Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2009] See more...
Aliases for NEU4 Gene
Aliases for NEU4 Gene
External Ids for NEU4 Gene
- HGNC: 21328
- NCBI Entrez Gene: 129807
- Ensembl: ENSG00000204099
- OMIM®: 608527
- UniProtKB/Swiss-Prot: Q8WWR8
Previous GeneCards Identifiers for NEU4 Gene
- GC02M238777
- GC02M239447
- GC02P242770
- GC02P243037
- GC02P243072
- GC02P242472
- GC02P242437
- GC02P242400
- GC02P234501
- GC02P242749
Summaries for NEU4 Gene
-
The protein encoded by this gene belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2009]
GeneCards Summary for NEU4 Gene
NEU4 (Neuraminidase 4) is a Protein Coding gene. Diseases associated with NEU4 include Galactosialidosis and Charcot-Marie-Tooth Disease, Axonal, Type 2V. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include exo-alpha-(2->3)-sialidase activity and exo-alpha-(2->8)-sialidase activity. An important paralog of this gene is NEU3.
UniProtKB/Swiss-Prot Summary for NEU4 Gene
-
Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:15847605, PubMed:21521691, PubMed:15213228). Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons (By similarity). May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation (PubMed:21521691). Has sialidase activity toward mucin, fetuin and sialyllactose (PubMed:15847605).
Additional gene information for NEU4 Gene
- HGNC (21328)
- NCBI Entrez Gene (129807)
- Ensembl (ENSG00000204099)
- OMIM® (608527)
- UniProtKB/Swiss-Prot (Q8WWR8)
- Open Targets Platform(ENSG00000204099)
- Search for NEU4 at DataMed
- Search for NEU4 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NEU4 Gene
Genomics for NEU4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NEU4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NEU4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NEU4
- Top Transcription factor binding sites by QIAGEN in the NEU4 gene promoter:
-
- AML1a
- AP-4
- CREB
- deltaCREB
- E47
- HEN1
- LCR-F1
- Olf-1
- RFX1
- RP58
Genomic Locations for NEU4 Gene
Latest Assembly
- chr2:241,809,065-241,817,413
- (GRCh38/hg38)
- Size:
- 8,349 bases
- Orientation:
- Plus strand
Previous Assembly
- chr2:242,750,288-242,758,739
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 8,452 bases
- Orientation:
- Plus strand
- chr2:242,749,920-242,758,739
- (GRCh37/hg19 by Ensembl)
- Size:
- 8,820 bases
- Orientation:
- Plus strand
Genomic View for NEU4 Gene
Genes around NEU4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q37.3 by HGNC
- 2q37.3 by Entrez Gene
- 2q37.3 by Ensembl
NEU4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NEU4 Gene
Proteins for NEU4 Gene
-
Protein details for NEU4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WWR8-NEUR4_HUMAN
- Recommended name:
- Sialidase-4
- Protein Accession:
- Q8WWR8
- A8K056
- J3KNJ5
- Q96D64
Protein attributes for NEU4 Gene
- Size:
- 484 amino acids
- Molecular mass:
- 51572 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAP34475.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for NEU4 Gene
Selected DME Specific Peptides for NEU4 Gene
- Q8WWR8:
-
- HRSMNPCP
- TFAVGPGH
Post-translational modifications for NEU4 Gene
- [Isoform 2]: N-glycosylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for NEU4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ NEU4 Antibody
- NSJ Bioreagents NEU4 Antibody
-
Custom Antibody ServicesOriGene Antibodies for NEU4
- Novus Biologicals Antibodies for NEU4
-
Abcam antibodies for NEU4
- Invitrogen Antibodies for NEU4 (AFLGC-NEU4)
-
Custom Antibody ServicesProSci Antibodies for NEU4
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for NEU4
- Origene Custom Protein Services for NEU4
- antibodies-online: Show 3 available NEU4 Proteins ranked by validation data
- Compare Top NEU4 Proteins
-
Quality Products:
Assay products for research
- antibodies-online: Search results for available NEU4 related products ranked by validation data
Domains & Families for NEU4 Gene
Gene Families for NEU4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for NEU4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for NEU4 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ54457, highly similar to Sialidase-4 (EC 3.2.1.18) (B3KR54_HUMAN)
- N-acetyl-alpha-neuraminidase 4 (NEUR4_HUMAN)
- Sialidase 4 (Q3KR05_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8WWR8- Family:
-
- Belongs to the glycosyl hydrolase 33 family.
