Aliases for NEURL1 Gene
External Ids for NEURL1 Gene
Previous HGNC Symbols for NEURL1 Gene
Previous GeneCards Identifiers for NEURL1 Gene
GeneCards Summary for NEURL1 Gene
NEURL1 (Neuralized E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Diseases associated with NEURL1 include Medulloblastoma and Mental Retardation, Autosomal Dominant 38. Among its related pathways are Signaling by NOTCH1 and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include ligase activity and translation factor activity, non-nucleic acid binding. An important paralog of this gene is NEURL1B.
UniProtKB/Swiss-Prot Summary for NEURL1 Gene
Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.