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NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 [PubMed 12612062]).[supplied by OMIM, Mar 2008]
NELFB (Negative Elongation Factor Complex Member B) is a Protein Coding gene. Among its related pathways are HIV Life Cycle and Formation of HIV-1 elongation complex containing HIV-1 Tat.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 11739404 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA, TAS | -- |
GO:0005737 | cytoplasm | IDA | -- |
GO:0032021 | NELF complex | IDA, IBA | 12612062 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Formation of HIV-1 elongation complex containing HIV-1 Tat | ||
2 | HIV Life Cycle |
.91
.64
|
.45
|
3 | Gene Expression |
.48
|
|
4 | Chromatin Regulation / Acetylation | ||
5 | Regulation of TP53 Activity |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006366 | transcription by RNA polymerase II | TAS | -- |
GO:0006368 | transcription elongation from RNA polymerase II promoter | TAS | -- |
GO:0008283 | cell proliferation | ISS | -- |
GO:0034244 | negative regulation of transcription elongation from RNA polymerase II promoter | ISS, IBA | -- |
GO:0045892 | negative regulation of transcription, DNA-templated | IEA | -- |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||||||||
SP6: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NELFB 31 |
|
OneToOne | |
COBRA1 30 |
|
||||
Cow (Bos Taurus) |
Mammalia | COBRA1 31 |
|
OneToOne | |
NELFB 30 |
|
||||
Oppossum (Monodelphis domestica) |
Mammalia | NELFB 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NELFB 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Nelfb 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Nelfb 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | NELFB 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | COBRA1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NELFB 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | nelfb 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.7402 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | nelfb 30 31 |
|
OneToOne | |
zgc55628 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012109 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | NELF-B 30 31 |
|
OneToOne | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.3713 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv13009n54 | CNV | loss | 21841781 |
dgv13011n54 | CNV | loss | 21841781 |
esv2422220 | CNV | deletion | 17116639 |
esv2739418 | CNV | deletion | 23290073 |
esv2739419 | CNV | deletion | 23290073 |
nsv1161918 | CNV | duplication | 26073780 |
nsv524322 | CNV | loss | 19592680 |
nsv951207 | CNV | deletion | 24416366 |
No disorders were found for NELFB Gene.