Aliases for NEURL1 Gene

Aliases for NEURL1 Gene

  • Neuralized E3 Ubiquitin Protein Ligase 1 2 3 5
  • RING-Type E3 Ubiquitin Transferase NEURL1 3 4
  • E3 Ubiquitin-Protein Ligase NEURL1 3 4
  • Neuralized-Like Protein 1A 3 4
  • RING Finger Protein 67 3 4
  • H-Neuralized 1 3 4
  • NEURL 3 4
  • RNF67 3 4
  • Neuralized Homolog (Drosophila) 2
  • Neuralized (Drosophila)-Like 2
  • Neuralized-Like (Drosophila) 2
  • Neuralized Homolog 3
  • EC 2.3.2.27 4
  • BA416N2.1 3
  • NEURL1A 4
  • NEUR1 3
  • Neu-1 3
  • H-Neu 4
  • Neu 3

External Ids for NEURL1 Gene

Previous HGNC Symbols for NEURL1 Gene

  • NEURL

Previous GeneCards Identifiers for NEURL1 Gene

  • GC10P105253

Summaries for NEURL1 Gene

GeneCards Summary for NEURL1 Gene

NEURL1 (Neuralized E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Diseases associated with NEURL1 include Medulloblastoma and Mental Retardation, Autosomal Dominant 38. Among its related pathways are Signaling by NOTCH1 and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include ligase activity and translation factor activity, non-nucleic acid binding. An important paralog of this gene is NEURL1B.

UniProtKB/Swiss-Prot Summary for NEURL1 Gene

  • Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.

Gene Wiki entry for NEURL1 Gene

Additional gene information for NEURL1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NEURL1 Gene

Genomics for NEURL1 Gene

GeneHancer (GH) Regulatory Elements for NEURL1 Gene

Promoters and enhancers for NEURL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NEURL1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NEURL1

Genomic Locations for NEURL1 Gene

Genomic Locations for NEURL1 Gene
chr10:103,493,890-103,592,552
(GRCh38/hg38)
Size:
98,663 bases
Orientation:
Plus strand
chr10:105,253,735-105,352,309
(GRCh37/hg19)
Size:
98,575 bases
Orientation:
Plus strand

Genomic View for NEURL1 Gene

Genes around NEURL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEURL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEURL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEURL1 Gene

Proteins for NEURL1 Gene

  • Protein details for NEURL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76050-NEUL1_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase NEURL1
    Protein Accession:
    O76050
    Secondary Accessions:
    • Q5TDR2
    • Q5TDR3
    • Q8TAN0
    • Q9H463

    Protein attributes for NEURL1 Gene

    Size:
    574 amino acids
    Molecular mass:
    61860 Da
    Quaternary structure:
    • Interacts with CPEB3 (via N-terminal domain); the interaction increases CPEB3 ubiquitination. Interacts with DLL1.

    Alternative splice isoforms for NEURL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEURL1 Gene

Post-translational modifications for NEURL1 Gene

No data available for DME Specific Peptides for NEURL1 Gene

Domains & Families for NEURL1 Gene

Gene Families for NEURL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NEURL1 Gene

Blocks:
  • Zn-finger, RING
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NEURL1 Gene

GenScript: Design optimal peptide antigens:
  • RING finger protein 67 (NEU1A_HUMAN)
genes like me logo Genes that share domains with NEURL1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NEURL1 Gene

Function for NEURL1 Gene

Molecular function for NEURL1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.
UniProtKB/Swiss-Prot Induction:
Down-regulated in medulloblastoma (MB).

Enzyme Numbers (IUBMB) for NEURL1 Gene

Phenotypes From GWAS Catalog for NEURL1 Gene

Gene Ontology (GO) - Molecular Function for NEURL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity ISS --
GO:0016740 transferase activity IEA --
GO:0045183 translation factor activity, non-nucleic acid binding ISS,IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA,IEA 21873635
genes like me logo Genes that share ontologies with NEURL1: view
genes like me logo Genes that share phenotypes with NEURL1: view

Animal Models for NEURL1 Gene

MGI Knock Outs for NEURL1:

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEURL1 Gene

Localization for NEURL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEURL1 Gene

Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein. Perikaryon. Cell projection, dendrite. Cell junction, synapse, postsynaptic density. Note=Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons (By similarity). Colocalized with JAG1 at the cell surface. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEURL1 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for NEURL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IBA,IDA 20847082
GO:0014069 postsynaptic density IBA,ISS --
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with NEURL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NEURL1 Gene

Pathways & Interactions for NEURL1 Gene

genes like me logo Genes that share pathways with NEURL1: view

UniProtKB/Swiss-Prot O76050-NEUL1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for NEURL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0006513 protein monoubiquitination IEA,ISS --
GO:0007219 Notch signaling pathway IEA --
GO:0007288 sperm axoneme assembly IEA --
GO:0007399 nervous system development IBA,TAS 21873635
genes like me logo Genes that share ontologies with NEURL1: view

No data available for SIGNOR curated interactions for NEURL1 Gene

Drugs & Compounds for NEURL1 Gene

No Compound Related Data Available

Transcripts for NEURL1 Gene

mRNA/cDNA for NEURL1 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEURL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - -
SP2: -
SP3:
SP4:

Relevant External Links for NEURL1 Gene

GeneLoc Exon Structure for
NEURL1

Expression for NEURL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NEURL1 Gene

mRNA differential expression in normal tissues according to GTEx for NEURL1 Gene

This gene is overexpressed in Brain - Cortex (x4.7), Muscle - Skeletal (x4.4), and Brain - Cerebellum (x4.0).

Protein differential expression in normal tissues from HIPED for NEURL1 Gene

This gene is overexpressed in Tlymphocyte (48.2) and Esophagus (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NEURL1 Gene



Protein tissue co-expression partners for NEURL1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NEURL1

mRNA Expression by UniProt/SwissProt for NEURL1 Gene:

O76050-NEUL1_HUMAN
Tissue specificity: Expressed in brain, testis, pituitary gland, pancreas and bone marrow. Also poorly expressed in malignant astrocytomas and several neuroectodermal tumor cell lines. Weakly expressed in medulloblastoma (MB) compared with normal cerebellar tissues.

Evidence on tissue expression from TISSUES for NEURL1 Gene

  • Nervous system(4.9)
  • Eye(3.8)
  • Pancreas(3.7)
  • Skin(3.6)
  • Lung(3.4)
  • Intestine(2.7)
  • Liver(2.6)
genes like me logo Genes that share expression patterns with NEURL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEURL1 Gene

Orthologs for NEURL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEURL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEURL 30
  • 98.94 (n)
NEURL1 31
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NEURL1 31
  • 96 (a)
OneToOne
NEURL 30
  • 93.03 (n)
dog
(Canis familiaris)
Mammalia NEURL1 31
  • 95 (a)
OneToOne
NEURL 30
  • 93.08 (n)
mouse
(Mus musculus)
Mammalia Neurl1a 17 31 30
  • 91.06 (n)
rat
(Rattus norvegicus)
Mammalia Neurl1 30
  • 90.05 (n)
oppossum
(Monodelphis domestica)
Mammalia NEURL1 31
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEURL1 31
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves NEURL 31 30
  • 73.39 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NEURL1 31
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia neurl1 30
  • 67.03 (n)
African clawed frog
(Xenopus laevis)
Amphibia neurl-A 30
zebrafish
(Danio rerio)
Actinopterygii neurl1aa 31 30
  • 65.99 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta neur 31
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F10D7.5 31
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 28 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
Species where no ortholog for NEURL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEURL1 Gene

ENSEMBL:
Gene Tree for NEURL1 (if available)
TreeFam:
Gene Tree for NEURL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NEURL1: view image

Paralogs for NEURL1 Gene

Paralogs for NEURL1 Gene

(1) SIMAP similar genes for NEURL1 Gene using alignment to 1 proteins:

  • NEUL1_HUMAN
genes like me logo Genes that share paralogs with NEURL1: view

Variants for NEURL1 Gene

Additional dbSNP identifiers (rs#s) for NEURL1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NEURL1 Gene

Variant ID Type Subtype PubMed ID
dgv966n100 CNV gain 25217958
esv27747 CNV gain 19812545
esv3577694 CNV gain 25503493
esv3624417 CNV loss 21293372
esv3624418 CNV gain 21293372
nsv524966 CNV loss 19592680

Variation tolerance for NEURL1 Gene

Residual Variation Intolerance Score: 41.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.47; 77.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NEURL1 Gene

Human Gene Mutation Database (HGMD)
NEURL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEURL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NEURL1 Gene

Disorders for NEURL1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NEURL1 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NEURL1

genes like me logo Genes that share disorders with NEURL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEURL1 Gene

Publications for NEURL1 Gene

  1. Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma. (PMID: 20847082) Teider N … Pomeroy SL (Neuro-oncology 2010) 2 3 4 54
  2. Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region. (PMID: 9519875) Nakamura H … Saya H (Oncogene 1998) 2 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 54
  5. Isolation of a murine homologue of the Drosophila neuralized gene, a gene required for axonemal integrity in spermatozoa and terminal maturation of the mammary gland. (PMID: 11585928) Vollrath B … Fitzgerald K (Molecular and cellular biology 2001) 3 4 54

Products for NEURL1 Gene

Sources for NEURL1 Gene