Aliases for NELFCD Gene
External Ids for NELFCD Gene
Previous HGNC Symbols for NELFCD Gene
Previous GeneCards Identifiers for NELFCD Gene
The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini. [provided by RefSeq, Jul 2008]
GeneCards Summary for NELFCD Gene
NELFCD (Negative Elongation Factor Complex Member C/D) is a Protein Coding gene. Diseases associated with NELFCD include Hyperlucent Lung and Ascaridiasis. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and Gene Expression.
UniProtKB/Swiss-Prot for NELFCD Gene
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Binds RNA which may help to stabilize the NELF complex on nucleic acid. In vitro, the NELFA:NELFCD subcomplex binds to ssDNA and ssRNA in a sequence- and structure-dependent manner.