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Aliases for NEMP1 Gene

Aliases for NEMP1 Gene

  • Nuclear Envelope Integral Membrane Protein 1 2 3 5
  • Transmembrane Protein 194A 2 3
  • Transmembrane Protein 194 2 3
  • TMEM194A 3 4
  • TMEM194 3 4
  • KIAA0286 4

External Ids for NEMP1 Gene

Previous HGNC Symbols for NEMP1 Gene

  • TMEM194
  • TMEM194A

Summaries for NEMP1 Gene

GeneCards Summary for NEMP1 Gene

NEMP1 (Nuclear Envelope Integral Membrane Protein 1) is a Protein Coding gene. An important paralog of this gene is NEMP2.

Additional gene information for NEMP1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEMP1 Gene

Genomics for NEMP1 Gene

GeneHancer (GH) Regulatory Elements for NEMP1 Gene

Promoters and enhancers for NEMP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I057077 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 600.1 +9.9 9860 3.2 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 NEMP1 BAZ2A ZC3H10 MBD6 ENSG00000258317 RN7SL809P CDK4 MYO1A ZBTB39 ATP23
GH12I057109 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 236.9 -22.4 -22397 3.8 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF416 ZNF143 ZNF548 MCM3 STAT6 NEMP1 EEF1AKMT3 ENSG00000257740 BAZ2A PAN2 SMARCC2 ANKRD52 CDK4 CTDSP2
GH12I056220 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 178.4 +866.0 865975 5.7 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 NABP2 RNF41 NEMP1 BAZ2A PAN2 DNAJC14 ANKRD52 PHC1P1 ZBTB39 RN7SL809P
GH12I056266 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 127.2 +821.7 821663 2 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 COQ10A GC12M056238 NEMP1 PAN2 BAZ2A PHC1P1 ANKRD52 DNAJC14 SMARCC2 RN7SL809P
GH12I056683 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 69.2 +402.1 402086 7.8 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 PTGES3 GC12M056688 BAZ2A NEMP1 RN7SL809P MBD6 DNAJC14 ZC3H10 ENSG00000258317 PYM1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NEMP1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NEMP1 Gene

Genomic Locations for NEMP1 Gene
chr12:57,055,643-57,088,857
(GRCh38/hg38)
Size:
33,215 bases
Orientation:
Minus strand
chr12:57,449,426-57,481,846
(GRCh37/hg19)

Genomic View for NEMP1 Gene

Genes around NEMP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEMP1 Gene

Proteins for NEMP1 Gene

  • Protein details for NEMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14524-NEMP1_HUMAN
    Recommended name:
    Nuclear envelope integral membrane protein 1
    Protein Accession:
    O14524
    Secondary Accessions:
    • Q17R72
    • Q68DH0
    • Q6IQ25

    Protein attributes for NEMP1 Gene

    Size:
    444 amino acids
    Molecular mass:
    50640 Da
    Quaternary structure:
    • Homooligomer. Interacts with RAN-GTP.
    SequenceCaution:
    • Sequence=AAH71597.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA22955.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NEMP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEMP1 Gene

Post-translational modifications for NEMP1 Gene

No data available for DME Specific Peptides for NEMP1 Gene

Domains & Families for NEMP1 Gene

Gene Families for NEMP1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for NEMP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NEMP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14524

UniProtKB/Swiss-Prot:

NEMP1_HUMAN :
  • The transmembrane domains are required and sufficient for its oligomerization.
  • Belongs to the NEMP family.
Domain:
  • The transmembrane domains are required and sufficient for its oligomerization.
Family:
  • Belongs to the NEMP family.
genes like me logo Genes that share domains with NEMP1: view

Function for NEMP1 Gene

Phenotypes From GWAS Catalog for NEMP1 Gene

Gene Ontology (GO) - Molecular Function for NEMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with NEMP1: view

Phenotypes for NEMP1 Gene

GenomeRNAi human phenotypes for NEMP1:
genes like me logo Genes that share phenotypes with NEMP1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEMP1 Gene

Localization for NEMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEMP1 Gene

Nucleus inner membrane; Multi-pass membrane protein; Nucleoplasmic side. Nucleus envelope. Note=Colocalizes with lamins and RAN-GTP at the nuclear envelope. {ECO:0000250 UniProtKB:Q6ZQE4}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEMP1 gene
Compartment Confidence
nucleus 5
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NEMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope ISS --
GO:0005637 nuclear inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NEMP1: view

Pathways & Interactions for NEMP1 Gene

SuperPathways for NEMP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NEMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NEMP1: view

No data available for Pathways by source and SIGNOR curated interactions for NEMP1 Gene

Drugs & Compounds for NEMP1 Gene

No Compound Related Data Available

Transcripts for NEMP1 Gene

mRNA/cDNA for NEMP1 Gene

(10) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEMP1 Gene

No ASD Table

Relevant External Links for NEMP1 Gene

GeneLoc Exon Structure for
NEMP1
ECgene alternative splicing isoforms for
NEMP1

Expression for NEMP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NEMP1 Gene:

NEMP1

Evidence on tissue expression from TISSUES for NEMP1 Gene

  • Liver(4.1)
  • Nervous system(4.1)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEMP1 Gene

Orthologs for NEMP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEMP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM194A 34 33
  • 99.77 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM194A 34 33
  • 91.48 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM194A 34 33
  • 89.41 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem194 34 33
  • 85.4 (n)
OneToOne
Nemp1 16
rat
(Rattus norvegicus)
Mammalia Tmem194 33
  • 84.55 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM194A 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM194A 34
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM194A 34 33
  • 65.84 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM194A 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem194a 33
  • 65.81 (n)
Str.3173 33
zebrafish
(Danio rerio)
Actinopterygii tmem194a 34 33
  • 59.98 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9723 34
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F10C5.2 34
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
OneToMany
Species where no ortholog for NEMP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEMP1 Gene

ENSEMBL:
Gene Tree for NEMP1 (if available)
TreeFam:
Gene Tree for NEMP1 (if available)

Paralogs for NEMP1 Gene

Paralogs for NEMP1 Gene

genes like me logo Genes that share paralogs with NEMP1: view

Variants for NEMP1 Gene

Sequence variations from dbSNP and Humsavar for NEMP1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000197083 -- 57,059,173(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000224945 -- 57,061,624(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000231914 -- 57,074,137(-) T/G intron_variant
rs1000287517 -- 57,072,180(-) A/G intron_variant
rs1000401430 -- 57,067,465(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NEMP1 Gene

Variant ID Type Subtype PubMed ID
nsv832428 CNV gain 17160897
nsv482992 CNV gain+loss 15286789

Variation tolerance for NEMP1 Gene

Residual Variation Intolerance Score: 68.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 52.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NEMP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEMP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEMP1 Gene

Disorders for NEMP1 Gene

Additional Disease Information for NEMP1

No disorders were found for NEMP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEMP1 Gene

Publications for NEMP1 Gene

  1. The Inner Nuclear Membrane Protein Nemp1 Is a New Type of RanGTP-Binding Protein in Eukaryotes. (PMID: 25946333) Shibano T … Taira M (PloS one 2015) 2 3 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D … Nagase T (DNA research : an international journal for rapid publication of reports on genes and genomes 2002) 3 4 58
  4. Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. (PMID: 9179496) Ohara O … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for NEMP1 Gene

Sources for NEMP1 Gene

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