Aliases for NEK4 Gene
External Ids for NEK4 Gene
Previous HGNC Symbols for NEK4 Gene
Previous GeneCards Identifiers for NEK4 Gene
The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017]
GeneCards Summary for NEK4 Gene
NEK4 (NIMA Related Kinase 4) is a Protein Coding gene. Diseases associated with NEK4 include Retinitis Pigmentosa 23 and Meckel Syndrome, Type 1. Among its related pathways are Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NEK1.
UniProtKB/Swiss-Prot for NEK4 Gene
Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage.