This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq, Jul 2008] See more...

Aliases for NEU3 Gene

Aliases for NEU3 Gene

  • Neuraminidase 3 2 3 5
  • Sialidase 3 (Membrane Sialidase) 2 3
  • N-Acetyl-Alpha-Neuraminidase 3 3 4
  • Ganglioside Sialidasedis 3 4
  • Membrane Sialidase 3 4
  • Sialidase-3 3 4
  • EC 3.2.1.18 4 50
  • Neuraminidase 3, Membrane Sialidase 2
  • Ganglioside Sialidase 3
  • SIAL3 3
  • NEU3 5

External Ids for NEU3 Gene

Previous GeneCards Identifiers for NEU3 Gene

  • GC11P077026
  • GC11P076238
  • GC11P074921
  • GC11P074425
  • GC11P074376
  • GC11P074699
  • GC11P070997

Summaries for NEU3 Gene

Entrez Gene Summary for NEU3 Gene

  • This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq, Jul 2008]

GeneCards Summary for NEU3 Gene

NEU3 (Neuraminidase 3) is a Protein Coding gene. Diseases associated with NEU3 include Galactosialidosis and Glycoproteinosis. Among its related pathways are Sphingolipid metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include exo-alpha-(2->3)-sialidase activity and exo-alpha-(2->8)-sialidase activity. An important paralog of this gene is NEU4.

UniProtKB/Swiss-Prot Summary for NEU3 Gene

  • Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:11298736, PubMed:15847605, PubMed:10861246, PubMed:20511247, PubMed:28646141, PubMed:10405317, PubMed:12011038). Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR (PubMed:17334392, PubMed:25922362). Desialylates EGFR and activates downstream signaling in proliferating cells (PubMed:25922362). Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes (PubMed:26251452).

Gene Wiki entry for NEU3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NEU3 Gene

Genomics for NEU3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NEU3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NEU3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NEU3

Top Transcription factor binding sites by QIAGEN in the NEU3 gene promoter:
  • AML1a
  • HOXA9
  • HOXA9B
  • Ik-2
  • Meis-1
  • MyoD
  • Pax-2
  • Pax-2a
  • RREB-1
  • STAT3

Genomic Locations for NEU3 Gene

Latest Assembly
chr11:74,988,279-75,018,893
(GRCh38/hg38)
Size:
30,615 bases
Orientation:
Plus strand

Previous Assembly
chr11:74,699,689-74,721,952
(GRCh37/hg19 by Entrez Gene)
Size:
22,264 bases
Orientation:
Plus strand

chr11:74,699,179-74,729,938
(GRCh37/hg19 by Ensembl)
Size:
30,760 bases
Orientation:
Plus strand

Genomic View for NEU3 Gene

Genes around NEU3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEU3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEU3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEU3 Gene

Proteins for NEU3 Gene

  • Protein details for NEU3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQ49-NEUR3_HUMAN
    Recommended name:
    Sialidase-3
    Protein Accession:
    Q9UQ49
    Secondary Accessions:
    • A8K327
    • Q9NQE1

    Protein attributes for NEU3 Gene

    Size:
    428 amino acids
    Molecular mass:
    48252 Da
    Quaternary structure:
    • Interacts with CAV1; this interaction enhances NEU3 sialidase activity within caveola (PubMed:12011038). Interacts with EGFR; this interaction mediates desialylation of EGFR and enhances downstream signaling (PubMed:17334392).
    SequenceCaution:
    • Sequence=CAB96131.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for NEU3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEU3 Gene

Selected DME Specific Peptides for NEU3 Gene

Q9UQ49:
  • GCQGSVVS
  • TFAVGPGH

Post-translational modifications for NEU3 Gene

  • Palmitoylated; may regulate intracellular trafficking and anchorage to plasma membrane and endomembranes.
  • Ubiquitination at Lys44, Lys74, Lys154, Lys301, and Lys426
  • Modification sites at PhosphoSitePlus

Domains & Families for NEU3 Gene

Gene Families for NEU3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NEU3 Gene

Suggested Antigen Peptide Sequences for NEU3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ78026 (A8K327_HUMAN)
  • cDNA FLJ53523, highly similar to Sialidase-3 (EC 3.2.1.18) (B4E0V4_HUMAN)
  • N-acetyl-alpha-neuraminidase 3 (NEUR3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UQ49

UniProtKB/Swiss-Prot:

NEUR3_HUMAN :
  • Belongs to the glycosyl hydrolase 33 family.
Family:
  • Belongs to the glycosyl hydrolase 33 family.
genes like me logo Genes that share domains with NEU3: view

Function for NEU3 Gene

Molecular function for NEU3 Gene

UniProtKB/Swiss-Prot Function:
Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:11298736, PubMed:15847605, PubMed:10861246, PubMed:20511247, PubMed:28646141, PubMed:10405317, PubMed:12011038). Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR (PubMed:17334392, PubMed:25922362). Desialylates EGFR and activates downstream signaling in proliferating cells (PubMed:25922362). Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes (PubMed:26251452).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.; EC=3.2.1.18; Evidence={ECO:0000269|PubMed:10405317, ECO:0000269|PubMed:10861246, ECO:0000269|PubMed:11298736, ECO:0000269|PubMed:12011038, ECO:0000269|PubMed:15847605, ECO:0000269|PubMed:20511247};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ganglioside GD1a + H2O = ganglioside GM1 + N-acetylneuraminate; Xref=Rhea:RHEA:47832, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:82637, ChEBI:CHEBI:82639; Evidence={ECO:0000269|PubMed:10405317, ECO:0000269|PubMed:11298736, ECO:0000269|PubMed:15847605, ECO:0000269|PubMed:25922362};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ganglioside GD1a (d18:1(4E)) + H2O = ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate; Xref=Rhea:RHEA:47856, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:77709, ChEBI:CHEBI:78445; Evidence={ECO:0000305|PubMed:10405317, ECO:0000305|PubMed:11298736, ECO:0000305|PubMed:15847605};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ganglioside GD1b + H2O = ganglioside GM1 + N-acetylneuraminate; Xref=Rhea:RHEA:47876, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:82639, ChEBI:CHEBI:82939; Evidence={ECO:0000269|PubMed:10405317};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ganglioside GD1b (d18:1(4E)) + H2O = ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate; Xref=Rhea:RHEA:48064, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:77709, ChEBI:CHEBI:87785; Evidence={ECO:0000305|PubMed:10405317};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ganglioside GD3 + H2O = ganglioside GM3 + N-acetylneuraminate; Xref=Rhea:RHEA:48120, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:79210, ChEBI:CHEBI:79214; Evidence={ECO:0000269|PubMed:10405317, ECO:0000269|PubMed:11298736, ECO:0000269|PubMed:15847605};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ganglioside GD3 (d18:1(4E)) + H2O = ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate; Xref=Rhea:RHEA:48124, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:60065, ChEBI:CHEBI:78436; Evidence={ECO:0000305|PubMed:10405317, ECO:0000305|PubMed:11298736, ECO:0000305|PubMed:15847605};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ganglioside GM3 + H2O = beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate; Xref=Rhea:RHEA:48136, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:79208, ChEBI:CHEBI:79210; Evidence={ECO:0000269|PubMed:10405317, ECO:0000269|PubMed:15847605, ECO:0000269|PubMed:17334392};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ganglioside GM1 + H2O = ganglioside GA1 + N-acetylneuraminate; Xref=Rhea:RHEA:47872, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:82639, ChEBI:CHEBI:88069; Evidence={ECO:0000250|UniProtKB:Q9JMH7};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ganglioside GM1 (d18:1(4E)) + H2O = ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate; Xref=Rhea:RHEA:48072, ChEBI:CHEBI:15377, ChEBI:CHEBI:27938, ChEBI:CHEBI:35418, ChEBI:CHEBI:77709; Evidence={ECO:0000250|UniProtKB:Q9JMH7};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ganglioside GM2 (d18:1(4E)) + H2O = ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate; Xref=Rhea:RHEA:48068, ChEBI:CHEBI:15377, ChEBI:CHEBI:27731, ChEBI:CHEBI:35418, ChEBI:CHEBI:71502; Evidence={ECO:0000250|UniProtKB:Q9JMH7};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ganglioside GM3 (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate; Xref=Rhea:RHEA:47900, ChEBI:CHEBI:15377, ChEBI:CHEBI:17950, ChEBI:CHEBI:35418, ChEBI:CHEBI:60065; Evidence={ECO:0000269|PubMed:10405317, ECO:0000269|PubMed:11298736, ECO:0000269|PubMed:15847605};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ganglioside GT1b + H2O = ganglioside GD1b + N-acetylneuraminate; Xref=Rhea:RHEA:47828, ChEBI:CHEBI:15377, ChEBI:CHEBI:35418, ChEBI:CHEBI:82939, ChEBI:CHEBI:82940; Evidence={ECO:0000250|UniProtKB:O97859};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=47 uM for ganglioside GD1a {ECO:0000269|PubMed:11298736}; pH dependence: Optimum pH is 4.5-6.5. {ECO:0000269|PubMed:10405317, ECO:0000269|PubMed:11298736}; Temperature dependence: Optimum temperature is 20 degrees Celsius. {ECO:0000269|PubMed:11298736};
GENATLAS Biochemistry:
neuraminidase 3,membrane sialidase

Enzyme Numbers (IUBMB) for NEU3 Gene

Gene Ontology (GO) - Molecular Function for NEU3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004308 exo-alpha-sialidase activity IEA,TAS --
GO:0005515 protein binding IPI 17334392
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
GO:0016997 alpha-sialidase activity IDA 12730204
genes like me logo Genes that share ontologies with NEU3: view
genes like me logo Genes that share phenotypes with NEU3: view

Animal Models for NEU3 Gene

MGI Knock Outs for NEU3:
  • Neu3 Neu3<tm1Yamk>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEU3

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEU3 Gene

Localization for NEU3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEU3 Gene

Cell membrane. Peripheral membrane protein. Membrane, caveola. Early endosome membrane. Peripheral membrane protein. Recycling endosome membrane. Peripheral membrane protein. Lysosome membrane. Peripheral membrane protein. Note=Associates with the external leaflet of the plasma membrane (By similarity). S-acylated NEU3 likely spans the lipid bilayer with a portion of C-terminus exposed to the cytosol and the catalytic region facing the extracellular space (PubMed:28646141). {ECO:0000250 UniProtKB:Q9JMH7, ECO:0000269 PubMed:28646141}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEU3 gene
Compartment Confidence
plasma membrane 5
endosome 5
lysosome 5
nucleus 3
cytosol 3
extracellular 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NEU3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA,IDA 26251452
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with NEU3: view

Pathways & Interactions for NEU3 Gene

genes like me logo Genes that share pathways with NEU3: view

Gene Ontology (GO) - Biological Process for NEU3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IDA 12730204
GO:0006629 lipid metabolic process IEA --
GO:0006687 glycosphingolipid metabolic process TAS --
GO:0006689 ganglioside catabolic process IBA,IDA 10861246
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with NEU3: view

No data available for SIGNOR curated interactions for NEU3 Gene

Drugs & Compounds for NEU3 Gene

(1) Drugs for NEU3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(65) Additional Compounds for NEU3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ganglioside GM1 (18:1/12:0)
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-ceramide
  • D-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-nacylsphingosine
Ganglioside GM1 (18:1/16:0)
  • (2S,4S,5R)-2-{[(2S,3R,4R,5S,6R)-2-{[(2R,3S,4R,6R)-4,5-dihydroxy-6-{[(2S,3R,4E)-3-hydroxy-2-[(1-hydroxyhexadecylidene)amino]octadec-4-en-1-yl]oxy}-2-(hydroxymethyl)oxan-3-yl]oxy}-3-hydroxy-5-{[(2S,3R,4R,5R,6R)-5-hydroxy-3-[(1-hydroxyethylidene)amino]-6-(hydroxymethyl)-4-{[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-6-(hydroxymethyl)oxan-4-yl]oxy}-4-hydroxy-5-[(1-hydroxyethylidene)amino]-6-[(1S,2S)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-ceramide
Ganglioside GM1 (18:1/18:0)
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-ceramide
  • D-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-nacylsphingosine
Ganglioside GM1 (18:1/20:0)
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-ceramide
  • D-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-nacylsphingosine
Ganglioside GM1 (18:1/22:0)
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-ceramide
  • D-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-nacylsphingosine
genes like me logo Genes that share compounds with NEU3: view

Transcripts for NEU3 Gene

mRNA/cDNA for NEU3 Gene

9 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEU3

Alternative Splicing Database (ASD) splice patterns (SP) for NEU3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - - -
SP2: -
SP3: - -
SP4:
SP5: - - -

Relevant External Links for NEU3 Gene

GeneLoc Exon Structure for
NEU3

Expression for NEU3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NEU3 Gene

mRNA differential expression in normal tissues according to GTEx for NEU3 Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for NEU3 Gene

This gene is overexpressed in Plasma (29.0), Esophagus (28.5), and Frontal cortex (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NEU3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NEU3

SOURCE GeneReport for Unigene cluster for NEU3 Gene:

Hs.191074

mRNA Expression by UniProt/SwissProt for NEU3 Gene:

Q9UQ49-NEUR3_HUMAN
Tissue specificity: Highly expressed in skeletal muscle, testis, adrenal gland and thymus, followed by pancreas, liver, heart and thymus. Weakly expressed in kidney, placenta, brain and lung.

Evidence on tissue expression from TISSUES for NEU3 Gene

  • Nervous system(4.4)
  • Muscle(4.4)
  • Kidney(2.4)
genes like me logo Genes that share expression patterns with NEU3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEU3 Gene

Orthologs for NEU3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NEU3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NEU3 29 30
  • 99.71 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NEU3 29 30
  • 88.53 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NEU3 29 30
  • 87.05 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Neu3 29 16 30
  • 77.62 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Neu3 29
  • 77.38 (n)
Chicken
(Gallus gallus)
Aves NEU3 29 30
  • 58.17 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 55 (a)
OneToMany
-- 30
  • 54 (a)
OneToMany
-- 30
  • 53 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100496715 29
  • 58.83 (n)
Zebrafish
(Danio rerio)
Actinopterygii neu3.1 29
  • 54.99 (n)
neu3.4 30
  • 47 (a)
OneToMany
neu3.2 30
  • 45 (a)
OneToMany
neu3.3 30
  • 43 (a)
OneToMany
neu3.5 30
  • 42 (a)
OneToMany
Species where no ortholog for NEU3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NEU3 Gene

ENSEMBL:
Gene Tree for NEU3 (if available)
TreeFam:
Gene Tree for NEU3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NEU3: view image
Alliance of Genome Resources:
Additional Orthologs for NEU3

Paralogs for NEU3 Gene

Paralogs for NEU3 Gene

(3) SIMAP similar genes for NEU3 Gene using alignment to 7 proteins:

  • NEUR3_HUMAN
  • A8K327_HUMAN
  • B4E0V4_HUMAN
  • E9PI40_HUMAN
  • E9PMZ3_HUMAN
  • E9PNK1_HUMAN
  • E9PR25_HUMAN
genes like me logo Genes that share paralogs with NEU3: view

Variants for NEU3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NEU3 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs1591760963 Uncertain Significance: Marfanoid habitus and intellectual disability 75,005,422(+) C/G
NM_006656.6(NEU3):c.316C>G (p.Leu106Val)
MISSENSE_VARIANT,SYNONYMOUS
rs7115499 -- p.Arg15Gln

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NEU3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NEU3 Gene

Variant ID Type Subtype PubMed ID
nsv832210 CNV gain+loss 17160897

Variation tolerance for NEU3 Gene

Residual Variation Intolerance Score: 94.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.81; 58.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NEU3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEU3
Leiden Open Variation Database (LOVD)
NEU3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEU3 Gene

Disorders for NEU3 Gene

MalaCards: The human disease database

(7) MalaCards diseases for NEU3 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
galactosialidosis
  • gsl
glycoproteinosis
  • mucolipidosis type i
clear cell adenocarcinoma of the ovary
  • ovarian clear cell adenocarcinoma
gm2-gangliosidosis, ab variant
  • hexosaminidase activator deficiency
mucolipidosis
- elite association - COSMIC cancer census association via MalaCards
Search NEU3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NEU3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with NEU3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEU3 Gene

Publications for NEU3 Gene

  1. Cloning, expression, and chromosomal mapping of a human ganglioside sialidase. (PMID: 10405317) Wada T … Miyagi T (Biochemical and biophysical research communications 1999) 2 3 4 22
  2. A crucial role of plasma membrane-associated sialidase in the survival of human cancer cells. (PMID: 17334392) Wada T … Miyagi T (Oncogene 2007) 3 4 22
  3. Site-directed mutagenesis of human membrane-associated ganglioside sialidase: identification of amino-acid residues contributing to substrate specificity. (PMID: 11298736) Wang Y … Miyagi T (European journal of biochemistry 2001) 3 4 22
  4. Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane. (PMID: 10861246) Monti E … Borsani G (The Biochemical journal 2000) 3 4 22
  5. Human Sialidase Neu3 is S-Acylated and Behaves Like an Integral Membrane Protein. (PMID: 28646141) Rodriguez-Walker M … Daniotti JL (Scientific reports 2017) 3 4

Products for NEU3 Gene

Sources for NEU3 Gene