Aliases for NETO1 Gene
External Ids for NETO1 Gene
Previous GeneCards Identifiers for NETO1 Gene
This gene encodes a transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. This protein is thought to play a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2017]
GeneCards Summary for NETO1 Gene
NETO1 (Neuropilin And Tolloid Like 1) is a Protein Coding gene. Diseases associated with NETO1 include Cleft Soft Palate and Chromosome 18Q Deletion Syndrome. Gene Ontology (GO) annotations related to this gene include ionotropic glutamate receptor binding. An important paralog of this gene is NETO2.
UniProtKB/Swiss-Prot Summary for NETO1 Gene
Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity).