Aliases for NEK3 Gene
External Ids for NEK3 Gene
Previous GeneCards Identifiers for NEK3 Gene
This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
GeneCards Summary for NEK3 Gene
NEK3 (NIMA Related Kinase 3) is a Protein Coding gene. Diseases associated with NEK3 include Muscular Phosphorylase Kinase Deficiency and Phosphorylase Kinase Deficiency. Among its related pathways are Prolactin Signaling Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NEK1.
UniProtKB/Swiss-Prot for NEK3 Gene
Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2.