Aliases for NEURL1B Gene

Aliases for NEURL1B Gene

  • Neuralized E3 Ubiquitin Protein Ligase 1B 2 3 5
  • RING-Type E3 Ubiquitin Transferase NEURL1B 3 4
  • E3 Ubiquitin-Protein Ligase NEURL1B 3 4
  • Neuralized-Like Protein 1B 3 4
  • Neuralized-Like Protein 3 3 4
  • Neuralized-2 3 4
  • NEURL3 3 4
  • RNF67B 2 3
  • Neur2 2 3
  • Neuralized Homolog 1B (Drosophila) 2
  • E3 Ubiquitin-Protein Ligase NEURL3 3
  • Neuralized 2 Alternative Protein 3
  • Neuralized Homolog 1B 3
  • DKFZP761M1511 2
  • EC 4
  • NEURL1B 5
  • HNeur2 3
  • NEUR2 4

External Ids for NEURL1B Gene

Previous GeneCards Identifiers for NEURL1B Gene

  • GC05P172002
  • GC05P167163
  • GC05P172068

Summaries for NEURL1B Gene

GeneCards Summary for NEURL1B Gene

NEURL1B (Neuralized E3 Ubiquitin Protein Ligase 1B) is a Protein Coding gene. Diseases associated with NEURL1B include Aortic Valve Disease 1. Among its related pathways are Signaling by GPCR and NOTCH2 Activation and Transmission of Signal to the Nucleus. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is NEURL1.

UniProtKB/Swiss-Prot Summary for NEURL1B Gene

  • E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands.

Additional gene information for NEURL1B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NEURL1B Gene

Genomics for NEURL1B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NEURL1B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J172640 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +1.7 1679 5.3 KDM1A ZIC2 POLR2A PATZ1 CTCF ZNF341 ZFX ZBTB44 KLF9 ZBTB20 NEURL1B piR-32813-014 DUSP1
GH05J172641 Enhancer 0.3 Ensembl 600.7 -1.6 -1562 0.2 ATF2 NEURL1B HSALNG0046631 SH3PXD2B
GH05J172571 Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 16 -68.3 -68264 7.2 ZNF512 RFX1 IKZF1 KDM1A ZIC2 MNT ZNF512B ZNF248 ZKSCAN1 NFE2 NEURL1B SH3PXD2B CREBRF lnc-SH3PXD2B-2 LINC01944
GH05J172657 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.7 +20.6 20629 8.6 GATAD2A CTCF ATF7 REST RFX1 ZIC2 PKNOX1 RXRB IRF2 SP1 MIR5003 NEURL1B SH3PXD2B ENSG00000204758 ENSG00000254295 RPL26L1 lnc-ERGIC1-5 piR-31462-027 DUSP1
GH05J172564 Enhancer 1 Ensembl ENCODE 11.4 -76.4 -76412 2.1 GATAD2A RCOR2 FOXA1 ZIC2 RXRB CEBPA SCRT2 MNT SOX13 RNF2 NEURL1B LINC01944 lnc-SH3PXD2B-2 SH3PXD2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NEURL1B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NEURL1B

Top Transcription factor binding sites by QIAGEN in the NEURL1B gene promoter:
  • AREB6
  • CUTL1
  • HEN1
  • Meis-1
  • Meis-1a
  • Meis-1b
  • NF-kappaB1
  • Pax-5
  • SRY
  • STAT3

Genomic Locations for NEURL1B Gene

Genomic Locations for NEURL1B Gene
50,278 bases
Plus strand
50,275 bases
Plus strand

Genomic View for NEURL1B Gene

Genes around NEURL1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEURL1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEURL1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEURL1B Gene

Proteins for NEURL1B Gene

  • Protein details for NEURL1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase NEURL1B
    Protein Accession:
    Secondary Accessions:
    • C9DQJ5
    • C9DQJ6
    • C9DQJ7

    Protein attributes for NEURL1B Gene

    555 amino acids
    Molecular mass:
    59270 Da
    Quaternary structure:
    • Interacts with JAG1, DLL1 and DLL4.

    Alternative splice isoforms for NEURL1B Gene


neXtProt entry for NEURL1B Gene

Post-translational modifications for NEURL1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NEURL1B Gene

No data available for DME Specific Peptides for NEURL1B Gene

Domains & Families for NEURL1B Gene

Gene Families for NEURL1B Gene

Protein Domains for NEURL1B Gene

Suggested Antigen Peptide Sequences for NEURL1B Gene

GenScript: Design optimal peptide antigens:
  • Neuralized 2 (C9DQJ5_HUMAN)
  • Neuralized-like protein 3 (NEU1B_HUMAN)
genes like me logo Genes that share domains with NEURL1B: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NEURL1B Gene

Function for NEURL1B Gene

Molecular function for NEURL1B Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=;.

Enzyme Numbers (IUBMB) for NEURL1B Gene

Phenotypes From GWAS Catalog for NEURL1B Gene

Gene Ontology (GO) - Molecular Function for NEURL1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19723503
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IEA,ISS --
genes like me logo Genes that share ontologies with NEURL1B: view

Animal Model Products

CRISPR Products

miRNA for NEURL1B Gene

miRTarBase miRNAs that target NEURL1B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEURL1B

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEURL1B Gene

Localization for NEURL1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEURL1B Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEURL1B gene
Compartment Confidence
endosome 4
nucleus 3
mitochondrion 2
plasma membrane 1
extracellular 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NEURL1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005769 early endosome IBA,ISS --
genes like me logo Genes that share ontologies with NEURL1B: view

Pathways & Interactions for NEURL1B Gene

genes like me logo Genes that share pathways with NEURL1B: view

UniProtKB/Swiss-Prot A8MQ27-NEU1B_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Interacting Proteins for NEURL1B Gene

Gene Ontology (GO) - Biological Process for NEURL1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007219 Notch signaling pathway IEA --
GO:0016567 protein ubiquitination IEA --
GO:0070086 ubiquitin-dependent endocytosis IBA,ISS --
genes like me logo Genes that share ontologies with NEURL1B: view

No data available for SIGNOR curated interactions for NEURL1B Gene

Drugs & Compounds for NEURL1B Gene

No Compound Related Data Available

Transcripts for NEURL1B Gene

mRNA/cDNA for NEURL1B Gene

9 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEURL1B

Alternative Splicing Database (ASD) splice patterns (SP) for NEURL1B Gene

No ASD Table

Relevant External Links for NEURL1B Gene

GeneLoc Exon Structure for

Expression for NEURL1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NEURL1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NEURL1B

SOURCE GeneReport for Unigene cluster for NEURL1B Gene:


mRNA Expression by UniProt/SwissProt for NEURL1B Gene:

Tissue specificity: Highest expression in brain, prostate and small intestine. In the brain the levels are higher in fetal than in adult stage. In the adult brain the highest levels are detected in the olfactory system, cerebellar cortex, optic nerve and the frontal lobe.

Evidence on tissue expression from TISSUES for NEURL1B Gene

  • Liver(4.3)
  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with NEURL1B: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEURL1B Gene

Orthologs for NEURL1B Gene

This gene was present in the common ancestor of animals.

Orthologs for NEURL1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NEURL1B 30 31
  • 99.7 (n)
(Canis familiaris)
Mammalia NEURL1B 30 31
  • 93.7 (n)
(Bos Taurus)
Mammalia NEURL1B 30 31
  • 92.31 (n)
(Mus musculus)
Mammalia Neurl1b 30 17 31
  • 86.81 (n)
(Rattus norvegicus)
Mammalia Neurl1b 30
  • 85.84 (n)
(Monodelphis domestica)
Mammalia NEURL1B 31
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia NEURL1B 31
  • 57 (a)
(Gallus gallus)
Aves NEURL1B 30 31
  • 70.36 (n)
(Anolis carolinensis)
Reptilia NEURL1B 31
  • 62 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia neurl1b 30
  • 62.23 (n)
(Danio rerio)
Actinopterygii neurl1b 31
  • 60 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001999 30
  • 54 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta neur 30 31
  • 49.02 (n)
(Caenorhabditis elegans)
Secernentea F10D7.5 30 31
  • 44.58 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 27 (a)
-- 31
  • 22 (a)
Species where no ortholog for NEURL1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for NEURL1B Gene

Gene Tree for NEURL1B (if available)
Gene Tree for NEURL1B (if available)
Evolutionary constrained regions (ECRs) for NEURL1B: view image

Paralogs for NEURL1B Gene

Paralogs for NEURL1B Gene

(3) SIMAP similar genes for NEURL1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NEURL1B: view

Variants for NEURL1B Gene

Additional dbSNP identifiers (rs#s) for NEURL1B Gene

Structural Variations from Database of Genomic Variants (DGV) for NEURL1B Gene

Variant ID Type Subtype PubMed ID
dgv10172n54 CNV loss 21841781
dgv10173n54 CNV gain 21841781
dgv208e55 CNV gain 17911159
dgv5831n100 CNV gain 25217958
dgv729n27 CNV gain 19166990
esv2759393 CNV gain 17122850
esv2763518 CNV gain 21179565
esv34432 CNV gain 17911159
esv3607596 CNV gain 21293372
esv3607597 CNV loss 21293372
nsv1032497 CNV gain 25217958
nsv1119049 CNV deletion 24896259
nsv441974 CNV gain 18776908
nsv462526 CNV loss 19166990
nsv471055 CNV gain 18288195
nsv522263 CNV loss 19592680
nsv523045 CNV gain 19592680
nsv600287 CNV loss 21841781
nsv600289 CNV loss 21841781
nsv818392 CNV gain 17921354

Variation tolerance for NEURL1B Gene

Gene Damage Index Score: 3.16; 51.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NEURL1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NEURL1B Gene

Disorders for NEURL1B Gene

MalaCards: The human disease database

(1) MalaCards diseases for NEURL1B Gene - From: DISEASES

Disorder Aliases PubMed IDs
aortic valve disease 1
  • aovd1
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with NEURL1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEURL1B Gene

Publications for NEURL1B Gene

  1. Neuralized-2: expression in human and rodents and interaction with Delta-like ligands. (PMID: 19723503) Rullinkov G … Timmusk T (Biochemical and biophysical research communications 2009) 3 4
  2. Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1. (PMID: 17003037) Song R … Kong YY (The Journal of biological chemistry 2006) 2 3
  3. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4
  4. Neuralized family member NEURL1 is a ubiquitin ligase for the cGMP-specific phosphodiesterase 9A. (PMID: 31068605) Taal K … Timmusk T (Scientific reports 2019) 3
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4

Products for NEURL1B Gene

Sources for NEURL1B Gene