This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein is activated in mitosis and, in turn, activates other family members during mitosis. This protein also mediates cellular processes that are essential for interphase progression. [provided by RefSeq, Jul 2016] See more...

Aliases for NEK9 Gene

Aliases for NEK9 Gene

  • NIMA Related Kinase 9 2 3 5
  • NERCC 2 3 4
  • NIMA (Never In Mitosis Gene A)- Related Kinase 9 2 3
  • Serine/Threonine-Protein Kinase Nek9 3 4
  • NimA-Related Protein Kinase 9 3 4
  • Nercc1 Kinase 3 4
  • EC 2.7.11.1 4 51
  • NERCC1 2 3
  • Nek8 2 4
  • Never In Mitosis A-Related Kinase 9 4
  • NimA-Related Kinase 8 4
  • DKFZp434D0935 2
  • MGC16714 2
  • KIAA1995 4
  • LCCS10 3
  • APUG 3
  • NEK9 5
  • NEK8 4
  • NC 3

External Ids for NEK9 Gene

Previous GeneCards Identifiers for NEK9 Gene

  • GC14M073077
  • GC14M069365
  • GC14M073538
  • GC14M073541
  • GC14M074618
  • GC14M075548
  • GC14M055716

Summaries for NEK9 Gene

Entrez Gene Summary for NEK9 Gene

  • This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein is activated in mitosis and, in turn, activates other family members during mitosis. This protein also mediates cellular processes that are essential for interphase progression. [provided by RefSeq, Jul 2016]

GeneCards Summary for NEK9 Gene

NEK9 (NIMA Related Kinase 9) is a Protein Coding gene. Diseases associated with NEK9 include Nevus Comedonicus and Arthrogryposis, Perthes Disease, And Upward Gaze Palsy. Among its related pathways are Mitotic Prophase and Transport of the SLBP independent Mature mRNA. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NEK8.

UniProtKB/Swiss-Prot Summary for NEK9 Gene

  • Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively.

Gene Wiki entry for NEK9 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NEK9 Gene

Genomics for NEK9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NEK9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NEK9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NEK9

Top Transcription factor binding sites by QIAGEN in the NEK9 gene promoter:
  • AML1a
  • c-Ets-1
  • CUTL1
  • Nkx2-5
  • Sox9
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT5A
  • YY1

Genomic Locations for NEK9 Gene

Genomic Locations for NEK9 Gene
chr14:75,079,353-75,127,637
(GRCh38/hg38)
Size:
48,285 bases
Orientation:
Minus strand
chr14:75,548,818-75,594,047
(GRCh37/hg19)
Size:
45,230 bases
Orientation:
Minus strand

Genomic View for NEK9 Gene

Genes around NEK9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEK9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEK9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEK9 Gene

Proteins for NEK9 Gene

  • Protein details for NEK9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD19-NEK9_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Nek9
    Protein Accession:
    Q8TD19
    Secondary Accessions:
    • Q52LK6
    • Q8NCN0
    • Q8TCY4
    • Q9UPI4
    • Q9Y6S4
    • Q9Y6S5
    • Q9Y6S6

    Protein attributes for NEK9 Gene

    Size:
    979 amino acids
    Molecular mass:
    107168 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer. Binds to Ran GTPase. Has a greater affinity for Ran-GDP over Ran-GTP. Interacts with NEK6, NEK7 and BICD2. Interacts with SSRP1 and SUPT16H, the 2 subunits of the FACT complex. Interacts with DYNLL1; phosphorylation at Ser-944 strongly reduces DYNLL1 binding.
    SequenceCaution:
    • Sequence=AAD31936.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC02704.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NEK9 Gene

neXtProt entry for NEK9 Gene

Selected DME Specific Peptides for NEK9 Gene

Q8TD19:
  • DKILRQK
  • GTPYYMSPE

Post-translational modifications for NEK9 Gene

  • Autophosphorylated on serine and threonine residues (PubMed:27153399). When complexed with FACT, exhibits markedly elevated phosphorylation on Thr-210. During mitosis, not phosphorylated on Thr-210. Phosphorylated by CDK1 in vitro.
  • Ubiquitination at Lys327, Lys606, and Lys650
  • Modification sites at PhosphoSitePlus

Domains & Families for NEK9 Gene

Gene Families for NEK9 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins
  • Transporters