Function for NEU4 Gene
Molecular function for NEU4 Gene
- UniProtKB/Swiss-Prot Function:
- Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:15847605, PubMed:21521691, PubMed:15213228). Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons (By similarity). May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation (PubMed:21521691). Has sialidase activity toward mucin, fetuin and sialyllactose (PubMed:15847605).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.; EC=3.2.1.18; Evidence={ECO:0000269|PubMed:14962670, ECO:0000269|PubMed:15213228, ECO:0000269|PubMed:15847605, ECO:0000269|PubMed:21521691};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ganglioside GM3 + H2O = beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate; Xref=Rhea:RHEA:48136, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:79208, ChEBI:CHEBI:79210; Evidence={ECO:0000269|PubMed:15847605};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ganglioside GM3 (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate; Xref=Rhea:RHEA:47900, ChEBI:CHEBI:15377, ChEBI:CHEBI:17950, ChEBI:CHEBI:35418, ChEBI:CHEBI:60065; Evidence={ECO:0000269|PubMed:15847605, ECO:0000269|PubMed:21521691};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ganglioside GM2 + H2O = N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetylneuraminate; Xref=Rhea:RHEA:48172, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:79218, ChEBI:CHEBI:90085; Evidence={ECO:0000269|PubMed:15847605};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ganglioside GM2 (d18:1(4E)) + H2O = ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate; Xref=Rhea:RHEA:48068, ChEBI:CHEBI:15377, ChEBI:CHEBI:27731, ChEBI:CHEBI:35418, ChEBI:CHEBI:71502; Evidence={ECO:0000269|PubMed:15847605};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ganglioside GD1a + H2O = ganglioside GM1 + N-acetylneuraminate; Xref=Rhea:RHEA:47832, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:82637, ChEBI:CHEBI:82639; Evidence={ECO:0000269|PubMed:15847605};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ganglioside GD1a (d18:1(4E)) + H2O = ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate; Xref=Rhea:RHEA:47856, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:77709, ChEBI:CHEBI:78445; Evidence={ECO:0000269|PubMed:15847605};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ganglioside GD3 + H2O = ganglioside GM3 + N-acetylneuraminate; Xref=Rhea:RHEA:48120, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:79210, ChEBI:CHEBI:79214; Evidence={ECO:0000269|PubMed:15847605};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ganglioside GD3 (d18:1(4E)) + H2O = ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate; Xref=Rhea:RHEA:48124, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:60065, ChEBI:CHEBI:78436; Evidence={ECO:0000269|PubMed:15847605};.
- UniProtKB/Swiss-Prot Induction:
- Down-regulated during monocyte to macrophage differentiation.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- pH dependence: Optimum pH is 3.2. {ECO:0000269|PubMed:14962670};
Enzyme Numbers (IUBMB) for NEU4 Gene
Phenotypes From GWAS Catalog for NEU4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004308 | exo-alpha-sialidase activity | IEA,IDA | 14962670 |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds | IEA | -- |
| GO:0052794 | exo-alpha-(2->3)-sialidase activity | IEA,IDA | 15847605 |
Phenotypes for NEU4 Gene
- MGI mutant phenotypes for NEU4:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for NEU4:
Animal Models for NEU4 Gene
- MGI Knock Outs for NEU4:
-
- Neu4 Neu4<tm1Avps>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for NEU4 - Starting at $85 >
- * NEU4 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for NEU4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NEU4
-
Santa Cruz Biotechnology (SCBT) CRISPR for NEU4
miRNA for NEU4 Gene
- miRTarBase miRNAs that target NEU4
-
- hsa-miR-124-3p (MIRT022484)
- mmu-miR-1839-5p (MIRT586499)
- mmu-miR-669f-3p (MIRT586500)
- mmu-miR-466n-3p (MIRT586501)
- mmu-miR-669m-3p (MIRT586502)
- mmu-miR-466a-3p (MIRT586503)
- mmu-miR-466e-3p (MIRT586504)
- mmu-miR-466d-3p (MIRT586505)
- mmu-miR-467g (MIRT586506)
- mmu-miR-297b-3p (MIRT586507)
- mmu-miR-376c-3p (MIRT586508)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NEU4
- Browse OriGene Inhibitory RNA Products For NEU4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEU4
Clone products for research
- Applied Biological Materials (abm): Clones for NEU4 - Starting at $45 >
- * NEU4 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG207670
- MR207670
- MR207670L3
- MR207670L4
- RC203948
- RC203948L1
- RC203948L2
- RC203948L3
- RC203948L4
- RC230160
- RC230160L3
- RC230160L4
- RC230161
- RC230161L3
- RC230161L4
- RC230162
- RC230162L3
- RC230162L4
- RC230177
- RC230177L3
- RC230177L4
- RG203948
- RG230160
- RG230161
- RG230162
- RG230177
- RR204230
- RR204230L3
- RR204230L4
- MR207670L3V
- MR207670L4V
- RC203948L1V
- RC203948L2V
- RC203948L3V
- RC203948L4V
- RC230160L3V
- RC230160L4V
- RC230161L3V
- RC230161L4V
- RC230162L3V
- RC230162L4V
- RC230177L3V
- RC230177L4V
- RR204230L3V
- RR204230L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NEU4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NEU4
Cell Lines for research
-
Horizon Cell Lines for NEU4
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEU4 Gene
Localization for NEU4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NEU4 Gene
- [Isoform 1]: Cell membrane. Peripheral membrane protein. Endoplasmic reticulum membrane. Peripheral membrane protein. Microsome membrane. Peripheral membrane protein. Mitochondrion membrane. Peripheral membrane protein. Cell projection, neuron projection. Note=Predominantly associates with endoplasmic reticulum membranes. Only a small fraction associates with mitochondrial and plasma membranes. {ECO:0000269 PubMed:19797320, ECO:0000269 PubMed:21521691}.
- [Isoform 2]: Mitochondrion inner membrane. Peripheral membrane protein. Mitochondrion outer membrane. Peripheral membrane protein. Lysosome lumen. Note=According to PubMed:15213228, isoform 2 is soluble, N-glycosylated and found in the lumen of lysosomes. However, no signal sequence nor N-glycosylation site is predicted from the sequence.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| lysosome | 5 |
| plasma membrane | 4 |
| nucleus | 2 |
| cytosol | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005741 | mitochondrial outer membrane | IEA | -- |
| GO:0005743 | mitochondrial inner membrane | IEA | -- |
| GO:0005764 | NOT lysosome | IDA | 14962670 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for NEU4 Gene
Pathways & Interactions for NEU4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism |
.40
|
|
| 2 | Sphingolipid metabolism | ||
| 3 | Synthesis of substrates in N-glycan biosythesis | ||
| 4 | Metabolism of proteins | ||
| 5 | Other glycan degradation | ||
Pathways by source for NEU4 Gene
3 KEGG pathways for NEU4 Gene
Interacting Proteins for NEU4 Gene
Selected Interacting proteins:
Q8WWR8-NEUR4_HUMAN
ENSP00000320318
for NEU4 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for NEU4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005975 | carbohydrate metabolic process | IEA | -- |
| GO:0006516 | glycoprotein catabolic process | IEA,IDA | 15213228 |
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006687 | glycosphingolipid metabolic process | TAS | -- |
| GO:0006689 | ganglioside catabolic process | IEA,IDA | 15213228 |
No data available for SIGNOR curated interactions for NEU4 Gene
Drugs & Compounds for NEU4 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| CE(20:2(6Z,9Z)) |
|
4201-62-1, 77715-45-8 |
|
|||
| Galactosylceramide (d18:1/16:0) |
|
|
||||
| Galactosylceramide (d18:1/18:0) |
|
|
||||
| Galactosylceramide (d18:1/18:1(9Z)) |
|
|
||||
| Galactosylceramide (d18:1/20:0) |
|
|
Transcripts for NEU4 Gene
mRNA/cDNA for NEU4 Gene
- 5 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000325935 2288 nts (view in UCSC)
- ENST00000391969 2526 nts (view in UCSC)
- ENST00000404257 2352 nts (view in UCSC)
- ENST00000405370 1907 nts (view in UCSC)
- ENST00000407683 1905 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for NEU4 - Starting at $85 >
- * NEU4 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for NEU4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NEU4
-
Santa Cruz Biotechnology (SCBT) CRISPR for NEU4
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NEU4
- Browse OriGene Inhibitory RNA Products For NEU4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEU4
Clone products for research
- Applied Biological Materials (abm): Clones for NEU4 - Starting at $45 >
- * NEU4 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG207670
- MR207670
- MR207670L3
- MR207670L4
- RC203948
- RC203948L1
- RC203948L2
- RC203948L3
- RC203948L4
- RC230160
- RC230160L3
- RC230160L4
- RC230161
- RC230161L3
- RC230161L4
- RC230162
- RC230162L3
- RC230162L4
- RC230177
- RC230177L3
- RC230177L4
- RG203948
- RG230160
- RG230161
- RG230162
- RG230177
- RR204230
- RR204230L3
- RR204230L4
- MR207670L3V
- MR207670L4V
- RC203948L1V
- RC203948L2V
- RC203948L3V
- RC203948L4V
- RC230160L3V
- RC230160L4V
- RC230161L3V
- RC230161L4V
- RC230162L3V
- RC230162L4V
- RC230177L3V
- RC230177L4V
- RR204230L3V
- RR204230L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NEU4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NEU4
Relevant External Links for NEU4 Gene
- GeneLoc Exon Structure for
- NEU4
Expression for NEU4 Gene
mRNA differential expression in normal tissues according to GTEx for NEU4 Gene
This gene is overexpressed in Liver (x14.8) and Colon - Transverse (x6.7).
This gene is overexpressed in Liver, secretome (68.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NEU4 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NEU4
SOURCE GeneReport for Unigene cluster for NEU4 Gene:
Hs.551747mRNA Expression by UniProt/SwissProt for NEU4 Gene:
Q8WWR8-NEUR4_HUMAN
Tissue specificity:
[Isoform 1]: Predominant form in liver. Also expressed in brain, kidney and colon.
Evidence on tissue expression from TISSUES for NEU4 Gene
- Nervous system(3.7)
- Intestine(2.1)
Primer products for research
-
OriGene qPCR primer pairs for NEU4
-
OriGene qPCR primer pairs and template standards for NEU4
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEU4 Gene
Orthologs for NEU4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Cow (Bos Taurus) |
Mammalia | NEU4 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Neu4 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Neu4 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | NEU4 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | NEU4 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | NEU4 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | NEU4 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100486976 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | neu4 30 31 |
|
OneToOne |
- Species where no ortholog for NEU4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for NEU4 Gene
- ENSEMBL:
- Gene Tree for NEU4 (if available)
- TreeFam:
- Gene Tree for NEU4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NEU4: view image
Paralogs for NEU4 Gene
(2) SIMAP similar genes for NEU4 Gene using alignment to 11 proteins:
- NEUR4_HUMAN
- B3KR54_HUMAN
- C9IZG9_HUMAN
- C9J295_HUMAN
- C9J2R4_HUMAN
- C9J2V4_HUMAN
- C9J5X2_HUMAN
- C9JEA3_HUMAN
- C9JRN9_HUMAN
- F8WE58_HUMAN
- Q3KR05_HUMAN
Variants for NEU4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NEU4 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs11545301 | - |
p.Gly301Arg |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv165e55 | CNV | loss | 17911159 |
| dgv4200n100 | CNV | loss | 25217958 |
| dgv4201n100 | CNV | gain | 25217958 |
| esv2664751 | CNV | deletion | 23128226 |
| esv4746 | CNV | loss | 18987735 |
| esv989515 | CNV | insertion | 20482838 |
| nsv1002941 | CNV | gain | 25217958 |
| nsv1006733 | CNV | gain | 25217958 |
| nsv10232 | CNV | gain+loss | 18304495 |
| nsv470533 | CNV | loss | 18288195 |
| nsv584982 | CNV | loss | 21841781 |
| nsv584991 | CNV | loss | 21841781 |
| nsv584996 | CNV | gain | 21841781 |
| nsv955301 | CNV | deletion | 24416366 |
| nsv997984 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
98.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.39;
63.62% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NEU4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NEU4
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEU4 Gene
Disorders for NEU4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| galactosialidosis |
|
|
| charcot-marie-tooth disease, axonal, type 2v |
|
|
| gm2-gangliosidosis, ab variant |
|
|
| glycoproteinosis |
|
|
| developmental and epileptic encephalopathy 15 |
|
|
Search NEU4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NEU4
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for NEU4 Gene
Publications for NEU4 Gene
- Evidence for mitochondrial localization of a novel human sialidase (NEU4). (PMID: 15847605) Yamaguchi K … Miyagi T (The Biochemical journal 2005) 3 4 23
- Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages. (PMID: 15885103) Stamatos NM … Pshezhetsky AV (The FEBS journal 2005) 3 4 23
- Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells. (PMID: 15213228) Seyrantepe V … Pshezhetsky AV (The Journal of biological chemistry 2004) 3 4 23
- Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family. (PMID: 14962670) Monti E … Borsani G (Genomics 2004) 3 4 23
- Regulation of sialyl Lewis antigen expression in colon cancer cells by sialidase NEU4. (PMID: 21521691) Shiozaki K … Miyagi T (The Journal of biological chemistry 2011) 3 4
ExternalLinks
Products for NEU4 Gene
- Custom Antibody ServicesOriGene Antibodies for NEU4
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for NEU4
- Origene Custom Protein Services for NEU4
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NEU4
- Browse OriGene Inhibitory RNA Products For NEU4
- OriGene qPCR primer pairs for NEU4
- OriGene qPCR primer pairs and template standards for NEU4
- OriGene CRISPR knockouts for NEU4
- MG207670
- MR207670
- MR207670L3
- MR207670L4
- RC203948
- RC203948L1
- RC203948L2
- RC203948L3
- RC203948L4
- RC230160
- RC230160L3
- RC230160L4
- RC230161
- RC230161L3
- RC230161L4
- RC230162
- RC230162L3
- RC230162L4
- RC230177
- RC230177L3
- RC230177L4
- RG203948
- RG230160
- RG230161
- RG230162
- RG230177
- RR204230
- RR204230L3
- RR204230L4
- MR207670L3V
- MR207670L4V
- RC203948L1V
- RC203948L2V
- RC203948L3V
- RC203948L4V
- RC230160L3V
- RC230160L4V
- RC230161L3V
- RC230161L4V
- RC230162L3V
- RC230162L4V
- RC230177L3V
- RC230177L4V
- RR204230L3V
- RR204230L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NEU4
- Sino Biological Human cDNA Clone for NEU4
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for NEU4
- Novus Biologicals proteins and lysates for NEU4
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for NEU4
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for NEU4 (AFLGC-NEU4)
- VectorBuilder Custom and pre-made DNA vectors for NEU4 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for NEU4 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for NEU4 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for NEU4 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for NEU4
- antibodies-online: Show 14 available NEU4 Antibodies ranked by validation data
- Compare Top NEU4 Antibodies
- antibodies-online: Search results for available NEU4 related products ranked by validation data
- antibodies-online: Show 3 available NEU4 Proteins ranked by validation data
- Compare Top NEU4 Proteins
- Quality Products:
- Custom Antibody ServicesProSci Antibodies for NEU4
- Search for NEU4 Proteins at ProSci
- Horizon Cell Lines for NEU4
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NEU4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NEU4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for NEU4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEU4
Sources for NEU4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB