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Aliases for NEIL2 Gene

Aliases for NEIL2 Gene

  • Nei Like DNA Glycosylase 2 2 3 5
  • DNA-(Apurinic Or Apyrimidinic Site) Lyase Neil2 3 4
  • DNA Glycosylase/AP Lyase Neil2 3 4
  • Nei-Like Protein 2 3 4
  • Nei Homolog 2 3 4
  • NEH2 3 4
  • Nei Endonuclease VIII-Like 2 (E. Coli) 2
  • Nei Endonuclease VIII-Like 2 3
  • Endonuclease VIII-Like 2 4
  • Endonuclease 8-Like 2 3
  • Nei Like 2 (E. Coli) 2
  • EC 4.2.99.18 4
  • EC 3.2.2.- 4
  • NEI2 3

External Ids for NEIL2 Gene

Previous GeneCards Identifiers for NEIL2 Gene

  • GC08U990169
  • GC08P011619
  • GC08P011498
  • GC08P011664
  • GC08P010558
  • GC08P011627

Summaries for NEIL2 Gene

Entrez Gene Summary for NEIL2 Gene

  • This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. [provided by RefSeq, Mar 2017]

GeneCards Summary for NEIL2 Gene

NEIL2 (Nei Like DNA Glycosylase 2) is a Protein Coding gene. Among its related pathways are Depyrimidination and Telomere C-strand (Lagging Strand) Synthesis. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and damaged DNA binding. An important paralog of this gene is NEIL3.

UniProtKB/Swiss-Prot for NEIL2 Gene

  • Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3- and 5-phosphates.

Gene Wiki entry for NEIL2 Gene

Additional gene information for NEIL2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEIL2 Gene

Genomics for NEIL2 Gene

GeneHancer (GH) Regulatory Elements for NEIL2 Gene

Promoters and enhancers for NEIL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I011768 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 572.9 +0.3 257 2.7 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 POLR2B NEIL2 PIR40911 FDFT1 LOC105379243 C8orf49 CTSB LOC105379241 BLK ENSG00000269918
GH08I011795 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 28.1 +27.0 27011 2.6 HDAC1 PKNOX1 ZNF335 ATF7 SMARCA5 NFYC ZNF148 ZFP69B ZSCAN16 BCL6B FDFT1 NEIL2 CTSB C8orf49 LOC105379243
GH08I011799 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.2 +35.2 35183 11.2 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 FDFT1 PINX1 LOC101929290 NEIL2 CTSB FAM86B2 LOC105379241 BLK RPS3AP34 ENSG00000255122
GH08I011765 Enhancer 1.2 Ensembl ENCODE dbSUPER 17.7 -4.0 -4023 1 RB1 ARID4B ZNF2 IRF4 RAD21 YY1 ARID2 SCRT2 ZNF143 IKZF2 NEIL2 C8orf49
GH08I011761 Enhancer 1.2 Ensembl ENCODE dbSUPER 14.5 -7.3 -7258 1.1 HDAC1 PKNOX1 SMAD1 ATF1 ARNT ZSCAN4 ZBTB40 TCF12 EGR1 FOS C8orf49 NEIL2 LOC101929290 PINX1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NEIL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NEIL2 gene promoter:

Genomic Locations for NEIL2 Gene

Genomic Locations for NEIL2 Gene
chr8:11,769,639-11,787,346
(GRCh38/hg38)
Size:
17,708 bases
Orientation:
Plus strand
chr8:11,627,148-11,644,855
(GRCh37/hg19)

Genomic View for NEIL2 Gene

Genes around NEIL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEIL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEIL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEIL2 Gene

Proteins for NEIL2 Gene

  • Protein details for NEIL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969S2-NEIL2_HUMAN
    Recommended name:
    Endonuclease 8-like 2
    Protein Accession:
    Q969S2
    Secondary Accessions:
    • B4DFR7
    • Q7Z3Q7
    • Q8N842
    • Q8NG52

    Protein attributes for NEIL2 Gene

    Size:
    332 amino acids
    Molecular mass:
    36826 Da
    Quaternary structure:
    • Binds EP300.

    Three dimensional structures from OCA and Proteopedia for NEIL2 Gene

    Alternative splice isoforms for NEIL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEIL2 Gene

Post-translational modifications for NEIL2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NEIL2 Gene

Domains & Families for NEIL2 Gene

Gene Families for NEIL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for NEIL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q969S2

UniProtKB/Swiss-Prot:

NEIL2_HUMAN :
  • The zinc-finger domain is important for DNA binding.
  • Belongs to the FPG family.
Domain:
  • The zinc-finger domain is important for DNA binding.
Family:
  • Belongs to the FPG family.
genes like me logo Genes that share domains with NEIL2: view

Function for NEIL2 Gene

Molecular function for NEIL2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
The C-O-P bond 3 to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3-terminal unsaturated sugar and a product with a terminal 5-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Acetylation of Lys-50 leads to loss of DNA nicking activity. Acetylation of Lys-154 has no effect.
UniProtKB/Swiss-Prot Function:
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3- and 5-phosphates.

Enzyme Numbers (IUBMB) for NEIL2 Gene

Phenotypes From GWAS Catalog for NEIL2 Gene

Gene Ontology (GO) - Molecular Function for NEIL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003684 damaged DNA binding IEA --
GO:0003824 catalytic activity IEA --
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NEIL2: view
genes like me logo Genes that share phenotypes with NEIL2: view

Animal Models for NEIL2 Gene

MGI Knock Outs for NEIL2:

Animal Model Products

miRNA for NEIL2 Gene

miRTarBase miRNAs that target NEIL2

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEIL2 Gene

Localization for NEIL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEIL2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEIL2 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NEIL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005876 spindle microtubule IEA --
genes like me logo Genes that share ontologies with NEIL2: view

Pathways & Interactions for NEIL2 Gene

genes like me logo Genes that share pathways with NEIL2: view

Gene Ontology (GO) - Biological Process for NEIL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006284 base-excision repair IEA --
GO:0006289 nucleotide-excision repair IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with NEIL2: view

No data available for SIGNOR curated interactions for NEIL2 Gene

Drugs & Compounds for NEIL2 Gene

(3) Drugs for NEIL2 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 202
Iron Approved Pharma Target 1259

(1) Additional Compounds for NEIL2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NEIL2: view

Transcripts for NEIL2 Gene

Unigene Clusters for NEIL2 Gene

Nei endonuclease VIII-like 2 (E. coli):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEIL2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP2: -
SP3:
SP4: - -
SP5:
SP6: - - -

Relevant External Links for NEIL2 Gene

GeneLoc Exon Structure for
NEIL2
ECgene alternative splicing isoforms for
NEIL2

Expression for NEIL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NEIL2 Gene

Protein differential expression in normal tissues from HIPED for NEIL2 Gene

This gene is overexpressed in Testis (17.0), Retina (15.7), Peripheral blood mononuclear cells (11.9), and Fetal ovary (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NEIL2 Gene



Protein tissue co-expression partners for NEIL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NEIL2 Gene:

NEIL2

SOURCE GeneReport for Unigene cluster for NEIL2 Gene:

Hs.293818

mRNA Expression by UniProt/SwissProt for NEIL2 Gene:

Q969S2-NEIL2_HUMAN
Tissue specificity: Detected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver.

Evidence on tissue expression from TISSUES for NEIL2 Gene

  • Nervous system(4.7)
  • Liver(4.3)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with NEIL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEIL2 Gene

Orthologs for NEIL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NEIL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEIL2 33 34
  • 99.3 (n)
dog
(Canis familiaris)
Mammalia NEIL2 33 34
  • 80.92 (n)
mouse
(Mus musculus)
Mammalia Neil2 33 16 34
  • 79.44 (n)
rat
(Rattus norvegicus)
Mammalia Neil2 33
  • 78.88 (n)
cow
(Bos Taurus)
Mammalia NEIL2 33 34
  • 77.13 (n)
oppossum
(Monodelphis domestica)
Mammalia NEIL2 34
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEIL2 34
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves NEIL2 33 34
  • 64.29 (n)
lizard
(Anolis carolinensis)
Reptilia NEIL2 34
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia neil2 33
  • 56.97 (n)
zebrafish
(Danio rerio)
Actinopterygii neil3 34
  • 13 (a)
OneToMany
Species where no ortholog for NEIL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEIL2 Gene

ENSEMBL:
Gene Tree for NEIL2 (if available)
TreeFam:
Gene Tree for NEIL2 (if available)

Paralogs for NEIL2 Gene

Paralogs for NEIL2 Gene

Pseudogenes.org Pseudogenes for NEIL2 Gene

genes like me logo Genes that share paralogs with NEIL2: view

Variants for NEIL2 Gene

Sequence variations from dbSNP and Humsavar for NEIL2 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs886043178 uncertain-significance, not specified 11,779,844(+) A/ coding_sequence_variant, frameshift, intron_variant
rs1000086539 -- 11,773,968(+) C/G intron_variant
rs1000266962 -- 11,784,479(+) C/T intron_variant
rs1000429127 -- 11,769,687(+) G/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000485662 -- 11,776,486(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NEIL2 Gene

Variant ID Type Subtype PubMed ID
nsv479711 CNV novel sequence insertion 20440878
nsv1032739 CNV loss 25217958
esv3616258 CNV loss 21293372
esv3572513 CNV loss 25503493

Variation tolerance for NEIL2 Gene

Residual Variation Intolerance Score: 95.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.82; 58.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NEIL2 Gene

Human Gene Mutation Database (HGMD)
NEIL2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEIL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEIL2 Gene

Disorders for NEIL2 Gene

Additional Disease Information for NEIL2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NEIL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEIL2 Gene

Publications for NEIL2 Gene

  1. Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3. (PMID: 18515411) Dallosso AR … Sampson JR (Gut 2008) 3 22 44 58
  2. Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx. (PMID: 18594018) Zhai X … Wei Q (Clinical cancer research : an official journal of the American Association for Cancer Research 2008) 3 22 44 58
  3. Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress. (PMID: 17686777) Das S … Hazra TK (The Journal of biological chemistry 2007) 2 3 22 58
  4. Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2. (PMID: 14522990) Dou H … Hazra TK (The Journal of biological chemistry 2003) 3 4 22 58
  5. Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions. (PMID: 12097317) Hazra TK … Izumi T (The Journal of biological chemistry 2002) 2 3 4 58

Products for NEIL2 Gene

Sources for NEIL2 Gene

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