This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regula... See more...

Aliases for NEDD4 Gene

Aliases for NEDD4 Gene

  • NEDD4 E3 Ubiquitin Protein Ligase 2 3 5
  • NEDD4-1 2 3 4
  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase 2 3
  • Cell Proliferation-Inducing Gene 53 Protein 3 4
  • HECT-Type E3 Ubiquitin Transferase NEDD4 3 4
  • E3 Ubiquitin-Protein Ligase NEDD4 3 4
  • Receptor-Potentiating Factor 1 2 3
  • KIAA0093 2 4
  • RPF1 2 3
  • Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 4 4
  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 4 2
  • EC 2.3.2.26 4
  • MGC176705 2
  • EC 6.3.2 50
  • NEDD-4 4
  • NEDD4 5

External Ids for NEDD4 Gene

Previous GeneCards Identifiers for NEDD4 Gene

  • GC15M051677
  • GC15M049166
  • GC15M053698
  • GC15M053835
  • GC15M053906
  • GC15M056119
  • GC15M032943

Summaries for NEDD4 Gene

Entrez Gene Summary for NEDD4 Gene

  • This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]

GeneCards Summary for NEDD4 Gene

NEDD4 (NEDD4 E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Diseases associated with NEDD4 include Liddle Syndrome 1 and Pseudohypoaldosteronism. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and protein domain specific binding. An important paralog of this gene is NEDD4L.

UniProtKB/Swiss-Prot Summary for NEDD4 Gene

  • E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (PubMed:23644597). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046).
  • (Microbial infection) Involved in the ubiquitination of Ebola virus protein VP40 which plays a role in viral budding.

Gene Wiki entry for NEDD4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NEDD4 Gene

Genomics for NEDD4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NEDD4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J055990 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 258.9 +0.6 592 4.4 IKZF1 ZNF600 ZIC2 CEBPB SMAD5 FEZF1 TBP ZNF341 CTCF MAX NEDD4 lnc-RFX7-3 lnc-TEX9-6 PRTG CNOT6LP1 HSALNG0106102 piR-39858-215
GH15J055912 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 258.4 +78.2 78204 6.9 ZNF654 BRCA1 CEBPB FEZF1 CTCF MAX EP300 FOXA2 RAD21 RFX5 NEDD4 PRTG HSALNG0106095 MK280073-203 lnc-PRTG-2
GH15J055401 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11.9 +588.0 587995 7.9 ZNF207 IKZF1 NCOR1 MYC ZNF600 SIX5 ZNF592 ATF2 POLR2A CEBPA C15orf65 CCPG1 RSL24D1 NEDD4 PYGO1 DNAAF4 PIGBOS1 PIGB HSALNG0106073 RF00017-1607
GH15J055941 Enhancer 0.9 Ensembl ENCODE 18.7 +50.3 50259 4 CEBPA THAP11 FOXA2 SMAD4 MIER3 RARA KAT7 FOXP1 BCL6 KDM1A NEDD4 PRTG PIGB MK280073-203 lnc-PRTG-2 HSALNG0106095
GH15J055969 Enhancer 0.6 Ensembl ENCODE 18.9 +23.7 23727 1.7 HNF4A FOXA1 RFX1 BMI1 SREBF1 NEDD4 PRTG RFX7 lnc-PRTG-2 MK280144-204
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NEDD4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NEDD4

Top Transcription factor binding sites by QIAGEN in the NEDD4 gene promoter:
  • AREB6
  • FOXF2
  • LCR-F1
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • NF-kappaB1
  • Nkx2-5

Genomic Locations for NEDD4 Gene

Latest Assembly
chr15:55,826,917-55,993,660
(GRCh38/hg38)
Size:
166,744 bases
Orientation:
Minus strand

Previous Assembly
chr15:56,119,115-56,285,810
(GRCh37/hg19 by Entrez Gene)
Size:
166,696 bases
Orientation:
Minus strand

chr15:56,119,120-56,285,944
(GRCh37/hg19 by Ensembl)
Size:
166,825 bases
Orientation:
Minus strand

Genomic View for NEDD4 Gene

Genes around NEDD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEDD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEDD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEDD4 Gene

Proteins for NEDD4 Gene

  • Protein details for NEDD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46934-NEDD4_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase NEDD4
    Protein Accession:
    P46934
    Secondary Accessions:
    • A1KY35
    • A6ND72
    • A7MD29
    • B4E2R7
    • B7ZM59
    • B7ZM60
    • B9EGN5
    • D6RF89

    Protein attributes for NEDD4 Gene

    Size:
    1319 amino acids
    Molecular mass:
    149114 Da
    Quaternary structure:
    • Interacts with UBE2D2. Binds SCNN1A, SCNN1B and SCNN1G. Binds, in vitro, through the WW2 and WW3 domains, to neural isoforms of ENAH that contain the PPSY motif. Interacts with BEAN1, LITAF, RNF11, WBP1, WBP2, PMEPAI and PRRG2 (By similarity). Interacts with NDFIP1 and NDFIP2; this interaction activates the E3 ubiquitin-protein ligase and may induce its recruitment to exosomes (By similarity). Interaction with PTEN is questionable according to PubMed:18562292. Interacts (via C2 domain) with GRB10 (via SH2 domain). Interacts with ERBB4 (By similarity). Interacts with TNIK; the interaction is direct, allows the TNIK-dependent recruitment of RAP2A and its ubiquitination by NEDD4. Interacts (via WW3 domain) with TNK2; EGF promotes this interaction. Interacts (via WW3 domain) with FGFR1 (via C-terminus). Interacts with OTUD7B. Interacts with ISG15. Interacts (via WW domain) with RAPGEF2; this interaction leads to ubiquitination and degradation via the proteasome pathway. Interacts (via WW domains) with ARRDC3 (via PPXY motifs) (PubMed:20559325, PubMed:24379409). Interacts with LAPTM4B; may play a role in the lysosomal sorting of LAPTM4B (PubMed:22096579). Interacts (via WW domains) with ARRDC1, ARRDC2 and ARRDC3 (PubMed:21191027). Interacts with ZBTB7B (By similarity). Interacts with PRRG4 (via cytoplasmic domain) (PubMed:23873930).
    • (Microbial infection) Interacts with viral proteins that contain a late-budding motif P-P-P-Y. This interaction is essential for viral particle budding of many retroviruses, like HTLV-1 Gag and MLV Gag. Interacts with Herpes simplex virus 2 (HHV-2) protein UL56; this interaction induces NEDD4 degradation (PubMed:18353951). Interacts with Ebola virus protein VP40 (PubMed:12559917).
    SequenceCaution:
    • Sequence=BAA07655.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • A cysteine residue is required for ubiquitin-thioester formation.

    Three dimensional structures from OCA and Proteopedia for NEDD4 Gene

    Alternative splice isoforms for NEDD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEDD4 Gene

Selected DME Specific Peptides for NEDD4 Gene

P46934:
  • FFIRPFYKMML
  • PLPPGWE
  • TQWEDPR
  • KNKKEYI
  • DHNTKTTTW
  • NPYYGLF
  • HTCFNRLDLPPY
  • RLLQFVTG
  • AGMAVYHGKLLD
  • HLSYFKF

Post-translational modifications for NEDD4 Gene

Domains & Families for NEDD4 Gene

Gene Families for NEDD4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Transporters

Protein Domains for NEDD4 Gene

InterPro:
Blocks:
  • C2 domain
  • HECT domain (Ubiquitin-protein ligase)

Suggested Antigen Peptide Sequences for NEDD4 Gene

GenScript: Design optimal peptide antigens:
  • Neural precursor cell expressed developmentally down-regulated protein 4 (NEDD4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P46934

UniProtKB/Swiss-Prot:

NEDD4_HUMAN :
  • The WW domains mediate interaction with PPxY motif-containing proteins (PubMed:21191027). The WW domains mediate interaction with LITAF, RNF11, WBP1, WBP2, PMEPAI, NDFIP1 and PRRG2 (By similarity).
Domain:
  • The WW domains mediate interaction with PPxY motif-containing proteins (PubMed:21191027). The WW domains mediate interaction with LITAF, RNF11, WBP1, WBP2, PMEPAI, NDFIP1 and PRRG2 (By similarity).
genes like me logo Genes that share domains with NEDD4: view

Function for NEDD4 Gene

Molecular function for NEDD4 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (PubMed:23644597). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Involved in the ubiquitination of Ebola virus protein VP40 which plays a role in viral budding.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Evidence={ECO:0000269|PubMed:17218260, ECO:0000269|PubMed:21399620};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by NDFIP1- and NDFIP2-binding.
GENATLAS Biochemistry:
neural precursor cell expressed gene 4,developmentally down-regulated 4,expressed in embryonic and adult tissues,homolog to ubiquitin-protein ligases (E3) and to yeast RSP5

Enzyme Numbers (IUBMB) for NEDD4 Gene

Phenotypes From GWAS Catalog for NEDD4 Gene

Gene Ontology (GO) - Molecular Function for NEDD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding IPI 9305852
GO:0016740 transferase activity IEA --
GO:0019871 sodium channel inhibitor activity IBA,IDA 10642508
GO:0019899 enzyme binding IPI 26006083
genes like me logo Genes that share ontologies with NEDD4: view
genes like me logo Genes that share phenotypes with NEDD4: view

Animal Models for research

  • Taconic Biosciences Mouse Models for NEDD4

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEDD4

Clone products for research

  • Addgene plasmids for NEDD4

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEDD4 Gene

Localization for NEDD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEDD4 Gene

Cytoplasm. Cell membrane. Peripheral membrane protein. Note=Recruited to the plasma membrane by GRB10. Once complexed with GRB10 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity). May be recruited to exosomes by NDFIP1. {ECO:0000250, ECO:0000269 PubMed:18819914}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEDD4 gene
Compartment Confidence
plasma membrane 5
cytosol 5
golgi apparatus 5
extracellular 4
cytoskeleton 3
nucleus 3
endosome 3
lysosome 3
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NEDD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex ISS --
GO:0000785 chromatin IDA 17996703
GO:0005737 cytoplasm IBA,IDA 12796489
GO:0005794 Golgi apparatus IDA 16118794
GO:0005829 cytosol ISS,TAS 9405440
genes like me logo Genes that share ontologies with NEDD4: view

Pathways & Interactions for NEDD4 Gene

genes like me logo Genes that share pathways with NEDD4: view

Pathways by source for NEDD4 Gene

2 GeneGo (Thomson Reuters) pathways for NEDD4 Gene
  • CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)
  • G-protein signaling_Rap1A regulation pathway
1 Qiagen pathway for NEDD4 Gene
  • Aldosterone Signaling in Epithelial Cells

UniProtKB/Swiss-Prot P46934-NEDD4_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for NEDD4 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NEDD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA 21873635
GO:0006511 ubiquitin-dependent protein catabolic process IMP 17218260
GO:0006622 protein targeting to lysosome IPI 17116753
GO:0007041 lysosomal transport IDA 18544533
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with NEDD4: view

Drugs & Compounds for NEDD4 Gene

(7) Drugs for NEDD4 Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Warfarin Approved Pharma 637
Adenosine monophosphate Approved, Investigational Nutra 0
Phosphate Experimental Pharma 0
ATP Investigational Nutra 0

(2) Additional Compounds for NEDD4 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(HO)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • Pyrophosphoric acid
14000-31-8
genes like me logo Genes that share compounds with NEDD4: view

Transcripts for NEDD4 Gene

mRNA/cDNA for NEDD4 Gene

6 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEDD4

Clone products for research

  • Addgene plasmids for NEDD4

Alternative Splicing Database (ASD) splice patterns (SP) for NEDD4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - - - -
SP2:
SP3: -
SP4: - - -
SP5:
SP6:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31
SP1:
SP2:
SP3:
SP4:
SP5: - -
SP6:

Relevant External Links for NEDD4 Gene

GeneLoc Exon Structure for
NEDD4

Expression for NEDD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NEDD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NEDD4 Gene

This gene is overexpressed in Muscle - Skeletal (x15.6).

Protein differential expression in normal tissues from HIPED for NEDD4 Gene

This gene is overexpressed in Placenta (14.8), Peripheral blood mononuclear cells (11.6), and Gallbladder (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NEDD4 Gene



Protein tissue co-expression partners for NEDD4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NEDD4

SOURCE GeneReport for Unigene cluster for NEDD4 Gene:

Hs.1565

Evidence on tissue expression from TISSUES for NEDD4 Gene

  • Nervous system(4.5)
  • Bone marrow(4.3)
  • Liver(3.3)
  • Muscle(2.9)
  • Kidney(2.6)
  • Skin(2.5)
  • Blood(2.2)
  • Heart(2.2)
  • Intestine(2.2)
  • Lung(2)
genes like me logo Genes that share expression patterns with NEDD4: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEDD4 Gene

Orthologs for NEDD4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NEDD4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NEDD4 30
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia NEDD4 29 30
  • 92.09 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NEDD4 29 30
  • 92.05 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia NEDD4 30
  • 76 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Nedd4 30
  • 72 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NEDD4 30
  • 61 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NEDD4 29 30
  • 73 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 89 (a)
OneToMany
-- 30
  • 47 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nedd4 29
  • 69.12 (n)
Zebrafish
(Danio rerio)
Actinopterygii NEDD4 30
  • 56 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Nedd4 30 31
  • 41 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea Y92H12A.2 30 31
  • 48 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSP5 30
  • 36 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 61 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.1579 29
Species where no ortholog for NEDD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for NEDD4 Gene

ENSEMBL:
Gene Tree for NEDD4 (if available)
TreeFam:
Gene Tree for NEDD4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NEDD4: view image
Alliance of Genome Resources:
Additional Orthologs for NEDD4

Paralogs for NEDD4 Gene

(13) SIMAP similar genes for NEDD4 Gene using alignment to 5 proteins:

  • NEDD4_HUMAN
  • H0Y8H4_HUMAN
  • H0Y8X6_HUMAN
  • H0Y9L1_HUMAN
  • H0YA37_HUMAN
genes like me logo Genes that share paralogs with NEDD4: view

Variants for NEDD4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NEDD4 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs10718511 Benign: not specified 55,951,594(-) TA/T
NM_006154.4(NEDD4):c.120-6del
INTRON
rs111308798 Likely Benign: not provided 55,916,624(-) C/G
NM_006154.4(NEDD4):c.291+8022G>C
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON
rs113502754 Likely Benign: not provided 55,916,547(-) C/T
NM_006154.4(NEDD4):c.291+8099G>A
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON
rs115484917 Benign: not provided 55,916,745(-) G/T
NM_006154.4(NEDD4):c.291+7901C>A
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON
rs12593255 Benign: not provided 55,916,336(-) C/T
NM_006154.4(NEDD4):c.291+8310G>A
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NEDD4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NEDD4 Gene

Variant ID Type Subtype PubMed ID
dgv319n27 CNV loss 19166990
dgv4548n54 CNV loss 21841781
esv2749725 CNV deletion 23290073
esv2761872 CNV gain 21179565
esv2761966 CNV loss 21179565
esv3374198 CNV insertion 20981092
esv3569620 CNV gain 25503493
esv3636572 CNV gain 21293372
esv3636573 CNV gain 21293372
esv3892698 CNV loss 25118596
nsv1543 CNV insertion 18451855
nsv509571 CNV insertion 20534489
nsv528617 CNV loss 19592680
nsv569539 CNV loss 21841781
nsv569542 CNV loss 21841781
nsv819986 CNV loss 19587683
nsv833017 CNV loss 17160897

Variation tolerance for NEDD4 Gene

Residual Variation Intolerance Score: 65.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.02; 84.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NEDD4 Gene

Human Gene Mutation Database (HGMD)
NEDD4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEDD4
Leiden Open Variation Database (LOVD)
NEDD4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEDD4 Gene

Disorders for NEDD4 Gene

MalaCards: The human disease database

(19) MalaCards diseases for NEDD4 Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards
Search NEDD4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NEDD4

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with NEDD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEDD4 Gene

Publications for NEDD4 Gene

  1. PPPYVEPTAP motif is the late domain of human T-cell leukemia virus type 1 Gag and mediates its functional interaction with cellular proteins Nedd4 and Tsg101 [corrected]. (PMID: 14581525) Bouamr F … Goff SP (Journal of virology 2003) 3 4 22
  2. Nedd4 regulates ubiquitination and stability of the guanine-nucleotide exchange factor CNrasGEF. (PMID: 11598133) Pham N … Rotin D (The Journal of biological chemistry 2001) 3 4 22
  3. cDNA cloning, expression analysis, and mapping of the mouse Nedd4 gene. (PMID: 9073511) Kumar S … Jenkins NA (Genomics 1997) 2 3 22
  4. Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response. (PMID: 25631046) Low LH … Tan SS (The Journal of biological chemistry 2015) 3 4
  5. Structural and biochemical basis for ubiquitin ligase recruitment by arrestin-related domain-containing protein-3 (ARRDC3). (PMID: 24379409) Qi S … Hurley JH (The Journal of biological chemistry 2014) 3 4

Products for NEDD4 Gene

Sources for NEDD4 Gene