Aliases for NEURL3 Gene

Aliases for NEURL3 Gene

  • Neuralized E3 Ubiquitin Protein Ligase 3 2 3 5
  • Lung-Inducible Neuralized-Related C3CH4 RING Domain Protein 3 4
  • RING-Type E3 Ubiquitin Transferase NEURL3 3 4
  • E3 Ubiquitin-Protein Ligase NEURL3 3 4
  • Neuralized-Like Protein 3 3 4
  • LINCR 3 4
  • Neuralized Homolog 3 (Drosophila) Pseudogene 2
  • Neuralized Homolog 3 Pseudogene 3
  • EC 2.3.2.27 4
  • RNF132 3

External Ids for NEURL3 Gene

Previous GeneCards Identifiers for NEURL3 Gene

  • GC02M097163
  • GC02M091124

Summaries for NEURL3 Gene

GeneCards Summary for NEURL3 Gene

NEURL3 (Neuralized E3 Ubiquitin Protein Ligase 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is NEURL1B.

UniProtKB/Swiss-Prot Summary for NEURL3 Gene

  • E3 ubiquitin-protein ligase. Seems to utilize UBE2E1. In vitro, generates polyubiquitin chains via non-canonical lysine residues suggesting that it is not involved in tagging substrates for proteasomal degradation.

Additional gene information for NEURL3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NEURL3 Gene

Genomics for NEURL3 Gene

GeneHancer (GH) Regulatory Elements for NEURL3 Gene

Promoters and enhancers for NEURL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J096508 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 -0.1 -65 1.2 CTCF SIN3A ZBTB10 ZNF263 REST KLF4 MYC RCOR1 RAD21 CTBP1 NEURL3 LOC105373496
GH02J096509 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 -1.4 -1397 0.9 ZNF217 CTCF SIN3A FOS REST MYC RAD21 CTBP1 SKI TRIM22 NEURL3 LOC105373496
GH02J096504 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 500.7 +2.5 2455 2.2 EZH2 RELA POLR2A USF1 TBP FOS SAP130 RFX5 GABPB1 JUND NEURL3 ADRA2B lnc-KANSL3-2
GH02J096526 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -19.8 -19766 2.7 ZBTB40 SIN3A SP1 CTCF EP300 RELA RCOR1 TRIM22 POLR2A EZH2 ENSG00000230747 ITPRIPL1 GPAT2 SNRNP200 LINC00342 LOC105373496 NEURL3
GH02J096501 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.4 +5.4 5436 3 POLR2G RELA ZBTB25 SKI TEAD1 ZKSCAN8 ZNF341 ZSCAN9 EZH2 KMT2B ITPRIPL1 GPAT2P1 lnc-KANSL3-2 NEURL3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NEURL3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NEURL3

Top Transcription factor binding sites by QIAGEN in the NEURL3 gene promoter:
  • Arnt
  • c-Rel
  • FOXO4
  • Lhx3a
  • LHX3b
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • Olf-1
  • Pax-5

Genomic Locations for NEURL3 Gene

Genomic Locations for NEURL3 Gene
chr2:96,497,643-96,508,136
(GRCh38/hg38)
Size:
10,494 bases
Orientation:
Minus strand
chr2:97,163,383-97,173,846
(GRCh37/hg19)
Size:
10,464 bases
Orientation:
Minus strand

Genomic View for NEURL3 Gene

Genes around NEURL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEURL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEURL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEURL3 Gene

Proteins for NEURL3 Gene

  • Protein details for NEURL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EH8-NEUL3_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase NEURL3
    Protein Accession:
    Q96EH8

    Protein attributes for NEURL3 Gene

    Size:
    262 amino acids
    Molecular mass:
    28789 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NEURL3 Gene

Post-translational modifications for NEURL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NEURL3 Gene

No data available for DME Specific Peptides for NEURL3 Gene

Domains & Families for NEURL3 Gene

Gene Families for NEURL3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NEURL3 Gene

Suggested Antigen Peptide Sequences for NEURL3 Gene

GenScript: Design optimal peptide antigens:
  • Neuralized-like protein 3 (NEUL3_HUMAN)
genes like me logo Genes that share domains with NEURL3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NEURL3 Gene

Function for NEURL3 Gene

Molecular function for NEURL3 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase. Seems to utilize UBE2E1. In vitro, generates polyubiquitin chains via non-canonical lysine residues suggesting that it is not involved in tagging substrates for proteasomal degradation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.

Enzyme Numbers (IUBMB) for NEURL3 Gene

Phenotypes From GWAS Catalog for NEURL3 Gene

Gene Ontology (GO) - Molecular Function for NEURL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IEA,IBA 21873635
genes like me logo Genes that share ontologies with NEURL3: view

Phenotypes for NEURL3 Gene

genes like me logo Genes that share phenotypes with NEURL3: view

Animal Model Products

CRISPR Products

miRNA for NEURL3 Gene

miRTarBase miRNAs that target NEURL3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEURL3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEURL3 Gene

Localization for NEURL3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEURL3 gene
Compartment Confidence
endosome 3
plasma membrane 1
extracellular 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for NEURL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IBA 21873635
genes like me logo Genes that share ontologies with NEURL3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for NEURL3 Gene

Pathways & Interactions for NEURL3 Gene

PathCards logo

SuperPathways for NEURL3 Gene

No Data Available

UniProtKB/Swiss-Prot Q96EH8-NEUL3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.
;

Gene Ontology (GO) - Biological Process for NEURL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0070086 ubiquitin-dependent endocytosis IBA 21873635
genes like me logo Genes that share ontologies with NEURL3: view

No data available for Pathways by source and SIGNOR curated interactions for NEURL3 Gene

Drugs & Compounds for NEURL3 Gene

No Compound Related Data Available

Transcripts for NEURL3 Gene

mRNA/cDNA for NEURL3 Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEURL3

Alternative Splicing Database (ASD) splice patterns (SP) for NEURL3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: - - -

Relevant External Links for NEURL3 Gene

GeneLoc Exon Structure for
NEURL3

Expression for NEURL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NEURL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NEURL3 Gene

This gene is overexpressed in Pancreas (x15.9), Kidney - Cortex (x6.6), and Minor Salivary Gland (x5.4).

Protein differential expression in normal tissues from HIPED for NEURL3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NEURL3 Gene



Protein tissue co-expression partners for NEURL3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NEURL3

SOURCE GeneReport for Unigene cluster for NEURL3 Gene:

Hs.149219
genes like me logo Genes that share expression patterns with NEURL3: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEURL3 Gene

Orthologs for NEURL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NEURL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC470439 30
  • 99.24 (n)
dog
(Canis familiaris)
Mammalia LOC102152163 30
  • 83.46 (n)
cow
(Bos Taurus)
Mammalia LOC511385 30
  • 82.11 (n)
mouse
(Mus musculus)
Mammalia Neurl3 17 30
  • 77.47 (n)
rat
(Rattus norvegicus)
Mammalia Neurl3 30
  • 77.34 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia neurl3 30
  • 48.63 (n)
Species where no ortholog for NEURL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NEURL3 Gene

ENSEMBL:
Gene Tree for NEURL3 (if available)
TreeFam:
Gene Tree for NEURL3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NEURL3: view image

Paralogs for NEURL3 Gene

Paralogs for NEURL3 Gene

(2) SIMAP similar genes for NEURL3 Gene using alignment to 1 proteins:

  • NEUL3_HUMAN
genes like me logo Genes that share paralogs with NEURL3: view

Variants for NEURL3 Gene

Additional dbSNP identifiers (rs#s) for NEURL3 Gene

Structural Variations from Database of Genomic Variants (DGV) for NEURL3 Gene

Variant ID Type Subtype PubMed ID
dgv607e201 CNV deletion 23290073
esv2720413 CNV deletion 23290073
esv3425717 CNV duplication 20981092
esv5003 OTHER complex 18987735
nsv1135873 CNV deletion 24896259
nsv2835 CNV insertion 18451855

Additional Variant Information for NEURL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEURL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for NEURL3 Gene

Disorders for NEURL3 Gene

Additional Disease Information for NEURL3

No disorders were found for NEURL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEURL3 Gene

Publications for NEURL3 Gene

  1. A novel inflammation-induced ubiquitin E3 ligase in alveolar type II cells. (PMID: 15936721) Hu Y … Smith JB (Biochemical and biophysical research communications 2005) 2 3 54
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 54

Products for NEURL3 Gene

Sources for NEURL3 Gene