Suggested Antigen Peptide Sequences for NEK9 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ46860 fis, clone UTERU3010919, highly similar to Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (B3KY50_HUMAN)
  • NimA-related kinase 8 (NEK9_HUMAN)
  • NEK9 protein (Q6PKF2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TD19

UniProtKB/Swiss-Prot:

NEK9_HUMAN :
  • Dimerizes through its coiled-coil domain.
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Domain:
  • Dimerizes through its coiled-coil domain.
Family:
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
genes like me logo Genes that share domains with NEK9: view

Function for NEK9 Gene

Molecular function for NEK9 Gene

UniProtKB/Swiss-Prot Function:
Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated during mitosis by intramolecular autophosphorylation. Activity and autophosphorylation is activated by manganese >> magnesium ions. Sensitive to increasing concentration of detergents. It is not cell-cycle regulated but activity is higher in G0-arrested cells.

Enzyme Numbers (IUBMB) for NEK9 Gene

Phenotypes From GWAS Catalog for NEK9 Gene

Gene Ontology (GO) - Molecular Function for NEK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 20562859
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NEK9: view
genes like me logo Genes that share phenotypes with NEK9: view

Human Phenotype Ontology for NEK9 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NEK9 Gene

MGI Knock Outs for NEK9:
  • Nek9 Nek9<tm1a(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for NEK9

CRISPR Products

miRNA for NEK9 Gene

miRTarBase miRNAs that target NEK9

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEK9

No data available for Transcription Factor Targets and HOMER Transcription for NEK9 Gene

Localization for NEK9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEK9 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEK9 gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 3
plasma membrane 2
extracellular 2
cytoskeleton 2
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NEK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005813 colocalizes_with centrosome IDA 20873783
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NEK9: view

Pathways & Interactions for NEK9 Gene

genes like me logo Genes that share pathways with NEK9: view

Pathways by source for NEK9 Gene

SIGNOR curated interactions for NEK9 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for NEK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007049 cell cycle IEA --
GO:0007077 mitotic nuclear envelope disassembly TAS --
GO:0016310 phosphorylation IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with NEK9: view

Drugs & Compounds for NEK9 Gene

(5) Drugs for NEK9 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
Manganese Approved Nutra 56
Guanosine triphosphate Experimental Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(1) Additional Compounds for NEK9 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
genes like me logo Genes that share compounds with NEK9: view

Transcripts for NEK9 Gene

mRNA/cDNA for NEK9 Gene

3 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEK9

Alternative Splicing Database (ASD) splice patterns (SP) for NEK9 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5:
SP6: - - - -
SP7:
SP8:
SP9:
SP10:

ExUns: 18a · 18b ^ 19 ^ 20a · 20b · 20c ^ 21 ^ 22 ^ 23 ^ 24a · 24b
SP1: - - -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7: - - -
SP8:
SP9:
SP10:

Relevant External Links for NEK9 Gene

GeneLoc Exon Structure for
NEK9

Expression for NEK9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NEK9 Gene

Protein differential expression in normal tissues from HIPED for NEK9 Gene

This gene is overexpressed in Lymph node (15.4) and Peripheral blood mononuclear cells (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NEK9 Gene



Protein tissue co-expression partners for NEK9 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NEK9

SOURCE GeneReport for Unigene cluster for NEK9 Gene:

Hs.7200

mRNA Expression by UniProt/SwissProt for NEK9 Gene:

Q8TD19-NEK9_HUMAN
Tissue specificity: Most abundant in heart, liver, kidney and testis. Also expressed in smooth muscle cells and fibroblasts.

Evidence on tissue expression from TISSUES for NEK9 Gene

  • Nervous system(4.7)
  • Liver(4.5)
  • Blood(4.4)
  • Spleen(4.3)
  • Lymph node(4.3)
  • Lung(2.9)
  • Kidney(2.7)
  • Eye(2.4)
  • Skin(2.3)
  • Heart(2.3)
  • Intestine(2.1)
  • Muscle(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with NEK9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEK9 Gene

Orthologs for NEK9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NEK9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NEK9 30 31
  • 99.47 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NEK9 30 31
  • 93.99 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NEK9 30 31
  • 92.73 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NEK9 31
  • 91 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nek9 30
  • 90.39 (n)
Mouse
(Mus musculus)
Mammalia Nek9 30 17 31
  • 90.31 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia NEK9 31
  • 78 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NEK9 30 31
  • 79.28 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NEK9 31
  • 81 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nek9 30
  • 70.15 (n)
Str.2930 30
African clawed frog
(Xenopus laevis)
Amphibia LOC398600 30
Zebrafish
(Danio rerio)
Actinopterygii LOC100334361 30
  • 59.37 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG10951 32
  • 30 (a)
Worm
(Caenorhabditis elegans)
Secernentea Y39G10AR.4 32
  • 35 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN3 31
  • 25 (a)
OneToMany
Species where no ortholog for NEK9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for NEK9 Gene

ENSEMBL:
Gene Tree for NEK9 (if available)
TreeFam:
Gene Tree for NEK9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NEK9: view image

Paralogs for NEK9 Gene

Paralogs for NEK9 Gene

genes like me logo Genes that share paralogs with NEK9: view

Variants for NEK9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NEK9 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
619170 Likely Benign: Cleft palate; Retinopathy 75,106,525(-) T/C MISSENSE_VARIANT
710039 Benign: not provided 75,084,618(-) T/G MISSENSE_VARIANT
710224 Likely Benign: not provided 75,091,266(-) T/C INTRON_VARIANT
712149 Likely Benign: not provided 75,095,373(-) A/G SYNONYMOUS_VARIANT
713005 Likely Benign: not provided 75,091,327(-) T/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for NEK9 Gene

Structural Variations from Database of Genomic Variants (DGV) for NEK9 Gene

Variant ID Type Subtype PubMed ID
nsv832833 CNV gain 17160897

Variation tolerance for NEK9 Gene

Residual Variation Intolerance Score: 18.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.36; 63.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NEK9 Gene

Human Gene Mutation Database (HGMD)
NEK9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEK9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEK9 Gene

Disorders for NEK9 Gene

MalaCards: The human disease database

(31) MalaCards diseases for NEK9 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search NEK9 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NEK9_HUMAN
  • Lethal congenital contracture syndrome 10 (LCCS10) [MIM:617022]: A form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy and congenital non-progressive joint contractures. The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. {ECO:0000269 PubMed:26908619}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Nevus comedonicus (NC) [MIM:617025]: A rare type of epidermal nevus characterized by closely arranged, dilated, plugged follicular ostia in a honeycomb pattern. The plugged ostia contain lamellated keratinaceous material, and their appearance resembles black dots. NC may be non-pyogenic with an acne-like appearance or associated with the formation of cysts, papules, pustules, and abscesses. Most commonly it affects the face and neck area and, by exception, other anatomical regions, including genital area, palms, and soles. NC lesions might present with various patterns of distribution: unilateral, bilateral, linear, interrupted, segmental, or blaschkoid. {ECO:0000269 PubMed:27153399}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Arthrogryposis, Perthes disease, and upward gaze palsy (APUG) [MIM:614262]: An autosomal recessive, syndromic form of arthrogryposis, a disease characterized by persistent joints flexure or contracture. APUG patients manifest an unusual combination of arthrogryposis, upward gaze palsy, and avascular necrosis of the hip (Perthes disease). {ECO:0000269 PubMed:26633546}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for NEK9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with NEK9: view

No data available for Genatlas for NEK9 Gene

Publications for NEK9 Gene

  1. Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2. (PMID: 11864968) Holland PM … Virca GD (The Journal of biological chemistry 2002) 2 3 4 23
  2. An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9. (PMID: 19941817) Richards MW … Bayliss R (Molecular cell 2009) 3 4 23
  3. Somatic Mutations in NEK9 Cause Nevus Comedonicus. (PMID: 27153399) Levinsohn JL … Choate KA (American journal of human genetics 2016) 3 4
  4. Recessive NEK9 mutation causes a lethal skeletal dysplasia with evidence of cell cycle and ciliary defects. (PMID: 26908619) Casey JP … Lynch SA (Human molecular genetics 2016) 3 4
  5. Structural analysis of the regulation of the DYNLL/LC8 binding to Nek9 by phosphorylation. (PMID: 23482567) Gallego P … Reverter D (The Journal of biological chemistry 2013) 3 4

Products for NEK9 Gene

Sources for NEK9 Gene