This locus represents naturally occurring read-through transcription between the neighboring NEDD8 (neural precursor cell expressed, developmentally down-regulated 8) and MDP1 (magnesium-dependent phosphatase 1) genes on chromosome 14. One of the read-through transcripts on this locus encodes a fusion protein that shares sequence identity with the products of each individual ge... See more...

Aliases for NEDD8-MDP1 Gene

Aliases for NEDD8-MDP1 Gene

  • NEDD8-MDP1 Readthrough 2 3 5 13
  • NEDD8-MDP1 Read-Through Transcript 3
  • NEDD8-MDP1 Protein 3

External Ids for NEDD8-MDP1 Gene

Previous GeneCards Identifiers for NEDD8-MDP1 Gene

  • GC14U901228
  • GC14M024685

Summaries for NEDD8-MDP1 Gene

Entrez Gene Summary for NEDD8-MDP1 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring NEDD8 (neural precursor cell expressed, developmentally down-regulated 8) and MDP1 (magnesium-dependent phosphatase 1) genes on chromosome 14. One of the read-through transcripts on this locus encodes a fusion protein that shares sequence identity with the products of each individual gene. [provided by RefSeq, Jul 2016]

GeneCards Summary for NEDD8-MDP1 Gene

NEDD8-MDP1 (NEDD8-MDP1 Readthrough) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatase activity. An important paralog of this gene is MDP1.

Additional gene information for NEDD8-MDP1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NEDD8-MDP1 Gene

Genomics for NEDD8-MDP1 Gene

GeneHancer (GH) Regulatory Elements for NEDD8-MDP1 Gene

Promoters and enhancers for NEDD8-MDP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NEDD8-MDP1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NEDD8-MDP1

Genomic Locations for NEDD8-MDP1 Gene

Genomic Locations for NEDD8-MDP1 Gene
chr14:24,213,937-24,232,370
(GRCh38/hg38)
Size:
18,434 bases
Orientation:
Minus strand
chr14:24,683,143-24,701,576
(GRCh37/hg19)
Size:
18,434 bases
Orientation:
Minus strand

Genomic View for NEDD8-MDP1 Gene

Genes around NEDD8-MDP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEDD8-MDP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEDD8-MDP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEDD8-MDP1 Gene

Proteins for NEDD8-MDP1 Gene

  • Protein details for NEDD8-MDP1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    S4R3E9-S4R3E9_HUMAN
    Recommended name:
    NEDD8-MDP1 readthrough
    Protein Accession:
    S4R3E9

    Protein attributes for NEDD8-MDP1 Gene

    Size:
    84 amino acids
    Molecular mass:
    9672 Da
    Quaternary structure:
    No Data Available
  • Protein details for NEDD8-MDP1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    E9PL57-E9PL57_HUMAN
    Recommended name:
    NEDD8-MDP1 readthrough
    Protein Accession:
    E9PL57

    Protein attributes for NEDD8-MDP1 Gene

    Size:
    170 amino acids
    Molecular mass:
    19536 Da
    Quaternary structure:
    No Data Available
  • Protein details for NEDD8-MDP1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    E9PS38-E9PS38_HUMAN
    Recommended name:
    NEDD8-MDP1 readthrough
    Protein Accession:
    E9PS38

    Protein attributes for NEDD8-MDP1 Gene

    Size:
    67 amino acids
    Molecular mass:
    7745 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NEDD8-MDP1 Gene

Post-translational modifications for NEDD8-MDP1 Gene

No Post-translational modifications

Other Protein References for NEDD8-MDP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NEDD8-MDP1 Gene

Domains & Families for NEDD8-MDP1 Gene

Gene Families for NEDD8-MDP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
genes like me logo Genes that share domains with NEDD8-MDP1: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NEDD8-MDP1 Gene

Function for NEDD8-MDP1 Gene

Phenotypes From GWAS Catalog for NEDD8-MDP1 Gene

Gene Ontology (GO) - Molecular Function for NEDD8-MDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with NEDD8-MDP1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NEDD8-MDP1 Gene

Localization for NEDD8-MDP1 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NEDD8-MDP1 Gene

Pathways & Interactions for NEDD8-MDP1 Gene

PathCards logo

SuperPathways for NEDD8-MDP1 Gene

No Data Available

Interacting Proteins for NEDD8-MDP1 Gene

;

Gene Ontology (GO) - Biological Process for NEDD8-MDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with NEDD8-MDP1: view

No data available for Pathways by source and SIGNOR curated interactions for NEDD8-MDP1 Gene

Drugs & Compounds for NEDD8-MDP1 Gene

No Compound Related Data Available

Transcripts for NEDD8-MDP1 Gene

mRNA/cDNA for NEDD8-MDP1 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEDD8-MDP1 Gene

No ASD Table

Relevant External Links for NEDD8-MDP1 Gene

GeneLoc Exon Structure for
NEDD8-MDP1

Expression for NEDD8-MDP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NEDD8-MDP1 Gene

mRNA expression in normal human tissues for NEDD8-MDP1 Gene
genes like me logo Genes that share expression patterns with NEDD8-MDP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEDD8-MDP1 Gene

Orthologs for NEDD8-MDP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NEDD8-MDP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEDD8-MDP1 31
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MDP-1 31
  • 64 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mdp1 31
  • 61 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 56 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 55 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 64 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii MDP1 31
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 31
  • 21 (a)
OneToMany
Species where no ortholog for NEDD8-MDP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEDD8-MDP1 Gene

ENSEMBL:
Gene Tree for NEDD8-MDP1 (if available)
TreeFam:
Gene Tree for NEDD8-MDP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NEDD8-MDP1: view image

Paralogs for NEDD8-MDP1 Gene

Paralogs for NEDD8-MDP1 Gene

(10) SIMAP similar genes for NEDD8-MDP1 Gene using alignment to 3 proteins:

  • E9PL57_HUMAN
  • E9PS38_HUMAN
  • S4R3E9_HUMAN
genes like me logo Genes that share paralogs with NEDD8-MDP1: view

Variants for NEDD8-MDP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NEDD8-MDP1 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs193921062 Uncertain Significance: Malignant tumor of prostate 24,214,313(-) G/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for NEDD8-MDP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NEDD8-MDP1 Gene

Variant ID Type Subtype PubMed ID
esv3633803 CNV loss 21293372

Variation tolerance for NEDD8-MDP1 Gene

Gene Damage Index Score: 0.04; 0.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NEDD8-MDP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEDD8-MDP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEDD8-MDP1 Gene

Disorders for NEDD8-MDP1 Gene

Additional Disease Information for NEDD8-MDP1

No disorders were found for NEDD8-MDP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEDD8-MDP1 Gene

Publications for NEDD8-MDP1 Gene

  1. Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II. (PMID: 30349055) Li Y … Lu X (Nature communications 2018) 3 54
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54
  4. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 54
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 13 54

Products for NEDD8-MDP1 Gene

Sources for NEDD8-MDP1 Gene