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Aliases for NEK5 Gene

Aliases for NEK5 Gene

  • NIMA Related Kinase 5 2 3 5
  • EC 4 56
  • NIMA (Never In Mitosis Gene A)-Related Kinase 5 2
  • Never In Mitosis A-Related Kinase 5 4
  • NimA-Related Protein Kinase 5 4
  • EC 2.7.11 56

External Ids for NEK5 Gene

Previous GeneCards Identifiers for NEK5 Gene

  • GC13U990078
  • GC13M051537
  • GC13M052610
  • GC13M033427

Summaries for NEK5 Gene

GeneCards Summary for NEK5 Gene

NEK5 (NIMA Related Kinase 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NEK1.

Additional gene information for NEK5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEK5 Gene

Genomics for NEK5 Gene

GeneHancer (GH) Regulatory Elements for NEK5 Gene

Promoters and enhancers for NEK5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I052127 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +1.8 1812 2.1 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 GLIS2 ARID2 ZNF143 ATF7 LOC101929657 NEK5 NEK3 TPTE2P2 ALG11 PIR48020 GC13P052032
GH13I052193 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 12.3 -64.3 -64294 2.7 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MRPS31P5 ALG11 RPS4XP16 UTP14C SUGT1 CKAP2 INTS6 SERPINE3 INTS6-AS1 TPTE2P2
GH13I051995 Enhancer 1.2 Ensembl ENCODE 17.9 +132.6 132620 5 FOXA2 MLX ARID4B FEZF1 DMAP1 ZNF48 YY1 TCF12 GLIS2 RXRA ATP7B NEK3 NEK5 TPTE2P2 UTP14C CCDC70 ENSG00000231856 DHRS12 FABP5P2
GH13I052158 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 7.9 -30.7 -30656 5.3 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ZNF766 NEK3 TPTE2P2 ATP7B NEK5 THSD1P1
GH13I052453 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 6.3 -325.1 -325056 4.3 PKNOX1 SMAD1 FOXA2 ARID4B SIN3A IRF4 POLR2B ZNF766 ZNF207 ZNF143 CKAP2 ENSG00000278238 TPTE2P2 THSD1 ALG11 NEK5 GC13M052475
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NEK5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NEK5 gene promoter:

Genomic Locations for NEK5 Gene

Genomic Locations for NEK5 Gene
96,756 bases
Minus strand

Genomic View for NEK5 Gene

Genes around NEK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEK5 Gene

Proteins for NEK5 Gene

  • Protein details for NEK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase Nek5
    Protein Accession:
    Secondary Accessions:
    • Q5TAP5

    Protein attributes for NEK5 Gene

    708 amino acids
    Molecular mass:
    81445 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for NEK5 Gene

Selected DME Specific Peptides for NEK5 Gene


Post-translational modifications for NEK5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for NEK5 Gene

Gene Families for NEK5 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for NEK5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
genes like me logo Genes that share domains with NEK5: view

Function for NEK5 Gene

Molecular function for NEK5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for NEK5 Gene

Phenotypes From GWAS Catalog for NEK5 Gene

Gene Ontology (GO) - Molecular Function for NEK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with NEK5: view
genes like me logo Genes that share phenotypes with NEK5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NEK5 Gene

Localization for NEK5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEK5 gene
Compartment Confidence
cytosol 3
cytoskeleton 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NEK5 Gene

Pathways & Interactions for NEK5 Gene

No Data Available

Interacting Proteins for NEK5 Gene

Gene Ontology (GO) - Biological Process for NEK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0051155 positive regulation of striated muscle cell differentiation IEA --
GO:2001056 positive regulation of cysteine-type endopeptidase activity IEA --
genes like me logo Genes that share ontologies with NEK5: view

No data available for Pathways by source and SIGNOR curated interactions for NEK5 Gene

Drugs & Compounds for NEK5 Gene

(2) Drugs for NEK5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved Nutra 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for NEK5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with NEK5: view

Transcripts for NEK5 Gene

mRNA/cDNA for NEK5 Gene

(7) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NEK5 Gene

NIMA-related kinase 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEK5 Gene

No ASD Table

Relevant External Links for NEK5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NEK5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NEK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NEK5 Gene

This gene is overexpressed in Testis (x15.4) and Fallopian Tube (x4.1).

Protein differential expression in normal tissues from HIPED for NEK5 Gene

This gene is overexpressed in Serum (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NEK5 Gene

Protein tissue co-expression partners for NEK5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NEK5 Gene:


SOURCE GeneReport for Unigene cluster for NEK5 Gene:

genes like me logo Genes that share expression patterns with NEK5: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEK5 Gene

Orthologs for NEK5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NEK5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NEK5 33 34
  • 99.53 (n)
(Bos Taurus)
Mammalia NEK5 33 34
  • 85.6 (n)
(Rattus norvegicus)
Mammalia Nek5 33
  • 79.79 (n)
(Mus musculus)
Mammalia Nek5 33 16 34
  • 79.65 (n)
(Monodelphis domestica)
Mammalia NEK5 34
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia NEK5 34
  • 50 (a)
(Gallus gallus)
Aves NEK5 33 34
  • 64.38 (n)
(Anolis carolinensis)
Reptilia NEK5 34
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nek5 33
  • 61.78 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15191 33
(Danio rerio)
Actinopterygii NEK5 34
  • 59 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 61 (a)
Species where no ortholog for NEK5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEK5 Gene

Gene Tree for NEK5 (if available)
Gene Tree for NEK5 (if available)

Paralogs for NEK5 Gene

Paralogs for NEK5 Gene

(22) SIMAP similar genes for NEK5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NEK5: view

Variants for NEK5 Gene

Sequence variations from dbSNP and Humsavar for NEK5 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000018567 -- 52,129,714(-) A/T upstream_transcript_variant
rs1000059191 -- 52,082,247(-) G/A/T coding_sequence_variant, genic_downstream_transcript_variant, intron_variant, synonymous_variant
rs1000076538 -- 52,129,617(-) A/C upstream_transcript_variant
rs1000104736 -- 52,094,611(-) G/A intron_variant
rs1000186218 -- 52,073,474(-) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NEK5 Gene

Variant ID Type Subtype PubMed ID
dgv1652n100 CNV loss 25217958
esv2549303 CNV deletion 19546169
esv2747423 CNV deletion 23290073
esv2747424 CNV deletion 23290073
nsv1037567 CNV gain 25217958

Variation tolerance for NEK5 Gene

Residual Variation Intolerance Score: 73.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.16; 75.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NEK5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEK5 Gene

Disorders for NEK5 Gene

Additional Disease Information for NEK5

No disorders were found for NEK5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEK5 Gene

Publications for NEK5 Gene

  1. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The NIMA kinase: a mitotic regulator in Aspergillus nidulans and vertebrate cells. (PMID: 9552363) Lu KP … Hunter T (Progress in cell cycle research 1995) 2 3 58
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58
  5. Nek5 interacts with mitochondrial proteins and interferes negatively in mitochondrial mediated cell death and respiration. (PMID: 25725288) Melo Hanchuk TD … Kobarg J (Cellular signalling 2015) 3 58

Products for NEK5 Gene

  • Addgene plasmids for NEK5

Sources for NEK5 Gene

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