Aliases for NEO1 Gene
External Ids for NEO1 Gene
Previous GeneCards Identifiers for NEO1 Gene
This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
GeneCards Summary for NEO1 Gene
NEO1 (Neogenin 1) is a Protein Coding gene. Diseases associated with NEO1 include Corneal Intraepithelial Neoplasm and Hemochromatosis Type 2. Among its related pathways are Adhesion and TGF-beta signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include cadherin binding. An important paralog of this gene is DCC.
UniProtKB/Swiss-Prot Summary for NEO1 Gene
Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.