Aliases for NEDD8 Gene

Aliases for NEDD8 Gene

  • NEDD8 Ubiquitin Like Modifier 2 3 5
  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 2 3
  • Ubiquitin-Like Protein Nedd8 3 4
  • Neddylin 3 4
  • NEDD-8 3 4
  • Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 8 4
  • NEDD8 4

External Ids for NEDD8 Gene

Previous GeneCards Identifiers for NEDD8 Gene

  • GC14M022058
  • GC14M018473
  • GC14M022674
  • GC14M022676
  • GC14M023755
  • GC14M024686
  • GC14M004801

Summaries for NEDD8 Gene

GeneCards Summary for NEDD8 Gene

NEDD8 (NEDD8 Ubiquitin Like Modifier) is a Protein Coding gene. Diseases associated with NEDD8 include Parkinson Disease, Late-Onset and Myeloma, Multiple. Among its related pathways are Metabolism of proteins and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is UBA52.

UniProtKB/Swiss-Prot Summary for NEDD8 Gene

  • Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.

Gene Wiki entry for NEDD8 Gene

Additional gene information for NEDD8 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NEDD8 Gene

Genomics for NEDD8 Gene

GeneHancer (GH) Regulatory Elements for NEDD8 Gene

Promoters and enhancers for NEDD8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NEDD8 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NEDD8

Top Transcription factor binding sites by QIAGEN in the NEDD8 gene promoter:
  • POU2F1
  • POU2F1a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for NEDD8 Gene

Genomic Locations for NEDD8 Gene
chr14:24,216,851-24,232,370
(GRCh38/hg38)
Size:
15,520 bases
Orientation:
Minus strand
chr14:24,686,057-24,701,660
(GRCh37/hg19)
Size:
15,604 bases
Orientation:
Minus strand

Genomic View for NEDD8 Gene

Genes around NEDD8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEDD8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEDD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEDD8 Gene

Proteins for NEDD8 Gene

  • Protein details for NEDD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15843-NEDD8_HUMAN
    Recommended name:
    NEDD8
    Protein Accession:
    Q15843
    Secondary Accessions:
    • Q3SXN8
    • Q6LES6

    Protein attributes for NEDD8 Gene

    Size:
    81 amino acids
    Molecular mass:
    9072 Da
    Quaternary structure:
    • Directly interacts with NUB1 and AHR. Covalently attached to cullins and p53.

    Three dimensional structures from OCA and Proteopedia for NEDD8 Gene

neXtProt entry for NEDD8 Gene

Post-translational modifications for NEDD8 Gene

  • Cleavage of precursor form by UCHL3 or SENP8 is necessary for function.
  • Ubiquitination at Lys11, Lys22, Lys48, Lys54, and Lys60
  • Modification sites at PhosphoSitePlus

Other Protein References for NEDD8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NEDD8 Gene

Domains & Families for NEDD8 Gene

Gene Families for NEDD8 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NEDD8 Gene

Suggested Antigen Peptide Sequences for NEDD8 Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin-like protein Nedd8 (NEDD8_HUMAN)
  • Neural cell expressed developmentally down-regulated protein 8 (Q96L81_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15843

UniProtKB/Swiss-Prot:

NEDD8_HUMAN :
  • Belongs to the ubiquitin family.
Family:
  • Belongs to the ubiquitin family.
genes like me logo Genes that share domains with NEDD8: view

Function for NEDD8 Gene

Molecular function for NEDD8 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.

Phenotypes From GWAS Catalog for NEDD8 Gene

Gene Ontology (GO) - Molecular Function for NEDD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15988528
GO:0031386 protein tag IBA 21873635
GO:0031625 ubiquitin protein ligase binding IPI 15694336
genes like me logo Genes that share ontologies with NEDD8: view
genes like me logo Genes that share phenotypes with NEDD8: view

Animal Model Products

CRISPR Products

miRNA for NEDD8 Gene

Clone Products

  • Addgene plasmids for NEDD8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEDD8 Gene

Localization for NEDD8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEDD8 Gene

Nucleus. Note=Mainly nuclear.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEDD8 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
lysosome 2
peroxisome 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NEDD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005634 nucleus IBA,TAS 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NEDD8: view

Pathways & Interactions for NEDD8 Gene

genes like me logo Genes that share pathways with NEDD8: view

Pathways by source for NEDD8 Gene

1 GeneGo (Thomson Reuters) pathway for NEDD8 Gene
  • Cell cycle Role of SCF complex in cell cycle regulation
1 Qiagen pathway for NEDD8 Gene
  • AHR Pathway

Gene Ontology (GO) - Biological Process for NEDD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0006464 cellular protein modification process TAS 9694792
GO:0006508 proteolysis TAS 9694792
GO:0006511 ubiquitin-dependent protein catabolic process TAS 9353319
GO:0006879 cellular iron ion homeostasis TAS --
genes like me logo Genes that share ontologies with NEDD8: view

No data available for SIGNOR curated interactions for NEDD8 Gene

Drugs & Compounds for NEDD8 Gene

(4) Drugs for NEDD8 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for NEDD8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NEDD8: view

Transcripts for NEDD8 Gene

mRNA/cDNA for NEDD8 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for NEDD8

Alternative Splicing Database (ASD) splice patterns (SP) for NEDD8 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: -
SP5:

Relevant External Links for NEDD8 Gene

GeneLoc Exon Structure for
NEDD8

Expression for NEDD8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NEDD8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NEDD8 Gene

This gene is overexpressed in Amniocyte (10.0) and Peripheral blood mononuclear cells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NEDD8 Gene



Protein tissue co-expression partners for NEDD8 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NEDD8

SOURCE GeneReport for Unigene cluster for NEDD8 Gene:

Hs.531064

mRNA Expression by UniProt/SwissProt for NEDD8 Gene:

Q15843-NEDD8_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes.

Evidence on tissue expression from TISSUES for NEDD8 Gene

  • Nervous system(3.5)
  • Lung(3.1)
  • Heart(3)
  • Kidney(2.9)
  • Intestine(2.5)
  • Spleen(2.5)
  • Muscle(2.3)
  • Liver(2.2)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with NEDD8: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEDD8 Gene

Orthologs for NEDD8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NEDD8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEDD8 30
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia NEDD8 31 30
  • 96.71 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NEDD8 31 30
  • 95.06 (n)
OneToMany
-- 31
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nedd8 30
  • 92.59 (n)
mouse
(Mus musculus)
Mammalia Nedd8 17 31 30
  • 92.18 (n)
oppossum
(Monodelphis domestica)
Mammalia NEDD8 31
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nedd8 30
  • 79.82 (n)
Str.10937 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.2952 30
zebrafish
(Danio rerio)
Actinopterygii nedd8 31 30 30
  • 81.58 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12683 30
fruit fly
(Drosophila melanogaster)
Insecta Nedd8 31 32 30
  • 75.53 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007913 30
  • 75 (n)
worm
(Caenorhabditis elegans)
Secernentea ned-8 31 30
  • 74.12 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RUB1 31 30
  • 60.61 (n)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17974g 30
  • 60.53 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL185W 30
  • 60.09 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ned8 30
  • 68.42 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03309 30
  • 67.54 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.2781 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2781 30
Species where no ortholog for NEDD8 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEDD8 Gene

ENSEMBL:
Gene Tree for NEDD8 (if available)
TreeFam:
Gene Tree for NEDD8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NEDD8: view image

Paralogs for NEDD8 Gene

(15) SIMAP similar genes for NEDD8 Gene using alignment to 3 proteins:

  • NEDD8_HUMAN
  • F8VSA6_HUMAN
  • Q96L81_HUMAN

Pseudogenes.org Pseudogenes for NEDD8 Gene

genes like me logo Genes that share paralogs with NEDD8: view

Variants for NEDD8 Gene

Additional dbSNP identifiers (rs#s) for NEDD8 Gene

Structural Variations from Database of Genomic Variants (DGV) for NEDD8 Gene

Variant ID Type Subtype PubMed ID
esv3633803 CNV loss 21293372

Variation tolerance for NEDD8 Gene

Residual Variation Intolerance Score: 57.6% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NEDD8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEDD8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NEDD8 Gene

Disorders for NEDD8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NEDD8 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
parkinson disease, late-onset
  • pd
myeloma, multiple
  • multiple myeloma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search NEDD8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NEDD8

genes like me logo Genes that share disorders with NEDD8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEDD8 Gene

Publications for NEDD8 Gene

  1. Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein. (PMID: 9353319) Kamitani T … Yeh ET (The Journal of biological chemistry 1997) 2 3 4 23 54
  2. Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. (PMID: 15242646) Xirodimas DP … Lane DP (Cell 2004) 3 4 23 54
  3. DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1. (PMID: 12759363) Wu K … Pan ZQ (The Journal of biological chemistry 2003) 3 4 23 54
  4. NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins. (PMID: 12730221) Mendoza HM … Hay RT (The Journal of biological chemistry 2003) 3 4 23 54
  5. The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. (PMID: 14690597) Walden H … Schulman BA (Molecular cell 2003) 3 4 23 54

Products for NEDD8 Gene

Sources for NEDD8 Gene