residues suggesting that it is not involved in tagging substrates for proteasomal degradation.
Additional gene information for NEURL3 Gene
- HGNC(25162)
- Entrez Gene(93082)
- Ensembl(ENSG00000163121)
- OMIM(617206)
- UniProtKB(Q96EH8)
- Open Targets Platform(ENSG00000163121)
- Search for NEURL3 at DataMed
- Search for NEURL3 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NEURL3 Gene
Genomics for NEURL3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NEURL3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NEURL3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NEURL3
- Top Transcription factor binding sites by QIAGEN in the NEURL3 gene promoter:
-
- Arnt
- c-Rel
- FOXO4
- Lhx3a
- LHX3b
- NF-kappaB
- NF-kappaB1
- NF-kappaB2
- Olf-1
- Pax-5
Genomic Locations for NEURL3 Gene
Genomic Locations for NEURL3 Gene
- chr2:96,497,643-96,508,157
- (GRCh38/hg38)
- Size:
- 10,515 bases
- Orientation:
- Minus strand
- chr2:97,163,383-97,173,846
- (GRCh37/hg19)
- Size:
- 10,464 bases
- Orientation:
- Minus strand
Genomic View for NEURL3 Gene
Genes around NEURL3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q11.2 by HGNC
- 2q11.2 by Entrez Gene
- 2q11.2 by Ensembl
NEURL3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NEURL3 Gene
Proteins for NEURL3 Gene
-
Protein details for NEURL3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96EH8-NEUL3_HUMAN
- Recommended name:
- E3 ubiquitin-protein ligase NEURL3
- Protein Accession:
- Q96EH8
Protein attributes for NEURL3 Gene
- Size:
- 262 amino acids
- Molecular mass:
- 28789 Da
- Quaternary structure:
- No Data Available
Protein Expression for NEURL3 Gene
Post-translational modifications for NEURL3 Gene
Other Protein References for NEURL3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Invitrogen Antibodies for NEURL3 (AFLGC-NEURL3)
- antibodies-online: Show 9 available NEURL3 Antibodies ranked by validation data
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for NEURL3
- Origene Custom Protein Services for NEURL3
No data available for DME Specific Peptides for NEURL3 Gene
Domains & Families for NEURL3 Gene
Gene Families for NEURL3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for NEURL3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for NEURL3 Gene
- GenScript: Design optimal peptide antigens:
-
- Neuralized-like protein 3 (NEUL3_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NEURL3 Gene
Function for NEURL3 Gene
Molecular function for NEURL3 Gene
- UniProtKB/Swiss-Prot Function:
- E3 ubiquitin-protein ligase. Seems to utilize UBE2E1. In vitro, generates polyubiquitin chains via non-canonical lysine residues suggesting that it is not involved in tagging substrates for proteasomal degradation.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.
Enzyme Numbers (IUBMB) for NEURL3 Gene
Phenotypes From GWAS Catalog for NEURL3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016740 | transferase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
| GO:0061630 | ubiquitin protein ligase activity | IEA,IBA | 21873635 |
Phenotypes for NEURL3 Gene
- GenomeRNAi human phenotypes for NEURL3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NEURL3 - Select products 50% OFF >
- * NEURL3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NEURL3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NEURL3
miRNA for NEURL3 Gene
- miRTarBase miRNAs that target NEURL3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NEURL3
- Browse OriGene Inhibitory RNA Products For NEURL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEURL3
Clone Products
- Applied Biological Materials (abm): Clones for NEURL3 - Select products 50% OFF >
- * NEURL3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for NEURL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NEURL3
Cell Line Products
-
Horizon Cell Lines for NEURL3
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEURL3 Gene
Localization for NEURL3 Gene
| Compartment | Confidence |
|---|---|
| endosome | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| nucleus | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005769 | early endosome | IBA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for NEURL3 Gene
Pathways & Interactions for NEURL3 Gene
UniProtKB/Swiss-Prot Q96EH8-NEUL3_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for NEURL3 Gene
GPS-Prot Interaction Network for NEURL3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0070086 | ubiquitin-dependent endocytosis | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for NEURL3 Gene
Transcripts for NEURL3 Gene
mRNA/cDNA for NEURL3 Gene
- 3 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000310865 1710 nts (view in UCSC)
- ENST00000435380 1675 nts (view in UCSC)
- ENST00000444588 1041 nts (view in UCSC)
- ENST00000451794 1458 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NEURL3 - Select products 50% OFF >
- * NEURL3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NEURL3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NEURL3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NEURL3
- Browse OriGene Inhibitory RNA Products For NEURL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEURL3
Clone Products
- Applied Biological Materials (abm): Clones for NEURL3 - Select products 50% OFF >
- * NEURL3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for NEURL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NEURL3
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||
| SP2: | - | - | - |
Relevant External Links for NEURL3 Gene
- GeneLoc Exon Structure for
- NEURL3
Expression for NEURL3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Pancreas (Endocrine System)
- Duct Cells Pancreatic Ducts
-
Epithelial Cells
- Duct Cells Pancreatic Ducts
mRNA differential expression in normal tissues according to GTEx for NEURL3 Gene
This gene is overexpressed in Pancreas (x15.9), Kidney - Cortex (x6.6), and Minor Salivary Gland (x5.4).
This gene is overexpressed in Peripheral blood mononuclear cells (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NEURL3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NEURL3
SOURCE GeneReport for Unigene cluster for NEURL3 Gene:
Hs.149219Primer Products
-
OriGene qPCR primer pairs for NEURL3
-
OriGene qPCR primer pairs and template standards for NEURL3
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEURL3 Gene
Orthologs for NEURL3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LOC470439 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | LOC102152163 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | LOC511385 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Neurl3 30 17 |
|
||
| Rat (Rattus norvegicus) |
Mammalia | Neurl3 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | neurl3 30 |
|
- Species where no ortholog for NEURL3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for NEURL3 Gene
- ENSEMBL:
- Gene Tree for NEURL3 (if available)
- TreeFam:
- Gene Tree for NEURL3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NEURL3: view image
Paralogs for NEURL3 Gene
Variants for NEURL3 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv607e201 | CNV | deletion | 23290073 |
| esv2720413 | CNV | deletion | 23290073 |
| esv3425717 | CNV | duplication | 20981092 |
| esv5003 | OTHER | complex | 18987735 |
| nsv1135873 | CNV | deletion | 24896259 |
| nsv2835 | CNV | insertion | 18451855 |
Additional Variant Information for NEURL3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NEURL3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for NEURL3 Gene
Disorders for NEURL3 Gene
Additional Disease Information for NEURL3
No disorders were found for NEURL3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEURL3 Gene
Publications for NEURL3 Gene
- A novel inflammation-induced ubiquitin E3 ligase in alveolar type II cells. (PMID: 15936721) Hu Y … Smith JB (Biochemical and biophysical research communications 2005) 2 3
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3
- Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4
ExternalLinks
Products for NEURL3 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for NEURL3
- Origene Custom Protein Services for NEURL3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NEURL3
- Browse OriGene Inhibitory RNA Products For NEURL3
- OriGene qPCR primer pairs for NEURL3
- OriGene qPCR primer pairs and template standards for NEURL3
- OriGene CRISPR knockouts for NEURL3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NEURL3
- Sino Biological Human cDNA Clone for NEURL3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Invitrogen Antibodies for NEURL3 (AFLGC-NEURL3)
- VectorBuilder Custom and pre-made DNA vectors for NEURL3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for NEURL3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for NEURL3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for NEURL3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for NEURL3
- antibodies-online: Show 9 available NEURL3 Antibodies ranked by validation data
- antibodies-online: Search results for available NEURL3 related products ranked by validation data
- antibodies-online: Search results for available NEURL3 related products ranked by validation data
- Horizon Cell Lines for NEURL3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NEURL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NEURL3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for NEURL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEURL3
Sources for NEURL3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB