Aliases for NENF Gene
External Ids for NENF Gene
Previous GeneCards Identifiers for NENF Gene
This gene encodes a neurotrophic factor that may play a role in neuron differentiation and development. A pseudogene of this gene is found on chromosome 12. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2009]
GeneCards Summary for NENF Gene
NENF (Neudesin Neurotrophic Factor) is a Protein Coding gene. Diseases associated with NENF include Combat Disorder and Deafness, Autosomal Dominant 9. Gene Ontology (GO) annotations related to this gene include growth factor activity and heme binding.
UniProtKB/Swiss-Prot Summary for NENF Gene
Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocyte. Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme. Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity). Plays a role in the human tumorigenesis (PubMed:22748190).