This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. [provided by RefSeq, Sep 2011] See more...

Aliases for NES Gene

Aliases for NES Gene

  • Nestin 2 3 4 5
  • Nbla00170 3

External Ids for NES Gene

Previous GeneCards Identifiers for NES Gene

  • GC00U990485
  • GC01M153416
  • GC01M153855
  • GC01M153451
  • GC01M154905
  • GC01M156639
  • GC01M127996

Summaries for NES Gene

Entrez Gene Summary for NES Gene

  • This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. [provided by RefSeq, Sep 2011]

GeneCards Summary for NES Gene

NES (Nestin) is a Protein Coding gene. Diseases associated with NES include Ependymoblastoma and Periventricular Leukomalacia. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include structural molecule activity and intermediate filament binding. An important paralog of this gene is NEFM.

UniProtKB/Swiss-Prot Summary for NES Gene

  • Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity).

Gene Wiki entry for NES Gene

Additional gene information for NES Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NES Gene

Genomics for NES Gene

GeneHancer (GH) Regulatory Elements for NES Gene

Promoters and enhancers for NES Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J156672 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 521.5 +1.7 1726 6.1 CTCF NRF1 POLR2G TEAD4 ZNF639 ZNF10 ZIC2 ZBTB10 SAP30 REST NES ENSG00000272068 LOC105371453
GH01J156656 Promoter/Enhancer 2.4 VISTA FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 7.3 +12.9 12941 14.9 RXRA FOXK2 HNRNPK ZBTB40 ZNF217 CTCF SIN3A NRF1 MYC TCF12 GON4L KHDC4 RRNAD1 ENSG00000237842 LMNA PRCC MSTO2P PMF1 ISG20L2 YY1AP1
GH01J156696 Enhancer 0.5 dbSUPER 12.5 -20.1 -20084 2 USF1 ZIC2 MXI1 POLR2A MITF TOE1 ZBTB33 GLIS2 PRDM1 RF00017-365 NES ENSG00000229953 BCAN ISG20L2 RRNAD1 HDGF PRCC NAXE CRABP2
GH01J156684 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.4 -7.9 -7856 3.3 CTCF FOS CEBPB SPI1 FOSL1 STAT3 JUND TCF7L2 RAD21 ZFP36 CRABP2 ENSG00000272068 ISG20L2 ENSG00000285570 NES
GH01J156682 Enhancer 0.4 Ensembl 0.7 -4.8 -4794 0.4 CTCF ZBTB48 TBP RAD21 NES ENSG00000285570
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NES on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NES

Top Transcription factor binding sites by QIAGEN in the NES gene promoter:
  • AhR
  • Bach1
  • E47
  • Ik-3
  • Olf-1
  • Pax-5
  • RP58
  • Tal-1beta

Genomic Locations for NES Gene

Genomic Locations for NES Gene
chr1:156,668,763-156,677,407
(GRCh38/hg38)
Size:
8,645 bases
Orientation:
Minus strand
chr1:156,638,555-156,647,189
(GRCh37/hg19)
Size:
8,635 bases
Orientation:
Minus strand

Genomic View for NES Gene

Genes around NES on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NES Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NES Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NES Gene

Proteins for NES Gene

  • Protein details for NES Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48681-NEST_HUMAN
    Recommended name:
    Nestin
    Protein Accession:
    P48681
    Secondary Accessions:
    • O00552
    • Q3LIF5
    • Q5SYZ6

    Protein attributes for NES Gene

    Size:
    1621 amino acids
    Molecular mass:
    177439 Da
    Quaternary structure:
    • Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such as vimentin and alpha-internexin, tis protein preferentially forms heterodimers which can assemble to form intermediate filaments if nestin does not exceed 25%. Interacts with FHOD3 (By similarity).

neXtProt entry for NES Gene

Post-translational modifications for NES Gene

  • Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NES Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for NES

No data available for DME Specific Peptides for NES Gene

Domains & Families for NES Gene

Gene Families for NES Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NES Gene

Suggested Antigen Peptide Sequences for NES Gene

GenScript: Design optimal peptide antigens:
  • NES protein (A5PKT9_HUMAN)
  • Nestin, isoform CRA_c (D3DVC4_HUMAN)
  • Nestin (NEST_HUMAN)
  • NES protein (Q05BW3_HUMAN)
  • NES protein (Q2YDX4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P48681

UniProtKB/Swiss-Prot:

NEST_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with NES: view

Function for NES Gene

Molecular function for NES Gene

UniProtKB/Swiss-Prot Function:
Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity).

Phenotypes From GWAS Catalog for NES Gene

Gene Ontology (GO) - Molecular Function for NES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 26496610
GO:0019215 intermediate filament binding ISS --
genes like me logo Genes that share ontologies with NES: view
genes like me logo Genes that share phenotypes with NES: view

miRNA for NES Gene

Clone Products

  • Addgene plasmids for NES

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NES Gene

Localization for NES Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NES gene
Compartment Confidence
cytoskeleton 5
nucleus 4
plasma membrane 3
extracellular 3
mitochondrion 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 19384922
GO:0005882 intermediate filament NAS 9917366
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with NES: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NES Gene

Pathways & Interactions for NES Gene

genes like me logo Genes that share pathways with NES: view

Pathways by source for NES Gene

1 GeneGo (Thomson Reuters) pathway for NES Gene
  • Cytoskeleton remodeling Neurofilaments

SIGNOR curated interactions for NES Gene

Other effect:

Gene Ontology (GO) - Biological Process for NES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IDA 19384922
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0007417 central nervous system development NAS 9917366
GO:0007420 brain development ISS --
genes like me logo Genes that share ontologies with NES: view

Drugs & Compounds for NES Gene

(11) Drugs for NES Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(16) Additional Compounds for NES Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NES: view

Transcripts for NES Gene

mRNA/cDNA for NES Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for NES

Alternative Splicing Database (ASD) splice patterns (SP) for NES Gene

No ASD Table

Relevant External Links for NES Gene

GeneLoc Exon Structure for
NES

Expression for NES Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NES Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NES Gene

This gene is overexpressed in Heart - Atrial Appendage (x6.0) and Heart - Left Ventricle (x4.7).

Protein differential expression in normal tissues from HIPED for NES Gene

This gene is overexpressed in Fetal Brain (18.4) and Fetal heart (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NES Gene



Protein tissue co-expression partners for NES Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NES

SOURCE GeneReport for Unigene cluster for NES Gene:

Hs.527971

mRNA Expression by UniProt/SwissProt for NES Gene:

P48681-NEST_HUMAN
Tissue specificity: CNS stem cells.

Evidence on tissue expression from TISSUES for NES Gene

  • Liver(4.5)
  • Nervous system(4.3)
  • Heart(3.2)
  • Muscle(3.2)
  • Lung(2.7)
  • Eye(2.6)
  • Kidney(2.6)
  • Intestine(2.4)
  • Pancreas(2.4)
  • Skin(2.4)
  • Adrenal gland(2.2)
  • Bone marrow(2.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with NES: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NES Gene

Orthologs for NES Gene

This gene was present in the common ancestor of chordates.

Orthologs for NES Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NES 31 30
  • 99.06 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NES 31 30
  • 79.21 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NES 31
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nes 31
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NES 31
  • 32 (a)
OneToOne
chicken
(Gallus gallus)
Aves NES 31
  • 19 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nes 31
  • 17 (a)
OneToOne
Species where no ortholog for NES was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NES Gene

ENSEMBL:
Gene Tree for NES (if available)
TreeFam:
Gene Tree for NES (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NES: view image

Paralogs for NES Gene

(1) SIMAP similar genes for NES Gene using alignment to 5 proteins:

  • NEST_HUMAN
  • A5PKT9_HUMAN
  • D3DVC4_HUMAN
  • Q05BW3_HUMAN
  • Q2YDX4_HUMAN
genes like me logo Genes that share paralogs with NES: view

Variants for NES Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NES Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
708056 Benign: not provided 156,673,163(-) C/T MISSENSE_VARIANT
712087 Likely Benign: not provided 156,670,875(-) C/A MISSENSE_VARIANT
720899 Likely Benign: not provided 156,669,753(-) C/T MISSENSE_VARIANT
729087 Likely Benign: not provided 156,671,002(-) C/A SYNONYMOUS_VARIANT
729711 Benign: not provided 156,671,817(-) G/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for NES Gene

Structural Variations from Database of Genomic Variants (DGV) for NES Gene

Variant ID Type Subtype PubMed ID
nsv523181 CNV loss 19592680

Variation tolerance for NES Gene

Residual Variation Intolerance Score: 73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.71; 73.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NES Gene

Human Gene Mutation Database (HGMD)
NES
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NES

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NES Gene

Disorders for NES Gene

MalaCards: The human disease database

(67) MalaCards diseases for NES Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ependymoblastoma
  • embryonal tumor with multilayered rosettes
periventricular leukomalacia
  • pvl
medulloepithelioma
  • diktyoma, malignant
central neurocytoma
  • neurolipocytoma
embryonal carcinoma
  • primary extragonadal embryonal carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search NES in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NES

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NES: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NES Gene

Publications for NES Gene

  1. Characterization of the human nestin gene reveals a close evolutionary relationship to neurofilaments. (PMID: 1478958) Dahlstrand J … Lendahl U (Journal of cell science 1992) 2 3 4 54
  2. Heterogeneous expression of nestin in myofibroblasts of various human tissues. (PMID: 20518888) Kishaba Y … Niki T (Pathology international 2010) 3 23 54
  3. Nestin expression in glial and neuronal progenitors of the developing human spinal ganglia. (PMID: 20044038) Vukojevic K … Saraga-Babic M (Gene expression patterns : GEP 2010) 3 23 54
  4. Expression of nestin in lymph node metastasis and lymphangiogenesis in non-small cell lung cancer patients. (PMID: 20132963) Chen Z … Xiang AP (Human pathology 2010) 3 23 54
  5. The stem cell marker nestin predicts poor prognosis in human melanoma. (PMID: 19956860) Piras F … Sirigu P (Oncology reports 2010) 3 23 54

Products for NES Gene

Sources for NES Gene