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Aliases for NES Gene

Aliases for NES Gene

  • Nestin 2 3 3 5
  • Nbla00170 3

External Ids for NES Gene

Previous GeneCards Identifiers for NES Gene

  • GC00U990485
  • GC01M153416
  • GC01M153855
  • GC01M153451
  • GC01M154905
  • GC01M156639
  • GC01M127996

Summaries for NES Gene

Entrez Gene Summary for NES Gene

  • This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. [provided by RefSeq, Sep 2011]

GeneCards Summary for NES Gene

NES (Nestin) is a Protein Coding gene. Diseases associated with NES include Brain Stem Cancer and Ependymoblastoma. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include structural molecule activity and intermediate filament binding. An important paralog of this gene is SYNM.

UniProtKB/Swiss-Prot for NES Gene

  • Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity).

Gene Wiki entry for NES Gene

Additional gene information for NES Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NES Gene

Genomics for NES Gene

GeneHancer (GH) Regulatory Elements for NES Gene

Promoters and enhancers for NES Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J156672 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 671.5 +1.7 1716 6.1 PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF143 SP3 SP5 REST NES ENSG00000272068 GC01P156668
GH01J156656 Enhancer 2.2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 7.2 +13.1 13138 15.3 CLOCK MLX ZFP64 DMAP1 IRF4 ZNF213 E2F8 ZNF416 ZNF143 ZNF263 GON4L KHDC4 RRNAD1 LOC246784 MSTO2P PRCC LMNA ISG20L2 YY1AP1 TSACC
GH01J156696 Enhancer 0.5 dbSUPER 12.5 -20.1 -20094 2 MITF GLIS2 USF1 ZBTB33 ZIC2 PRDM1 NES LOC105371453 BCAN RRNAD1 ISG20L2 HDGF PRCC NAXE CRABP2 ENSG00000237588
GH01J156684 Enhancer 0.8 ENCODE dbSUPER 0.4 -7.2 -7226 1.1 FOSL1 CTCF JUND BRD9 IKZF1 ZFP36 RUNX3 SPI1 ENSG00000272068 ENSG00000237588 NES
GH01J156686 Enhancer 0.5 ENCODE 0.4 -9.1 -9067 0.2 JUND CEBPA CEBPB FOS THRB TCF7L2 ENSG00000237588 NES
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NES on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NES gene promoter:
  • Bach1
  • AhR
  • E47
  • Pax-5
  • Ik-3
  • Olf-1
  • Tal-1beta
  • RP58

Genomic Locations for NES Gene

Genomic Locations for NES Gene
chr1:156,668,763-156,677,397
(GRCh38/hg38)
Size:
8,635 bases
Orientation:
Minus strand
chr1:156,638,555-156,647,189
(GRCh37/hg19)
Size:
8,635 bases
Orientation:
Minus strand

Genomic View for NES Gene

Genes around NES on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NES Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NES Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NES Gene

Proteins for NES Gene

  • Protein details for NES Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48681-NEST_HUMAN
    Recommended name:
    Nestin
    Protein Accession:
    P48681
    Secondary Accessions:
    • O00552
    • Q3LIF5
    • Q5SYZ6

    Protein attributes for NES Gene

    Size:
    1621 amino acids
    Molecular mass:
    177439 Da
    Quaternary structure:
    • Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such as vimentin and alpha-internexin, tis protein preferentially forms heterodimers which can assemble to form intermediate filaments if nestin does not exceed 25%. Interacts with FHOD3 (By similarity).

neXtProt entry for NES Gene

Post-translational modifications for NES Gene

  • Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NES Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NES Gene

Domains & Families for NES Gene

Gene Families for NES Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NES Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NES Gene

Graphical View of Domain Structure for InterPro Entry

P48681

UniProtKB/Swiss-Prot:

NEST_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with NES: view

Function for NES Gene

Molecular function for NES Gene

UniProtKB/Swiss-Prot Function:
Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity).

Gene Ontology (GO) - Molecular Function for NES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005198 structural molecule activity IEA --
GO:0019215 intermediate filament binding ISS --
genes like me logo Genes that share ontologies with NES: view
genes like me logo Genes that share phenotypes with NES: view

Animal Model Products

miRNA for NES Gene

Clone Products

  • Addgene plasmids for NES

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NES Gene

Localization for NES Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NES gene
Compartment Confidence
extracellular 5
cytoskeleton 5
nucleus 4
plasma membrane 2
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19384922
GO:0005882 intermediate filament NAS 9917366
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with NES: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NES Gene

Pathways & Interactions for NES Gene

genes like me logo Genes that share pathways with NES: view

Gene Ontology (GO) - Biological Process for NES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IDA 19384922
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0007417 central nervous system development NAS 9917366
GO:0007420 brain development ISS --
genes like me logo Genes that share ontologies with NES: view

No data available for SIGNOR curated interactions for NES Gene

Drugs & Compounds for NES Gene

(12) Drugs for NES Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(15) Additional Compounds for NES Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NES: view

Transcripts for NES Gene

mRNA/cDNA for NES Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(49) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NES Gene

Nestin:
Representative Sequences:

Clone Products

  • Addgene plasmids for NES

Alternative Splicing Database (ASD) splice patterns (SP) for NES Gene

No ASD Table

Relevant External Links for NES Gene

GeneLoc Exon Structure for
NES
ECgene alternative splicing isoforms for
NES

Expression for NES Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NES Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NES Gene

This gene is overexpressed in Heart - Atrial Appendage (x6.0) and Heart - Left Ventricle (x4.7).

Protein differential expression in normal tissues from HIPED for NES Gene

This gene is overexpressed in Fetal Brain (18.4) and Fetal heart (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NES Gene



Protein tissue co-expression partners for NES Gene

NURSA nuclear receptor signaling pathways regulating expression of NES Gene:

NES

SOURCE GeneReport for Unigene cluster for NES Gene:

Hs.527971

mRNA Expression by UniProt/SwissProt for NES Gene:

P48681-NEST_HUMAN
Tissue specificity: CNS stem cells.

Evidence on tissue expression from TISSUES for NES Gene

  • Liver(4.5)
  • Nervous system(4.3)
  • Heart(3.2)
  • Muscle(3.2)
  • Lung(2.7)
  • Eye(2.6)
  • Kidney(2.6)
  • Intestine(2.4)
  • Pancreas(2.4)
  • Skin(2.4)
  • Adrenal gland(2.2)
  • Bone marrow(2.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with NES: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NES Gene

Orthologs for NES Gene

This gene was present in the common ancestor of chordates.

Orthologs for NES Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NES 34 33
  • 99.06 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NES 34 33
  • 79.21 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NES 34
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nes 34
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NES 34
  • 32 (a)
OneToOne
chicken
(Gallus gallus)
Aves NES 34
  • 19 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nes 34
  • 17 (a)
OneToOne
Species where no ortholog for NES was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NES Gene

ENSEMBL:
Gene Tree for NES (if available)
TreeFam:
Gene Tree for NES (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NES: view image

Paralogs for NES Gene

Paralogs for NES Gene

(1) SIMAP similar genes for NES Gene using alignment to 5 proteins:

  • NEST_HUMAN
  • A5PKT9_HUMAN
  • D3DVC4_HUMAN
  • Q05BW3_HUMAN
  • Q2YDX4_HUMAN
genes like me logo Genes that share paralogs with NES: view

Variants for NES Gene

Sequence variations from dbSNP and Humsavar for NES Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs114406081 benign, not specified 156,672,363(-) C/G coding_sequence_variant, missense_variant
rs1000043642 -- 156,670,849(-) A/T coding_sequence_variant, missense_variant
rs1000138137 -- 156,671,132(-) G/C coding_sequence_variant, missense_variant
rs1000643984 -- 156,674,354(-) T/A intron_variant
rs1000949570 -- 156,676,321(-) G/C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NES Gene

Variant ID Type Subtype PubMed ID
nsv523181 CNV loss 19592680

Variation tolerance for NES Gene

Residual Variation Intolerance Score: 73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.71; 73.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NES Gene

Human Gene Mutation Database (HGMD)
NES
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NES

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NES Gene

Disorders for NES Gene

MalaCards: The human disease database

(48) MalaCards diseases for NES Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
brain stem cancer
  • malignant neoplasm of brain stem
ependymoblastoma
periventricular leukomalacia
  • pvl
spinal cord neuroblastoma
  • neuroblastoma of the spinal cord
medulloepithelioma
  • diktyoma, malignant
- elite association - COSMIC cancer census association via MalaCards
Search NES in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NES

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NES: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NES Gene

Publications for NES Gene

  1. Characterization of the human nestin gene reveals a close evolutionary relationship to neurofilaments. (PMID: 1478958) Dahlstrand J … Lendahl U (Journal of cell science 1992) 2 3 4 58
  2. The stem cell marker nestin predicts poor prognosis in human melanoma. (PMID: 19956860) Piras F … Sirigu P (Oncology reports 2010) 3 22 58
  3. Nestin expression in glial and neuronal progenitors of the developing human spinal ganglia. (PMID: 20044038) Vukojevic K … Saraga-Babic M (Gene expression patterns : GEP 2010) 3 22 58
  4. Expression of nestin in lymph node metastasis and lymphangiogenesis in non-small cell lung cancer patients. (PMID: 20132963) Chen Z … Xiang AP (Human pathology 2010) 3 22 58
  5. Heterogeneous expression of nestin in myofibroblasts of various human tissues. (PMID: 20518888) Kishaba Y … Niki T (Pathology international 2010) 3 22 58

Products for NES Gene

Sources for NES Gene

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