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The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini. [provided by RefSeq, Jul 2008]
NELFCD (Negative Elongation Factor Complex Member C/D) is a Protein Coding gene. Diseases associated with NELFCD include Glanders and Hyperlucent Lung. Among its related pathways are HIV Transcription Elongation and Chromatin Regulation / Acetylation.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 12612062 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0016020 | membrane | HDA | 19946888 |
GO:0032021 | NELF complex | IBA,IDA | 12612062 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | HIV Transcription Elongation | ||
2 | HIV Life Cycle |
.91
.65
|
.45
|
3 | Gene Expression |
.48
|
|
4 | Chromatin Regulation / Acetylation | ||
5 | MAP Kinase Signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006366 | transcription by RNA polymerase II | TAS | -- |
GO:0006368 | transcription elongation from RNA polymerase II promoter | TAS | -- |
GO:0034244 | negative regulation of transcription elongation from RNA polymerase II promoter | IBA | 21873635 |
GO:0045892 | negative regulation of transcription, DNA-templated | IEA | -- |
GO:0050434 | positive regulation of viral transcription | TAS | -- |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: |
ExUns: | 15b | ^ | 16a | · | 16b |
---|---|---|---|---|---|
SP1: | |||||
SP2: | |||||
SP3: | |||||
SP4: | |||||
SP5: | |||||
SP6: | |||||
SP7: | |||||
SP8: | |||||
SP9: | |||||
SP10: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TH1L 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NELFCD 31 |
|
OneToOne | |
LOC477276 30 |
|
||||
Cow (Bos Taurus) |
Mammalia | NELFCD 31 |
|
OneToOne | |
LOC514958 30 |
|
||||
Platypus (Ornithorhynchus anatinus) |
Mammalia | NELFCD 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | NELFCD 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Nelfcd 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Nelfcd 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TH1L 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NELFCD 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | nelfcd 30 |
|
||
Str.10276 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.3030 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | nelfcd 30 31 |
|
OneToOne | |
zgc55482 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000391 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | TH1 30 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.4834 30 |
|
SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
784412 | Benign: not provided | 58,993,122(+) | C/T |
Disorder | Aliases | PubMed IDs |
---|---|---|
glanders |
|
|
hyperlucent lung |
|
|
tuberculoid leprosy |
|
|
mucocutaneous leishmaniasis |
|
|
inflammatory bowel disease 16 |
|
|