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Aliases for NEMP2 Gene

Aliases for NEMP2 Gene

  • Nuclear Envelope Integral Membrane Protein 2 2 3 5
  • Transmembrane Protein 194B 2 3
  • TMEM194B 3 4
  • UPF0571 Transmembrane Protein 3

External Ids for NEMP2 Gene

Previous HGNC Symbols for NEMP2 Gene

  • TMEM194B

Summaries for NEMP2 Gene

GeneCards Summary for NEMP2 Gene

NEMP2 (Nuclear Envelope Integral Membrane Protein 2) is a Protein Coding gene. An important paralog of this gene is NEMP1.

Additional gene information for NEMP2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEMP2 Gene

Genomics for NEMP2 Gene

GeneHancer (GH) Regulatory Elements for NEMP2 Gene

Promoters and enhancers for NEMP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I190532 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 557.5 +9.2 9152 4.8 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B NEMP2 ENSG00000233654 MFSD6 NAB1 ORMDL1 GC02M190517 GC02P190518
GH02I190541 Enhancer 0.3 FANTOM5 550.8 +1.9 1869 0.3 SETDB1 NEMP2 MFSD6 ENSG00000233654
GH02I190545 Enhancer 0.2 Ensembl 550.8 -1.9 -1876 0.2 NEMP2 MFSD6 GC02M190554 ENSG00000233654
GH02I190406 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 23.6 +135.3 135276 3.1 RB1 ZFP64 ZNF76 SIN3A THRB ZNF335 GLIS2 BCLAF1 IKZF2 EGR2 MFSD6 NEMP2 ENSG00000233654 INPP1 GC02M190388
GH02I190605 Enhancer 1.3 Ensembl ENCODE dbSUPER 35.4 -63.8 -63790 3.4 HDGF HDAC1 PKNOX1 TAF9B SIN3A IRF4 TCF12 EGR1 ATF7 FOS NEMP2 NAB1 MFSD6 ENSG00000233654 ENSG00000228509 GC02M190569 ENSG00000284052
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NEMP2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NEMP2 Gene

Genomic Locations for NEMP2 Gene
chr2:190,454,092-190,543,625
(GRCh38/hg38)
Size:
89,534 bases
Orientation:
Minus strand
chr2:191,369,068-191,399,468
(GRCh37/hg19)

Genomic View for NEMP2 Gene

Genes around NEMP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEMP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEMP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEMP2 Gene

Proteins for NEMP2 Gene

  • Protein details for NEMP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NFY4-NEMP2_HUMAN
    Recommended name:
    Nuclear envelope integral membrane protein 2
    Protein Accession:
    A6NFY4
    Secondary Accessions:
    • B4DYG6

    Protein attributes for NEMP2 Gene

    Size:
    417 amino acids
    Molecular mass:
    48664 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NEMP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEMP2 Gene

Post-translational modifications for NEMP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NEMP2 Gene

Domains & Families for NEMP2 Gene

Gene Families for NEMP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NEMP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NEMP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NFY4

UniProtKB/Swiss-Prot:

NEMP2_HUMAN :
  • Belongs to the NEMP family.
Family:
  • Belongs to the NEMP family.
genes like me logo Genes that share domains with NEMP2: view

Function for NEMP2 Gene

Phenotypes From GWAS Catalog for NEMP2 Gene

Phenotypes for NEMP2 Gene

GenomeRNAi human phenotypes for NEMP2:
genes like me logo Genes that share phenotypes with NEMP2: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEMP2 Gene

Localization for NEMP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEMP2 Gene

Nucleus inner membrane; Multi-pass membrane protein; Nucleoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEMP2 gene
Compartment Confidence
nucleus 4
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NEMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IBA --
GO:0005637 nuclear inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NEMP2: view

Pathways & Interactions for NEMP2 Gene

SuperPathways for NEMP2 Gene

No Data Available

Interacting Proteins for NEMP2 Gene

Gene Ontology (GO) - Biological Process for NEMP2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NEMP2 Gene

Drugs & Compounds for NEMP2 Gene

No Compound Related Data Available

Transcripts for NEMP2 Gene

mRNA/cDNA for NEMP2 Gene

(8) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEMP2 Gene

No ASD Table

Relevant External Links for NEMP2 Gene

GeneLoc Exon Structure for
NEMP2
ECgene alternative splicing isoforms for
NEMP2

Expression for NEMP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NEMP2 Gene:

NEMP2
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEMP2 Gene

Orthologs for NEMP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEMP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM194B 33 34
  • 99.12 (n)
cow
(Bos Taurus)
Mammalia TMEM194B 33 34
  • 80.75 (n)
mouse
(Mus musculus)
Mammalia Tmem194b 33 34
  • 80.67 (n)
Nemp2 16
dog
(Canis familiaris)
Mammalia TMEM194B 33 34
  • 80 (n)
rat
(Rattus norvegicus)
Mammalia Tmem194b 33
  • 79.64 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM194B 34
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM194B 33 34
  • 59.55 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM194B 34
  • 44 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem194b 33 34
  • 48.09 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9723 34
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F10C5.2 34
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 20 (a)
OneToMany
Species where no ortholog for NEMP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NEMP2 Gene

ENSEMBL:
Gene Tree for NEMP2 (if available)
TreeFam:
Gene Tree for NEMP2 (if available)

Paralogs for NEMP2 Gene

Paralogs for NEMP2 Gene

genes like me logo Genes that share paralogs with NEMP2: view

Variants for NEMP2 Gene

Sequence variations from dbSNP and Humsavar for NEMP2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000018158 -- 190,499,584(-) C/G genic_downstream_transcript_variant, intron_variant
rs1000023906 -- 190,546,697(-) T/A genic_upstream_transcript_variant, intron_variant
rs1000026890 -- 190,460,331(-) T/A genic_downstream_transcript_variant, intron_variant
rs1000058512 -- 190,517,930(-) A/C intron_variant
rs1000078690 -- 190,460,536(-) T/C genic_downstream_transcript_variant, intron_variant

Variation tolerance for NEMP2 Gene

Gene Damage Index Score: 5.02; 68.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NEMP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEMP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NEMP2 Gene

Disorders for NEMP2 Gene

Additional Disease Information for NEMP2

No disorders were found for NEMP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEMP2 Gene

Publications for NEMP2 Gene

  1. The Inner Nuclear Membrane Protein Nemp1 Is a New Type of RanGTP-Binding Protein in Eukaryotes. (PMID: 25946333) Shibano T … Taira M (PloS one 2015) 2 3 58
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for NEMP2 Gene

Sources for NEMP2 Gene

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