This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and diffe... See more...

Aliases for NEO1 Gene

Aliases for NEO1 Gene

  • Neogenin 1 2 3 5
  • IGDCC2 2 3 4
  • NGN 2 3 4
  • Immunoglobulin Superfamily DCC Subclass Member 2 3 4
  • Neogenin 3 4
  • NTN1R2 2 3
  • Immunoglobulin Superfamily, DCC Subclass, Member 2 2
  • Neogenin (Chicken) Homolog 1 2
  • Neogenin Homolog 1 3
  • HsT17534 2
  • NEO1 5

External Ids for NEO1 Gene

Previous GeneCards Identifiers for NEO1 Gene

  • GC15P069350
  • GC15P066449
  • GC15P070920
  • GC15P071060
  • GC15P071131
  • GC15P073346
  • GC15P050240

Summaries for NEO1 Gene

Entrez Gene Summary for NEO1 Gene

  • This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

GeneCards Summary for NEO1 Gene

NEO1 (Neogenin 1) is a Protein Coding gene. Diseases associated with NEO1 include Corneal Intraepithelial Neoplasm and Hemochromatosis Type 2. Among its related pathways are Neuroscience and Netrin-1 signaling. Gene Ontology (GO) annotations related to this gene include cadherin binding. An important paralog of this gene is DCC.

UniProtKB/Swiss-Prot Summary for NEO1 Gene

  • Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.

Gene Wiki entry for NEO1 Gene

Additional gene information for NEO1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NEO1 Gene

Genomics for NEO1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NEO1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J073050 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 608.4 +1.3 1269 4.8 BRCA1 PRDM10 ZNF629 ZNF692 TARDBP LARP7 PRDM1 PHF21A ZIC2 ZSCAN4 NEO1 lnc-ADPGK-4 TMEM202-AS1 ARIH1 HEXA BBS4 ENSG00000261460 PML MYO9A ENSG00000261187
GH15J073027 Enhancer 0.7 Ensembl ENCODE 24.1 -22.2 -22243 4.1 POLR2A ZNF316 MAFF MAFK MAFG NR2F2 EMSY HSALNG0107101 NEO1 HSALNG0107099 ADPGK
GH15J073082 Enhancer 0.8 Ensembl ENCODE 19 +31.4 31384 0.8 PRDM1 SP1 GABPA YY1 JUND RAD21 CREM HNF4A RXRA MAX NEO1 lnc-ADPGK-4 piR-49189 HCN4
GH15J073077 Enhancer 0.9 Ensembl dbSUPER 15.6 +27.7 27691 3.2 ZNF629 ZNF692 PRDM1 SOX6 CEBPA SOX13 ZBTB44 CEBPB ZXDB ZSCAN5C NEO1 lnc-ADPGK-4 piR-49189 HCN4
GH15J073072 Enhancer 0.7 Ensembl dbSUPER 17.1 +23.6 23591 1.4 ZNF629 ZNF600 ZXDB CEBPB SCRT1 ZFHX2 PRDM6 ZNF2 YY2 HLF NEO1 lnc-ADPGK-4 piR-49189 HCN4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NEO1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NEO1

Top Transcription factor binding sites by QIAGEN in the NEO1 gene promoter:
  • AREB6
  • ATF6
  • Chx10
  • HOXA5
  • Lhx3a
  • LHX3b
  • Pax-4a
  • POU3F2
  • RSRFC4
  • SRY

Genomic Locations for NEO1 Gene

Genomic Locations for NEO1 Gene
chr15:73,051,710-73,305,206
(GRCh38/hg38)
Size:
253,497 bases
Orientation:
Plus strand
chr15:73,344,051-73,597,547
(GRCh37/hg19)
Size:
253,497 bases
Orientation:
Plus strand

Genomic View for NEO1 Gene

Genes around NEO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEO1 Gene

Proteins for NEO1 Gene

  • Protein details for NEO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92859-NEO1_HUMAN
    Recommended name:
    Neogenin
    Protein Accession:
    Q92859
    Secondary Accessions:
    • B7ZKM9
    • B7ZKN0
    • O00340
    • Q17RX1

    Protein attributes for NEO1 Gene

    Size:
    1461 amino acids
    Molecular mass:
    160017 Da
    Quaternary structure:
    • Interacts with MYO10 (By similarity). Interacts with RGMA and RGMB. Interacts with BMP2, BMP4, BMP6, and BMP7.
    Miscellaneous:
    • Knockdown of NEO1 in C2C12 cells results in the enhancement of the BMP-2-induced processes of osteoblastic differentiation and phosphorylation of Smad1, Smad5, and Smad8. Conversely, overexpression suppresses these processes.

    Three dimensional structures from OCA and Proteopedia for NEO1 Gene

    Alternative splice isoforms for NEO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEO1 Gene

Post-translational modifications for NEO1 Gene

  • Glycosylation at Asn73, Asn210, Asn326, Asn470, Asn489, Asn639, Asn715, Asn909, Asn1146, and Asn1298
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

No data available for DME Specific Peptides for NEO1 Gene

Domains & Families for NEO1 Gene

Gene Families for NEO1 Gene

Protein Domains for NEO1 Gene

InterPro:
Blocks:
  • Immunoglobulin C-2 type
  • Fibronectin type III repeat signature
  • Neogenin, C-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for NEO1 Gene

GenScript: Design optimal peptide antigens:
  • NEO1 protein (B7ZKN0_HUMAN)
  • Immunoglobulin superfamily DCC subclass member 2 (NEO1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92859

UniProtKB/Swiss-Prot:

NEO1_HUMAN :
  • The Fibronectin repeats 5 and 6 mediate interaction with RGM family molecules.
  • Belongs to the immunoglobulin superfamily. DCC family.
Domain:
  • The Fibronectin repeats 5 and 6 mediate interaction with RGM family molecules.
Family:
  • Belongs to the immunoglobulin superfamily. DCC family.
genes like me logo Genes that share domains with NEO1: view

Function for NEO1 Gene

Molecular function for NEO1 Gene

UniProtKB/Swiss-Prot Function:
Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.
GENATLAS Biochemistry:
neogenin,cell surface protein,DCC related member of the Ig superfamily,expressed in nervous system of embryo

Phenotypes From GWAS Catalog for NEO1 Gene

Gene Ontology (GO) - Molecular Function for NEO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18335997
GO:0038023 signaling receptor activity IEA --
GO:0039706 co-receptor binding IPI 18335997
genes like me logo Genes that share ontologies with NEO1: view
genes like me logo Genes that share phenotypes with NEO1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NEO1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEO1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEO1 Gene

Localization for NEO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEO1 Gene

Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEO1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
golgi apparatus 4
extracellular 2
cytoskeleton 2
mitochondrion 2
endosome 2
cytosol 2
endoplasmic reticulum 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Golgi apparatus (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NEO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane NAS,TAS --
GO:0005887 integral component of plasma membrane TAS,IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NEO1: view

Pathways & Interactions for NEO1 Gene

genes like me logo Genes that share pathways with NEO1: view

Pathways by source for NEO1 Gene

3 Cell Signaling Technology pathways for NEO1 Gene

Gene Ontology (GO) - Biological Process for NEO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion NAS,IEA --
GO:0007399 nervous system development IEA --
GO:0007411 axon guidance IEA --
GO:0030513 positive regulation of BMP signaling pathway IEA --
GO:0055072 iron ion homeostasis IGI 16075058
genes like me logo Genes that share ontologies with NEO1: view

No data available for SIGNOR curated interactions for NEO1 Gene

Drugs & Compounds for NEO1 Gene

No Compound Related Data Available

Transcripts for NEO1 Gene

mRNA/cDNA for NEO1 Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEO1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEO1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: -
SP2: - -

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29
SP1:
SP2:

Relevant External Links for NEO1 Gene

GeneLoc Exon Structure for
NEO1

Expression for NEO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NEO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NEO1 Gene

This gene is overexpressed in Serum (23.3), Lavage (10.7), Cerebrospinal fluid (7.0), and Fetal Brain (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NEO1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NEO1

SOURCE GeneReport for Unigene cluster for NEO1 Gene:

Hs.388613

mRNA Expression by UniProt/SwissProt for NEO1 Gene:

Q92859-NEO1_HUMAN
Tissue specificity: Widely expressed and also in cancer cell lines.

Evidence on tissue expression from TISSUES for NEO1 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Bone marrow(4.3)
  • Intestine(3.4)
  • Kidney(2.7)
  • Skin(2.6)
  • Muscle(2.6)
  • Lung(2.5)
  • Eye(2.4)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with NEO1: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEO1 Gene

Orthologs for NEO1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEO1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NEO1 30 31
  • 99.61 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NEO1 30 31
  • 93.27 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NEO1 30 31
  • 93.11 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia NEO1 31
  • 92 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NEO1 31
  • 91 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Neo1 30 17 31
  • 90.74 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Neo1 30
  • 90.5 (n)
Chicken
(Gallus gallus)
Aves NEO1 30 31
  • 79.73 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NEO1 31
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.16267 30
Zebrafish
(Danio rerio)
Actinopterygii neo1 30 31
  • 68.01 (n)
OneToMany
NEO1 (2 of 2) 31
  • 64 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta fra 30 31 32
  • 47.08 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006083 30
  • 46.44 (n)
Worm
(Caenorhabditis elegans)
Secernentea unc-40 31 32
  • 29 (a)
OneToMany
Species where no ortholog for NEO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for NEO1 Gene

ENSEMBL:
Gene Tree for NEO1 (if available)
TreeFam:
Gene Tree for NEO1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NEO1: view image

Paralogs for NEO1 Gene

(3) SIMAP similar genes for NEO1 Gene using alignment to 2 proteins:

  • NEO1_HUMAN
  • Q59FP8_HUMAN
genes like me logo Genes that share paralogs with NEO1: view

Variants for NEO1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NEO1 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
732123 Likely Benign: not provided 73,135,923(+) G/A MISSENSE_VARIANT
771006 Benign: not provided 73,135,883(+) T/A INTRON_VARIANT
777250 Benign: not provided 73,122,739(+) C/T SYNONYMOUS_VARIANT
786275 Benign: not provided 73,236,456(+) C/T SYNONYMOUS_VARIANT
786276 Benign: not provided 73,301,421(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for NEO1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NEO1 Gene

Variant ID Type Subtype PubMed ID
esv2061446 CNV deletion 18987734
esv2672004 CNV deletion 23128226
esv2749869 CNV deletion 23290073
esv2749870 CNV deletion 23290073
esv3552673 CNV deletion 23714750
nsv1118318 CNV deletion 24896259
nsv1121512 CNV deletion 24896259
nsv1134468 CNV deletion 24896259
nsv474887 CNV novel sequence insertion 20440878
nsv517966 CNV gain 19592680
nsv525462 CNV loss 19592680
nsv527236 CNV gain 19592680
nsv94493 CNV insertion 16902084
nsv958015 CNV deletion 24416366
nsv977734 CNV duplication 23825009

Variation tolerance for NEO1 Gene

Residual Variation Intolerance Score: 1.27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NEO1 Gene

Human Gene Mutation Database (HGMD)
NEO1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEO1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEO1 Gene

Disorders for NEO1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for NEO1 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search NEO1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NEO1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with NEO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEO1 Gene

Publications for NEO1 Gene

  1. Identification and characterization of neogenin, a DCC-related gene. (PMID: 9121761) Meyerhardt JA … Fearon ER (Oncogene 1997) 2 3 4 23
  2. Molecular characterization of human neogenin, a DCC-related protein, and the mapping of its gene (NEO1) to chromosomal position 15q22.3-q23. (PMID: 9169140) Vielmetter J … Dreyer WJ (Genomics 1997) 3 4 23
  3. Neogenin, a receptor for bone morphogenetic proteins. (PMID: 21149453) Hagihara M … Yamashita T (The Journal of biological chemistry 2011) 3 4
  4. Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin. (PMID: 18287331) Kuns-Hashimoto R … Rotwein P (American journal of physiology. Cell physiology 2008) 3 4
  5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4

Products for NEO1 Gene

  • Signalway ELISA kits for NEO1
  • Signalway Proteins for NEO1

Sources for NEO1 Gene