The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apo... See more...

Aliases for NEDD9 Gene

Aliases for NEDD9 Gene

  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 9 2 3 5
  • Cas Scaffolding Protein Family Member 2 2 3 4
  • CAS-L 2 3 4
  • CASS2 2 3 4
  • HEF1 2 3 4
  • Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 9 3 4
  • Renal Carcinoma Antigen NY-REN-12 3 4
  • Enhancer Of Filamentation 1 3 4
  • CASL 3 4
  • Crk-Associated Substrate Related Protein Cas-L 3
  • CRK-Associated Substrate-Related Protein 4
  • Enhancer Of Filamentation 1 P55 3
  • P130Cas-Related Protein 3
  • Cas-Like Docking 3
  • Cas-Like 2
  • NEDD-9 4
  • NEDD9 5
  • CAS2 3
  • CasL 4
  • P105 4

External Ids for NEDD9 Gene

Previous GeneCards Identifiers for NEDD9 Gene

  • GC00U990223
  • GC06M011246
  • GC06M011291

Summaries for NEDD9 Gene

Entrez Gene Summary for NEDD9 Gene

  • The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

CIViC Summary for NEDD9 Gene

GeneCards Summary for NEDD9 Gene

NEDD9 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 9) is a Protein Coding gene. Diseases associated with NEDD9 include Gastrointestinal Stromal Tumor and Meckel Syndrome, Type 1. Among its related pathways are Adhesion and TGF-beta Signaling Pathway (WikiPathways). An important paralog of this gene is BCAR1.

UniProtKB/Swiss-Prot Summary for NEDD9 Gene

  • Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form. Required for correct adhesion and migration of T-cells (PubMed:17174122).

Gene Wiki entry for NEDD9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NEDD9 Gene

Genomics for NEDD9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NEDD9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NEDD9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NEDD9

Top Transcription factor binding sites by QIAGEN in the NEDD9 gene promoter:
  • FAC1
  • GR
  • GR-alpha
  • GR-beta
  • Hlf
  • Nkx2-5
  • STAT5A

Genomic Locations for NEDD9 Gene

Latest Assembly
chr6:11,183,298-11,382,348
(GRCh38/hg38)
Size:
199,051 bases
Orientation:
Minus strand

Previous Assembly
chr6:11,183,531-11,382,581
(GRCh37/hg19 by Entrez Gene)
Size:
199,051 bases
Orientation:
Minus strand

chr6:11,183,531-11,382,581
(GRCh37/hg19 by Ensembl)
Size:
199,051 bases
Orientation:
Minus strand

Genomic View for NEDD9 Gene

Genes around NEDD9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEDD9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEDD9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEDD9 Gene

Proteins for NEDD9 Gene

  • Protein details for NEDD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14511-CASL_HUMAN
    Recommended name:
    Enhancer of filamentation 1
    Protein Accession:
    Q14511
    Secondary Accessions:
    • A8K9G7
    • A8MSJ9
    • G5E9Y9
    • Q5T9R4
    • Q5XKI0

    Protein attributes for NEDD9 Gene

    Size:
    834 amino acids
    Molecular mass:
    92861 Da
    Quaternary structure:
    • Homodimer. Can heterodimerize with HLH proteins ID2, E12, E47 and also with p130cas. Forms complexes in vivo with related adhesion focal tyrosine kinase (RAFTK), adapter protein CRKL and LYN kinase. Interacts with MICAL and TXNL4/DIM1. Interacts with BCAR3 (via Ras-GEF domain) (By similarity). Interacts with SH2D3C isoform 1 and isoform 2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for NEDD9 Gene

    Alternative splice isoforms for NEDD9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEDD9 Gene

Post-translational modifications for NEDD9 Gene

  • Cell cycle-regulated processing produces four isoforms: p115, p105, p65, and p55. Isoform p115 arises from p105 phosphorylation and appears later in the cell cycle. Isoform p55 arises from p105 as a result of cleavage at a caspase cleavage-related site and it appears specifically at mitosis. The p65 isoform is poorly detected.
  • PTK2/FAK1 phosphorylates the protein at the YDYVHL motif (conserved among all cas proteins). The SRC family kinases (FYN, SRC, LCK and CRK) are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Ligation of either integrin beta-1 or B-cell antigen receptor on tonsillar B-cells and B-cell lines promotes tyrosine phosphorylation and both integrin and BCR-mediated tyrosine phosphorylation requires an intact actin network. In fibroblasts transformation with oncogene v-ABL results in an increase in tyrosine phosphorylation. Transiently phosphorylated following CD3 cross-linking and this phosphorylated form binds to CRK and C3G. A mutant lacking the SH3 domain is phosphorylated upon CD3 cross-linking but not upon integrin beta-1 cross-linking. Tyrosine phosphorylation occurs upon stimulation of the G-protein coupled C1a calcitonin receptor. Calcitonin-stimulated tyrosine phosphorylation is mediated by calcium- and protein kinase C-dependent mechanisms and requires the integrity of the actin cytoskeleton. Phosphorylation at Ser-369 induces proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NEDD9 Gene

Domains & Families for NEDD9 Gene

Gene Families for NEDD9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NEDD9 Gene

Suggested Antigen Peptide Sequences for NEDD9 Gene

GenScript: Design optimal peptide antigens:
  • p105 (CASL_HUMAN)
  • Neural cell expressed, developmentally down-regulated 9 (Q5TI59_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14511

UniProtKB/Swiss-Prot:

CASL_HUMAN :
  • Contains a central domain containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains. The HLH motif confers specific interaction with the HLH proteins ID2, E12 and E47. It is absolutely required for the induction of pseudohyphal growth in yeast and mediates homodimerization and heterodimerization with p130cas.
  • Belongs to the CAS family.
Domain:
  • Contains a central domain containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains. The HLH motif confers specific interaction with the HLH proteins ID2, E12 and E47. It is absolutely required for the induction of pseudohyphal growth in yeast and mediates homodimerization and heterodimerization with p130cas.
  • The SH3 domain interacts with two proline-rich regions of PTK2/FAK1.
Family:
  • Belongs to the CAS family.
genes like me logo Genes that share domains with NEDD9: view

Function for NEDD9 Gene

Molecular function for NEDD9 Gene

UniProtKB/Swiss-Prot Function:
Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form. Required for correct adhesion and migration of T-cells (PubMed:17174122).
UniProtKB/Swiss-Prot Induction:
Activated upon induction of cell growth.

Phenotypes From GWAS Catalog for NEDD9 Gene

Gene Ontology (GO) - Molecular Function for NEDD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 11827972
GO:1990782 protein tyrosine kinase binding IPI 18256281
genes like me logo Genes that share ontologies with NEDD9: view
genes like me logo Genes that share phenotypes with NEDD9: view

Animal Models for NEDD9 Gene

MGI Knock Outs for NEDD9:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEDD9

Clone products for research

  • Addgene plasmids for NEDD9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEDD9 Gene

Localization for NEDD9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEDD9 Gene

Cytoplasm, cell cortex. Nucleus. Golgi apparatus. Cell projection, lamellipodium. Cytoplasm. Cell junction, focal adhesion. Note=Localizes to both the cell nucleus and the cell periphery and is differently localized in fibroblasts and epithelial cells. In fibroblasts is predominantly nuclear and in some cells is present in the Golgi apparatus. In epithelial cells localized predominantly in the cell periphery with particular concentration in lamellipodia but is also found in the nucleus. Isoforms p105 and p115 are predominantly cytoplasmic and associate with focal adhesions while p55 associates with mitotic spindle.
[Enhancer of filamentation 1 p55]: Cytoplasm, cytoskeleton, spindle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEDD9 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 5
golgi apparatus 5
extracellular 2
endoplasmic reticulum 2
endosome 2
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NEDD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005634 nucleus TAS 8668148
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IBA 21873635
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with NEDD9: view

Pathways & Interactions for NEDD9 Gene

PathCards logo

SuperPathways for NEDD9 Gene

genes like me logo Genes that share pathways with NEDD9: view

Pathways by source for NEDD9 Gene

1 BioSystems pathway for NEDD9 Gene
1 Cell Signaling Technology pathway for NEDD9 Gene

SIGNOR curated interactions for NEDD9 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for NEDD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization NAS 11827972
GO:0007049 cell cycle IEA --
GO:0007155 cell adhesion NAS,IEA --
GO:0007165 signal transduction TAS 8668148
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with NEDD9: view

Drugs & Compounds for NEDD9 Gene

(4) Drugs for NEDD9 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 6959

(3) Additional Compounds for NEDD9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NEDD9: view

Transcripts for NEDD9 Gene

mRNA/cDNA for NEDD9 Gene

4 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEDD9

Clone products for research

  • Addgene plasmids for NEDD9

Alternative Splicing Database (ASD) splice patterns (SP) for NEDD9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - -
SP5:
SP6: -
SP7: - - - -
SP8:
SP9:

Relevant External Links for NEDD9 Gene

GeneLoc Exon Structure for
NEDD9

Expression for NEDD9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NEDD9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NEDD9 Gene

This gene is overexpressed in Lung (x4.2) and Adipose - Subcutaneous (x4.2).

Protein differential expression in normal tissues from HIPED for NEDD9 Gene

This gene is overexpressed in Ovary (28.3), Peripheral blood mononuclear cells (16.5), and CD8 Tcells (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NEDD9 Gene



Protein tissue co-expression partners for NEDD9 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NEDD9

SOURCE GeneReport for Unigene cluster for NEDD9 Gene:

Hs.37982

mRNA Expression by UniProt/SwissProt for NEDD9 Gene:

Q14511-CASL_HUMAN
Tissue specificity: Widely expressed. Higher levels detected in kidney, lung, and placenta. Also detected in T-cells, B-cells and diverse cell lines. The protein has been detected in lymphocytes, in diverse cell lines, and in lung tissues.

Evidence on tissue expression from TISSUES for NEDD9 Gene

  • Nervous system(4.8)
  • Lung(4.7)
  • Lymph node(2.5)
  • Kidney(2.5)
  • Intestine(2.4)
  • Heart(2.3)
  • Blood(2.3)
  • Muscle(2.1)
  • Spleen(2.1)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with NEDD9: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NEDD9 Gene

Orthologs for NEDD9 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEDD9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NEDD9 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia NEDD9 29 30
  • 87.53 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Nedd9 29 16 30
  • 84.75 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nedd9 29
  • 84.19 (n)
Cow
(Bos Taurus)
Mammalia NEDD9 29 30
  • 81.99 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NEDD9 30
  • 80 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia NEDD9 30
  • 75 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NEDD9 29 30
  • 70.18 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NEDD9 30
  • 66 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nedd9 29
  • 61.08 (n)
Zebrafish
(Danio rerio)
Actinopterygii nedd9 29 30
  • 58.54 (n)
OneToMany
NEDD9 (2 of 2) 30
  • 51 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta p130CAS 30
  • 23 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6681 30
  • 29 (a)
OneToMany
Species where no ortholog for NEDD9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NEDD9 Gene

ENSEMBL:
Gene Tree for NEDD9 (if available)
TreeFam:
Gene Tree for NEDD9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NEDD9: view image
Alliance of Genome Resources:
Additional Orthologs for NEDD9

Paralogs for NEDD9 Gene

Paralogs for NEDD9 Gene

(2) SIMAP similar genes for NEDD9 Gene using alignment to 5 proteins:

  • CASL_HUMAN
  • D6RBQ2_HUMAN
  • D6RDV1_HUMAN
  • D6REP7_HUMAN
  • D6RGD7_HUMAN
genes like me logo Genes that share paralogs with NEDD9: view

Variants for NEDD9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NEDD9 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs143967808 Benign: not provided 11,190,126(-) G/A
NM_006403.4(NEDD9):c.1743C>T (p.His581=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs146864079 Benign: not provided 11,189,970(-) G/A
NM_006403.4(NEDD9):c.1899C>T (p.His633=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs150123400 Likely Benign: not provided 11,190,358(-) T/C
NM_006403.4(NEDD9):c.1511A>G (p.His504Arg)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs11546959 -- p.Asp178Asn
rs34184473 -- p.Pro304Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NEDD9 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NEDD9 Gene

Variant ID Type Subtype PubMed ID
esv2514916 CNV deletion 19546169
esv2673287 CNV deletion 23128226
esv2731591 CNV deletion 23290073
esv3352794 CNV duplication 20981092
esv3360064 CNV duplication 20981092
esv3389668 CNV insertion 20981092
esv3567274 CNV deletion 23714750
esv3608096 CNV loss 21293372
esv6920 OTHER inversion 19470904
esv7143 CNV gain 19470904
nsv1073536 CNV deletion 25765185
nsv1124032 CNV deletion 24896259
nsv1151580 CNV deletion 26484159
nsv478328 CNV novel sequence insertion 20440878

Variation tolerance for NEDD9 Gene

Residual Variation Intolerance Score: 54.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.58; 56.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NEDD9 Gene

Human Gene Mutation Database (HGMD)
NEDD9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEDD9
Leiden Open Variation Database (LOVD)
NEDD9

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEDD9 Gene

Disorders for NEDD9 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NEDD9 Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards
Search NEDD9 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NEDD9

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with NEDD9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEDD9 Gene

Publications for NEDD9 Gene

  1. Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments. (PMID: 9584194) Law SF … Golemis EA (Molecular and cellular biology 1998) 3 4 22
  2. T cell receptor-mediated tyrosine phosphorylation of Cas-L, a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3G. (PMID: 9497377) Ohashi Y … Morimoto C (The Journal of biological chemistry 1998) 3 4 22
  3. Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates. (PMID: 9360983) Tachibana K … Morimoto C (The Journal of biological chemistry 1997) 3 4 22
  4. Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae. (PMID: 8668148) Law SF … Golemis EA (Molecular and cellular biology 1996) 3 4 22
  5. Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes. (PMID: 8879209) Minegishi M … Morimoto C (The Journal of experimental medicine 1996) 3 4 22

Products for NEDD9 Gene

Sources for NEDD9 Gene