Aliases for NEK5 Gene

Aliases for NEK5 Gene

  • NIMA Related Kinase 5 2 3 5
  • NIMA (Never In Mitosis Gene A)-Related Kinase 5 2 3
  • Serine/Threonine-Protein Kinase Nek5 3 4
  • NimA-Related Protein Kinase 5 3 4
  • EC 2.7.11.1 4 51
  • Never In Mitosis A-Related Kinase 5 4
  • EC 2.7.11 51
  • NEK5 5

External Ids for NEK5 Gene

Previous GeneCards Identifiers for NEK5 Gene

  • GC13U990078
  • GC13M051537
  • GC13M052610
  • GC13M033427

Summaries for NEK5 Gene

GeneCards Summary for NEK5 Gene

NEK5 (NIMA Related Kinase 5) is a Protein Coding gene. Diseases associated with NEK5 include Corneal Dystrophy, Avellino Type and Primary Autosomal Recessive Microcephaly. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NEK3.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NEK5 Gene

Genomics for NEK5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NEK5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NEK5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NEK5

Top Transcription factor binding sites by QIAGEN in the NEK5 gene promoter:
  • E47
  • FOXF2
  • MyoD
  • Nkx2-2
  • Pbx1a
  • POU2F1
  • POU2F1a
  • Tal-1

Genomic Locations for NEK5 Gene

Genomic Locations for NEK5 Gene
chr13:52,033,611-52,129,092
(GRCh38/hg38)
Size:
95,482 bases
Orientation:
Minus strand
chr13:52,611,093-52,703,214
(GRCh37/hg19)
Size:
92,122 bases
Orientation:
Minus strand

Genomic View for NEK5 Gene

Genes around NEK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEK5 Gene

Proteins for NEK5 Gene

  • Protein details for NEK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P3R8-NEK5_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Nek5
    Protein Accession:
    Q6P3R8
    Secondary Accessions:
    • Q5TAP5

    Protein attributes for NEK5 Gene

    Size:
    708 amino acids
    Molecular mass:
    81445 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for NEK5 Gene

Selected DME Specific Peptides for NEK5 Gene

Q6P3R8:
  • GTPYYLSPE
  • SPRDRPSI

Post-translational modifications for NEK5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for NEK5 Gene

Gene Families for NEK5 Gene

Protein Domains for NEK5 Gene

Suggested Antigen Peptide Sequences for NEK5 Gene

GenScript: Design optimal peptide antigens:
  • Never in mitosis A-related kinase 5 (NEK5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6P3R8

UniProtKB/Swiss-Prot:

NEK5_HUMAN :
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Family:
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
genes like me logo Genes that share domains with NEK5: view

Function for NEK5 Gene

Molecular function for NEK5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.

Enzyme Numbers (IUBMB) for NEK5 Gene

Phenotypes From GWAS Catalog for NEK5 Gene

Gene Ontology (GO) - Molecular Function for NEK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with NEK5: view
genes like me logo Genes that share phenotypes with NEK5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEK5

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NEK5 Gene

Localization for NEK5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEK5 gene
Compartment Confidence
cytosol 3
cytoskeleton 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NEK5 Gene

Pathways & Interactions for NEK5 Gene

PathCards logo

SuperPathways for NEK5 Gene

No Data Available

Interacting Proteins for NEK5 Gene

Gene Ontology (GO) - Biological Process for NEK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0051155 positive regulation of striated muscle cell differentiation IEA --
GO:2001056 positive regulation of cysteine-type endopeptidase activity IEA --
genes like me logo Genes that share ontologies with NEK5: view

No data available for Pathways by source and SIGNOR curated interactions for NEK5 Gene

Drugs & Compounds for NEK5 Gene

(3) Drugs for NEK5 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(1) Additional Compounds for NEK5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
genes like me logo Genes that share compounds with NEK5: view

Transcripts for NEK5 Gene

mRNA/cDNA for NEK5 Gene

2 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEK5

Alternative Splicing Database (ASD) splice patterns (SP) for NEK5 Gene

No ASD Table

Relevant External Links for NEK5 Gene

GeneLoc Exon Structure for
NEK5

Expression for NEK5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NEK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NEK5 Gene

This gene is overexpressed in Testis (x15.4) and Fallopian Tube (x4.1).

Protein differential expression in normal tissues from HIPED for NEK5 Gene

This gene is overexpressed in Serum (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NEK5 Gene



Protein tissue co-expression partners for NEK5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NEK5

SOURCE GeneReport for Unigene cluster for NEK5 Gene:

Hs.672144
genes like me logo Genes that share expression patterns with NEK5: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEK5 Gene

Orthologs for NEK5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NEK5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NEK5 30 31
  • 99.53 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NEK5 30 31
  • 85.6 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nek5 30
  • 79.79 (n)
Mouse
(Mus musculus)
Mammalia Nek5 30 17 31
  • 79.65 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NEK5 31
  • 52 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia NEK5 31
  • 50 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NEK5 30 31
  • 64.38 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NEK5 31
  • 52 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nek5 30
  • 61.78 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15191 30
Zebrafish
(Danio rerio)
Actinopterygii NEK5 31
  • 59 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 61 (a)
OneToMany
Species where no ortholog for NEK5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NEK5 Gene

ENSEMBL:
Gene Tree for NEK5 (if available)
TreeFam:
Gene Tree for NEK5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NEK5: view image

Paralogs for NEK5 Gene

Paralogs for NEK5 Gene

(22) SIMAP similar genes for NEK5 Gene using alignment to 2 proteins:

  • NEK5_HUMAN
  • E9PIX7_HUMAN
genes like me logo Genes that share paralogs with NEK5: view

Variants for NEK5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NEK5 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
rs34756139 - p.Lys255Gln
VAR_040922 - p.Arg290His
VAR_040923 - p.Cys531Arg

Additional dbSNP identifiers (rs#s) for NEK5 Gene

Structural Variations from Database of Genomic Variants (DGV) for NEK5 Gene

Variant ID Type Subtype PubMed ID
dgv1652n100 CNV loss 25217958
esv2549303 CNV deletion 19546169
esv2747423 CNV deletion 23290073
esv2747424 CNV deletion 23290073
nsv1037567 CNV gain 25217958

Variation tolerance for NEK5 Gene

Residual Variation Intolerance Score: 73.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.16; 75.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NEK5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEK5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEK5 Gene

Disorders for NEK5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NEK5 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search NEK5 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with NEK5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEK5 Gene

Publications for NEK5 Gene

  1. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. The NIMA kinase: a mitotic regulator in Aspergillus nidulans and vertebrate cells. (PMID: 9552363) Lu KP … Hunter T (Progress in cell cycle research 1995) 2 3
  4. Expression of the NEK family in normal and cancer tissue: an immunohistochemical study. (PMID: 31906878) Melo-Hanchuk TD … Kobarg J (BMC cancer 2020) 3
  5. NEK5 promotes breast cancer cell proliferation through up-regulation of Cyclin A2. (PMID: 30675923) Pei J … Wang B (Molecular carcinogenesis 2019) 3

Products for NEK5 Gene

Sources for NEK5 Gene