Aliases for NEMF Gene
External Ids for NEMF Gene
Previous HGNC Symbols for NEMF Gene
Previous GeneCards Identifiers for NEMF Gene
This gene encodes a component of the ribosome quality control complex. The encoded protein facilitates the recognition and ubiquitination of stalled 60S subunits by the ubiquitin ligase listerin. A similar protein in fly functions as a tumor suppressor. [provided by RefSeq, Jul 2016]
GeneCards Summary for NEMF Gene
NEMF (Nuclear Export Mediator Factor) is a Protein Coding gene. Diseases associated with NEMF include Atrial Septal Defect 6.
UniProtKB/Swiss-Prot Summary for NEMF Gene
Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. NEMF is important for the stable association of LTN1 to the complex (PubMed:25578875). May indirectly play a role in nuclear export (PubMed:16103875).